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Aliases for PLXNB1 Gene

Aliases for PLXNB1 Gene

  • Plexin B1 2 3
  • SEP 3 4 6
  • Semaphorin Receptor SEP 3 4
  • PLXN5 3 4
  • PLEXIN-B1 3
  • Plexin 5 3
  • KIAA0407 4

External Ids for PLXNB1 Gene

Previous HGNC Symbols for PLXNB1 Gene

  • PLXN5

Previous GeneCards Identifiers for PLXNB1 Gene

  • GC03M048246
  • GC03M047727
  • GC03M048405

Summaries for PLXNB1 Gene

GeneCards Summary for PLXNB1 Gene

PLXNB1 (Plexin B1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and L1CAM interactions. GO annotations related to this gene include receptor activity and semaphorin receptor activity. An important paralog of this gene is PLXNB2.

UniProtKB/Swiss-Prot for PLXNB1 Gene

  • Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.

Gene Wiki entry for PLXNB1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLXNB1 Gene

Genomics for PLXNB1 Gene

Regulatory Elements for PLXNB1 Gene

Transcription factor binding sites by QIAGEN in the PLXNB1 gene promoter:

Genomic Location for PLXNB1 Gene

Start:
48,403,854 bp from pter
End:
48,430,087 bp from pter
Size:
26,234 bases
Orientation:
Minus strand

Genomic View for PLXNB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLXNB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLXNB1 Gene

Proteins for PLXNB1 Gene

  • Protein details for PLXNB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43157-PLXB1_HUMAN
    Recommended name:
    Plexin-B1
    Protein Accession:
    O43157
    Secondary Accessions:
    • A6H8Y2
    • Q6NY20
    • Q9UIV7
    • Q9UJ92
    • Q9UJ93

    Protein attributes for PLXNB1 Gene

    Size:
    2135 amino acids
    Molecular mass:
    232298 Da
    Quaternary structure:
    • Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Binds PLXNA1 (By similarity). Interacts with ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RRAS, RHOD, RND1, NRP1 and NRP2.
    SequenceCaution:
    • Sequence=BAA23703.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLXNB1 Gene

    Alternative splice isoforms for PLXNB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLXNB1 Gene

Proteomics data for PLXNB1 Gene at MOPED

Post-translational modifications for PLXNB1 Gene

  • Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.
  • Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.
  • Glycosylation at Asn31, Asn334, Asn543, Ser691, Ser693, Thr696, Asn1183, Asn1253, and Asn1330
  • Modification sites at PhosphoSitePlus

Other Protein References for PLXNB1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PLXNB1 Gene

Domains for PLXNB1 Gene

Gene Families for PLXNB1 Gene

HGNC:

Suggested Antigen Peptide Sequences for PLXNB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43157

UniProtKB/Swiss-Prot:

PLXB1_HUMAN :
  • O43157
Domain:
  • Contains 3 IPT/TIG domains.
  • Contains 1 Sema domain.
Family:
  • Belongs to the plexin family.
genes like me logo Genes that share domains with PLXNB1: view

Function for PLXNB1 Gene

Molecular function for PLXNB1 Gene

GENATLAS Biochemistry: plexin B1,calcium-dependent cell adhesion molecule at the neuronal cell surface,also expressed in hematopoietic and endothelial cells,receptor for the semaphorin,homologous to the hepatocyte growth factor receptor family
UniProtKB/Swiss-Prot Function: Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.

Gene Ontology (GO) - Molecular Function for PLXNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 8570614
GO:0004888 transmembrane signaling receptor activity NAS 10520995
GO:0005515 protein binding IPI 12730235
GO:0017154 semaphorin receptor activity TAS 10520995
GO:0030215 semaphorin receptor binding TAS 10520995
genes like me logo Genes that share ontologies with PLXNB1: view
genes like me logo Genes that share phenotypes with PLXNB1: view

Animal Models for PLXNB1 Gene

MGI Knock Outs for PLXNB1:

miRNA for PLXNB1 Gene

miRTarBase miRNAs that target PLXNB1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PLXNB1 Gene

Localization for PLXNB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLXNB1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLXNB1 Gene COMPARTMENTS Subcellular localization image for PLXNB1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLXNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002116 semaphorin receptor complex TAS 19909241
GO:0005576 extracellular region IEA --
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 10520995
genes like me logo Genes that share ontologies with PLXNB1: view

Pathways for PLXNB1 Gene

genes like me logo Genes that share pathways with PLXNB1: view

Pathways by source for PLXNB1 Gene

Gene Ontology (GO) - Biological Process for PLXNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007162 negative regulation of cell adhesion IDA 15218527
GO:0007165 signal transduction TAS 8570614
GO:0007275 multicellular organismal development --
GO:0007411 axon guidance TAS --
GO:0008360 regulation of cell shape IDA 19843518
genes like me logo Genes that share ontologies with PLXNB1: view

Compounds for PLXNB1 Gene

(1) HMDB Compounds for PLXNB1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(4) Novoseek inferred chemical compound relationships for PLXNB1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 47.4 19
guanosine 36.8 1
phosphatidylinositol 12.5 1
arginine 0 2
genes like me logo Genes that share compounds with PLXNB1: view

Transcripts for PLXNB1 Gene

Unigene Clusters for PLXNB1 Gene

Plexin B1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLXNB1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^
SP1: -
SP2: - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12: - - - - - - - - - -
SP13: -
SP14:

ExUns: 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31a · 31b · 31c ^ 32 ^ 33 ^ 34a · 34b ^ 35a · 35b ^
SP1: - -
SP2: - -
SP3:
SP4: -
SP5:
SP6: - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PLXNB1 Gene

GeneLoc Exon Structure for
PLXNB1
ECgene alternative splicing isoforms for
PLXNB1

Expression for PLXNB1 Gene

mRNA expression in normal human tissues for PLXNB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLXNB1 Gene

SOURCE GeneReport for Unigene cluster for PLXNB1 Gene Hs.476209

mRNA Expression by UniProt/SwissProt for PLXNB1 Gene

O43157-PLXB1_HUMAN
Tissue specificity: Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver.
genes like me logo Genes that share expressions with PLXNB1: view

No data available for mRNA differential expression in normal tissues for PLXNB1 Gene

Orthologs for PLXNB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLXNB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLXNB1 35
  • 99.63 (n)
  • 99.53 (a)
PLXNB1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLXNB1 35
  • 87.41 (n)
  • 89.93 (a)
PLXNB1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLXNB1 35
  • 88.93 (n)
  • 90.73 (a)
PLXNB1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plxnb1 35
  • 85.94 (n)
  • 87.35 (a)
Plxnb1 16
Plxnb1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLXNB1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLXNB1 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plxnb1 35
  • 85.54 (n)
  • 87.03 (a)
chicken
(Gallus gallus)
Aves PLXNB1 35
  • 68.57 (n)
  • 69.7 (a)
PLXNB1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLXNB1 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plxnb1 35
  • 61.53 (n)
  • 60.85 (a)
Str.10773 35
zebrafish
(Danio rerio)
Actinopterygii plxnb1a 36
  • 76 (a)
OneToMany
plxnb1b 35
  • 60.03 (n)
  • 59.5 (a)
plxnb1b 36
  • 54 (a)
OneToMany
wufb83a09 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011139 35
  • 49.08 (n)
  • 37.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta plexB 35
  • 45.09 (n)
  • 37.51 (a)
plexB 36
  • 31 (a)
OneToMany
plexB 37
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea plx-2 36
  • 27 (a)
OneToMany
plx-2 37
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for PLXNB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLXNB1 Gene

ENSEMBL:
Gene Tree for PLXNB1 (if available)
TreeFam:
Gene Tree for PLXNB1 (if available)

Paralogs for PLXNB1 Gene

Paralogs for PLXNB1 Gene

Selected SIMAP similar genes for PLXNB1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLXNB1: view

Variants for PLXNB1 Gene

Sequence variations from dbSNP and Humsavar for PLXNB1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs968429 -- 48,429,015(+) TCCCC(C/G)GCGGC intron-variant
rs1002069 -- 48,404,744(+) AGGGC(C/G)TCGCT intron-variant
rs1037773 -- 48,426,493(+) AAGCG(C/T)TTGCT intron-variant, upstream-variant-2KB
rs1061488 -- 48,404,099(-) CCTGT(C/T)TGCCT utr-variant-3-prime, nc-transcript-variant
rs1531317 -- 48,404,973(-) TTGAT(C/T)AGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLXNB1 Gene

Variant ID Type Subtype PubMed ID
nsv834683 CNV Gain 17160897
nsv834684 CNV Gain 17160897
nsv508917 CNV Insertion 20534489
nsv876761 CNV Loss 21882294

Relevant External Links for PLXNB1 Gene

HapMap Linkage Disequilibrium report
PLXNB1
Human Gene Mutation Database (HGMD)
PLXNB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLXNB1 Gene

Disorders for PLXNB1 Gene

(4) Novoseek inferred disease relationships for PLXNB1 Gene

Disease -log(P) Hits PubMed IDs
metastasis 26.5 1
cancer 12.8 6
tumors 10.6 15
carcinoma squamous cell 0 1

Relevant External Links for PLXNB1

Genetic Association Database (GAD)
PLXNB1
Human Genome Epidemiology (HuGE) Navigator
PLXNB1
genes like me logo Genes that share disorders with PLXNB1: view

No data available for UniProtKB/Swiss-Prot for PLXNB1 Gene

Publications for PLXNB1 Gene

  1. The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner. (PMID: 11035813) Vikis H.G. … Guan K.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 23
  2. Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates. (PMID: 10520995) Tamagnone L. … Comoglio P.M. (Cell 1999) 3 4 23
  3. The semaphorin 4D receptor controls invasive growth by coupling with Met. (PMID: 12198496) Giordano S. … Comoglio P.M. (Nat. Cell Biol. 2002) 3 4 23
  4. Functional regulation of semaphorin receptors by proprotein convertases. (PMID: 12533544) Artigiani S. … Tamagnone L. (J. Biol. Chem. 2003) 3 4 23
  5. Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF- mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells. (PMID: 12730235) Oinuma I. … Negishi M. (J. Biol. Chem. 2003) 3 4 23

Products for PLXNB1 Gene

  • antibodies-online proteins for PLXNB1
  • antibodies-online antibodies for PLXNB1
  • antibodies-online kits for PLXNB1

Sources for PLXNB1 Gene

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