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Aliases for PLSCR4 Gene

Aliases for PLSCR4 Gene

  • Phospholipid Scramblase 4 2 3 5
  • Ca(2+)-Dependent Phospholipid Scramblase 4 3 4
  • PL Scramblase 4 3 4
  • TRA1 3 4
  • Cell Growth-Inhibiting Gene 43 Protein 4
  • Cell Growth Inhibiting Protein 43 3

External Ids for PLSCR4 Gene

Previous GeneCards Identifiers for PLSCR4 Gene

  • GC03M142702
  • GC03M146769
  • GC03M147191
  • GC03M147231
  • GC03M147392
  • GC03M145910
  • GC03M143286

Summaries for PLSCR4 Gene

GeneCards Summary for PLSCR4 Gene

PLSCR4 (Phospholipid Scramblase 4) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and SH3 domain binding. An important paralog of this gene is PLSCR1.

UniProtKB/Swiss-Prot for PLSCR4 Gene

  • May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.

Gene Wiki entry for PLSCR4 Gene

Additional gene information for PLSCR4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLSCR4 Gene

Genomics for PLSCR4 Gene

Regulatory Elements for PLSCR4 Gene

Enhancers for PLSCR4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H146221 1.2 Ensembl ENCODE 25.6 +28.7 28725 2 FOXA2 ATF1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 FOS SP5 PLSCR4 PLOD2 ENSG00000243415 LOC105374145
GH03H146151 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +91.6 91582 15 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 LNCSRLR PLOD2 PLSCR4 ENSG00000243415 ENSG00000261051 GC03P146077
GH03H146313 1.2 FANTOM5 Ensembl ENCODE 16.7 -63.0 -62998 2 JUN MAX CEBPB NR3C1 EP300 RFX5 ZKSCAN1 JUND POLR2A PRDM1 PLSCR4 PLSCR1 PLSCR2 LOC100419967
GH03H146307 1 Ensembl ENCODE 16.1 -57.5 -57515 2 TBP JUN MAX RAD21 POLR2A RCOR1 NFE2L2 CEBPB EP300 GABPA PLSCR4 PLSCR1 LOC100419967
GH03H146550 1.3 FANTOM5 Ensembl ENCODE 9.8 -300.1 -300114 1 PKNOX1 HLF JUN BHLHE40 USF2 JUNB BATF FOSL1 ZNF217 JUND PLSCR1 PLSCR4 PLSCR2 GC03P146572
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLSCR4 on UCSC Golden Path with GeneCards custom track

Promoters for PLSCR4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000159700 678 2200 KLF1 SREBF2 SIN3A CEBPG HIC1 E2F1 GLIS2 CTBP1 ZNF316 POLR2A

Genomic Location for PLSCR4 Gene

Chromosome:
3
Start:
146,192,335 bp from pter
End:
146,251,179 bp from pter
Size:
58,845 bases
Orientation:
Minus strand

Genomic View for PLSCR4 Gene

Genes around PLSCR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLSCR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLSCR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLSCR4 Gene

Proteins for PLSCR4 Gene

  • Protein details for PLSCR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRQ2-PLS4_HUMAN
    Recommended name:
    Phospholipid scramblase 4
    Protein Accession:
    Q9NRQ2
    Secondary Accessions:
    • A8K2E9
    • Q2TTR3
    • Q658L3
    • Q6ZR73
    • Q7Z505

    Protein attributes for PLSCR4 Gene

    Size:
    329 amino acids
    Molecular mass:
    37005 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PDCD6.
    SequenceCaution:
    • Sequence=AAP97186.1; Type=Frameshift; Positions=152, 155, 163, 325; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLSCR4 Gene

    Alternative splice isoforms for PLSCR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLSCR4 Gene

Post-translational modifications for PLSCR4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLSCR4 Gene

Domains & Families for PLSCR4 Gene

Gene Families for PLSCR4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PLSCR4 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NRQ2

UniProtKB/Swiss-Prot:

PLS4_HUMAN :
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
  • Belongs to the phospholipid scramblase family.
Domain:
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
Family:
  • Belongs to the phospholipid scramblase family.
genes like me logo Genes that share domains with PLSCR4: view

Function for PLSCR4 Gene

Molecular function for PLSCR4 Gene

UniProtKB/Swiss-Prot Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.

Phenotypes From GWAS Catalog for PLSCR4 Gene

Gene Ontology (GO) - Molecular Function for PLSCR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 10930526
GO:0005515 protein binding IPI 16189514
GO:0017124 SH3 domain binding IEA --
GO:0017128 phospholipid scramblase activity NAS 10930526
GO:0019899 enzyme binding IPI 19333378
genes like me logo Genes that share ontologies with PLSCR4: view
genes like me logo Genes that share phenotypes with PLSCR4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLSCR4 Gene

Localization for PLSCR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLSCR4 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLSCR4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 3
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLSCR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 19333378
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PLSCR4: view

Pathways & Interactions for PLSCR4 Gene

SuperPathways for PLSCR4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLSCR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017121 phospholipid scrambling NAS 10930526
GO:0071222 cellular response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with PLSCR4: view

No data available for Pathways by source and SIGNOR curated interactions for PLSCR4 Gene

Drugs & Compounds for PLSCR4 Gene

(1) Drugs for PLSCR4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(511) Additional Compounds for PLSCR4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
PE(P-16:0e/16:0)
  • 2-Hexadecanoyl-1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine
PEP-16:0/18:1(11Z))
  • 1-(1-Enyl-palmitoyl)-2-vaccenoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:1)
  • GPEtn(16:0/18:1n7)
  • GPEtn(16:0/18:1w7)
  • GPEtn(34:1)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-Trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
68737-67-7
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-a-linolenoyl-sn-glycero-3-phosphocholine
  • 1-(1-Enyl-palmitoyl)-2-alpha-linolenoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/18:3)
  • GPCho(16:0/18:3n3)
  • GPCho(16:0/18:3w3)
88542-95-4
genes like me logo Genes that share compounds with PLSCR4: view

Transcripts for PLSCR4 Gene

Unigene Clusters for PLSCR4 Gene

Phospholipid scramblase 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLSCR4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11
SP1:
SP2: -
SP3: - - - - - - - -
SP4: -
SP5: -
SP6: - -
SP7: - - - -

Relevant External Links for PLSCR4 Gene

GeneLoc Exon Structure for
PLSCR4
ECgene alternative splicing isoforms for
PLSCR4

Expression for PLSCR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLSCR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLSCR4 Gene

This gene is overexpressed in Testis (8.8) and Spinal cord (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLSCR4 Gene



NURSA nuclear receptor signaling pathways regulating expression of PLSCR4 Gene:

PLSCR4

SOURCE GeneReport for Unigene cluster for PLSCR4 Gene:

Hs.477869

mRNA Expression by UniProt/SwissProt for PLSCR4 Gene:

Q9NRQ2-PLS4_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, uterus, small intestine and colon. Not detected in peripheral blood lymphocytes.

Evidence on tissue expression from TISSUES for PLSCR4 Gene

  • Nervous system(4.5)
  • Pancreas(4.2)
  • Stomach(4.1)
genes like me logo Genes that share expression patterns with PLSCR4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLSCR4 Gene

Orthologs for PLSCR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLSCR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLSCR4 34 33
  • 99.19 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PLSCR4 34 33
  • 89.13 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PLSCR4 34 33
  • 85.67 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Plscr4 34 16 33
  • 84.52 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plscr4 33
  • 84.26 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 61 (a)
OneToMany
-- 34
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 42 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
-- 34
  • 37 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-71m22.5 34
  • 44 (a)
ManyToMany
si:ch211-71m22.1 34
  • 43 (a)
ManyToMany
si:ch73-206p6.1 34
  • 42 (a)
ManyToMany
si:ch211-71m22.3 34
  • 33 (a)
ManyToMany
FP245465.1 34
  • 30 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta scramb2 34
  • 39 (a)
ManyToMany
scramb1 34
  • 31 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea scrm-8 34
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2436 34
  • 43 (a)
OneToMany
Species where no ortholog for PLSCR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLSCR4 Gene

ENSEMBL:
Gene Tree for PLSCR4 (if available)
TreeFam:
Gene Tree for PLSCR4 (if available)

Paralogs for PLSCR4 Gene

Paralogs for PLSCR4 Gene

(4) SIMAP similar genes for PLSCR4 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for PLSCR4 Gene

genes like me logo Genes that share paralogs with PLSCR4: view

Variants for PLSCR4 Gene

Sequence variations from dbSNP and Humsavar for PLSCR4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000068707 -- 146,245,294(+) TAAAA(A/T)CCTAT intron-variant
rs1000088790 -- 146,244,981(+) CAAAA(C/T)ATAAA intron-variant
rs1000157552 -- 146,198,777(+) TGATT(-/A)AAAAA intron-variant
rs1000210565 -- 146,223,259(+) AAAAA(A/T)AAGGC intron-variant, upstream-variant-2KB
rs1000266883 -- 146,239,091(+) GAATT(-/AAAG)AAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLSCR4 Gene

Variant ID Type Subtype PubMed ID
dgv2614n106 CNV deletion 24896259
esv1197123 CNV deletion 17803354
esv2265170 CNV deletion 18987734
esv2415943 CNV deletion 18987734
esv2442002 CNV deletion 19546169
esv2726021 CNV deletion 23290073
esv2726022 CNV deletion 23290073
esv3416330 CNV duplication 20981092
esv3562676 CNV deletion 23714750
esv3598087 CNV loss 21293372
esv3893781 CNV loss 25118596
esv4008 CNV loss 18987735
esv9695 CNV loss 19470904
nsv1011146 CNV loss 25217958
nsv1149841 CNV deletion 26484159
nsv955544 CNV deletion 24416366

Variation tolerance for PLSCR4 Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.16; 51.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLSCR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLSCR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLSCR4 Gene

Disorders for PLSCR4 Gene

Relevant External Links for PLSCR4

Genetic Association Database (GAD)
PLSCR4
Human Genome Epidemiology (HuGE) Navigator
PLSCR4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLSCR4

No disorders were found for PLSCR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLSCR4 Gene

Publications for PLSCR4 Gene

  1. Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants. (PMID: 18256029) Shibata H … Maki M (The Journal of biological chemistry 2008) 3 4 22 60
  2. Identification of three new members of the phospholipid scramblase gene family. (PMID: 10930526) Wiedmer T … Sims PJ (Biochimica et biophysica acta 2000) 2 3 4 60
  3. Biochemical and functional characterization of human phospholipid scramblase 4 (hPLSCR4). (PMID: 23089641) Francis VG … Gummadi SN (Biological chemistry 2012) 3 4 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane. (PMID: 19333378) Py B … Benichou S (PloS one 2009) 3 22 60

Products for PLSCR4 Gene

Sources for PLSCR4 Gene

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