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Aliases for PLXNA4 Gene

Aliases for PLXNA4 Gene

  • Plexin A4 2 3 5
  • PLXNA4A 3 4
  • PLXNA4B 3 4
  • Plexin A4, A 2
  • Plexin A4, B 2
  • FAYV2820 3
  • PRO34003 3
  • KIAA1550 4
  • PLEXA4 3

External Ids for PLXNA4 Gene

Previous HGNC Symbols for PLXNA4 Gene

  • PLXNA4A
  • PLXNA4B

Previous GeneCards Identifiers for PLXNA4 Gene

  • GC07U990159
  • GC07M131215
  • GC07M131228
  • GC07M131269
  • GC07M131467
  • GC07M131720
  • GC07M126124

Summaries for PLXNA4 Gene

GeneCards Summary for PLXNA4 Gene

PLXNA4 (Plexin A4) is a Protein Coding gene. Among its related pathways are Developmental Biology and Semaphorin interactions. GO annotations related to this gene include receptor activity and semaphorin receptor activity. An important paralog of this gene is PLXNB2.

UniProtKB/Swiss-Prot for PLXNA4 Gene

  • Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLXNA4 Gene

Genomics for PLXNA4 Gene

Regulatory Elements for PLXNA4 Gene

Enhancers for PLXNA4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLXNA4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLXNA4 Gene

Chromosome:
7
Start:
132,123,332 bp from pter
End:
132,648,688 bp from pter
Size:
525,357 bases
Orientation:
Minus strand

Genomic View for PLXNA4 Gene

Genes around PLXNA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLXNA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLXNA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLXNA4 Gene

Proteins for PLXNA4 Gene

  • Protein details for PLXNA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCM2-PLXA4_HUMAN
    Recommended name:
    Plexin-A4
    Protein Accession:
    Q9HCM2
    Secondary Accessions:
    • A4D1N6
    • E9PAM2
    • Q6UWC6
    • Q6ZW89
    • Q8N969
    • Q8ND00
    • Q8NEN3
    • Q9NTD4

    Protein attributes for PLXNA4 Gene

    Size:
    1894 amino acids
    Molecular mass:
    212455 Da
    Quaternary structure:
    • Interacts with NRP1 and NRP2.
    SequenceCaution:
    • Sequence=AAQ89209.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLXNA4 Gene

    Alternative splice isoforms for PLXNA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLXNA4 Gene

Proteomics data for PLXNA4 Gene at MOPED

Post-translational modifications for PLXNA4 Gene

  • Glycosylation at Asn 655, Asn 1007, Asn 1132, and Asn 1180
  • Modification sites at PhosphoSitePlus

Other Protein References for PLXNA4 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PLXNA4 (PLXNA4)

No data available for DME Specific Peptides for PLXNA4 Gene

Domains & Families for PLXNA4 Gene

Gene Families for PLXNA4 Gene

Suggested Antigen Peptide Sequences for PLXNA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCM2

UniProtKB/Swiss-Prot:

PLXA4_HUMAN :
  • Contains 4 IPT/TIG domains.
  • Belongs to the plexin family.
Domain:
  • Contains 4 IPT/TIG domains.
  • Contains 3 PSI domains.
  • Contains 1 Sema domain.
Family:
  • Belongs to the plexin family.
genes like me logo Genes that share domains with PLXNA4: view

Function for PLXNA4 Gene

Molecular function for PLXNA4 Gene

GENATLAS Biochemistry:
plexin A4,calcium-dependent cell adhesion molecule at the neuronal cell surface,receptor for the semaphorin 7A (SEMA7A)
UniProtKB/Swiss-Prot Function:
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
genes like me logo Genes that share phenotypes with PLXNA4: view

Animal Models for PLXNA4 Gene

MGI Knock Outs for PLXNA4:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLXNA4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLXNA4 Gene

Localization for PLXNA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLXNA4 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLXNA4 Gene COMPARTMENTS Subcellular localization image for PLXNA4 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PLXNA4 Gene

Pathways & Interactions for PLXNA4 Gene

genes like me logo Genes that share pathways with PLXNA4: view

Pathways by source for PLXNA4 Gene

1 Cell Signaling Technology pathway for PLXNA4 Gene

Gene Ontology (GO) - Biological Process for PLXNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007399 nervous system development IEA --
GO:0007411 axon guidance TAS --
GO:0008045 motor neuron axon guidance IEA --
GO:0021610 facial nerve morphogenesis IEA --
genes like me logo Genes that share ontologies with PLXNA4: view

No data available for SIGNOR curated interactions for PLXNA4 Gene

Drugs & Compounds for PLXNA4 Gene

No Compound Related Data Available

Transcripts for PLXNA4 Gene

mRNA/cDNA for PLXNA4 Gene

Unigene Clusters for PLXNA4 Gene

Plexin A4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLXNA4 Gene

No ASD Table

Relevant External Links for PLXNA4 Gene

GeneLoc Exon Structure for
PLXNA4
ECgene alternative splicing isoforms for
PLXNA4

Expression for PLXNA4 Gene

mRNA expression in normal human tissues for PLXNA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLXNA4 Gene

This gene is overexpressed in Fetal Brain (25.1), Brain (17.7), Frontal cortex (12.0), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLXNA4 Gene



SOURCE GeneReport for Unigene cluster for PLXNA4 Gene Hs.511454

genes like me logo Genes that share expression patterns with PLXNA4: view

Protein tissue co-expression partners for PLXNA4 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PLXNA4 Gene

Orthologs for PLXNA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLXNA4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLXNA4 35
  • 91.37 (n)
  • 97.52 (a)
PLEX2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLXNA4 35
  • 91.92 (n)
  • 97.99 (a)
PLXNA4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plxna4 35
  • 89.54 (n)
  • 97.78 (a)
Plxna4 16
Plxna4 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLXNA4 35
  • 99.54 (n)
  • 99.89 (a)
PLXNA4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plxna4a 35
  • 89.51 (n)
  • 97.68 (a)
oppossum
(Monodelphis domestica)
Mammalia PLXNA4 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves PLXNA4B 35
  • 82.24 (n)
  • 92.28 (a)
PLXNA4 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLXNA4 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plxna4 35
  • 73.57 (n)
  • 86.02 (a)
zebrafish
(Danio rerio)
Actinopterygii plxna4 35
  • 72.64 (n)
  • 79.48 (a)
plxna4 36
  • 79 (a)
OneToOne
Species with no ortholog for PLXNA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLXNA4 Gene

ENSEMBL:
Gene Tree for PLXNA4 (if available)
TreeFam:
Gene Tree for PLXNA4 (if available)

Paralogs for PLXNA4 Gene

Paralogs for PLXNA4 Gene

(10) SIMAP similar genes for PLXNA4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLXNA4: view

Variants for PLXNA4 Gene

Sequence variations from dbSNP and Humsavar for PLXNA4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs768559 -- 132,232,852(-) TTGCC(C/T)GGCCA intron-variant
rs869318 -- 132,634,000(+) cagat(A/G)cacct intron-variant
rs869319 -- 132,634,228(+) gttcc(C/T)aggta intron-variant
rs869320 -- 132,634,229(+) TTCCC(A/G)GGTAG intron-variant
rs869321 -- 132,633,776(+) AGCTT(C/T)GCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLXNA4 Gene

Variant ID Type Subtype PubMed ID
nsv889204 CNV Gain 21882294
nsv831135 CNV Loss 17160897
nsv831136 CNV Loss 17160897
esv2735160 CNV Deletion 23290073
esv2735161 CNV Deletion 23290073
esv996570 CNV Deletion 20482838
esv2735163 CNV Deletion 23290073
esv271610 CNV Insertion 20981092
esv272272 CNV Insertion 20981092
nsv526514 CNV Loss 19592680
nsv464724 CNV Loss 19166990
esv2735164 CNV Deletion 23290073
nsv522425 CNV Gain 19592680
nsv525647 CNV Loss 19592680
nsv831138 CNV Gain 17160897
nsv889206 CNV Gain 21882294
nsv889207 CNV Gain 21882294
nsv831139 CNV Loss 17160897
nsv889208 CNV Gain 21882294
nsv831140 CNV Loss 17160897
nsv526523 CNV Loss 19592680
nsv831141 CNV Loss 17160897
esv2662010 CNV Deletion 23128226
esv2667603 CNV Deletion 23128226
esv2735165 CNV Deletion 23290073
nsv820471 CNV Deletion 20802225
nsv824308 CNV Loss 20364138
esv2735166 CNV Deletion 23290073
esv2665361 CNV Deletion 23128226
esv2735167 CNV Deletion 23290073
esv2735168 CNV Deletion 23290073
nsv507418 CNV Insertion 20534489
esv2462922 CNV Insertion 19546169
dgv2138e1 CNV Complex 17122850

Variation tolerance for PLXNA4 Gene

Residual Variation Intolerance Score: 3.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.46; 64.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLXNA4 Gene

Human Gene Mutation Database (HGMD)
PLXNA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLXNA4 Gene

Disorders for PLXNA4 Gene

Relevant External Links for PLXNA4

Genetic Association Database (GAD)
PLXNA4
Human Genome Epidemiology (HuGE) Navigator
PLXNA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLXNA4

No disorders were found for PLXNA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLXNA4 Gene

Publications for PLXNA4 Gene

  1. Genome-wide association study of lung function decline in adults with and without asthma. (PMID: 22424883) Imboden M. … Probst-Hensch N.M. (J. Allergy Clin. Immunol. 2012) 3 48 67
  2. Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment. (PMID: 24939585) Fransen E. … Friedman R.A. (Eur. J. Hum. Genet. 2015) 3
  3. PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure. (PMID: 25518740) Belyk M. … Brown S. (J. Hum. Genet. 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PLXNA4 Gene

Sources for PLXNA4 Gene

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