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PLXNA3 Gene

protein-coding   GIFtS: 60
GCID: GC0XP153686

Plexin A3


(Previous symbol: PLXN4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Plexin A31 2     PLXN32
PLXN41 2 3     XAP-62
Semaphorin Receptor SEX2 3     plexin-42
SEX3 5     plexin-A32
6.32     Sex Chromosome X Transmembrane Protein Of HGF Receptor Family 32
HSSEXGENE2     Plexin-43

External Ids:    HGNC: 91011   Entrez Gene: 555582   Ensembl: ENSG000001308277   OMIM: 3000225   UniProtKB: P518053   

Export aliases for PLXNA3 gene to outside databases

Previous GC identifers: GC0XU990185 GC0XM150067 GC0XP151274 GC0XP152154 GC0XP152118 GC0XP153250 GC0XP153339 GC0XP142263


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLXNA3 Gene:
This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor,
and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish
suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated
with tumor progression. (provided by RefSeq, Aug 2013)

GeneCards Summary for PLXNA3 Gene:
PLXNA3 (plexin A3) is a protein-coding gene. GO annotations related to this gene include transmembrane signaling receptor activity and semaphorin receptor activity. An important paralog of this gene is PLXNA1.

UniProtKB/Swiss-Prot: PLXA3_HUMAN, P51805
Function: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent
remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the
migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine
morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the
developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The
plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for
the activation of down-stream signaling events in the cytoplasm

Gene Wiki entry for PLXNA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011681.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLXNA3 gene promoter:
         GR   CREB   GR-beta   deltaCREB   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLXNA3 promoter sequence
   Search Chromatin IP Primers for PLXNA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLXNA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

PLXNA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLXNA3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP153686:  view genomic region     (about GC identifiers)

Start:
153,686,621 bp from pter      End:
153,701,989 bp from pter
Size:
15,369 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PLXA3_HUMAN, P51805 (See protein sequence)
Recommended Name: Plexin-A3 precursor  
Size: 1871 amino acids; 207703 Da
Subunit: Interacts with CBFA2T3/MTG16
Secondary accessions: Q5HY36

Explore the universe of human proteins at neXtProt for PLXNA3: NX_P51805

Explore proteomics data for PLXNA3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn59, Asn548, Asn637, Asn738, Asn746, Asn1009, Asn1036, Asn1073, Asn1115, Asn1162
  • Modification sites at PhosphoSitePlus

  • See PLXNA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_059984.3  
    ENSEMBL proteins: 
     ENSP00000358696  
    Reactome Protein details: P51805

    PLXNA3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PLXNA3

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLXN: Plexins

    Selected InterPro protein domains (see all 9):
     IPR014756 Ig_E-set
     IPR002165 Plexin_repeat
     IPR002909 IPT
     IPR008936 Rho_GTPase_activation_prot
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P51805

    ProtoNet protein and cluster: P51805

    1 Blocks protein domain: IPB013548 Plexin cytoplasmic region

    UniProtKB/Swiss-Prot: PLXA3_HUMAN, P51805
    Similarity: Belongs to the plexin family
    Similarity: Contains 4 IPT/TIG domains
    Similarity: Contains 1 Sema domain


    Find genes that share domains with PLXNA3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLXA3_HUMAN, P51805
    Function: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent
    remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the
    migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine
    morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the
    developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The
    plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for
    the activation of down-stream signaling events in the cytoplasm

         Genatlas biochemistry entry for PLXNA3:
    plexin A3,calcium-dependent cell adhesion molecule at the neuronal cell surface,homologous to the hepatocyte
    growth factor receptor family, expressed in fetal brain,putatively involved in signal transduction

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0004888transmembrane signaling receptor activity NAS8570614
    GO:0005515protein binding IPI--
    GO:0017154semaphorin receptor activity IEA--
         
    Find genes that share ontologies with PLXNA3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PLXNA3:
     Decreased DCP1a protein expres  Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Plxna3):
     cellular  nervous system  vision/eye 

    Find genes that share phenotypes with PLXNA3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLXNA3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PLXNA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLXNA3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLXNA3

    miRNA
    Products:
        
    miRTarBase miRNAs that target PLXNA3:
    hsa-mir-335-5p (MIRT018079)

    Block miRNA regulation of human, mouse, rat PLXNA3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLXNA3 (see all 10):
    hsa-miR-3910 hsa-miR-124 hsa-miR-137 hsa-miR-186* hsa-miR-3121-3p hsa-miR-330-3p hsa-miR-506 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidPLXNA3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PLXNA3
    Predesigned siRNA for gene silencing in human, mouse, rat PLXNA3

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PLXNA3 (NM_017514)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXNA3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLXA3_HUMAN, P51805: Cell membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002116semaphorin receptor complex TAS19909241
    GO:0005622intracellular IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane TAS8570614
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PLXNA3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLXNA3 About    
    See pathways by source

    SuperPathContained pathways About
    1Semaphorin interactions
    Semaphorin interactions0.43
    CRMPs in Sema3A signaling0.00
    SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion0.00
    Sema3A PAK dependent Axon repulsion0.00
    2L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    3Neuroscience
    Neuroscience
    4Axon guidance
    Axon guidance


    Find genes that share SuperPaths with PLXNA3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PLXNA3
        Neuroscience

    3 Reactome Pathways for PLXNA3
        CRMPs in Sema3A signaling
    Sema3A PAK dependent Axon repulsion
    SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion


    1 Kegg Pathway  (Kegg details for PLXNA3):
        Axon guidance

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLXNA3
    Interactions:

        Search GeneGlobe Interaction Network for PLXNA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLXNA3 (P518051, 2, 3 ENSP000003586964) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBFA2T3O750811, 2, 3, ENSP000002686794EBI-7135904,EBI-1190217 MINT-7556975 MINT-7556989 I2D: score=1 STRING: ENSP00000268679
    CSNK2BP678702, 3MINT-8253539 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253539 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253539 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253539 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007275multicellular organismal development TAS8570614
    GO:0007411axon guidance TAS--
    GO:0021766hippocampus development IEA--
    GO:0021860pyramidal neuron development IEA--

    Find genes that share ontologies with PLXNA3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PLXNA3 (PLXA3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLXNA3 gene: 
    NM_017514.4  

    Unigene Cluster for PLXNA3:

    Plexin A3
    Hs.632839  [show with all ESTs]
    Unigene Representative Sequence: NM_017514
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369682(uc004flm.3) ENST00000495040 ENST00000482598 ENST00000478236
    ENST00000467463 ENST00000480645 ENST00000491066 ENST00000493546 ENST00000497802

    miRNA
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    Block miRNA regulation of human, mouse, rat PLXNA3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLXNA3 (see all 10):
    hsa-miR-3910 hsa-miR-124 hsa-miR-137 hsa-miR-186* hsa-miR-3121-3p hsa-miR-330-3p hsa-miR-506 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidPLXNA3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: PLXNA3 (NM_017514)
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      QuantiTect SYBR Green Assays in human, mouse, rat PLXNA3
      QuantiFast Probe-based Assays in human, mouse, rat PLXNA3

    Additional mRNA sequence: 

    X74609.1 X87197.1 X87852.1 

    11 DOTS entries:

    DT.113260  DT.92428284  DT.101981599  DT.100754871  DT.121293951  DT.121294249  DT.121294272  DT.91973380 
    DT.95170448  DT.97800759  DT.92061761 

    Selected AceView cDNA sequences (see all 135):

    BU158888 BQ218646 CN484803 CD514759 AI018541 BQ573785 AI751311 BM552802 
    BG994320 X87197 BF766452 AA321842 BF527763 BF725116 BQ962177 AW082176 
    CA314443 AA648960 AW134554 AI905051 BQ718472 BQ574190 AI872345 BQ447116 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLXNA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATGTTTTT
    PLXNA3 Expression
    About this image


    PLXNA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
    PLXNA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLXNA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632839
        Custom PCR Arrays for PLXNA3
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXNA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PLXNA3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plxna31 , 5 plexin A31, 5 86.55(n)1
    94.6(a)1
      X (38.00 cM)5
    188461  NM_008883.21  NP_032909.21 
     743290665 
    lizard
    (Anolis carolinensis)
    Reptilia PLXNA36
    plexin A3
    72(a)
    1 ↔ 1
    1(204580547-204678754)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978052 plexin 76.15(n)    D38175.1 
    zebrafish
    (Danio rerio)
    Actinopterygii plxna31 plexin A3 70.71(n)
    74.43(a)
      567422  NM_001098489.1  NP_001091959.1 


    ENSEMBL Gene Tree for PLXNA3 (if available)
    TreeFam Gene Tree for PLXNA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLXNA3 gene
    PLXNA12  PLXNA22  PLXNB12  PLXNB22  PLXND12  PLXNC12  PLXNB32  PLXNA42  
    10 SIMAP similar genes for PLXNA3 using alignment to 2 protein entries:     PLXA3_HUMAN (see all proteins):
    DKFZp761P19121    PLXNA1    PLXNA2    PLXNA4    DKFZp434G0625    PLXNC1
    PLXNB2    MM1    PLXNB3    PLXND1

    Find genes that share paralogs with PLXNA3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLXNA3 (see all 666)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1114076991,2
    C--153685207(+) GTCACG/ACCACT 2 -- us2k12Minor allele frequency- A:0.33NA WA 3
    rs1137273111,2
    C--153685249(+) TGTCTC/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1474262071,2
    --153685461(+) CCCAGC/TATATG 2 -- us2k10--------
    rs735715971,2
    C--153685466(+) CATATC/GCCAGT 2 -- us2k12Minor allele frequency- G:0.33NA WA 3
    rs1924947251,2
    --153685536(+) CAGTGG/TAGCAA 2 -- us2k10--------
    rs125587681,2
    C,H--153685740(+) ATCTGG/TCTATC 2 -- us2k10--------
    rs70539561,2
    C,F,H--153685796(+) ttgaaT/Cagaca 2 -- us2k15Minor allele frequency- C:0.02NS EA WA 420
    rs1497767051,2
    C--153686095(+) GCCCTC/TGGTTC 2 -- us2k10--------
    rs1837819091,2
    --153686654(+) CGCGCG/TTGGGG 2 -- ut510--------
    rs1456935451,2
    C--153687009(+) ACTTCC/TCTCCC 2 -- int10--------

    HapMap Linkage Disequilibrium report for PLXNA3 (153686621 - 153701989 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PLXNA3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519042CNV Gain19592680
    esv33199CNV Gain+Loss17666407
    esv33784CNV Gain+Loss17666407

    Locus Specific Mutation Databases (LSDB): PLXNA3

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLXNA3
    DNA2.0 Custom Variant and Variant Library Synthesis for PLXNA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300022    OMIM disorders: --


    Find genes that share disorders with PLXNA3           About GenesLikeMe


    Export disorders for PLXNA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLXNA3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with PLXNA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of transmembrane proteins with homology to the MET- hepatocyte growth factor receptor. (PubMed id 8570614)1, 2, 9 Maestrini E.... Comoglio P.M. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner. (PubMed id 20138877)1, 2 Fiedler S.E.... Carr D.W. (FEBS Lett. 2010)
    3. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PubMed id 8733135)1, 3 Chen E.Y....D'Urso M. (Hum. Mol. Genet. 1996)
    4. Transcriptional organization of a 450-kb region of the human X chromosome in Xq28. (PubMed id 8248200)1, 3 Bione S.... Toniolo D. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    5. Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages. (PubMed id 19480842)1, 9 Ji J.D....Ivashkiv L.B. (Hum. Immunol. 2009)
    6. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    7. Semaphorin-plexin signalling genes associated with human breast tumourigenesis. (PubMed id 21925246)1 Gabrovska P.N....Griffiths L.R. (Gene 2011)
    8. The role of neuropilins in cell signalling. (PubMed id 19909241)1 Zachary I.C....Pellet-Many C. (Biochem. Soc. Trans. 2009)
    9. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
    10. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PubMed id 15203218)1 Fu G.K....Stuve L.L. (Genomics 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55558 HGNC: 9101 AceView: PLXNA3 Ensembl:ENSG00000130827 euGenes: HUgn55558
    ECgene: PLXNA3 Kegg: 55558 H-InvDB: PLXNA3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PLXNA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLXNA3 gene:
    Search GeneIP for patents involving PLXNA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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