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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PLXNB1 Gene

protein-coding GIFtS: 66
GCID: GC03M048420

plexin B1

(Previous symbol: PLXN5)

Explore 22 diseases affiliated with
PLXNB1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Plexin B1¹ ²		Semaphorin Receptor SEP² ³
SEP¹ ² ³ ⁵		PLEXIN-B1²
PLXN5¹ ² ³		Plexin 5²
KIAA0407¹ ³		Plexin-B1¹

External Ids:	HGNC: 9103¹	Entrez Gene: 5364²	Ensembl: ENSG00000164050⁷	OMIM: 601053⁵	UniProtKB: O43157³

Export aliases for PLXNB1 gene to outside databases

Previous GC identifers: GC03M048246 GC03M047727 GC03M048405

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PLXB1_HUMAN, O43157

Function: Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays

a role in axon guidance, invasive growth and cell migration

Gene Wiki entry for PLXNB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PLXNB1 gene promoter:
HEN1 p53
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PLXNB1 promoter sequence

Search SABiosciences Chromatin IP Primers for PLXNB1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLXNB1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.31

PLXNB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLXNB1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M048420: view genomic region (about GC identifiers)

Start:	48,445,261 bp from pter	End:	48,471,594 bp from pter
Size:	26,334 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PLXB1_HUMAN, O43157 (See protein sequence)

Recommended Name: Plexin-B1 precursor

Size: 2135 amino acids; 232298 Da

Subunit: Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP

binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Binds PLXNA1 (By similarity). Interacts with

ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RRAS, RHOD, RND1, NRP1 and NRP2

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Secreted

Subcellular location: Isoform 3: Secreted

Sequence caution: Sequence=BAA23703.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

6/8 PDB 3D structures from and Proteopedia for PLXNB1 (see all 8):

2JPH (3D)

2OS6 (3D)

2R2O (3D)

2REX (3D)

3HM6 (3D)

3OL2 (3D)

Secondary accessions: A6H8Y2 Q6NY20 Q9UIV7 Q9UJ92 Q9UJ93

Alternative splicing: 3 isoforms: O43157-1 O43157-2 O43157-3

Explore the universe of human proteins at neXtProt for PLXNB1: NX_O43157

Post-translational modifications:

Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding¹

Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O43157

PLXNB1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001123554.1 NP_002664.2

ENSEMBL proteins:

ENSP00000296440 ENSP00000351338 ENSP00000414199 ENSP00000395987 ENSP00000351242

ENSP00000389320

Reactome Protein details: O43157
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: PLXNB1 OriGene Custom Protein Services for PLXNB1
	GenScript Custom Purified and Recombinant Proteins Services for PLXNB1
	Novus Biologicals PLXNB1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PLXNB1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002116	semaphorin receptor complex	TAS	19909241
GO:0005576	extracellular region	IEA	--
GO:0005622	intracellular	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	NAS	10520995

PLXNB1 for ontologies About GeneDecksing

PLXNB1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PLXNB1
	R&D Systems Antibodies for PLXNB1 (Plexin B1)
	OriGene Antibodies: PLXNB1 OriGene Custom Antibody Services for PLXNB1
	GenScript Custom Superior Antibodies Services for PLXNB1
	Novus Biologicals PLXNB1 Antibody
	Search for Antibodies for PLXNB1 at Abcam
	Uscn Antibodies for PLXNB1
	Search ThermoFisher Antibodies for PLXNB1

Assay Products for PLXNB1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PLXNB1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PLXNB1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PLXNB1 for domains About GeneDecksing

5/11 InterPro domains/families (see all 11):

IPR014756 Ig_E-set

IPR002165 Plexin_repeat

IPR002909 IPT_TIG_rcpt

IPR008936 Rho_GTPase_activation_prot

IPR013783 Ig-like_fold

Graphical View of Domain Structure for InterPro Entry O43157

ProtoNet protein and cluster: O43157

1 Blocks protein family: IPB013548 Plexin cytoplasmic region

UniProtKB/Swiss-Prot: PLXB1_HUMAN, O43157

Similarity: Belongs to the plexin family

Similarity: Contains 3 IPT/TIG domains

Similarity: Contains 1 Sema domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PLXB1_HUMAN, O43157

Function: Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays

a role in axon guidance, invasive growth and cell migration

Genatlas biochemistry entry for PLXNB1:

plexin B1,calcium-dependent cell adhesion molecule at the neuronal cell surface,also expressed in hematopoietic and

endothelial cells,receptor for the semaphorin,homologous to the hepatocyte growth factor receptor family

miRNA Products:		miRTarBase miRNAs that target PLXNB1: hsa-mir-214 (MIRT005765)

		OriGene 3'-UTR Clone (see all 2): PLXNB1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLXNB1
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate PLXNB1 (see all 10):
		hsa-miR-15a hsa-miR-497 hsa-miR-3667-3p hsa-miR-424 hsa-miR-501-5p hsa-miR-362-5p hsa-miR-195 hsa-miR-16

		SwitchGear 3'UTR luciferase reporter plasmid: PLXNB1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLXNB1 (see all 7) OriGene shRNA RFP: PLXNB1 OriGene siRNA: PLXNB1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLXNB1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PLXNB1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 2): PLXNB1 (NM_002673)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLXNB1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLXNB1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PLXNB1
		Search LifeMap BioReagents cell lines for PLXNB1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXNB1

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	8570614
GO:0004888	transmembrane signaling receptor activity	NAS	10520995
GO:0005096	GTPase activator activity	--	--
GO:0005515	protein binding	IPI	--
GO:0017154	semaphorin receptor activity	TAS	10520995

PLXNB1 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for PLXNB1:

Decreased focal adhesion (FA)

Decreased viability with TRAIL

Elongated cells with protrusio

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for PLXNB1: Plxnb1^tm1Rkun Plxnb1^tm1Mom
5 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Plxnb1):

nervous system

no phenotypic analysis

normal

renal/urinary system

vision/eye

PLXNB1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Sema4D in semaphorin signaling

	Sema4D in semaphorin signaling	1.00			Semaphorin interactions	0.44
	Sema4D induced cell migration and growth-cone collapse	0.83

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Axon guidance

Axon guidance

1.00

Developmental Biology

0.69

Neurophysiological process Receptor-mediated axon growth repulsion

Neurophysiological process Receptor-mediated axon growth repulsion

1.00

Neurophysiological process_Receptor-mediated axon growth repulsion

0.94

Sema4D mediated inhibition of cell attachment and migration

Sema4D mediated inhibition of cell attachment and migration

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PLXNB1

Neurophysiological process Receptor-mediated axon growth repulsion

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLXNB1

	Guidance Cues and Growth Cone Motility
	Semaphorin Signaling

1 GeneGo (Thomson Reuters) Pathway for PLXNB1

Neurophysiological process Receptor-mediated axon growth repulsion

5/10 Reactome Pathways for PLXNB1 (see all 10)

	GPCR downstream signaling
	Developmental Biology
	G alpha (12/13) signalling events
	Signaling by GPCR
	Sema4D induced cell migration and growth-cone collapse

1 Kegg Pathway (Kegg details for PLXNB1):

Axon guidance

PLXNB1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PLXNB1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/34 Interacting proteins for PLXNB1 (O43157^{1, 2, 3} ENSP00000296440⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 34)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MET	P08581¹^,²^,³, ENSP00000317272⁴	EBI-1111488,EBI-1039152 MINT-49661 MINT-49668 I2D: score=3 STRING: ENSP00000317272
RND1	Q92730²^,³, ENSP00000308461⁴	MINT-16324 MINT-16325 I2D: score=6 STRING: ENSP00000308461
MRAS	O14807²^,³, ENSP00000289104⁴	MINT-7228875 I2D: score=1 STRING: ENSP00000289104
MST1R	Q04912¹^,³, ENSP00000296474⁴	EBI-1111488,EBI-2637518 I2D: score=1 STRING: ENSP00000296474
SEMA4A	Q9H3S1²^,³, ENSP00000347117⁴	MINT-4507855 I2D: score=1 STRING: ENSP00000347117

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	8570614
GO:0007411	axon guidance	TAS	--
GO:0008360	regulation of cell shape	IDA	19843518
GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	ISS	--
GO:0016477	cell migration	NAS	10520995

PLXNB1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PLXNB1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PLXNB1

1 HMDB Compound for PLXNB1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

4 Novoseek chemical compound relationships for PLXNB1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	47.4	23	19805522 (3), 16055703 (3), 19433062 (2), 15210733 (2) (see all 13)
guanosine	36.8	1	18321527 (1)
phosphatidylinositol	12.5	1	17855350 (1)
arginine	0	2	15210733 (1), 14712228 (1)

Search CenterWatch for drugs/clinical trials and news about PLXNB1 / PLXB1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PLXNB1 gene (2 alternative transcripts):

NM_001130082.1 NM_002673.4

Unigene Cluster for PLXNB1:

Plexin B1

Hs.476209 [show with all ESTs]

Unigene Representative Sequence: BC146793

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000296440(uc003csu.2 uc003csx.2) ENST00000485535(uc003cst.2)

ENST00000358536(uc003csw.2) ENST00000456774 ENST00000483753 ENST00000497627

ENST00000483676 ENST00000478171 ENST00000470525 ENST00000461261 ENST00000473996

ENST00000449094(uc003csy.1) ENST00000465117 ENST00000467913 ENST00000464294

ENST00000484485 ENST00000462738 ENST00000466353

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PLXNB1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLXNB1
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate PLXNB1 (see all 10):
		hsa-miR-15a hsa-miR-497 hsa-miR-3667-3p hsa-miR-424 hsa-miR-501-5p hsa-miR-362-5p hsa-miR-195 hsa-miR-16

		SwitchGear 3'UTR luciferase reporter plasmid: PLXNB1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLXNB1 (see all 7) OriGene shRNA RFP: PLXNB1 OriGene siRNA: PLXNB1
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		GenScript: all cDNA clones in your preferred vector (see all 2): PLXNB1 (NM_002673)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLXNB1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLXNB1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLXNB1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PLXNB1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLXNB1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLXNB1

Additional cDNA sequence:

AB007867.1 AJ011415.1 AK091832.1 AK092609.1 AK296776.1 BC066773.1 BC127793.1 BC129947.1

BC146793.1 X87904.2

20 DOTS entries:

DT.95180011 DT.100785290 DT.101956392 DT.220348 DT.92444253 DT.92444266 DT.91686892 DT.120886190

DT.91658702 DT.91747488 DT.95352688 DT.100785291 DT.120886196 DT.92039943 DT.92444254 DT.92444262

DT.92444269 DT.95180020 DT.95186413 DT.95260010

24/900 AceView cDNA sequences (see all 900):

CR593606 CR598876 BE886721 BQ669718 BM458412 BM457644 BM710896 CR605105

BP373320 CR617710 CF146474 BQ927328 BM920526 BU557089 CR620430 CR596912

CA447885 BU180311 BU849964 BQ653160 AA643057 CR624287 BM917854 CR608469

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for PLXNB1 (see all 14) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	·	12c	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b	^	19a	·	19b	^
SP1:																																													-
SP2:																													-																-
SP3:																											-		-																-
SP4:
SP5:

ExUns:	20	^	21	^	22a	·	22b	^	23a	·	23b	^	24a	·	24b	·	24c	^	25	^	26a	·	26b	^	27a	·	27b	^	28	^	29	^	30	^	31a	·	31b	·	31c	^	32	^	33	^	34a	·	34b	^	35a	·	35b	^
SP1:																			-																										-
SP2:																			-																										-
SP3:
SP4:																																													-
SP5:

ExUns:	36	^	37	^	38	^	39	^	40a	·	40b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for PLXNB1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PLXNB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGAGGGCTA

About this image

PLXNB1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PLXNB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLXNB1

SOURCE GeneReport for Unigene cluster: Hs.476209

UniProtKB/Swiss-Prot: PLXB1_HUMAN, O43157

Tissue specificity: Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver

SABiosciences Custom PCR Arrays for PLXNB1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLXNB1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXNB1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PLXNB1 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PLXNB1¹	plexin B1	68.45(n) 69.56(a)		100859325 XM_003642011.1 XP_003642059.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	86(a) 57(a)	1 ↔ many 1 ↔ many	2(190637300-190647265) 2(190551956-190636204)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.10773²	Transcribed sequence with moderate similarity to protein more	76.04(n)		BX733874.1
zebrafish (Danio rerio)	Actinopterygii	wufb83a09²	Transcribed sequence with moderate similarity to protein more	79.81(n)		BG304969.1
fruit fly (Drosophila melanogaster)	Insecta	plexB³	axon guidance semaphorin receptor	40(a)		102A1 --
worm (Caenorhabditis elegans)	Secernentea	plx-2³	--	28(a)		II(14413677-14421269) --

ENSEMBL Gene Tree for PLXNB1 (if available)
TreeFam Gene Tree for PLXNB1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PLXNB1 gene

PLXNB2² PLXND1² PLXNA3² PLXNA1² PLXNA2² PLXNC1² PLXNB3² PLXNA4²

7 SIMAP similar genes for PLXNB1 using alignment to 3 protein entries: PLXB1_HUMAN (see all proteins):

DKFZp761P19121 Nbla00445 PLXNB3 PLXNB2 PLXND1 PLXNC1

MM1

PLXNB1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145675426^1,2		--	48444884(+)	`GCCCTC/TGAGAC`	2	--	int¹		0	--	--	--	--
rs189352044^1,2		--	48445004(+)	`CCCCCC/TTGAAG`	2	--	int¹		0	--	--	--	--
rs201362693^1,2		--	48445188(+)	`TCCCC-/CTGGTAC`	2	--	int¹		0	--	--	--	--
rs147317706^1,2		--	48445239(+)	`TAGGCC/TGGGCT`	2	--	int¹		0	--	--	--	--
rs182000547^1,2		--	48445409(+)	`TGTAGC/TGGCCT`	2	--	ut3¹		0	--	--	--	--
rs1061488^1,2	C	--	48445506(-)	`CCTGTC/TTGCCT`	2	--	ut3¹		3		MN NA	188
rs186236865^1,2		--	48445541(+)	`CTCCGA/GATCCC`	2	--	ut3¹		0	--	--	--	--
rs76859970^1,2	C,F,	--	48445571(+)	`TTCAGG/AAACAG`	2	--	ut3¹		1		WA	118
rs140998624^1,2		--	48445593(+)	`CAGGGA/GCCTGG`	2	--	ut3¹		0	--	--	--	--
rs201621064^1,2	C	--	48445606(-)	`GCTGGA/GAGAGA`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PLXNB1 (48445261 - 48471594 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PLXNB1: --
Human Gene Mutation Database (HGMD): PLXNB1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLXNB1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PLXNB1 for disorders           About GeneDecksing

OMIM gene information: 601053    OMIM disorders: --

20/22 diseases for PLXNB1 (see all 22):    About MalaCards

estrogen-receptor positive breast cancer chronic lymphocytic leukemia acute myeloid leukemia lymphocytic leukemia

myeloid leukemia renal cell carcinoma breast cancer leukemia

cervical cancer cervicitis periodontitis ovarian cancer

pancreatic cancer prostate cancer pancreatitis carcinoma

hypoxia retinitis prostatitis schizophrenia

4 Novoseek disease relationships for PLXNB1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	26.5	1	20164843 (1)
cancer	12.8	7	19461072 (1), 17204469 (1), 19805522 (1), 16055703 (1) (see all 6)
tumors	10.6	20	19483722 (4), 18818766 (3), 20164843 (2), 17317819 (2) (see all 8)
carcinoma squamous cell	0	1	16754882 (1)

Human Genome Epidemiology (HuGE) Navigator: PLXNB1 (1 document)

Export disorders for PLXNB1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PLXNB1 gene, integrated from 9 sources (see all 123):
(articles sorted by number of sources associating them with PLXNB1)

Utopia: connect your pdf to the dynamic
world of online information

The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner. (PubMed id 11035813)^{1, 2, 3, 9} Vikis H.G....Guan K.L. (2000)
A family of transmembrane proteins with homology to the MET- hepatocyte growth factor receptor. (PubMed id 8570614)^{1, 2, 3} Maestrini E.... Comoglio P.M. (1996)
Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF- mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells. (PubMed id 12730235)^{1, 2, 9} Oinuma I.... Negishi M. (2003)
Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2. (PubMed id 15210733)^{1, 2, 9} Swiercz J.M.... Offermanns S. (2004)
Functional regulation of semaphorin receptors by proprotein convertases. (PubMed id 12533544)^{1, 2, 9} Artigiani S.... Tamagnone L. (2003)
Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain. (PubMed id 17916560)^{1, 2, 9} Tong Y....Buck M. (2007)
Interplay between scatter factor receptors and B plexins controls invasive growth. (PubMed id 15184888)^{1, 2, 9} Conrotto P.... Giordano S. (2004)
Insights into oncogenic mutations of plexin-B1 based on the solution structure of the Rho GTPase binding domain. (PubMed id 18275816)^{1, 2, 9} Tong Y....Buck M. (2008)
The semaphorin 4D receptor controls invasive growth by coupling with Met. (PubMed id 12198496)^{1, 2, 9} Giordano S.... Comoglio P.M. (2002)
Structure and function of the intracellular region of the plexin-b1 transmembrane receptor. (PubMed id 19843518)^{1, 2, 9} Tong Y....Buck M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5364	HGNC: 9103	AceView: PLXNB1.1	Ensembl:ENSG00000164050	euGenes: HUgn5364
ECgene: PLXNB1	Kegg: 5364	H-InvDB: PLXNB1

(According to HUGE)
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HUGE: KIAA0407

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PLXNB1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PLXNB1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PLXNB1 gene:
Search GeneIP for patents involving PLXNB1

GeneCards and IP:
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