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Aliases for PLXNA3 Gene

Aliases for PLXNA3 Gene

  • Plexin A3 2 3 5
  • Semaphorin Receptor SEX 3 4
  • Plexin-4 3 4
  • PLXN4 3 4
  • Sex Chromosome X Transmembrane Protein Of HGF Receptor Family 3 3
  • HSSEXGENE 3
  • Plexin-A3 3
  • PLXN3 3
  • XAP-6 3
  • 6.3 3
  • SEX 4

External Ids for PLXNA3 Gene

Previous HGNC Symbols for PLXNA3 Gene

  • PLXN4

Previous GeneCards Identifiers for PLXNA3 Gene

  • GC0XU990185
  • GC0XM150067
  • GC0XP151274
  • GC0XP152154
  • GC0XP152118
  • GC0XP153250
  • GC0XP153339
  • GC0XP153686
  • GC0XP142263

Summaries for PLXNA3 Gene

Entrez Gene Summary for PLXNA3 Gene

  • This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013]

GeneCards Summary for PLXNA3 Gene

PLXNA3 (Plexin A3) is a Protein Coding gene. Among its related pathways are Semaphorin interactions and Axon guidance. GO annotations related to this gene include receptor activity and semaphorin receptor activity. An important paralog of this gene is PLXNA1.

UniProtKB/Swiss-Prot for PLXNA3 Gene

  • Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

Gene Wiki entry for PLXNA3 Gene

Additional gene information for PLXNA3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLXNA3 Gene

Genomics for PLXNA3 Gene

Regulatory Elements for PLXNA3 Gene

Enhancers for PLXNA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH154364 1.6 VISTA ENCODE dbSUPER 51.1 -88.1 -88092 10.7 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 FOS SP3 PLXNA3 EMD FLNA FAM50A HCFC1 DKC1 CH17-340M24.3 GC0XM154352 GC0XM154351
GH0XH154396 1.4 ENCODE dbSUPER 50.1 -58.8 -58802 6.2 HNRNPUL1 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B PLXNA3 HCFC1 DKC1 FLNA EMD SNORA70 SNORA56 DNASE1L1 SLC10A3 FAM50A
GH0XH154346 1.2 Ensembl ENCODE dbSUPER 52 -108.8 -108796 6.6 BCOR GTF2F1 ESRRA KLF1 NFIB HIC1 POLR2A ZNF600 PRDM10 SMARCA5 PLXNA3 FAM50A FAM3A GC0XM154351 GC0XM154352 LOC105373386
GH0XH154723 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.5 +273.1 273144 16 FOXA2 ZFP64 YY1 FOS RUNX3 ZC3H11A JUNB REST ZNF623 ZNF518A DKC1 SNORA70 HCFC1 F8A1 SNORA56 EMD GAB3 PLXNA3 F8A2 SLC10A3
GH0XH154457 0.9 ENCODE 43.7 +0.7 725 3.2 TBP RB1 SIN3A ZBTB40 ZEB1 ZNF766 GLIS2 ELK1 EGR1 ZNF366 PLXNA3 FAM3A FAM50A HCFC1 LAGE3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLXNA3 on UCSC Golden Path with GeneCards custom track

Promoters for PLXNA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000249676 219 2201 TBP RB1 SIN3A ZBTB40 ZEB1 ZNF766 GLIS2 ELK1 ZNF366 SCRT2

Genomic Locations for PLXNA3 Gene

Genomic Locations for PLXNA3 Gene
chrX:154,458,281-154,477,779
(GRCh38/hg38)
Size:
19,499 bases
Orientation:
Plus strand
chrX:153,686,621-153,701,989
(GRCh37/hg19)

Genomic View for PLXNA3 Gene

Genes around PLXNA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLXNA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLXNA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLXNA3 Gene

Proteins for PLXNA3 Gene

  • Protein details for PLXNA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51805-PLXA3_HUMAN
    Recommended name:
    Plexin-A3
    Protein Accession:
    P51805
    Secondary Accessions:
    • Q5HY36

    Protein attributes for PLXNA3 Gene

    Size:
    1871 amino acids
    Molecular mass:
    207703 Da
    Quaternary structure:
    • Interacts with CBFA2T3/MTG16.

neXtProt entry for PLXNA3 Gene

Post-translational modifications for PLXNA3 Gene

  • Glycosylation at posLast=5959, Asn548, Asn637, Asn738, Asn746, posLast=10091009, Asn1036, Asn1073, posLast=11151115, and Asn1162
  • Modification sites at PhosphoSitePlus

Other Protein References for PLXNA3 Gene

No data available for DME Specific Peptides for PLXNA3 Gene

Domains & Families for PLXNA3 Gene

Gene Families for PLXNA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for PLXNA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51805

UniProtKB/Swiss-Prot:

PLXA3_HUMAN :
  • Belongs to the plexin family.
Family:
  • Belongs to the plexin family.
genes like me logo Genes that share domains with PLXNA3: view

Function for PLXNA3 Gene

Molecular function for PLXNA3 Gene

GENATLAS Biochemistry:
plexin A3,calcium-dependent cell adhesion molecule at the neuronal cell surface,homologous to the hepatocyte growth factor receptor family, expressed in fetal brain,putatively involved in signal transduction
UniProtKB/Swiss-Prot Function:
Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

Phenotypes From GWAS Catalog for PLXNA3 Gene

Gene Ontology (GO) - Molecular Function for PLXNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity NAS 8570614
GO:0005515 protein binding IPI 20138877
GO:0017154 semaphorin receptor activity IEA --
genes like me logo Genes that share ontologies with PLXNA3: view
genes like me logo Genes that share phenotypes with PLXNA3: view

Animal Models for PLXNA3 Gene

MGI Knock Outs for PLXNA3:

Animal Model Products

CRISPR Products

miRNA for PLXNA3 Gene

miRTarBase miRNAs that target PLXNA3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLXNA3 Gene

Localization for PLXNA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLXNA3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLXNA3 gene
Compartment Confidence
plasma membrane 5
nucleus 4
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Plasma membrane (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLXNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002116 semaphorin receptor complex TAS 19909241
GO:0005634 nucleus IDA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 8570614
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLXNA3: view

Pathways & Interactions for PLXNA3 Gene

genes like me logo Genes that share pathways with PLXNA3: view

Pathways by source for PLXNA3 Gene

1 KEGG pathway for PLXNA3 Gene

Gene Ontology (GO) - Biological Process for PLXNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organism development TAS 8570614
GO:0007411 axon guidance IEA --
GO:0021612 facial nerve structural organization IEA --
GO:0021637 trigeminal nerve structural organization IEA --
genes like me logo Genes that share ontologies with PLXNA3: view

No data available for SIGNOR curated interactions for PLXNA3 Gene

Drugs & Compounds for PLXNA3 Gene

No Compound Related Data Available

Transcripts for PLXNA3 Gene

Unigene Clusters for PLXNA3 Gene

Plexin A3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLXNA3 Gene

No ASD Table

Relevant External Links for PLXNA3 Gene

GeneLoc Exon Structure for
PLXNA3
ECgene alternative splicing isoforms for
PLXNA3

Expression for PLXNA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLXNA3 Gene

Protein differential expression in normal tissues from HIPED for PLXNA3 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLXNA3 Gene



Protein tissue co-expression partners for PLXNA3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLXNA3 Gene:

PLXNA3

SOURCE GeneReport for Unigene cluster for PLXNA3 Gene:

Hs.632839

Evidence on tissue expression from TISSUES for PLXNA3 Gene

  • Nervous system(4.6)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with PLXNA3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLXNA3 Gene

Orthologs for PLXNA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLXNA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLXNA3 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GDI1 34
  • 95 (a)
OneToOne
PLXNA3 33
  • 90.22 (n)
cow
(Bos Taurus)
Mammalia PLXNA3 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plxna3 33 16 34
  • 86.55 (n)
rat
(Rattus norvegicus)
Mammalia Plxna3 33
  • 86.44 (n)
oppossum
(Monodelphis domestica)
Mammalia PLXNA3 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLXNA3 34
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLXNA3 34
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397805 33
zebrafish
(Danio rerio)
Actinopterygii plxna3 33 34
  • 70.71 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2624 33
Species where no ortholog for PLXNA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLXNA3 Gene

ENSEMBL:
Gene Tree for PLXNA3 (if available)
TreeFam:
Gene Tree for PLXNA3 (if available)

Paralogs for PLXNA3 Gene

Paralogs for PLXNA3 Gene

(10) SIMAP similar genes for PLXNA3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLXNA3: view

Variants for PLXNA3 Gene

Sequence variations from dbSNP and Humsavar for PLXNA3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs200042650 Benign 154,464,420(+) TGTGC(A/G)GCTGC nc-transcript-variant, reference, missense
rs1000612271 -- 154,470,910(+) AGCTG(C/T)GGAGG intron-variant, nc-transcript-variant
rs1000735586 -- 154,464,302(+) TCTTA(C/G)CAGGG nc-transcript-variant, reference, missense
rs1001999944 -- 154,463,287(+) ACCAG(C/G)TCCTG intron-variant
rs1002250042 -- 154,459,922(+) ACCCC(C/T)TTGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLXNA3 Gene

Variant ID Type Subtype PubMed ID
nsv519042 CNV gain 19592680
esv33784 CNV gain+loss 17666407
esv33199 CNV gain+loss 17666407

Variation tolerance for PLXNA3 Gene

Residual Variation Intolerance Score: 1.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.37; 85.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLXNA3 Gene

Human Gene Mutation Database (HGMD)
PLXNA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLXNA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLXNA3 Gene

Disorders for PLXNA3 Gene

Relevant External Links for PLXNA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLXNA3

No disorders were found for PLXNA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLXNA3 Gene

Publications for PLXNA3 Gene

  1. A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor. (PMID: 8570614) Maestrini E … Comoglio PM (Proceedings of the National Academy of Sciences of the United States of America 1996) 3 4 22 60
  2. Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner. (PMID: 20138877) Fiedler SE … Carr DW (FEBS letters 2010) 3 4 60
  3. Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages. (PMID: 19480842) Ji JD … Ivashkiv LB (Human immunology 2009) 3 22 60
  4. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PMID: 8733135) Chen EY … D'Urso M (Human molecular genetics 1996) 2 3 60
  5. Transcriptional organization of a 450-kb region of the human X chromosome in Xq28. (PMID: 8248200) Bione S … Toniolo D (Proceedings of the National Academy of Sciences of the United States of America 1993) 2 3 60

Products for PLXNA3 Gene

Sources for PLXNA3 Gene

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