Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLTP Gene

Aliases for PLTP Gene

  • Phospholipid Transfer Protein 2 3
  • BPI Fold Containing Family E 2 3
  • Lipid Transfer Protein II 3 4
  • HDLCQ9 3 6
  • BPIFE 3

External Ids for PLTP Gene

Previous GeneCards Identifiers for PLTP Gene

  • GC20M044255
  • GC20M044215
  • GC20M045165
  • GC20M045212
  • GC20M043960
  • GC20M044528
  • GC20M041269

Summaries for PLTP Gene

Entrez Gene Summary for PLTP Gene

  • The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLTP Gene

PLTP (Phospholipid Transfer Protein) is a Protein Coding gene. Diseases associated with PLTP include hyperalphalipoproteinemia and hypoalphalipoproteinemia. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include lipid binding. An important paralog of this gene is BPI.

UniProtKB/Swiss-Prot for PLTP Gene

  • Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability

Gene Wiki entry for PLTP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLTP Gene

Genomics for PLTP Gene

Regulatory Elements for PLTP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PLTP Gene

Start:
45,898,620 bp from pter
End:
45,912,364 bp from pter
Size:
13,745 bases
Orientation:
Minus strand

Genomic View for PLTP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLTP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLTP Gene

Proteins for PLTP Gene

  • Protein details for PLTP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55058-PLTP_HUMAN
    Recommended name:
    Phospholipid transfer protein
    Protein Accession:
    P55058
    Secondary Accessions:
    • A8K006
    • B4DDD5
    • B4DRB4
    • E1P5N8
    • E7EV16
    • Q8WTT1
    • Q9BR07
    • Q9BSH8

    Protein attributes for PLTP Gene

    Size:
    493 amino acids
    Molecular mass:
    54739 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLTP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLTP Gene

Proteomics data for PLTP Gene at MOPED

Post-translational modifications for PLTP Gene

  • Glycosylation at Asn64, Asn94, Asn117, Asn143, Asn245, Asn398, Ser483, Thr484, Thr487, Ser489, and Thr490
  • Modification sites at PhosphoSitePlus

Other Protein References for PLTP Gene

Antibody Products

No data available for DME Specific Peptides for PLTP Gene

Domains for PLTP Gene

Gene Families for PLTP Gene

HGNC:
  • BPIF :BPI fold containing

Suggested Antigen Peptide Sequences for PLTP Gene

Graphical View of Domain Structure for InterPro Entry

P55058

UniProtKB/Swiss-Prot:

PLTP_HUMAN :
  • P55058
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with PLTP: view

Function for PLTP Gene

Molecular function for PLTP Gene

GENATLAS Biochemistry:
plasma phospholipid transfer protein,81kDa,partially overlapping PPGB,in opposite orientation,with high homology to LBP
UniProtKB/Swiss-Prot Function:
Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability

Gene Ontology (GO) - Molecular Function for PLTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with PLTP: view
genes like me logo Genes that share phenotypes with PLTP: view

Animal Models for PLTP Gene

MGI Knock Outs for PLTP:

Animal Model Products

miRNA for PLTP Gene

miRTarBase miRNAs that target PLTP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLTP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PLTP Gene

Localization for PLTP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLTP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLTP Gene COMPARTMENTS Subcellular localization image for PLTP gene
Compartment Confidence
extracellular 5
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PLTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 7654777
GO:0005615 extracellular space IDA 16502470
genes like me logo Genes that share ontologies with PLTP: view

Pathways for PLTP Gene

genes like me logo Genes that share pathways with PLTP: view

Pathways by source for PLTP Gene

1 PharmGKB pathway for PLTP Gene
1 KEGG pathway for PLTP Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PLTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006869 lipid transport IEA --
GO:0010189 vitamin E biosynthetic process IEA --
GO:0010875 positive regulation of cholesterol efflux IDA 24369175
GO:0030317 sperm motility IEA --
genes like me logo Genes that share ontologies with PLTP: view

Compounds for PLTP Gene

(2601) HMDB Compounds for PLTP Gene

Compound Synonyms Cas Number PubMed IDs
PA(16:0/16:0)
  • Dipalmitoylphosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • PA(16:0/18:1n7)
Not Available
PA(16:0/18:1(9Z))
  • PA(16:0/18:1n9)
Not Available
PA(16:0/18:2(9Z,12Z))
  • PA(34:2)
Not Available
PA(16:0e/18:0)
  • 2-octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
Not Available

(32) Novoseek inferred chemical compound relationships for PLTP Gene

Compound -log(P) Hits PubMed IDs
phospholipid 93 261
cholesterol 76.6 187
cholesterol ester 73.2 14
lipid 69.4 88
fenofibrate 57.2 18
genes like me logo Genes that share compounds with PLTP: view

Transcripts for PLTP Gene

Unigene Clusters for PLTP Gene

Phospholipid transfer protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLTP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLTP Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - -
SP5: - - - -
SP6: - - - - - - - - -
SP7: - - -
SP8: - - - - - -
SP9:
SP10: -
SP11: - -
SP12:
SP13:
SP14:

ExUns: 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PLTP Gene

GeneLoc Exon Structure for
PLTP
ECgene alternative splicing isoforms for
PLTP

Expression for PLTP Gene

mRNA expression in normal human tissues for PLTP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PLTP Gene

This gene is overexpressed in Synovial fluid (13.4) and Serum (11.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PLTP Gene

SOURCE GeneReport for Unigene cluster for PLTP Gene Hs.439312

mRNA Expression by UniProt/SwissProt for PLTP Gene

P55058-PLTP_HUMAN
Tissue specificity: Wide tissue distribution. Placenta > pancreas > lung > kidney > heart > liver > skeletal muscle > brain
genes like me logo Genes that share expressions with PLTP: view

Expression partners for PLTP Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PLTP Gene

Orthologs for PLTP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLTP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLTP 35
  • 89.45 (n)
  • 90.72 (a)
PLTP 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLTP 35
  • 89.92 (n)
  • 94.29 (a)
PLTP 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pltp 35
  • 82.67 (n)
  • 82.81 (a)
Pltp 16
Pltp 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLTP 35
  • 99.39 (n)
  • 98.78 (a)
PLTP 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pltp 35
  • 82.6 (n)
  • 81.97 (a)
oppossum
(Monodelphis domestica)
Mammalia PLTP 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLTP 35
  • 71.46 (n)
  • 67.23 (a)
PLTP 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLTP 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pltp 35
  • 65.17 (n)
  • 64.88 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3003 35
zebrafish
(Danio rerio)
Actinopterygii pltp 35
  • 61.26 (n)
  • 55.7 (a)
pltp 36
  • 53 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13919 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
OneToMany
Species with no ortholog for PLTP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLTP Gene

ENSEMBL:
Gene Tree for PLTP (if available)
TreeFam:
Gene Tree for PLTP (if available)

Paralogs for PLTP Gene

Paralogs for PLTP Gene

Selected SIMAP similar genes for PLTP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLTP: view

Variants for PLTP Gene

Sequence variations from dbSNP and Humsavar for PLTP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs378114 -- 45,909,788(+) AAACC(C/T)TCCTA intron-variant
rs389877 -- 45,903,845(-) ttttt(C/G)ggtgg intron-variant
rs394643 -- 45,911,539(+) GTGGG(A/G)ACTAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs414686 -- 45,906,725(-) tttag(C/T)ggaga intron-variant
rs429207 -- 45,900,280(+) TTTGT(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLTP Gene

Variant ID Type Subtype PubMed ID
nsv833990 CNV Loss 17160897
nsv517296 CNV Loss 19592680
nsv833991 CNV Loss 17160897
nsv912894 CNV Gain 21882294
nsv3393 CNV Loss 18451855
esv2722456 CNV Deletion 23290073
esv2658653 CNV Deletion 23128226

Relevant External Links for PLTP Gene

HapMap Linkage Disequilibrium report
PLTP
Human Gene Mutation Database (HGMD)
PLTP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLTP Gene

Disorders for PLTP Gene

(1) University of Copenhagen DISEASES for PLTP Gene

(26) Novoseek inferred disease relationships for PLTP Gene

Disease -log(P) Hits PubMed IDs
hyperalphalipoproteinemia 79.2 3
cetp deficiency 76.7 8
hypoalphalipoproteinemia 66.9 2
atherosclerosis 60.2 48
tangier disease 57.4 1

Relevant External Links for PLTP

Genetic Association Database (GAD)
PLTP
Human Genome Epidemiology (HuGE) Navigator
PLTP
genes like me logo Genes that share disorders with PLTP: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for PLTP Gene

Publications for PLTP Gene

  1. Role of cysteine residues in human plasma phospholipid transfer protein. (PMID: 10333293) Qu S.J. … Pownall H.J. (J. Protein Chem. 1999) 3 4 23
  2. Complete cDNA encoding human phospholipid transfer protein from human endothelial cells. (PMID: 8132678) Day J.R. … Adolphson J.L. (J. Biol. Chem. 1994) 3 4 23
  3. Genetic variation of PLTP modulates lipoprotein profiles in hypoalphalipoproteinemia. (PMID: 16388083) Aouizerat B.E. … Pullinger C.R. (J. Lipid Res. 2006) 3 23 48
  4. Common variants at 30 loci contribute to polygenic dyslipidemia. (PMID: 19060906) Kathiresan S. … Cupples L.A. (Nat. Genet. 2009) 3 23 48
  5. Genetic variation in phospholipid transfer protein modulates lipoprotein profiles in hyperalphalipoproteinemia. (PMID: 19013296) Engler M.B. … Aouizerat B.E. (Metab. Clin. Exp. 2008) 3 23 48

Products for PLTP Gene

Sources for PLTP Gene

Back to Top

Content