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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLXNA3 Gene

protein-coding   GIFtS: 57
GCID: GC0XP153686

plexin A3


(Previous symbol: PLXN4)
 Explore 3 diseases affiliated with
PLXNA3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PLXNA3    

Aliases
for PLXNA3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Plexin A31 2     HSSEXGENE2
SEX1 2 3 5     PLEXIN-A32
PLXN41 2 3     PLXN32
6.31 2     Plexin-43
XAP-61 2     Plexin-A31
Semaphorin Receptor SEX2 3     Sex Chromosome X Transmembrane Protein Of HGF Receptor Family 32
Plxn31     Plexin-43

External Ids:    HGNC: 91011   Entrez Gene: 555582   Ensembl: ENSG000001308277   OMIM: 3000225   UniProtKB: P518053   

Export aliases for PLXNA3 gene to outside databases

Previous GC identifers: GC0XU990185 GC0XM150067 GC0XP151274 GC0XP152154 GC0XP152118 GC0XP153250 GC0XP153339 GC0XP142263


Summaries
for PLXNA3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PLXNA3:
The protein encoded by this gene is a member of the plexin class of proteins. The encoded protein is a transmembrane
protein that is exposed on the cell surface. This gene is thought to be involved in epithelial and neural tissue
development. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: PLXA3_HUMAN, P51805
Function: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of
the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of
sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal
neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system.
Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the
complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling
events in the cytoplasm

Gene Wiki entry for PLXNA3


Genomic Views
for PLXNA3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLXNA3 gene promoter:
         GR   CREB   GR-beta   deltaCREB   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PLXNA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PLXNA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLXNA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

PLXNA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLXNA3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP153686:  view genomic region     (about GC identifiers)

Start:
 153,686,621 bp from pter      End:
 153,701,989 bp from pter
Size:
 15,369 bases      Orientation:
 plus strand

Proteins
for PLXNA3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PLXA3_HUMAN, P51805 (See protein sequence)
Recommended Name: Plexin-A3 precursor  
Size: 1871 amino acids; 207703 Da
Subunit: Interacts with CBFA2T3/MTG16
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: Q5HY36

Explore the universe of human proteins at neXtProt for PLXNA3: NX_P51805

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51805

    • PLXNA3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_059984.2  
    ENSEMBL proteins: 
     ENSP00000358696  
    Reactome Protein details: P51805
    Human Recombinant Protein Products: 
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    Uscn Proteins for PLXNA3

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002116semaphorin receptor complex TAS19909241
    GO:0005622intracellular IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane TAS8570614
    GO:0016021integral to membrane IEA--


    PLXNA3 for ontologies           About GeneDecksing



    PLXNA3 Antibody Products: 
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    Assay Products for PLXNA3: 
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    Uscn ELISAs and CLIAs for PLXNA3

    Protein Domains /
    Families
    for PLXNA3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PLXNA3 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR014756 Ig_E-set
     IPR002165 Plexin_repeat
     IPR002909 IPT_TIG_rcpt
     IPR008936 Rho_GTPase_activation_prot
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P51805

    ProtoNet protein and cluster: P51805

    1 Blocks protein family: IPB013548 Plexin cytoplasmic region

    UniProtKB/Swiss-Prot: PLXA3_HUMAN, P51805
    Similarity: Belongs to the plexin family
    Similarity: Contains 4 IPT/TIG domains
    Similarity: Contains 1 Sema domain


    Function
    for PLXNA3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PLXA3_HUMAN, P51805
    Function: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of
    the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of
    sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal
    neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system.
    Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the
    complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling
    events in the cytoplasm

         Genatlas biochemistry entry for PLXNA3:
    plexin A3,calcium-dependent cell adhesion molecule at the neuronal cell surface,homologous to the hepatocyte growth
    factor receptor family, expressed in fetal brain,putatively involved in signal transduction

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLXNA3
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate PLXNA3 (see all 10):
    hsa-miR-3910 hsa-miR-124 hsa-miR-137 hsa-miR-186* hsa-miR-3121-3p hsa-miR-330-3p hsa-miR-506 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmid: PLXNA3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLXNA3 (see all 7)
    OriGene shRNA RFP: PLXNA3
    OriGene siRNA: PLXNA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLXNA3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PLXNA3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLXNA3 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: PLXNA3 (NM_017514)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLXNA3 

    Cell Line
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    Search LifeMap BioReagents cell lines for PLXNA3

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity NAS8570614
    GO:0017154semaphorin receptor activity IEA--


    PLXNA3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PLXNA3:
     Decreased DCP1a protein expres  Increased gamma-H2AX phosphory 

    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Plxna3):
     cellular  nervous system  vision/eye 

    PLXNA3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PLXNA3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
    		SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion1.00
    		CRMPs in Sema3A signaling0.36
    		Sema3A PAK dependent Axon repulsion0.45
    2Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69
    3Neuroscience
    		Neuroscience1.00
    4Axon guidance
    		Axon guidance1.00
    5Sema4D in semaphorin signaling
    		Semaphorin interactions0.44

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PLXNA3
        Neuroscience

    5/6        Reactome Pathways for PLXNA3 (see all 6)
        CRMPs in Sema3A signaling
    Developmental Biology
    Semaphorin interactions
    Sema3A PAK dependent Axon repulsion
    SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion


    1         Kegg Pathway  (Kegg details for PLXNA3):
        Axon guidance


    PLXNA3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLXNA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for PLXNA3 (P518052, 3 ENSP000003586964) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBFA2T3O750812, 3, ENSP000002686794MINT-7556975 MINT-7556989 I2D: score=1 STRING: ENSP00000268679
    SMN1Q166372, 3MINT-8271410 I2D: score=2 
    SMN2Q166372, 3MINT-8271410 I2D: score=2 
    CSNK2BP678702, 3MINT-8253539 I2D: score=2 
    MAPK8IP2Q133872, 3MINT-8262558 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development TAS8570614
    GO:0007411axon guidance TAS--
    GO:0021766hippocampus development IEA--
    GO:0021860pyramidal neuron development IEA--
    GO:0048843negative regulation of axon extension involved in axon guidance IEA--


    PLXNA3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PLXNA3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PLXNA3
    Search CenterWatch for drugs/clinical trials and news about PLXNA3 / PLXA3 

    Transcripts
    for PLXNA3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PLXNA3 gene: 
    NM_017514.3  

    Unigene Cluster for PLXNA3:

    Plexin A3
    Hs.632839  [show with all ESTs]
    Unigene Representative Sequence: NM_017514
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369682(uc004flm.3) ENST00000495040 ENST00000482598 ENST00000478236
    ENST00000467463 ENST00000480645 ENST00000491066 ENST00000493546 ENST00000497802


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLXNA3
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate PLXNA3 (see all 10):
    hsa-miR-3910 hsa-miR-124 hsa-miR-137 hsa-miR-186* hsa-miR-3121-3p hsa-miR-330-3p hsa-miR-506 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmid: PLXNA3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLXNA3 (see all 7)
    OriGene shRNA RFP: PLXNA3
    OriGene siRNA: PLXNA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLXNA3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLXNA3 (see all 3)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLXNA3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLXNA3

    Additional cDNA sequence: 

    X74609.1 X87197.1 X87852.1 

    11 DOTS entries:

    DT.113260  DT.92428284  DT.101981599  DT.100754871  DT.121293951  DT.121294249  DT.121294272  DT.91973380 
    DT.95170448  DT.97800759  DT.92061761 

    24/135 AceView cDNA sequences (see all 135):

    BU158888 AW082176 CD514759 BQ962177 BF766452 AA321842 X87197 BQ218646 
    BQ718472 AI905051 AW134554 CA314443 AA648960 AI751311 BQ573785 AI018541 
    CN484803 BM552802 BF527763 BG994320 BF725116 BG911281 BX283834 BQ708128 

    GeneLoc Exon Structure


    Expression
    for PLXNA3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLXNA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAATGTTTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PLXNA3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainCerebral CortexBrain
    BrainHypothalamusBrain
    BrainThalamusBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PLXNA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLXNA3

    SOURCE GeneReport for Unigene cluster: Hs.632839
        SABiosciences Custom PCR Arrays for PLXNA3
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLXNA3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXNA3

    Orthologs
    for PLXNA3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PLXNA3 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia PLXNA36
    		 --
    		 71(a)
    		 1 ↔ 1
    		 1(204580547-204674196)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3978052 plexin 76.15(n)    D38175.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii plxna31 plexin A3 70.43(n)
    73.9(a)    		   567422  NM_001098489.1  NP_001091959.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta plexA6
    		 plexin A
    		 38(a)
    		 1 → many
    		 4(1030521-1047720)
    worm
    (Caenorhabditis elegans)    		 Secernentea plx-16
    		 PLeXin family member (plx-1)
    		 29(a)
    		 possible ortholog
    		 IV(959452-984392)


    ENSEMBL Gene Tree for PLXNA3 (if available)
    TreeFam Gene Tree for PLXNA3 (if available) 

    Paralogs
    for PLXNA3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLXNA3 gene
    PLXNB22  PLXND12  PLXNA12  PLXNB12  PLXNA22  PLXNC12  PLXNB32  PLXNA42  
    10 SIMAP similar genes for PLXNA3 using alignment to 2 protein entries:     PLXA3_HUMAN (see all proteins):
    DKFZp761P19121    PLXNA1    PLXNA2    PLXNA4    DKFZp434G0625    PLXNC1
    PLXNB2    MM1    PLXNB3    PLXND1

    PLXNA3 for paralogs           About GeneDecksing



    Genomic Variants
    for PLXNA3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/427 NCBI SNPs in PLXNA3 are shown (see all 427)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1114076991,2
    		C--153685207(+) GTCACG/ACCACT 1 -- us2k12Minor allele frequency- A:0.33NA WA 3
    rs1137273111,2
    		C--153685249(+) TGTCTC/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1474262071,2
    		--153685461(+) CCCAGC/TATATG 1 -- us2k10--------
    rs735715971,2
    		C,--153685466(+) CATATC/GCCAGT 1 -- us2k12Minor allele frequency- G:0.33NA WA 3
    rs1924947251,2
    		--153685536(+) CAGTGG/TAGCAA 1 -- us2k10--------
    rs125587681,2
    		C,H--153685740(+) ATCTGG/TCTATC 1 -- us2k10--------
    rs70539561,2
    		C,F,H,--153685796(+) TTGAAT/CAGACA 1 -- us2k15Minor allele frequency- C:0.02NS EA WA 420
    rs1497767051,2
    		--153686095(+) GCCCTC/TGGTTC 1 -- us2k10--------
    rs1837819091,2
    		--153686654(+) CGCGCG/TTGGGG 1 -- ut510--------
    rs1456935451,2
    		--153687009(+) ACTTCC/TCTCCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for PLXNA3 (153686621 - 153701989 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PLXNA3: --
    Locus Specific Mutation Databases (LSDB): PLXNA3

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    Disorders / Diseases
    for PLXNA3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PLXNA3 for disorders           About GeneDecksing

    OMIM gene information: 300022    OMIM disorders: --

    3 diseases for PLXNA3:    About MalaCards
    rett syndrome    ovarian cancer    neuronitis


    Export disorders for PLXNA3 gene to outside databases

    Publications
    for PLXNA3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLXNA3 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with PLXNA3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of transmembrane proteins with homology to the MET- hepatocyte growth factor receptor. (PubMed id 8570614)1, 2, 9 Maestrini E.... Comoglio P.M. (1996)
    2. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PubMed id 8733135)1, 3 Chen E.Y....D'Urso M. (1996)
    3. Transcriptional organization of a 450-kb region of the human X chromosome in Xq28. (PubMed id 8248200)1, 3 Bione S.... Toniolo D. (1993)
    4. Expression and function of semaphorin 3A and its rece ptors in human monocyte-derived macrophages. (PubMed id 19480842)1, 9 Ji J.D....Ivashkiv L.B. (2009)
    5. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    6. Semaphorin-plexin signalling genes associated with hu man breast tumourigenesis. (PubMed id 21925246)1 Gabrovska P.N....Griffiths L.R. (2011)
    7. Myeloid translocation gene 16b is a dual A-kinase anc horing protein that interacts selectively with plexins in a phospho-regulated m anner. (PubMed id 20138877)2 Fiedler S.E....Carr D.W. (2010)
    8. The role of neuropilins in cell signalling. (PubMed id 19909241)1 Zachary I.C....Pellet-Many C. (2009)
    9. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
    10. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PubMed id 15203218)1 Fu G.K....Stuve L.L. (2004)

    External Searches for PLXNA3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PLXNA3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55558 HGNC: 9101 AceView: PLXNA3 Ensembl:ENSG00000130827 euGenes: HUgn55558
    ECgene: PLXNA3 Kegg: 55558 H-InvDB: PLXNA3

    Other Databases showing PLXNA3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PLXNA3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLXNA3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PLXNA3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PLXNA3 gene:
    Search GeneIP for patents involving PLXNA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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