Free for academic non-profit institutions. Other users need a Commercial license

PLXNB2 Gene(Protein Coding)

Plexin B2

GCID:
GC22M050274
GIFtS:
53
Genes Participants
UDN Logo

Aliases for PLXNB2 Gene

Aliases for PLXNB2 Gene

  • Plexin B2 2 3 5
  • MM1 3 4
  • DJ402G11.3 3
  • Nbla00445 3
  • KIAA0315 4
  • PLEXB2 3

External Ids for PLXNB2 Gene

Previous GeneCards Identifiers for PLXNB2 Gene

  • GC22M047264
  • GC22M048895
  • GC22M049016
  • GC22M049055
  • GC22M050713
  • GC22M033610

Summaries for PLXNB2 Gene

Entrez Gene Summary for PLXNB2 Gene

  • Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PLXNB2 Gene

PLXNB2 (Plexin B2) is a Protein Coding gene. Among its related pathways are Axon guidance. GO annotations related to this gene include receptor activity and semaphorin receptor activity. An important paralog of this gene is PLXNB3.

UniProtKB/Swiss-Prot for PLXNB2 Gene

  • Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at Tyr-1248. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity).

Gene Wiki entry for PLXNB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLXNB2 Gene

Genomics for PLXNB2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for PLXNB2 Gene

Enhancers for PLXNB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLXNB2 on UCSC Golden Path with GeneCards custom track

Promoters for PLXNB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLXNB2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PLXNB2 gene promoter:

Genomic Location for PLXNB2 Gene

Chromosome:
22
Start:
50,274,979 bp from pter
End:
50,307,642 bp from pter
Size:
32,664 bases
Orientation:
Minus strand

Genomic View for PLXNB2 Gene

Genes around PLXNB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLXNB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLXNB2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PLXNB2 Gene

Proteins for PLXNB2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PLXNB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15031-PLXB2_HUMAN
    Recommended name:
    Plexin-B2
    Protein Accession:
    O15031
    Secondary Accessions:
    • A6QRH0
    • Q7KZU3
    • Q9BSU7

    Protein attributes for PLXNB2 Gene

    Size:
    1838 amino acids
    Molecular mass:
    205127 Da
    Quaternary structure:
    • Monomer, and heterodimer with PLXNB1. Interacts with SEMA4C, SEMA4D and SEMA4G (By similarity). Binds MET, ARHGEF11 and ARHGEF12. May also interact with MST1R.
    SequenceCaution:
    • Sequence=BAA21571.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLXNB2 Gene

neXtProt entry for PLXNB2 Gene

Proteomics data for PLXNB2 Gene at MOPED

Protein Expression for PLXNB2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PLXNB2 Gene

  • Ubiquitination at Lys 1423
  • Glycosylation at Asn 127, Asn 242, Asn 391, Asn 402, Asn 528, Asn 733, Asn 759, Asn 795, Asn 844, Asn 1002, Asn 1049, Asn 1068, and Asn 1099
  • Modification sites at PhosphoSitePlus

Other Protein References for PLXNB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLXNB2 Gene

Domains & Families for PLXNB2 Gene

Gene Families for PLXNB2 Gene

HGNC:

Protein Domains for PLXNB2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PLXNB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15031

UniProtKB/Swiss-Prot:

PLXB2_HUMAN :
  • Contains 3 IPT/TIG domains.
  • Belongs to the plexin family.
Domain:
  • Contains 3 IPT/TIG domains.
  • Contains 1 Sema domain.
Family:
  • Belongs to the plexin family.
genes like me logo Genes that share domains with PLXNB2: view

Function for PLXNB2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for PLXNB2 Gene

GENATLAS Biochemistry:
plexin B2,calcium-dependent cell adhesion molecule at the neuronal cell surface,receptor for the semaphorin 7A (SEMA7A),expressed in brain and differentially in brain tumors
UniProtKB/Swiss-Prot Function:
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at Tyr-1248. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity).

Phenotypes for PLXNB2 Gene

MGI mutant phenotypes for PLXNB2:
inferred from 4 alleles
GenomeRNAi human phenotypes for PLXNB2:
genes like me logo Genes that share phenotypes with PLXNB2: view

Animal Models for PLXNB2 Gene

MGI Knock Outs for PLXNB2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLXNB2

miRNA for PLXNB2 Gene

miRTarBase miRNAs that target PLXNB2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLXNB2 Gene

Localization for PLXNB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLXNB2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLXNB2 Gene COMPARTMENTS Subcellular localization image for PLXNB2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLXNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PLXNB2: view

Pathways & Interactions for PLXNB2 Gene

SuperPathways for PLXNB2 Gene

PathCards logoMore details on SuperPathways for PLXNB2
Superpath Contained pathways
1 Axon guidance
Axon guidance
1
genes like me logo Genes that share pathways with PLXNB2: view

Pathways by source for PLXNB2 Gene

1 KEGG pathway for PLXNB2 Gene

Gene Ontology (GO) - Biological Process for PLXNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007405 neuroblast proliferation ISS --
GO:0008360 regulation of cell shape ISS --
GO:0030334 regulation of cell migration IBA --
GO:0050772 positive regulation of axonogenesis IBA --
genes like me logo Genes that share ontologies with PLXNB2: view

No data available for SIGNOR curated interactions for PLXNB2 Gene

Drugs & Compounds for PLXNB2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for PLXNB2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for PLXNB2 Gene

(8) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(478) Selected AceView cDNA sequences:
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLXNB2 Gene

Plexin B2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLXNB2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ·
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10: - - - - - - - - - - - - - - - - - - - - - -
SP11:
SP12: - -
SP13: - -
SP14: - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23: - - - -
SP24: -
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:

ExUns: 13c ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16: -
SP17: -
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: - - -
SP26:
SP27:
SP28:
SP29:
SP30:

ExUns: 28a · 28b ^ 29a · 29b ^ 30a · 30b · 30c ^ 31 ^ 32 ^ 33a · 33b · 33c ^ 34a · 34b · 34c ^ 35 ^ 36a · 36b ^ 37
SP1:
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: - - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28: - -
SP29:
SP30:

Relevant External Links for PLXNB2 Gene

GeneLoc Exon Structure for
PLXNB2
ECgene alternative splicing isoforms for
PLXNB2

Expression for PLXNB2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for PLXNB2 Gene

mRNA expression in normal human tissues for PLXNB2 Gene
mRNA expression by BioGPS for PLXNB2 GenemRNA expression by GTEx for PLXNB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLXNB2 Gene

This gene is overexpressed in Nasal epithelium (27.0) and Bone (17.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLXNB2 Gene



SOURCE GeneReport for Unigene cluster for PLXNB2 Gene Hs.3989

genes like me logo Genes that share expression patterns with PLXNB2: view

Protein tissue co-expression partners for PLXNB2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PLXNB2 Gene

Orthologs for PLXNB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLXNB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia PLXNB2 35
  • 86.42 (n)
  • 87.45 (a)
PLXNB2 36
  • 87 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia PLXNB2 35
  • 87.4 (n)
  • 89.66 (a)
PLXNB2 36
  • 90 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Plxnb2 35
  • 84.58 (n)
  • 87.73 (a)
Plxnb2 16
Plxnb2 36
  • 87 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia PLXNB2 35
  • 97.32 (n)
  • 96.87 (a)
rat
(Rattus norvegicus)
 Mammalia Plxnb2 35
  • 83.99 (n)
  • 88.28 (a)
oppossum
(Monodelphis domestica)
 Mammalia PLXNB2 36
  • 77 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia PLXNB2 36
  • 63 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves PLXNB2 35
  • 63.52 (n)
  • 68.3 (a)
PLXNB2 36
  • 61 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia PLXNB2 36
  • 66 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii plxnb2a 35
  • 58.79 (n)
  • 53.82 (a)
wufb75d06 35
PLXNB2 (3 of 5) 36
  • 34 (a)
 OneToMany
PLXNB2 (4 of 5) 36
  • 35 (a)
 OneToMany
plxnb2a 36
  • 51 (a)
 OneToMany
plxnb2a 36
  • 36 (a)
 OneToMany
plxnb2b 36
  • 37 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta plexB 36
  • 28 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea plx-2 36
  • 26 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 36 (a)
 OneToMany
Species with no ortholog for PLXNB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLXNB2 Gene

ENSEMBL:
Gene Tree for PLXNB2 (if available)
TreeFam:
Gene Tree for PLXNB2 (if available)

Paralogs for PLXNB2 Gene

Paralogs for PLXNB2 Gene

(12) SIMAP similar genes for PLXNB2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PLXNB2: view

Variants for PLXNB2 Gene

Sequence variations from dbSNP and Humsavar for PLXNB2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs28379706 - 50,289,633(+) CACCT(C/T)GTCCA reference, missense
rs11547731 - 50,283,705(-) TCACC(A/G)TCCTG reference, missense
rs14186 -- 50,275,194(-) TCTGG(A/G)TGGAC utr-variant-3-prime
rs7510738 -- 50,276,425(+) GGGCA(C/G)GGCCT intron-variant
rs34130750 -- 50,288,038(+) AACAC(-/C)TAGGG splice-acceptor-variant

Structural Variations from Database of Genomic Variants (DGV) for PLXNB2 Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
dgv5051n71 CNV Loss 21882294
dgv5054n71 CNV Loss 21882294
dgv781n67 CNV Gain 20364138
nsv914517 CNV Loss 21882294
dgv5058n71 CNV Loss 21882294
nsv914523 CNV Loss 21882294
nsv914524 CNV Loss 21882294
nsv914525 CNV Loss 21882294
dgv5059n71 CNV Loss 21882294
dgv5060n71 CNV Loss 21882294
dgv5061n71 CNV Loss 21882294
esv1579920 CNV Insertion 17803354
esv2724763 CNV Deletion 23290073
esv1272171 CNV Insertion 17803354
nsv191216 CNV Insertion 16902084

Variation tolerance for PLXNB2 Gene

Residual Variation Intolerance Score: 4.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.07; 75.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PLXNB2 Gene

Disorders for PLXNB2 Gene

Relevant External Links for PLXNB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLXNB2

No disorders were found for PLXNB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLXNB2 Gene

Publications for PLXNB2 Gene

  1. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. (PMID: 12183458) Perrot V. … Gutkind J.S. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. Functional regulation of semaphorin receptors by proprotein convertases. (PMID: 12533544) Artigiani S. … Tamagnone L. (J. Biol. Chem. 2003) 3 23
  3. Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates. (PMID: 10520995) Tamagnone L. … Comoglio P.M. (Cell 1999) 2 3
  4. Endometrial apical glycoproteomic analysis reveals roles for cadherin 6, desmoglein-2 and plexin b2 in epithelial integrity. (PMID: 25237006) Singh H. … Aplin J.D. (Mol. Hum. Reprod. 2015) 3
  5. Plexin-B2 promotes invasive growth of malignant glioma. (PMID: 25762646) Le A.P. … Friedel R.H. (Oncotarget 2015) 3

Products for PLXNB2 Gene

Sources for PLXNB2 Gene

Content