Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PLXNA1 Gene

protein-coding   GIFtS: 66
GCID: GC03P126738

Plexin A1


(Previous symbol: PLXN1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Plexin A11 2     NOVP2 5
PLXN11 2 3 5     PLEXIN-A12
NOV2 3 5     Plexin 12
Semaphorin Receptor NOV2 3     plexin-A12

External Ids:    HGNC: 90991   Entrez Gene: 53612   Ensembl: ENSG000001145547   OMIM: 6010555   UniProtKB: Q9UIW23   

Export aliases for PLXNA1 gene to outside databases

Previous GC identifers: GC03P123491 GC03P127989 GC03P128028 GC03P128190 GC03P124086


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for PLXNA1 Gene:
PLXNA1 (plexin A1) is a protein-coding gene. Diseases associated with PLXNA1 include hereditary congenital facial paresis, and gastroenteritis. GO annotations related to this gene include semaphorin receptor activity and receptor activity. An important paralog of this gene is PLXNA2.

UniProtKB/Swiss-Prot: PLXA1_HUMAN, Q9UIW2
Function: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and
subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.
Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of
the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream
signaling events in the cytoplasm (By similarity)

Gene Wiki entry for PLXNA1 (Plexin A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLXNA1 gene promoter:
         Bach1   NRSF form 1   XBP-1   CUTL1   NRSF form 2   HEN1   CREB   S8   deltaCREB   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PLXNA1 promoter sequence
   Search Chromatin IP Primers for PLXNA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLXNA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21.2

PLXNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLXNA1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P126738:  view genomic region     (about GC identifiers)

Start:
126,707,437 bp from pter      End:
126,756,235 bp from pter
Size:
48,799 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PLXA1_HUMAN, Q9UIW2 (See protein sequence)
Recommended Name: Plexin-A1 precursor  
Size: 1896 amino acids; 211067 Da
Subunit: Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads
to dissociation of FARP2 (By similarity)

Explore the universe of human proteins at neXtProt for PLXNA1: NX_Q9UIW2

Explore proteomics data for PLXNA1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1418
  • Glycosylation2 at Asn77, Asn660, Asn672, Asn701, Thr726, Asn1043, Asn1187, Asn1212
  • Modification sites at PhosphoSitePlus

  • See PLXNA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115618.3  
    ENSEMBL proteins: 
     ENSP00000377061   ENSP00000251772  
    Reactome Protein details: Q9UIW2

    PLXNA1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PLXNA1
    OriGene Protein Over-expression Lysate for PLXNA1
    OriGene MassSpec for PLXNA1
    OriGene Custom Protein Services for PLXNA1
    GenScript Custom Purified and Recombinant Proteins Services for PLXNA1
    Novus Biologicals PLXNA1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PLXNA1

    PLXNA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PLXNA1
    R&D Systems Antibodies for PLXNA1 (Plexin A1)
    Cell Signaling Technology (CST) Antibodies for PLXNA1 
    OriGene Antibodies for PLXNA1
    OriGene Custom Antibody Services for PLXNA1
    Novus Biologicals PLXNA1 Antibodies
    Abcam antibodies for PLXNA1
    Cloud-Clone Corp. Antibodies for PLXNA1
    ThermoFisher Antibodies for PLXNA1
    LSBio Antibodies in human, mouse, rat for PLXNA1

    PLXNA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PLXNA1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PLXNA1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PLXNA1
    Cloud-Clone Corp. CLIAs for PLXNA1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PLXN: Plexins

    Selected InterPro protein domains (see all 9):
     IPR014756 Ig_E-set
     IPR002165 Plexin_repeat
     IPR002909 IPT
     IPR008936 Rho_GTPase_activation_prot
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9UIW2

    ProtoNet protein and cluster: Q9UIW2

    1 Blocks protein domain: IPB013548 Plexin cytoplasmic region

    UniProtKB/Swiss-Prot: PLXA1_HUMAN, Q9UIW2
    Similarity: Belongs to the plexin family
    Similarity: Contains 4 IPT/TIG domains
    Similarity: Contains 1 Sema domain


    PLXNA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLXA1_HUMAN, Q9UIW2
    Function: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and
    subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.
    Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of
    the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream
    signaling events in the cytoplasm (By similarity)

         Genatlas biochemistry entry for PLXNA1:
    plexin A1,calcium-dependent cell adhesion molecule at the neuronal cell surface,homologous to the hepatocyte
    growth factor receptor family,expressed in fetal brain,putatively involved in signal transduction

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS8570614
    GO:0005515protein binding ----
    GO:0017154semaphorin receptor activity TAS10520995
         
    PLXNA1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PLXNA1:
     Decreased G3BP1 protein expres  Decreased nuclei size in G2M  Increased G2M DNA content, inc  Increased HPV18 LCR reporter a 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Plxna1):
     hematopoietic system  immune system  nervous system  skeleton  vision/eye 

    PLXNA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Plxna1tm1Kik for PLXNA1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLXNA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PLXNA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLXNA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLXNA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PLXNA1:
    hsa-mir-484 (MIRT041934), hsa-mir-20a-5p (MIRT050583), hsa-mir-615-3p (MIRT040286), hsa-mir-335-5p (MIRT018527), hsa-mir-186-5p (MIRT045283), hsa-mir-17-5p (MIRT050900), hsa-mir-146a-3p (MIRT038621)

    Block miRNA regulation of human, mouse, rat PLXNA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLXNA1 (see all 77):
    hsa-miR-26a-2* hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-4272 hsa-miR-1260b hsa-miR-30d hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PLXNA1
    Predesigned siRNA for gene silencing in human, mouse, rat PLXNA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PLXNA1

    Clone
    Products:
         
    OriGene clones in human, mouse for PLXNA1 (see all 5)
    OriGene ORF clones in mouse, rat for PLXNA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PLXNA1 (NM_032242)
    Sino Biological Human cDNA Clone for PLXNA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLXNA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLXNA1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PLXNA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PLXNA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXNA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PLXA1_HUMAN, Q9UIW2: Cell membrane (Probable); Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    plasma membrane4
    cytoskeleton1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002116semaphorin receptor complex TAS19909241
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane TAS--

    PLXNA1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PLXNA1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Semaphorin interactions
    Semaphorin interactions0.43
    CRMPs in Sema3A signaling0.00
    SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion0.00
    Sema3A PAK dependent Axon repulsion0.00
    Other semaphorin interactions0.00
    2L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    3Development Slit Robo signaling
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    4Neuroscience
    Neuroscience
    5Axon guidance
    Axon guidance

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PLXNA1
        Signaling in Gap Junctions

    1 Cell Signaling Technology (CST) Pathway for PLXNA1
        Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for PLXNA1
        Neurophysiological process Receptor-mediated axon growth repulsion


    4 Reactome Pathways for PLXNA1
        CRMPs in Sema3A signaling
    Other semaphorin interactions
    Sema3A PAK dependent Axon repulsion
    SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion


    1 Kegg Pathway  (Kegg details for PLXNA1):
        Axon guidance


    PLXNA1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLXNA1
    Interactions:

        GeneGlobe Interaction Network for PLXNA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLXNA1 (Q9UIW22, 3 ENSP000002517724) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDIA3P301012, 3MINT-4301370 I2D: score=1 
    PLXNB1O431573, ENSP000002964404I2D: score=2 STRING: ENSP00000296440
    NPR1P160663, ENSP000003576694I2D: score=1 STRING: ENSP00000357669
    NRP2O604623, ENSP000003535824I2D: score=1 STRING: ENSP00000353582
    RND1Q927303, ENSP000003084614I2D: score=1 STRING: ENSP00000308461
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007275multicellular organismal development TAS8570614
    GO:0007411axon guidance TAS--
    GO:0014910regulation of smooth muscle cell migration IEA--
    GO:0060666dichotomous subdivision of terminal units involved in salivary gland branching IEA--

    PLXNA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PLXNA1 (PLXA1)

    1 Novoseek inferred chemical compound relationship for PLXNA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 51.3 6 17520388 (2), 17369861 (1), 19176370 (1), 15867361 (1)



    PLXNA1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PLXNA1 gene: 
    NM_032242.3  

    Unigene Cluster for PLXNA1:

    Plexin A1
    Hs.432329  [show with all ESTs]
    Unigene Representative Sequence: NM_032242
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393409 ENST00000503234 ENST00000503363 ENST00000505278 ENST00000251772(uc003ejg.3 uc003ejh.3)


    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PLXNA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLXNA1 (see all 77):
    hsa-miR-26a-2* hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-4272 hsa-miR-1260b hsa-miR-30d hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PLXNA1
    Predesigned siRNA for gene silencing in human, mouse, rat PLXNA1
    Clone
    Products:
         
    OriGene clones in human, mouse for PLXNA1 (see all 5)
    OriGene ORF clones in mouse, rat for PLXNA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PLXNA1 (NM_032242)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLXNA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLXNA1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PLXNA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLXNA1
      QuantiTect SYBR Green Assays in human, mouse, rat PLXNA1
      QuantiFast Probe-based Assays in human, mouse, rat PLXNA1

    Additional mRNA sequence: 

    AK054675.1 AK055605.1 AK126101.1 AK127254.1 AK128612.1 AK293425.1 AL136663.1 BC017323.2 
    BC032432.1 BC042904.1 X87832.2 

    6 DOTS entries:

    DT.87016942  DT.101981599  DT.92370941  DT.95370603  DT.100779718  DT.91818504 

    Selected AceView cDNA sequences (see all 242):

    BQ683335 AW275194 AL134739 AA984010 AW298404 BM782135 BM128020 F36920 
    AI693175 AF279131 BC017323 BQ678617 AK128612 N24431 CB130771 BQ772361 
    BF475346 NM_032242 BQ007046 AI143269 AI825793 CA442850 CA431077 BQ684860 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PLXNA1 expression in normal human tissues (normalized intensities)      PLXNA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGTGAAA
    PLXNA1 Expression
    About this image


    PLXNA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Eye (Sensory Organs)
             Retina
    PLXNA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLXNA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.432329

    UniProtKB/Swiss-Prot: PLXA1_HUMAN, Q9UIW2
    Tissue specificity: Detected in fetal brain, lung, liver and kidney

        Custom PCR Arrays for PLXNA1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PLXNA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLXNA1
    QuantiTect SYBR Green Assays in human, mouse, rat PLXNA1
    QuantiFast Probe-based Assays in human, mouse, rat PLXNA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXNA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for PLXNA1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plxna11 , 5 plexin A11, 5 87.84(n)1
    96.15(a)1
      6 (39.91 cM)5
    188441  NM_008881.21  NP_032907.11 
     893163165 
    chicken
    (Gallus gallus)
    Aves PLXNA11 plexin A1 80.81(n)
    88.3(a)
      416030  XM_414370.4  XP_414370.4 
    lizard
    (Anolis carolinensis)
    Reptilia PLXNA16
    plexin A1
    85(a)
    1 ↔ 1
    2(166765491-167150556)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia plxna11 plexin A1 75.51(n)
    85.8(a)
      100037845  NM_001097291.1  NP_001090760.1 
    zebrafish
    (Danio rerio)
    Actinopterygii plxna1b1 plexin A1b 74.08(n)
    80.21(a)
      558065  NM_001110010.1  NP_001103480.1 


    ENSEMBL Gene Tree for PLXNA1 (if available)
    TreeFam Gene Tree for PLXNA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PLXNA1 gene
    PLXNA22  PLXNB12  PLXNB22  PLXND12  PLXNA32  PLXNC12  PLXNB32  PLXNA42  
    11 SIMAP similar genes for PLXNA1 using alignment to 2 protein entries:     PLXA1_HUMAN (see all proteins):
    DKFZp761P19121    PLXNA3    PLXNA2    PLXNA4    DKFZp434G0625    PLXNB2
    Nbla00445    PLXNC1    MM1    PLXNB3    PLXND1

    PLXNA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PLXNA1 (see all 1235)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1167129461,2
    C,F--126705520(+) TGGCCG/AGGAGA 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1464146421,2
    --126705521(+) GGCCGC/GGAGAA 1 -- us2k10--------
    rs68020491,2
    C,F,A--126705763(+) GGGGCA/CAGACC 1 -- us2k1 tfbs310Minor allele frequency- C:0.48NA WA CSA EA 371
    rs1851130011,2
    --126705992(+) GAGAAA/GAGAGC 1 -- us2k10--------
    rs1408166451,2
    C--126706066(+) CATCTA/GCCTAC 1 -- us2k10--------
    rs1899197701,2
    --126706381(+) GGGCCC/GGATGT 1 -- us2k10--------
    rs1500974311,2
    --126706390(+) GTGGAA/GCAAGG 1 -- us2k10--------
    rs1158139051,2
    F--126706525(+) GAGTTG/AGGTGT 1 -- us2k11Minor allele frequency- A:0.07NA 120
    rs76163191,2
    C,F,A,H--126706551(+) ACTGGC/TGGCTT 1 -- us2k116Minor allele frequency- T:0.01EA NS NA WA CSA 674
    rs1386330581,2
    --126706552(+) CTGGTA/GGCTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PLXNA1 (126707437 - 126756235 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for PLXNA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725882CNV Deletion23290073
    nsv3987CNV Insertion18451855
    nsv521490CNV Loss19592680
    nsv877445CNV Loss21882294
    nsv460846CNV Loss19166990
    dgv5248n71CNV Loss21882294
    nsv829719CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLXNA1
    DNA2.0 Custom Variant and Variant Library Synthesis for PLXNA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601055    OMIM disorders: --

    15 diseases for PLXNA1:    About MalaCards
    hereditary congenital facial paresis    gastroenteritis    malignant mesothelioma    malignant glioma
    multiple myeloma    myeloma    pancreatic cancer    ovarian cancer
    alzheimer's disease    pancreatitis    endotheliitis    retinitis
    adenocarcinoma    cerebritis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for PLXNA1:
    Gastroenteritis

    PLXNA1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for PLXNA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 8.9 5 17631638 (1), 17520388 (1), 15867361 (1)
    cancer 2.02 1 17520388 (1)

    Genetic Association Database (GAD): PLXNA1
    Human Genome Epidemiology (HuGE) Navigator: PLXNA1 (1 document)

    Export disorders for PLXNA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PLXNA1 gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with PLXNA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of transmembrane proteins with homology to the MET- hepatocyte growth factor receptor. (PubMed id 8570614)1, 2, 3 Maestrini E.... Comoglio P.M. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    3. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (Nature 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. [Expression of Plexin A1 in gastric carcinoma and its relationship with tumor angiogenesis and proliferation]. (PubMed id 17520388)1, 9 Zhao X.Y....Li Y.H. (Zhonghua Wei Chang Wai Ke Za Zhi 2007)
    6. Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2. (PubMed id 14977921)1, 9 Toyofuku T....Kikutani H. (amp 2004)
    7. The plexin-A1 receptor activates vascular endothelial growth factor-receptor 2 and nuclear factor-kappaB to mediate survival and anchorage-independent growth of malignant mesothelioma cells. (PubMed id 19176370)1, 9 Catalano A....Procopio A. (Cancer Res. 2009)
    8. The activity of the plexin-A1 receptor is regulated by Rac. (PubMed id 15187088)1, 9 Turner L.J....Hall A. (J. Biol. Chem. 2004)
    9. Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse. (PubMed id 11784792)1, 9 Zanata S.M....PA1schel A.W. (J. Neurosci. 2002)
    10. Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages. (PubMed id 19480842)1, 9 Ji J.D....Ivashkiv L.B. (Hum. Immunol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5361 HGNC: 9099 AceView: PLXNA1 Ensembl:ENSG00000114554 euGenes: HUgn5361
    ECgene: PLXNA1 Kegg: 5361 H-InvDB: PLXNA1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PLXNA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PLXNA1 gene:
    Search GeneIP for patents involving PLXNA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PLXNA1
     
     EMD Millipore genomic analysis products

      
     Antibodies for PLXNA1 (Plexin A1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PLXNA1   OriGene RNAi products in human, mouse, rat for PLXNA1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PLXNA1  
     OriGene MassSpec something-or-other for PLXNA1   OriGene clones in human, mouse for PLXNA1  
     OriGene qSTAR qPCR primer pairs in human, mouse for PLXNA1   OriGene Purified Protein for PLXNA1  
     OriGene ORF clones in mouse, rat for PLXNA1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PLXNA1   OriGene Custom Protein Services for PLXNA1  

     
     
     Block miRNA regulation of human, mouse, rat PLXNA1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PLXNA1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLXNA1 Predesigned siRNA for gene silencing in human, mouse, rat PLXNA1
     QuantiFast Probe-based Assays in human, mouse, rat PLXNA1 QuantiTect SYBR Green Assays in human, mouse, rat PLXNA1
     Custom PCR Arrays for PLXNA1 Search Chromatin IP Primers for PLXNA1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLXNA1  GeneGlobe Interaction Network for PLXNA1
     Regulatory tfbs in PLXNA1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PLXNA1 GenScript cDNA clones with any tag delivered in your preferred vector for PLXNA1
     GenScript Custom Assay Services for PLXNA1 GenScript Custom overexpressing Cell Line Services for PLXNA1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for PLXNA1 

     Search Tocris compounds for PLXNA1 (PLXA1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for PLXNA1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PLXNA1 antibodies
     PLXNA1 lysates
     Antibodies for PLXNA1
     See all of Abcam's Antibodies, Kits and Proteins for PLXNA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PLXNA1
     Antibodies for PLXNA1
     ELISAs for PLXNA1
     CLIAs for PLXNA1



     Browse ESI BIO Cell Lines and PureStem Progenitors for PLXNA1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXNA1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PLXNA1
     SwitchGear Promoter luciferase reporter plasmids for PLXNA1
     ThermoFisher Antibodies for PLXNA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLXNA1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLXNA1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PLXNA1
     LSBio Antibodies in human, mouse, rat for PLXNA1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PLXNA1 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4