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PLXNB1 Gene

protein-coding   GIFtS: 70
GCID: GC03M048420

Plexin B1


(Previous symbol: PLXN5)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Plexin B11 2     PLEXIN-B12
PLXN51 2 3     Plexin 52
SEP2 3 5     plexin-B12
Semaphorin Receptor SEP2 3     KIAA04073

External Ids:    HGNC: 91031   Entrez Gene: 53642   Ensembl: ENSG000001640507   OMIM: 6010535   UniProtKB: O431573   

Export aliases for PLXNB1 gene to outside databases

Previous GC identifers: GC03M048246 GC03M047727 GC03M048405


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PLXNB1 Gene:
PLXNB1 (plexin B1) is a protein-coding gene. GO annotations related to this gene include semaphorin receptor activity and receptor activity. An important paralog of this gene is PLXNA1.

UniProtKB/Swiss-Prot: PLXB1_HUMAN, O43157
Function: Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton.
Plays a role in axon guidance, invasive growth and cell migration

Gene Wiki entry for PLXNB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLXNB1 gene promoter:
         HEN1   p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLXNB1 promoter sequence
   Search Chromatin IP Primers for PLXNB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLXNB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

PLXNB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLXNB1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M048420:  view genomic region     (about GC identifiers)

Start:
48,445,261 bp from pter      End:
48,471,594 bp from pter
Size:
26,334 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PLXB1_HUMAN, O43157 (See protein sequence)
Recommended Name: Plexin-B1 precursor  
Size: 2135 amino acids; 232298 Da
Subunit: Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by
GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Binds PLXNA1 (By similarity).
Interacts with ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RRAS, RHOD, RND1, NRP1 and NRP2
Sequence caution: Sequence=BAA23703.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for PLXNB1 (see all 8):
2JPH (3D)        2OS6 (3D)        2R2O (3D)        2REX (3D)        3HM6 (3D)        3OL2 (3D)    
Secondary accessions: A6H8Y2 Q6NY20 Q9UIV7 Q9UJ92 Q9UJ93
Alternative splicing: 3 isoforms:  O43157-1   O43157-2   O43157-3   

Explore the universe of human proteins at neXtProt for PLXNB1: NX_O43157

Explore proteomics data for PLXNB1 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding1
  • Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding1
  • Glycosylation2 at Asn31, Asn334, Asn543, Ser691, Ser693, Thr696, Asn1183, Asn1253, Asn1330
  • Modification sites at PhosphoSitePlus

  • See PLXNB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123554.1  NP_002664.2  

    ENSEMBL proteins: 
     ENSP00000296440   ENSP00000351338   ENSP00000414199   ENSP00000395987   ENSP00000351242  
     ENSP00000389320  
    Reactome Protein details: O43157

    PLXNB1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for PLXNB1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PLXNB1
    GenScript Custom Purified and Recombinant Proteins Services for PLXNB1
    Novus Biologicals PLXNB1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PLXNB1

     
    Search eBioscience for Proteins for PLXNB1 

    PLXNB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PLXNB1
    R&D Systems Antibodies for PLXNB1 (Plexin B1)
    OriGene Antibodies for PLXNB1
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    Novus Biologicals PLXNB1 Antibody
    Abcam antibodies for PLXNB1
    Cloud-Clone Corp. Antibodies for PLXNB1
    Search ThermoFisher Antibodies for PLXNB1
    LSBio Antibodies in human, mouse, rat for PLXNB1

    PLXNB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PLXNB1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PLXNB1
    Cloud-Clone Corp. CLIAs for PLXNB1
    Search eBioscience for ELISAs for PLXNB1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLXN: Plexins

    Selected InterPro protein domains (see all 9):
     IPR014756 Ig_E-set
     IPR002165 Plexin_repeat
     IPR002909 IPT
     IPR008936 Rho_GTPase_activation_prot
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry O43157

    ProtoNet protein and cluster: O43157

    1 Blocks protein domain: IPB013548 Plexin cytoplasmic region

    UniProtKB/Swiss-Prot: PLXB1_HUMAN, O43157
    Similarity: Belongs to the plexin family
    Similarity: Contains 3 IPT/TIG domains
    Similarity: Contains 1 Sema domain


    Find genes that share domains with PLXNB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLXB1_HUMAN, O43157
    Function: Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton.
    Plays a role in axon guidance, invasive growth and cell migration

         Genatlas biochemistry entry for PLXNB1:
    plexin B1,calcium-dependent cell adhesion molecule at the neuronal cell surface,also expressed in hematopoietic
    and endothelial cells,receptor for the semaphorin,homologous to the hepatocyte growth factor receptor family

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS8570614
    GO:0004888transmembrane signaling receptor activity NAS10520995
    GO:0005515protein binding IPI12730235
    GO:0017154semaphorin receptor activity TAS10520995
    GO:0030215semaphorin receptor binding TAS10520995
         
    Find genes that share ontologies with PLXNB1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for PLXNB1:
     Decreased focal adhesion (FA)   Decreased viability with TRAIL  Elongated cells with protrusio  Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Plxnb1):
     nervous system  no phenotypic analysis  normal  renal/urinary system  vision/eye 

    Find genes that share phenotypes with PLXNB1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PLXNB1: Plxnb1tm1Rkun Plxnb1tm1Mom

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLXNB1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PLXNB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLXNB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLXNB1

    miRNA
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    miRTarBase miRNAs that target PLXNB1:
    hsa-mir-214-3p (MIRT005765)

    Block miRNA regulation of human, mouse, rat PLXNB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLXNB1 (see all 10):
    hsa-miR-15a hsa-miR-497 hsa-miR-3667-3p hsa-miR-424 hsa-miR-501-5p hsa-miR-362-5p hsa-miR-195 hsa-miR-16
    SwitchGear 3'UTR luciferase reporter plasmidPLXNB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PLXNB1
    Predesigned siRNA for gene silencing in human, mouse, rat PLXNB1

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for PLXNB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PLXNB1 (NM_002673)
    Sino Biological Human cDNA Clone for PLXNB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLXNB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLXNB1
    Addgene plasmids for PLXNB1 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PLXNB1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXNB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLXB1_HUMAN, O43157: Isoform 1: Cell membrane; Single-pass type I membrane protein
    PLXB1_HUMAN, O43157: Isoform 2: Secreted
    PLXB1_HUMAN, O43157: Isoform 3: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002116semaphorin receptor complex TAS19909241
    GO:0005576extracellular region IEA--
    GO:0005622intracellular IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS10520995

    Find genes that share ontologies with PLXNB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLXNB1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Semaphorin interactions
    Sema4D in semaphorin signaling0.90
    Semaphorin interactions0.43
    Sema4D induced cell migration and growth-cone collapse0.90
    Sema4D mediated inhibition of cell attachment and migration0.00
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    4p75 NTR receptor-mediated signalling
    G alpha (12/13) signalling events0.44
    5Development Slit Robo signaling
    Neurophysiological process Receptor mediated axon growth repulsion0.41


    Find genes that share SuperPaths with PLXNB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PLXNB1
        Guidance Cues and Growth Cone Motility
    Semaphorin Signaling

    1 GeneGo (Thomson Reuters) Pathway for PLXNB1
        Neurophysiological process Receptor-mediated axon growth repulsion


    3 Reactome Pathways for PLXNB1
        Sema4D induced cell migration and growth-cone collapse
    G alpha (12/13) signalling events
    Sema4D mediated inhibition of cell attachment and migration


    1 Kegg Pathway  (Kegg details for PLXNB1):
        Axon guidance

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLXNB1
    Interactions:

        GeneGlobe Interaction Network for PLXNB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLXNB1 (O431571, 2, 3 ENSP000002964404) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RND1Q927301, 2, 3, ENSP000003084614EBI-1111488,EBI-448618 MINT-16324 MINT-16325 I2D: score=6 STRING: ENSP00000308461
    METP085811, 2, 3, ENSP000003172724EBI-1111488,EBI-1039152 MINT-49661 MINT-49668 I2D: score=3 STRING: ENSP00000317272
    MRASO148072, 3, ENSP000002891044MINT-7228875 I2D: score=1 STRING: ENSP00000289104
    MST1RQ049121, 3, ENSP000002964744EBI-1111488,EBI-2637518 I2D: score=1 STRING: ENSP00000296474
    SEMA4AQ9H3S12, 3, ENSP000003471174MINT-4507855 I2D: score=1 STRING: ENSP00000347117
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8570614
    GO:0007275multicellular organismal development ----
    GO:0007411axon guidance TAS--
    GO:0008360regulation of cell shape IDA19843518
    GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling ISS--

    Find genes that share ontologies with PLXNB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PLXNB1 (PLXB1)

    1 HMDB Compound for PLXNB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    4 Novoseek inferred chemical compound relationships for PLXNB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 47.4 23 19805522 (3), 16055703 (3), 19433062 (2), 15210733 (2) (see all 13)
    guanosine 36.8 1 18321527 (1)
    phosphatidylinositol 12.5 1 17855350 (1)
    arginine 0 2 15210733 (1), 14712228 (1)



    Find genes that share compounds with PLXNB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLXNB1 gene (2 alternative transcripts): 
    NM_001130082.2  NM_002673.5  

    Unigene Cluster for PLXNB1:

    Plexin B1
    Hs.476209  [show with all ESTs]
    Unigene Representative Sequence: BC146793
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000296440(uc003csu.2 uc003csx.2) ENST00000485535(uc003cst.2)
    ENST00000358536(uc003csw.2) ENST00000456774 ENST00000483753 ENST00000497627
    ENST00000483676 ENST00000478171 ENST00000470525 ENST00000461261 ENST00000473996
    ENST00000449094(uc003csy.1) ENST00000465117 ENST00000467913 ENST00000464294
    ENST00000484485 ENST00000462738 ENST00000466353
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PLXNB1 (see all 10):
    hsa-miR-15a hsa-miR-497 hsa-miR-3667-3p hsa-miR-424 hsa-miR-501-5p hsa-miR-362-5p hsa-miR-195 hsa-miR-16
    SwitchGear 3'UTR luciferase reporter plasmidPLXNB1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PLXNB1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): PLXNB1 (NM_002673)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLXNB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLXNB1
    Addgene plasmids for PLXNB1 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLXNB1
      QuantiTect SYBR Green Assays in human, mouse, rat PLXNB1
      QuantiFast Probe-based Assays in human, mouse, rat PLXNB1

    Additional mRNA sequence: 

    AB007867.1 AJ011415.1 AK091832.1 AK092609.1 AK296776.1 BC066773.1 BC127793.1 BC129947.1 
    BC146793.1 X87904.2 

    20 DOTS entries:

    DT.95180011  DT.100785290  DT.101956392  DT.220348  DT.92444253  DT.92444266  DT.91686892  DT.120886190 
    DT.91658702  DT.91747488  DT.95352688  DT.100785291  DT.120886196  DT.92039943  DT.92444254  DT.92444262 
    DT.92444269  DT.95180020  DT.95186413  DT.95260010 

    Selected AceView cDNA sequences (see all 900):

    CR623003 CR622754 CR593080 BU195061 BM917076 BU168153 CR592862 CR596992 
    BM762959 AA630101 BQ018920 BQ883995 AI000923 AI718508 BM857186 BE906777 
    BQ711444 AJ133825 CB110974 BU528149 BU629455 BG289633 BQ937547 BU195681 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PLXNB1 (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^
    SP1:                                                                                                                                      -                     
    SP2:                                                                                      -                                               -                     
    SP3:                                                                                -     -                                               -                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31a · 31b · 31c ^ 32 ^ 33 ^ 34a · 34b ^ 35a · 35b ^
    SP1:                                                        -                                                                             -                     
    SP2:                                                        -                                                                             -                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                      -                     
    SP5:                                                                                                                                                            

    ExUns: 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for PLXNB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLXNB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAGGGCTA
    PLXNB1 Expression
    About this image


    PLXNB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Kidney (Urinary System)
             Metanephros
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
    PLXNB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLXNB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.476209

    UniProtKB/Swiss-Prot: PLXB1_HUMAN, O43157
    Tissue specificity: Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PLXNB1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plxnb11 , 5 plexin B11, 5 85.94(n)1
    87.35(a)1
      9 (59.63 cM)5
    2356111  NM_172775.21  NP_766363.21 
     1090954365 
    chicken
    (Gallus gallus)
    Aves PLXNB11 plexin B1 68.57(n)
    69.7(a)
      100859325  NM_001257265.1  NP_001244194.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLXNB16
    plexin B1
    61(a)
    1 ↔ 1
    2(190551950-190651879)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.107732 Transcribed sequence with moderate similarity to protein more 76.04(n)    BX733874.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb83a092 Transcribed sequence with moderate similarity to protein more 79.81(n)    BG304969.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta plexB1 , 3 axon guidance semaphorin receptor3
    plexin B1
    40(a)3
    45.09(n)1
    37.51(a)1
      102A13
    437661  NM_079877.41  NP_524616.21 
    worm
    (Caenorhabditis elegans)
    Secernentea plx-23   -- 28(a)   II(14413677-14421269)   --


    ENSEMBL Gene Tree for PLXNB1 (if available)
    TreeFam Gene Tree for PLXNB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLXNB1 gene
    PLXNA12  PLXNA22  PLXNB22  PLXND12  PLXNA32  PLXNC12  PLXNB32  PLXNA42  
    7 SIMAP similar genes for PLXNB1 using alignment to 3 protein entries:     PLXB1_HUMAN (see all proteins):
    DKFZp761P19121    Nbla00445    PLXNB3    PLXNB2    PLXND1    PLXNC1
    MM1

    Find genes that share paralogs with PLXNB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLXNB1 (see all 728)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360744
    A breast cancer sample4--see VAR_0360742 D V mis40--------
    rs1456754261,2
    --48444884(+) GCCCTC/TGAGAC 2 -- int10--------
    rs1893520441,2
    --48445004(+) CCCCCC/TTGAAG 2 -- int10--------
    rs2013626931,2
    --48445188(+) TCCCC-/CTGGTAC 2 -- int10--------
    rs1473177061,2
    --48445239(+) TAGGCC/TGGGCT 2 -- int10--------
    rs1820005471,2
    --48445409(+) TGTAGC/TGGCCT 2 -- ut310--------
    rs10614881,2
    C--48445506(-) CCTGTC/TTGCCT 2 -- ut313Minor allele frequency- T:0.00MN NA 188
    rs1862368651,2
    --48445541(+) CTCCGA/GATCCC 2 -- ut310--------
    rs768599701,2
    C,F--48445571(+) TTCAGG/AAACAG 2 -- ut311Minor allele frequency- A:0.08WA 118
    rs1409986241,2
    C--48445593(+) CAGGGA/GCCTGG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for PLXNB1 (48445261 - 48471594 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PLXNB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508917CNV Insertion20534489
    nsv876761CNV Loss21882294
    nsv834683CNV Gain17160897
    nsv834684CNV Gain17160897

    Human Gene Mutation Database (HGMD): PLXNB1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLXNB1
    DNA2.0 Custom Variant and Variant Library Synthesis for PLXNB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601053    OMIM disorders: --


    Find genes that share disorders with PLXNB1           About GenesLikeMe

    4 Novoseek inferred disease relationships for PLXNB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 26.5 1 20164843 (1)
    cancer 12.8 7 19461072 (1), 17204469 (1), 19805522 (1), 16055703 (1) (see all 6)
    tumors 10.6 20 19483722 (4), 18818766 (3), 20164843 (2), 17317819 (2) (see all 8)
    carcinoma squamous cell 0 1 16754882 (1)

    Genetic Association Database (GAD): PLXNB1
    Human Genome Epidemiology (HuGE) Navigator: PLXNB1 (1 document)

    Export disorders for PLXNB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLXNB1 gene, integrated from 10 sources (see all 125):
    (articles sorted by number of sources associating them with PLXNB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner. (PubMed id 11035813)1, 2, 3, 9 Vikis H.G.... Guan K.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    2. A family of transmembrane proteins with homology to the MET- hepatocyte growth factor receptor. (PubMed id 8570614)1, 2, 3 Maestrini E.... Comoglio P.M. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    3. Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF- mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells. (PubMed id 12730235)1, 2, 9 Oinuma I.... Negishi M. (J. Biol. Chem. 2003)
    4. Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2. (PubMed id 15210733)1, 2, 9 Swiercz J.M.... Offermanns S. (J. Cell Biol. 2004)
    5. Functional regulation of semaphorin receptors by proprotein convertases. (PubMed id 12533544)1, 2, 9 Artigiani S.... Tamagnone L. (J. Biol. Chem. 2003)
    6. Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain. (PubMed id 17916560)1, 2, 9 Tong Y.... Buck M. (J. Biol. Chem. 2007)
    7. Interplay between scatter factor receptors and B plexins controls invasive growth. (PubMed id 15184888)1, 2, 9 Conrotto P.... Giordano S. (Oncogene 2004)
    8. Insights into oncogenic mutations of plexin-B1 based on the solution structure of the Rho GTPase binding domain. (PubMed id 18275816)1, 2, 9 Tong Y.... Buck M. (Structure 2008)
    9. The semaphorin 4D receptor controls invasive growth by coupling with Met. (PubMed id 12198496)1, 2, 9 Giordano S.... Comoglio P.M. (Nat. Cell Biol. 2002)
    10. Structure and function of the intracellular region of the plexin-B1 transmembrane receptor. (PubMed id 19843518)1, 2, 9 Tong Y....Buck M. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5364 HGNC: 9103 AceView: PLXNB1.1 Ensembl:ENSG00000164050 euGenes: HUgn5364
    ECgene: PLXNB1 Kegg: 5364 H-InvDB: PLXNB1

    (According to HUGE)
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    HUGE: KIAA0407

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PLXNB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PLXNB1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLXNB1 gene:
    Search GeneIP for patents involving PLXNB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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