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Aliases for PLXDC1 Gene

Aliases for PLXDC1 Gene

  • Plexin Domain Containing 1 2 3 5
  • Tumor Endothelial Marker 3 3 4
  • Tumor Endothelial Marker 7 3 4
  • TEM3 3 4
  • TEM7 3 4
  • Tumor Endothelial Marker 7 Precursor 2
  • 2410003I07Rik 3

External Ids for PLXDC1 Gene

Previous GeneCards Identifiers for PLXDC1 Gene

  • GC17M037129
  • GC17M037594
  • GC17M034473
  • GC17M033015
  • GC17M037219

Summaries for PLXDC1 Gene

GeneCards Summary for PLXDC1 Gene

PLXDC1 (Plexin Domain Containing 1) is a Protein Coding gene. Diseases associated with PLXDC1 include endocardium disease. GO annotations related to this gene include receptor activity. An important paralog of this gene is PLXDC2.

UniProtKB/Swiss-Prot for PLXDC1 Gene

  • Plays a critical role in endothelial cell capillary morphogenesis.

Gene Wiki entry for PLXDC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLXDC1 Gene

Genomics for PLXDC1 Gene

Regulatory Elements for PLXDC1 Gene

Promoters for PLXDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLXDC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLXDC1 Gene

Chromosome:
17
Start:
39,063,303 bp from pter
End:
39,154,394 bp from pter
Size:
91,092 bases
Orientation:
Minus strand

Genomic View for PLXDC1 Gene

Genes around PLXDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLXDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLXDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLXDC1 Gene

Proteins for PLXDC1 Gene

  • Protein details for PLXDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUK5-PLDX1_HUMAN
    Recommended name:
    Plexin domain-containing protein 1
    Protein Accession:
    Q8IUK5
    Secondary Accessions:
    • B2R7I8
    • Q5QCZ7
    • Q5QCZ8
    • Q5QCZ9
    • Q9HCT9

    Protein attributes for PLXDC1 Gene

    Size:
    500 amino acids
    Molecular mass:
    55760 Da
    Quaternary structure:
    • Interacts with NID1. May interact with CTTN.

    Alternative splice isoforms for PLXDC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLXDC1 Gene

Proteomics data for PLXDC1 Gene at MOPED

Post-translational modifications for PLXDC1 Gene

Antibody Products

No data available for DME Specific Peptides for PLXDC1 Gene

Domains & Families for PLXDC1 Gene

Protein Domains for PLXDC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IUK5

UniProtKB/Swiss-Prot:

PLDX1_HUMAN :
  • Belongs to the plexin family.
Family:
  • Belongs to the plexin family.
genes like me logo Genes that share domains with PLXDC1: view

No data available for Gene Families for PLXDC1 Gene

Function for PLXDC1 Gene

Molecular function for PLXDC1 Gene

UniProtKB/Swiss-Prot Function:
Plays a critical role in endothelial cell capillary morphogenesis.
genes like me logo Genes that share phenotypes with PLXDC1: view

Animal Models for PLXDC1 Gene

MGI Knock Outs for PLXDC1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLXDC1

CRISPR Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLXDC1 Gene

Localization for PLXDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLXDC1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.
Isoform 2: Secreted.
Isoform 3: Secreted.
Isoform 4: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLXDC1 Gene COMPARTMENTS Subcellular localization image for PLXDC1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLXDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005622 intracellular NAS 15574754
GO:0005886 plasma membrane NAS 15574754
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLXDC1: view

Pathways & Interactions for PLXDC1 Gene

SuperPathways for PLXDC1 Gene

No Data Available

Interacting Proteins for PLXDC1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000323927%0d%0a9606.ENSP00000264187%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000323927 Q8IUK5-PLDX1_HUMAN for PLXDC1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for PLXDC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PLXDC1 Gene

Drugs & Compounds for PLXDC1 Gene

No Compound Related Data Available

Transcripts for PLXDC1 Gene

Unigene Clusters for PLXDC1 Gene

Plexin domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLXDC1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a ·
SP1: - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - - - -
SP9:
SP10: - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - - -
SP14: - - - - - - - -
SP15: - - - - - - - - - -
SP16:

ExUns: 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b
SP1: -
SP2: - -
SP3: - - -
SP4: - -
SP5: - - -
SP6: - -
SP7:
SP8:
SP9: - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for PLXDC1 Gene

GeneLoc Exon Structure for
PLXDC1
ECgene alternative splicing isoforms for
PLXDC1

Expression for PLXDC1 Gene

mRNA expression in normal human tissues for PLXDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLXDC1 Gene

This gene is overexpressed in Heart (31.5), Vitreous humor (19.8), and Retina (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLXDC1 Gene



SOURCE GeneReport for Unigene cluster for PLXDC1 Gene Hs.125036

mRNA Expression by UniProt/SwissProt for PLXDC1 Gene

Q8IUK5-PLDX1_HUMAN
Tissue specificity: Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy.
genes like me logo Genes that share expression patterns with PLXDC1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PLXDC1 Gene

Orthologs for PLXDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLXDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLXDC1 35
  • 99.13 (n)
  • 98.6 (a)
PLXDC1 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLXDC1 36
  • 85 (a)
OneToOne
PLXDC1 35
  • 89.27 (n)
  • 89.6 (a)
dog
(Canis familiaris)
Mammalia PLXDC1 35
  • 89.6 (n)
  • 90.4 (a)
PLXDC1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plxdc1 16
Plxdc1 35
  • 83.77 (n)
  • 81.76 (a)
Plxdc1 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLXDC1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLXDC1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plxdc1 35
  • 84.77 (n)
  • 82.57 (a)
chicken
(Gallus gallus)
Aves PLXDC1 35
  • 75.19 (n)
  • 75.11 (a)
PLXDC1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLXDC1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plxdc1 35
  • 61.81 (n)
  • 59.58 (a)
zebrafish
(Danio rerio)
Actinopterygii plxdc1 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta l(1)G0289 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pxd-1 36
  • 29 (a)
OneToMany
Species with no ortholog for PLXDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLXDC1 Gene

ENSEMBL:
Gene Tree for PLXDC1 (if available)
TreeFam:
Gene Tree for PLXDC1 (if available)

Paralogs for PLXDC1 Gene

Paralogs for PLXDC1 Gene

(1) SIMAP similar genes for PLXDC1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with PLXDC1: view

Variants for PLXDC1 Gene

Sequence variations from dbSNP and Humsavar for PLXDC1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_064050 -
rs16228 -- 39,108,502(+) GACTC(A/G)CAGCT intron-variant
rs16229 -- 39,110,808(+) ATAAG(C/T)GACAC intron-variant
rs16230 -- 39,112,161(+) ATGGC(C/T)GCCTC intron-variant
rs16231 -- 39,114,545(+) TAAGA(C/T)CGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLXDC1 Gene

Variant ID Type Subtype PubMed ID
nsv2046 CNV Loss 18451855
nsv833440 CNV Loss 17160897
nsv908200 CNV Gain 21882294
esv2664163 CNV Deletion 23128226
esv2715899 CNV Deletion 23290073

Variation tolerance for PLXDC1 Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.24; 70.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLXDC1 Gene

HapMap Linkage Disequilibrium report
PLXDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLXDC1 Gene

Disorders for PLXDC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLXDC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
endocardium disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLXDC1

Genetic Association Database (GAD)
PLXDC1
Human Genome Epidemiology (HuGE) Navigator
PLXDC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLXDC1
genes like me logo Genes that share disorders with PLXDC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLXDC1 Gene

Publications for PLXDC1 Gene

  1. Cell surface tumor endothelial markers are conserved in mice and humans. (PMID: 11559528) Carson-Walter E.B. … St Croix B. (Cancer Res. 2001) 2 3 4 67
  2. Genes expressed in human tumor endothelium. (PMID: 10947988) St Croix B. … Kinzler K.W. (Science 2000) 2 3
  3. Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF. (PMID: 25535841) Cheng G. … Sun H. (Elife 2014) 3
  4. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. (PMID: 23382219) Ghai R. … Collins B.M. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for PLXDC1 Gene

Sources for PLXDC1 Gene

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