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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLXNA1 Gene

protein-coding   GIFtS: 61
GCID: GC03P126738

plexin A1


(Previous symbol: PLXN1)
 Explore 13 diseases affiliated with
PLXNA1 via our new
 Human Malady Compendium 
Biological research products
for PLXNA1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Plexin A11 2     NOVP2 5
NOV1 2 3 5     PLEXIN-A12
PLXN11 2 3 5     Plexin 12
Semaphorin Receptor NOV2 3     Plexin-A11

External Ids:    HGNC: 90991   Entrez Gene: 53612   Ensembl: ENSG000001145547   OMIM: 6010555   UniProtKB: Q9UIW23   

Export aliases for PLXNA1 gene to outside databases

Previous GC identifers: GC03P123491 GC03P127989 GC03P128028 GC03P128190 GC03P124086


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PLXA1_HUMAN, Q9UIW2
Function: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and
subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3
semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex
for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in
the cytoplasm (By similarity)

Gene Wiki entry for PLXNA1 (Plexin A1)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLXNA1 gene promoter:
         Bach1   NRSF form 1   XBP-1   CUTL1   NRSF form 2   HEN1   CREB   S8   deltaCREB   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PLXNA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PLXNA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLXNA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21.2

PLXNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLXNA1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P126738:  view genomic region     (about GC identifiers)

Start:
126,707,437 bp from pter      End:
126,756,235 bp from pter
Size:
48,799 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PLXA1_HUMAN, Q9UIW2 (See protein sequence)
Recommended Name: Plexin-A1 precursor  
Size: 1896 amino acids; 211067 Da
Subunit: Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to
dissociation of FARP2 (By similarity)
Subcellular location: Cell membrane (Probable); Single-pass type I membrane protein (By similarity)

Explore the universe of human proteins at neXtProt for PLXNA1: NX_Q9UIW2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UIW2

  • PLXNA1 Protein expression data from MOPED and PaxDb:    About this image 
    PLXNA1 Protein Expression
    REFSEQ proteins: NP_115618.3  
    ENSEMBL proteins: 
     ENSP00000377061   ENSP00000251772  
    Reactome Protein details: Q9UIW2
    Human Recombinant Protein Products for PLXNA1: 
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    Novus Biologicals PLXNA1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PLXNA1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002116semaphorin receptor complex TAS19909241
    GO:0005622intracellular ----
    GO:0005624membrane fraction ----
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--

    PLXNA1 for ontologies           About GeneDecksing



    PLXNA1 Antibody Products: 
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    Uscn ELISAs and CLIAs for PLXNA1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PLXNA1 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR014756 Ig_E-set
     IPR002165 Plexin_repeat
     IPR002909 IPT_TIG_rcpt
     IPR008936 Rho_GTPase_activation_prot
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9UIW2

    ProtoNet protein and cluster: Q9UIW2

    1 Blocks protein family: IPB013548 Plexin cytoplasmic region

    UniProtKB/Swiss-Prot: PLXA1_HUMAN, Q9UIW2
    Similarity: Belongs to the plexin family
    Similarity: Contains 4 IPT/TIG domains
    Similarity: Contains 1 Sema domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLXA1_HUMAN, Q9UIW2
    Function: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and
    subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3
    semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex
    for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in
    the cytoplasm (By similarity)

         Genatlas biochemistry entry for PLXNA1:
    plexin A1,calcium-dependent cell adhesion molecule at the neuronal cell surface,homologous to the hepatocyte growth
    factor receptor family,expressed in fetal brain,putatively involved in signal transduction

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS8570614
    GO:0005515protein binding ----
    GO:0017154semaphorin receptor activity TAS10520995
         
    PLXNA1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PLXNA1:
     Decreased G3BP1 protein expres  Decreased nuclei size in G2M  Increased G2M DNA content, inc  Increased HPV18 LCR reporter a 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Plxna1):
     cellular  hematopoietic system  immune system  nervous system  skeleton 
     vision/eye 

    PLXNA1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Plxna1tm1Kik for PLXNA1
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PLXNA1 

    miRNA
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    8/77 QIAGEN miScript miRNA Assays for microRNAs that regulate PLXNA1 (see all 77):
    hsa-miR-26a-2* hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-4272 hsa-miR-1260b hsa-miR-30d hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXNA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
    SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion1.00
    CRMPs in Sema3A signaling0.36
    Sema3A PAK dependent Axon repulsion0.45
    2Axon guidance
    Axon guidance1.00
    Developmental Biology0.69
    3Semaphorin interactions
    Semaphorin interactions1.00
    Fcgamma receptor (FCGR) dependent phagocytosis0.67
    4Neurophysiological process Receptor-mediated axon growth repulsion
    Neurophysiological process Receptor-mediated axon growth repulsion1.00
    Neurophysiological process_Receptor-mediated axon growth repulsion0.94
    5Neuroscience
    Neuroscience1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for PLXNA1
        Neurophysiological process Receptor-mediated axon growth repulsion


    1 Cell Signaling Technology (CST) Pathway for PLXNA1
        Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for PLXNA1
        Neurophysiological process Receptor-mediated axon growth repulsion

    5/10        Reactome Pathways for PLXNA1 (see all 10)
        CRMPs in Sema3A signaling
    Developmental Biology
    Fcgamma receptor (FCGR) dependent phagocytosis
    Immune System
    Other semaphorin interactions


    1         Kegg Pathway  (Kegg details for PLXNA1):
        Axon guidance


    PLXNA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PLXNA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for PLXNA1 (Q9UIW22, 3 ENSP000002517724) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDIA3P301012, 3MINT-4301370 I2D: score=1 
    PLXNB1O431573, ENSP000002964404I2D: score=2 STRING: ENSP00000296440
    NRP2O604623, ENSP000003535824I2D: score=1 STRING: ENSP00000353582
    RND1Q927303, ENSP000003084614I2D: score=1 STRING: ENSP00000308461
    SEMA6DQ8NFY43, ENSP000003248574I2D: score=1 STRING: ENSP00000324857
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development TAS8570614
    GO:0007411axon guidance TAS--
    GO:0060666dichotomous subdivision of terminal units involved in salivary gland branching IEA--
    GO:0071526semaphorin-plexin signaling pathway ----

    PLXNA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PLXNA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PLXNA1
    1 Novoseek chemical compound relationship for PLXNA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 51.3 6 17520388 (2), 17369861 (1), 19176370 (1), 15867361 (1)

    Search CenterWatch for drugs/clinical trials and news about PLXNA1 / PLXA1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLXNA1 gene: 
    NM_032242.3  

    Unigene Cluster for PLXNA1:

    Plexin A1
    Hs.432329  [show with all ESTs]
    Unigene Representative Sequence: NM_032242
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393409 ENST00000503234 ENST00000503363 ENST00000505278 ENST00000251772(uc003ejg.3 uc003ejh.3)


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    hsa-miR-26a-2* hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-4272 hsa-miR-1260b hsa-miR-30d hsa-miR-30a
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    Additional cDNA sequence: 

    AK054675.1 AK055605.1 AK126101.1 AK127254.1 AK128612.1 AK293425.1 AL136663.1 BC017323.2 
    BC032432.1 BC042904.1 X87832.2 

    6 DOTS entries:

    DT.87016942  DT.101981599  DT.92370941  DT.95370603  DT.100779718  DT.91818504 

    24/242 AceView cDNA sequences (see all 242):

    BC017323 AW298404 AF279131 NM_032242 CK819133 N24431 BQ007046 BM128020 
    BQ878090 BF514988 AK128612 BQ684860 CA431077 F36920 BQ678617 AA984010 
    AI143269 BM782135 BU615919 AI825793 AI693175 N34259 CD107670 CB130771 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLXNA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCTGTGAAA
    PLXNA1 Expression
    About this image
    See PLXNA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLXNA1

    SOURCE GeneReport for Unigene cluster: Hs.432329

    UniProtKB/Swiss-Prot: PLXA1_HUMAN, Q9UIW2
    Tissue specificity: Detected in fetal brain, lung, liver and kidney

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXNA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PLXNA1 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PLXNA11 plexin A1 80.66(n)
    88.03(a)
      416030  XM_003641979.1  XP_003642027.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLXNA16
    --
    85(a)
    1 ↔ 1
    2(166830388-167150556)
    zebrafish
    (Danio rerio)
    Actinopterygii plxna11 plexin A1 73.8(n)
    79.76(a)
      558065  NM_001110010.1  NP_001103480.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta plexA3 axon guidance receptor 41(a)
    (best of 2)
      102D1   --
    worm
    (Caenorhabditis elegans)
    Secernentea plx-13 Expression: P lineage, V lineage,
    intestinal, more
    34(a)
    (best of 2)
      IV(959527-983149)   --


    ENSEMBL Gene Tree for PLXNA1 (if available)
    TreeFam Gene Tree for PLXNA1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLXNA1 gene
    PLXNB22  PLXND12  PLXNA32  PLXNB12  PLXNA22  PLXNC12  PLXNB32  PLXNA42  
    11 SIMAP similar genes for PLXNA1 using alignment to 2 protein entries:     PLXA1_HUMAN (see all proteins):
    DKFZp761P19121    PLXNA3    PLXNA2    PLXNA4    DKFZp434G0625    PLXNB2
    Nbla00445    PLXNC1    MM1    PLXNB3    PLXND1

    PLXNA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/847 NCBI SNPs in PLXNA1 are shown (see all 847    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1167129461,2
    F--126705520(+) TGGCCG/AGGAGA 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1464146421,2
    --126705521(+) GGCCGC/GGAGAA 1 -- us2k10--------
    rs68020491,2
    C,F,A--126705763(+) GGGGCA/CAGACC 1 -- us2k1 tfbs310Minor allele frequency- C:0.48NA WA CSA EA 371
    rs1851130011,2
    --126705992(+) GAGAAA/GAGAGC 1 -- us2k10--------
    rs1408166451,2
    --126706066(+) CATCTA/GCCTAC 1 -- us2k10--------
    rs1899197701,2
    --126706381(+) GGGCCC/GGATGT 1 -- us2k10--------
    rs1500974311,2
    --126706390(+) GTGGAA/GCAAGG 1 -- us2k10--------
    rs1158139051,2
    F--126706525(+) GAGTTG/AGGTGT 1 -- us2k11Minor allele frequency- A:0.07NA 120
    rs76163191,2
    C,F,A,H--126706551(+) ACTGGC/TGGCTT 1 -- us2k116Minor allele frequency- T:0.01EA NS NA WA CSA 674
    rs1386330581,2
    --126706552(+) CTGGTA/GGCTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PLXNA1 (126707437 - 126756235 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PLXNA1: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PLXNA1 for disorders           About GeneDecksing

    OMIM gene information: 601055    OMIM disorders: --

    13 diseases for PLXNA1:    About MalaCards
    hereditary congenital facial paresis    malignant mesothelioma    malignant glioma    multiple myeloma
    myeloma    alzheimer's disease    colon cancer    ovarian cancer
    pancreatic cancer    pancreatitis    adenocarcinoma    neuronitis
    carcinoma

    2 Novoseek disease relationships for PLXNA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 8.9 5 17631638 (1), 17520388 (1), 15867361 (1)
    cancer 2.02 1 17520388 (1)

    Human Genome Epidemiology (HuGE) Navigator: PLXNA1 (1 document)

    Export disorders for PLXNA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLXNA1 gene, integrated from 9 sources (see all 69):
    (articles sorted by number of sources associating them with PLXNA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of transmembrane proteins with homology to the MET- hepatocyte growth factor receptor. (PubMed id 8570614)1, 2, 3 Maestrini E.... Comoglio P.M. (1996)
    2. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. [Expression of Plexin A1 in gastric carcinoma and its relationship with tumor angiogenesis and proliferation] (PubMed id 17520388)1, 9 Zhao X.Y....Li Y.H. (2007)
    5. Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vas cular endothelial growth factor receptor type 2. (PubMed id 14977921)1, 9 Toyofuku T....Kikutani H. (2004)
    6. The plexin-A1 receptor activates vascular endothelial growth factor-receptor 2 and nuclear factor-kappaB to mediate survival and anchorage-independent growth of malignant mesothelioma cells. (PubMed id 19176370)1, 9 Catalano A....Procopio A. (2009)
    7. The activity of the plexin-A1 receptor is regulated by Rac. (PubMed id 15187088)1, 9 Turner L.J....Hall A. (2004)
    8. Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse. (PubMed id 11784792)1, 9 Zanata S.M....Puschel A.W. (2002)
    9. Expression and function of semaphorin 3A and its rece ptors in human monocyte-derived macrophages. (PubMed id 19480842)1, 9 Ji J.D....Ivashkiv L.B. (2009)
    10. Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells. (PubMed id 14500350)1, 9 Bachelder R.E....Mercurio A.M. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5361 HGNC: 9099 AceView: PLXNA1 Ensembl:ENSG00000114554 euGenes: HUgn5361
    ECgene: PLXNA1 Kegg: 5361 H-InvDB: PLXNA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLXNA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLXNA1 gene:
    Search GeneIP for patents involving PLXNA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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