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Aliases for PLXNA3 Gene

Aliases for PLXNA3 Gene

  • Plexin A3 2 3 5
  • Semaphorin Receptor SEX 3 4
  • Plexin-4 3 4
  • PLXN4 3 4
  • Sex Chromosome X Transmembrane Protein Of HGF Receptor Family 3 3
  • HSSEXGENE 3
  • Plexin-A3 3
  • PLXN3 3
  • XAP-6 3
  • 6.3 3
  • SEX 4

External Ids for PLXNA3 Gene

Previous HGNC Symbols for PLXNA3 Gene

  • PLXN4

Previous GeneCards Identifiers for PLXNA3 Gene

  • GC0XU990185
  • GC0XM150067
  • GC0XP151274
  • GC0XP152154
  • GC0XP152118
  • GC0XP153250
  • GC0XP153339
  • GC0XP153686
  • GC0XP142263

Summaries for PLXNA3 Gene

Entrez Gene Summary for PLXNA3 Gene

  • This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013]

GeneCards Summary for PLXNA3 Gene

PLXNA3 (Plexin A3) is a Protein Coding gene. Diseases associated with PLXNA3 include Rett Syndrome. Among its related pathways are Semaphorin interactions and Developmental Biology. GO annotations related to this gene include receptor activity and semaphorin receptor activity. An important paralog of this gene is PLXNA1.

UniProtKB/Swiss-Prot for PLXNA3 Gene

  • Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

Gene Wiki entry for PLXNA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLXNA3 Gene

Genomics for PLXNA3 Gene

Regulatory Elements for PLXNA3 Gene

Enhancers for PLXNA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF154340 0.9 Ensembl ENCODE 52 -111.7 -111696 12.4 BCOR CTCF KLF1 PKNOX1 ESRRA SIN3A ZIC2 RAD21 HIC1 POLR2A PLXNA3 FAM50A FAM3A GC0XM154351 GC0XM154352 LOC105373386
GH0XF154364 1.2 VISTA ENCODE 51.1 -88.1 -88092 10.7 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 FOS PLXNA3 FAM50A EMD CH17-340M24.3 FLNA GC0XM154351 GC0XM154352
GH0XF154457 0.6 ENCODE 43.8 +0.7 725 3.2 ATF1 SIN3A ZNF2 GLIS2 ELK1 ZNF263 SP3 REST MBD2 SMARCA4 PLXNA3 FAM3A FAM50A HCFC1 LAGE3
GH0XF154396 0.6 ENCODE 40.3 -58.8 -58802 6.2 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 PLXNA3 DNASE1L1 FAM50A EMD SNORA70 HCFC1 TMEM187 ENSG00000280195 GC0XP154401 GC0XP154402
GH0XF154325 1 Ensembl ENCODE 36.7 -131.2 -131186 2.2 CTCF RAD21 ZNF335 E2F1 GATA3 SCRT2 ZNF143 SMC3 ZNF600 CREM PLXNA3 ATP6AP1 CH17-340M24.3 GDI1 FAM50A DNASE1L1 GC0XP154343 GC0XP154344 PIR36226 TEX28
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PLXNA3 on UCSC Golden Path with GeneCards custom track

Promoters for PLXNA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000483221 619 3000 ATF1 SIN3A ZNF2 GLIS2 ELK1 FOS ZNF263 SP3 REST MBD2

Genomic Location for PLXNA3 Gene

Chromosome:
X
Start:
154,458,281 bp from pter
End:
154,477,779 bp from pter
Size:
19,499 bases
Orientation:
Plus strand

Genomic View for PLXNA3 Gene

Genes around PLXNA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLXNA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLXNA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLXNA3 Gene

Proteins for PLXNA3 Gene

  • Protein details for PLXNA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51805-PLXA3_HUMAN
    Recommended name:
    Plexin-A3
    Protein Accession:
    P51805
    Secondary Accessions:
    • Q5HY36

    Protein attributes for PLXNA3 Gene

    Size:
    1871 amino acids
    Molecular mass:
    207703 Da
    Quaternary structure:
    • Interacts with CBFA2T3/MTG16.

neXtProt entry for PLXNA3 Gene

Post-translational modifications for PLXNA3 Gene

  • Glycosylation at Asn 59, Asn 548, Asn 637, Asn 738, Asn 746, Asn 1009, Asn 1036, Asn 1073, Asn 1115, and Asn 1162
  • Modification sites at PhosphoSitePlus

Other Protein References for PLXNA3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PLXNA3 (PLXNA3)

No data available for DME Specific Peptides for PLXNA3 Gene

Domains & Families for PLXNA3 Gene

Gene Families for PLXNA3 Gene

Suggested Antigen Peptide Sequences for PLXNA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51805

UniProtKB/Swiss-Prot:

PLXA3_HUMAN :
  • Contains 4 IPT/TIG domains.
  • Belongs to the plexin family.
Domain:
  • Contains 4 IPT/TIG domains.
  • Contains 1 Sema domain.
Family:
  • Belongs to the plexin family.
genes like me logo Genes that share domains with PLXNA3: view

Function for PLXNA3 Gene

Molecular function for PLXNA3 Gene

GENATLAS Biochemistry:
plexin A3,calcium-dependent cell adhesion molecule at the neuronal cell surface,homologous to the hepatocyte growth factor receptor family, expressed in fetal brain,putatively involved in signal transduction
UniProtKB/Swiss-Prot Function:
Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

Gene Ontology (GO) - Molecular Function for PLXNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity NAS 8570614
GO:0005515 protein binding IPI 20138877
GO:0017154 semaphorin receptor activity IBA --
genes like me logo Genes that share ontologies with PLXNA3: view
genes like me logo Genes that share phenotypes with PLXNA3: view

Animal Models for PLXNA3 Gene

MGI Knock Outs for PLXNA3:

Animal Model Products

miRNA for PLXNA3 Gene

miRTarBase miRNAs that target PLXNA3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLXNA3 Gene

Localization for PLXNA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLXNA3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLXNA3 Gene COMPARTMENTS Subcellular localization image for PLXNA3 gene
Compartment Confidence
plasma membrane 5
nucleus 4
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLXNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002116 semaphorin receptor complex TAS 19909241
GO:0005634 nucleus IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane TAS 8570614
genes like me logo Genes that share ontologies with PLXNA3: view

Pathways & Interactions for PLXNA3 Gene

genes like me logo Genes that share pathways with PLXNA3: view

Pathways by source for PLXNA3 Gene

1 KEGG pathway for PLXNA3 Gene

Gene Ontology (GO) - Biological Process for PLXNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organism development TAS 8570614
GO:0007411 axon guidance IEA --
GO:0021612 facial nerve structural organization IEA --
GO:0021637 trigeminal nerve structural organization IEA --
genes like me logo Genes that share ontologies with PLXNA3: view

No data available for SIGNOR curated interactions for PLXNA3 Gene

Transcripts for PLXNA3 Gene

Unigene Clusters for PLXNA3 Gene

Plexin A3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLXNA3 Gene

No ASD Table

Relevant External Links for PLXNA3 Gene

GeneLoc Exon Structure for
PLXNA3
ECgene alternative splicing isoforms for
PLXNA3

Expression for PLXNA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLXNA3 Gene

Protein differential expression in normal tissues from HIPED for PLXNA3 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLXNA3 Gene



Protein tissue co-expression partners for PLXNA3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLXNA3 Gene:

PLXNA3

SOURCE GeneReport for Unigene cluster for PLXNA3 Gene:

Hs.632839
genes like me logo Genes that share expression patterns with PLXNA3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PLXNA3 Gene

Orthologs for PLXNA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLXNA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLXNA3 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GDI1 35
  • 95 (a)
OneToOne
PLXNA3 34
  • 90.22 (n)
cow
(Bos Taurus)
Mammalia PLXNA3 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plxna3 34 16 35
  • 86.55 (n)
rat
(Rattus norvegicus)
Mammalia Plxna3 34
  • 86.44 (n)
oppossum
(Monodelphis domestica)
Mammalia PLXNA3 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLXNA3 35
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLXNA3 35
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397805 34
zebrafish
(Danio rerio)
Actinopterygii plxna3 34 35
  • 70.71 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2624 34
Species where no ortholog for PLXNA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLXNA3 Gene

ENSEMBL:
Gene Tree for PLXNA3 (if available)
TreeFam:
Gene Tree for PLXNA3 (if available)

Paralogs for PLXNA3 Gene

Paralogs for PLXNA3 Gene

(10) SIMAP similar genes for PLXNA3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLXNA3: view

Variants for PLXNA3 Gene

Sequence variations from dbSNP and Humsavar for PLXNA3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs200042650 Benign 154,464,420(+) TGTGC(A/G)GCTGC nc-transcript-variant, reference, missense
rs111354353 -- 154,469,012(+) AGAGA(C/G)AGGCC intron-variant, downstream-variant-500B
rs111359932 -- 154,470,885(+) AGGTG(G/T)TGAGA intron-variant, nc-transcript-variant
rs111364741 -- 154,470,712(+) CCAGG(A/C)AGGAG intron-variant
rs111407699 -- 154,456,860(+) GTCAC(A/G)CCACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLXNA3 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
esv33784 CNV gain+loss 17666407
nsv519042 CNV gain 19592680

Variation tolerance for PLXNA3 Gene

Residual Variation Intolerance Score: 1.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.37; 85.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLXNA3 Gene

Human Gene Mutation Database (HGMD)
PLXNA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLXNA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLXNA3 Gene

Disorders for PLXNA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLXNA3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rett syndrome
  • rett syndrome, preserved speech variant
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLXNA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLXNA3
genes like me logo Genes that share disorders with PLXNA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLXNA3 Gene

Publications for PLXNA3 Gene

  1. A family of transmembrane proteins with homology to the MET- hepatocyte growth factor receptor. (PMID: 8570614) Maestrini E. … Comoglio P.M. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 22 64
  2. Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner. (PMID: 20138877) Fiedler S.E. … Carr D.W. (FEBS Lett. 2010) 3 4 64
  3. Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages. (PMID: 19480842) Ji J.D. … Ivashkiv L.B. (Hum. Immunol. 2009) 3 22 64
  4. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PMID: 8733135) Chen E.Y. … D'Urso M. (Hum. Mol. Genet. 1996) 2 3 64
  5. Transcriptional organization of a 450-kb region of the human X chromosome in Xq28. (PMID: 8248200) Bione S. … Toniolo D. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 64

Products for PLXNA3 Gene

Sources for PLXNA3 Gene

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