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Aliases for PLXNA1 Gene

Aliases for PLXNA1 Gene

  • Plexin A1 2 3 5
  • Semaphorin Receptor NOV 3 4
  • PLXN1 3 4
  • NOV 3 4
  • PLEXIN-A1 3
  • Plexin 1 3
  • NOVP 3

External Ids for PLXNA1 Gene

Previous HGNC Symbols for PLXNA1 Gene

  • PLXN1

Previous GeneCards Identifiers for PLXNA1 Gene

  • GC03P123491
  • GC03P126738
  • GC03P127989
  • GC03P128028
  • GC03P128190
  • GC03P124086

Summaries for PLXNA1 Gene

GeneCards Summary for PLXNA1 Gene

PLXNA1 (Plexin A1) is a Protein Coding gene. Diseases associated with PLXNA1 include Hereditary Congenital Facial Paresis. Among its related pathways are Semaphorin interactions and Developmental Biology. GO annotations related to this gene include receptor activity and semaphorin receptor activity. An important paralog of this gene is PLXNA3.

UniProtKB/Swiss-Prot for PLXNA1 Gene

  • Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

Gene Wiki entry for PLXNA1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLXNA1 Gene

Genomics for PLXNA1 Gene

Regulatory Elements for PLXNA1 Gene

Enhancers for PLXNA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F126981 1.8 FANTOM5 Ensembl ENCODE 20.7 +1.5 1537 4.3 HDGF MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF207 ZNF143 PLXNA1 TXNRD3 PIR55562
GH03F126998 1.3 FANTOM5 Ensembl ENCODE 17.5 +19.5 19513 5.9 RING1 CTCF TEAD4 SIN3A EBF1 ZIC2 RAD21 ETS1 POLR2A SCRT2 PLXNA1 CHST13 PIR55562
GH03F127035 1.1 Ensembl ENCODE 19.4 +53.7 53731 2.4 KLF1 KLF17 MAX ZIC2 TEAD3 ZFHX2 GATA3 POLR2A PATZ1 ZNF600 PLXNA1 PIR55562
GH03F126959 1.4 FANTOM5 Ensembl ENCODE 13 -21.1 -21074 2.7 SIN3A ZNF2 RAD21 ZNF143 FOS EGR2 DEK ZNF654 MXD4 REST PLXNA1 CHST13 PIR43717 ENSG00000280053
GH03F126971 1 FANTOM5 Ensembl ENCODE 14.3 -10.1 -10125 1.3 NR2F1 IKZF1 NR2F2 PLXNA1 CHST13 ZXDC ENSG00000280053 PIR43717
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLXNA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLXNA1 Gene

Chromosome:
3
Start:
126,982,119 bp from pter
End:
127,037,392 bp from pter
Size:
55,274 bases
Orientation:
Plus strand

Genomic View for PLXNA1 Gene

Genes around PLXNA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLXNA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLXNA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLXNA1 Gene

Proteins for PLXNA1 Gene

  • Protein details for PLXNA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIW2-PLXA1_HUMAN
    Recommended name:
    Plexin-A1
    Protein Accession:
    Q9UIW2

    Protein attributes for PLXNA1 Gene

    Size:
    1896 amino acids
    Molecular mass:
    211067 Da
    Quaternary structure:
    • Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2 (By similarity).

neXtProt entry for PLXNA1 Gene

Post-translational modifications for PLXNA1 Gene

  • Ubiquitination at Lys 1418
  • Modification sites at PhosphoSitePlus

Other Protein References for PLXNA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PLXNA1 (PLXNA1)
  • Cloud-Clone Corp. Antibodies for PLXNA1

No data available for DME Specific Peptides for PLXNA1 Gene

Domains & Families for PLXNA1 Gene

Gene Families for PLXNA1 Gene

Suggested Antigen Peptide Sequences for PLXNA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIW2

UniProtKB/Swiss-Prot:

PLXA1_HUMAN :
  • Contains 4 IPT/TIG domains.
  • Belongs to the plexin family.
Domain:
  • Contains 4 IPT/TIG domains.
  • Contains 1 Sema domain.
Family:
  • Belongs to the plexin family.
genes like me logo Genes that share domains with PLXNA1: view

Function for PLXNA1 Gene

Molecular function for PLXNA1 Gene

GENATLAS Biochemistry:
plexin A1,calcium-dependent cell adhesion molecule at the neuronal cell surface,homologous to the hepatocyte growth factor receptor family,expressed in fetal brain,putatively involved in signal transduction
UniProtKB/Swiss-Prot Function:
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

Gene Ontology (GO) - Molecular Function for PLXNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 8570614
GO:0017154 semaphorin receptor activity TAS 10520995
genes like me logo Genes that share ontologies with PLXNA1: view
genes like me logo Genes that share phenotypes with PLXNA1: view

Animal Models for PLXNA1 Gene

MGI Knock Outs for PLXNA1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLXNA1 Gene

Localization for PLXNA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLXNA1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLXNA1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLXNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002116 semaphorin receptor complex TAS 19909241
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with PLXNA1: view

Pathways & Interactions for PLXNA1 Gene

genes like me logo Genes that share pathways with PLXNA1: view

Pathways by source for PLXNA1 Gene

1 Cell Signaling Technology pathway for PLXNA1 Gene
1 KEGG pathway for PLXNA1 Gene
1 GeneGo (Thomson Reuters) pathway for PLXNA1 Gene

Gene Ontology (GO) - Biological Process for PLXNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organism development TAS 8570614
GO:0014910 regulation of smooth muscle cell migration IEA --
GO:0021785 branchiomotor neuron axon guidance IBA --
GO:0030334 regulation of cell migration IBA --
genes like me logo Genes that share ontologies with PLXNA1: view

No data available for SIGNOR curated interactions for PLXNA1 Gene

Drugs & Compounds for PLXNA1 Gene

(1) Additional Compounds for PLXNA1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PLXNA1: view

Transcripts for PLXNA1 Gene

Unigene Clusters for PLXNA1 Gene

Plexin A1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLXNA1 Gene

No ASD Table

Relevant External Links for PLXNA1 Gene

GeneLoc Exon Structure for
PLXNA1
ECgene alternative splicing isoforms for
PLXNA1

Expression for PLXNA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLXNA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLXNA1 Gene

This gene is overexpressed in Heart (29.1), Fetal Brain (17.4), and Frontal cortex (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLXNA1 Gene



Protein tissue co-expression partners for PLXNA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLXNA1 Gene:

PLXNA1

SOURCE GeneReport for Unigene cluster for PLXNA1 Gene:

Hs.432329

mRNA Expression by UniProt/SwissProt for PLXNA1 Gene:

Q9UIW2-PLXA1_HUMAN
Tissue specificity: Detected in fetal brain, lung, liver and kidney.
genes like me logo Genes that share expression patterns with PLXNA1: view

Primer Products

No data available for mRNA differential expression in normal tissues for PLXNA1 Gene

Orthologs for PLXNA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLXNA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLXNA1 34 35
  • 98.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 96 (a)
OneToMany
-- 35
  • 96 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PLXNA1 34 35
  • 90.23 (n)
cow
(Bos Taurus)
Mammalia PLXNA1 34 35
  • 89.49 (n)
mouse
(Mus musculus)
Mammalia Plxna1 34 16 35
  • 87.84 (n)
rat
(Rattus norvegicus)
Mammalia Plxna1 34
  • 87.73 (n)
oppossum
(Monodelphis domestica)
Mammalia PLXNA1 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLXNA1 34 35
  • 80.81 (n)
lizard
(Anolis carolinensis)
Reptilia PLXNA1 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plxna1 34
  • 75.51 (n)
zebrafish
(Danio rerio)
Actinopterygii PLXNA1 (2 of 3) 35
  • 83 (a)
OneToMany
PLXNA1 (1 of 3) 35
  • 79 (a)
OneToMany
PLXNA1 (3 of 3) 35
  • 77 (a)
OneToMany
plxna1b 34
  • 74.08 (n)
fruit fly
(Drosophila melanogaster)
Insecta plexA 36
  • 41 (a)
plexB 36
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea plx-1 36
  • 34 (a)
plx-2 36
  • 25 (a)
Species where no ortholog for PLXNA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLXNA1 Gene

ENSEMBL:
Gene Tree for PLXNA1 (if available)
TreeFam:
Gene Tree for PLXNA1 (if available)

Paralogs for PLXNA1 Gene

Paralogs for PLXNA1 Gene

(11) SIMAP similar genes for PLXNA1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLXNA1: view

Variants for PLXNA1 Gene

Sequence variations from dbSNP and Humsavar for PLXNA1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1036136 -- 127,023,738(-) ATGTC(C/T)GGCCA intron-variant
rs1106863 -- 126,988,533(+) GCTCC(C/T)GGCAC upstream-variant-2KB, utr-variant-5-prime
rs111621752 -- 127,009,649(+) TTCCT(A/G)CTGAG intron-variant
rs111834153 -- 127,027,513(+) TGGGC(A/G)GTGGG intron-variant
rs111856163 -- 126,982,959(+) CCCCT(A/G)CAGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLXNA1 Gene

Variant ID Type Subtype PubMed ID
nsv955340 CNV deletion 24416366
nsv829719 CNV gain 17160897
nsv591563 CNV loss 21841781
nsv521490 CNV loss 19592680
nsv460846 CNV loss 19166990
nsv3987 CNV insertion 18451855
nsv1001475 CNV loss 25217958
esv3562513 CNV deletion 23714750
esv2725882 CNV deletion 23290073
dgv8559n54 CNV loss 21841781

Variation tolerance for PLXNA1 Gene

Residual Variation Intolerance Score: 0.211% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLXNA1 Gene

Human Gene Mutation Database (HGMD)
PLXNA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLXNA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLXNA1 Gene

Disorders for PLXNA1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLXNA1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hereditary congenital facial paresis
  • facial paresis hereditary congenital
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLXNA1

Genetic Association Database (GAD)
PLXNA1
Human Genome Epidemiology (HuGE) Navigator
PLXNA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLXNA1
genes like me logo Genes that share disorders with PLXNA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLXNA1 Gene

Publications for PLXNA1 Gene

  1. A family of transmembrane proteins with homology to the MET- hepatocyte growth factor receptor. (PMID: 8570614) Maestrini E. … Comoglio P.M. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 64
  2. The plexin-A1 receptor activates vascular endothelial growth factor-receptor 2 and nuclear factor-kappaB to mediate survival and anchorage-independent growth of malignant mesothelioma cells. (PMID: 19176370) Catalano A. … Procopio A. (Cancer Res. 2009) 3 22 64
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  4. Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages. (PMID: 19480842) Ji J.D. … Ivashkiv L.B. (Hum. Immunol. 2009) 3 22 64
  5. [Expression of Plexin A1 in gastric carcinoma and its relationship with tumor angiogenesis and proliferation]. (PMID: 17520388) Zhao X.Y. … Li Y.H. (Zhonghua Wei Chang Wai Ke Za Zhi 2007) 3 22 64

Products for PLXNA1 Gene

Sources for PLXNA1 Gene

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