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PLSCR3 Gene

protein-coding   GIFtS: 52
GCID: GC17M007294

Phospholipid Scramblase 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phospholipid Scramblase 31 2
Ca(2+)-Dependent Phospholipid Scramblase 32 3
PL Scramblase 32 3

External Ids:    HGNC: 164951   Entrez Gene: 570482   Ensembl: ENSG000001878387   OMIM: 6076115   UniProtKB: Q9NRY63   

Export aliases for PLSCR3 gene to outside databases

Previous GC identifers: GC16P055602 GC17M008022 GC17M007235 GC17M007493 GC17M007233


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PLSCR3 Gene:
PLSCR3 (phospholipid scramblase 3) is a protein-coding gene. GO annotations related to this gene include calcium-dependent protein binding and calcium ion binding. An important paralog of this gene is PLSCR1.

UniProtKB/Swiss-Prot: PLS3_HUMAN, Q9NRY6
Function: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon
binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central
role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of
apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through
translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment
and enhances tBid-induced mitochondrial damages

Gene Wiki entry for PLSCR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLSCR3 gene promoter:
         Max1   Bach2   p300   AP-2gamma   Evi-1   AP-2beta   AP-2alpha   c-Myc   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLSCR3 promoter sequence
   Search Chromatin IP Primers for PLSCR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLSCR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

PLSCR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLSCR3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007294:  view genomic region     (about GC identifiers)

Start:
7,293,046 bp from pter      End:
7,307,416 bp from pter
Size:
14,371 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PLS3_HUMAN, Q9NRY6 (See protein sequence)
Recommended Name: Phospholipid scramblase 3  
Size: 295 amino acids; 31648 Da
Cofactor: Calcium (By similarity)
Subunit: Interacts with PDCD6 in a calcium-dependent manner
Secondary accessions: A8K252 Q567U0 Q8NBW6 Q96F13

Explore the universe of human proteins at neXtProt for PLSCR3: NX_Q9NRY6

Explore proteomics data for PLSCR3 at MOPED

Post-translational modifications: 

  • Phosphorylation at Thr-21 by PKC/PRKCD upon apoptotic stimuli enhances flip-flop activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PLSCR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001188505.1  NP_065093.2  

    ENSEMBL proteins: 
     ENSP00000316021   ENSP00000459122   ENSP00000459419   ENSP00000459019   ENSP00000460800  
     ENSP00000461843   ENSP00000458596   ENSP00000461205   ENSP00000458988   ENSP00000438547  

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    Cloud-Clone Corp. Proteins for PLSCR3

     
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    Cloud-Clone Corp. ELISAs for PLSCR3
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005552 Scramblase

    Graphical View of Domain Structure for InterPro Entry Q9NRY6

    ProtoNet protein and cluster: Q9NRY6

    1 Blocks protein domain: IPB005552 Scramblase

    UniProtKB/Swiss-Prot: PLS3_HUMAN, Q9NRY6
    Similarity: Belongs to the phospholipid scramblase family


    Find genes that share domains with PLSCR3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLS3_HUMAN, Q9NRY6
    Function: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon
    binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central
    role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of
    apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through
    translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment
    and enhances tBid-induced mitochondrial damages

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding NAS10930526
    GO:0005515protein binding IPI18256029
    GO:0017124SH3 domain binding IEA--
    GO:0017128phospholipid scramblase activity NAS10930526
    GO:0048306calcium-dependent protein binding IPI18256029
         
    Find genes that share ontologies with PLSCR3           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Plscr3):
     adipose tissue  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with PLSCR3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Plscr3tm1Sims for PLSCR3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLSCR3
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    miRNA
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    miRTarBase miRNAs that target PLSCR3:
    hsa-mir-149-5p (MIRT045514), hsa-mir-124-3p (MIRT002909)

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    Selected qRT-PCR Assays for microRNAs that regulate PLSCR3 (see all 13):
    hsa-miR-3910 hsa-miR-1226 hsa-miR-520d-5p hsa-miR-561 hsa-miR-29a hsa-miR-29c hsa-miR-548s hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidPLSCR3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PLSCR3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLS3_HUMAN, Q9NRY6: Mitochondrion membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    plasma membrane5
    cytosol2
    extracellular2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane NAS10930526
    GO:0016021integral component of membrane IEA--
    GO:0031966mitochondrial membrane IEA--

    Find genes that share ontologies with PLSCR3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLSCR3
    Interactions:

        GeneGlobe Interaction Network for PLSCR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for PLSCR3 (Q9NRY61, 2, 3 ENSP000003160214) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDCD6O753401, 3EBI-750734,EBI-352915 I2D: score=1 
    TRIP13Q156452, 3, ENSP000001663454MINT-68032 I2D: score=5 STRING: ENSP00000166345
    PLSCR1O151622, 3, ENSP000003454944MINT-67892 I2D: score=5 STRING: ENSP00000345494
    PRKCDQ056553, ENSP000003316024I2D: score=2 STRING: ENSP00000331602
    AHRRENSP000003238164STRING: ENSP00000323816
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    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0017121phospholipid scrambling NAS10930526
    GO:0042593glucose homeostasis IEA--
    GO:0042632cholesterol homeostasis IEA--
    GO:0071222cellular response to lipopolysaccharide IEA--

    Find genes that share ontologies with PLSCR3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PLSCR3 (PLS3)

    Selected HMDB Compounds for PLSCR3 (see all 2714)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    PE(P-16:0e/0:0)2-azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate;1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine ;LysoPE(dm16:0e) --12486725
    PE(P-16:0e/18:1(9Z))2-(9Z-octadecanoyl)-1-hexadecyl-sn-glycero-3-phosphoethanolamine --12486725
    PS(16:0/16:0)Phosphatidylserine (16:0/16:0) (see all 14)3036-82-612486725
    CalciumCa (see all 2)7440-70-2--
    PC(14:0/14:0)Phosphatidylcholine(14:0/14:0) (see all 8)----
    PC(14:0/14:1(9Z))Phosphatidylcholine(14:0/14:1) (see all 14)----
    PC(14:0/15:0)GPCho(14:0/15:0) (see all 8)----

    4 Novoseek inferred chemical compound relationships for PLSCR3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-benzyladriamycin-14-valerate 96.3 2 16267027 (1)
    cardiolipin 82.3 4 16939411 (2), 19428821 (1)
    phospholipid 68.9 21 18256029 (2), 12649167 (2), 16267027 (2), 19428821 (2) (see all 9)
    lipid 21.1 1 14573790 (1)



    Find genes that share compounds with PLSCR3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLSCR3 gene (2 alternative transcripts): 
    NM_001201576.1  NM_020360.3  

    Unigene Cluster for PLSCR3:

    Phospholipid scramblase 3
    Hs.534591  [show with all ESTs]
    Unigene Representative Sequence: NM_020360
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324822 ENST00000573070(uc002ggp.2 uc002ggq.2) ENST00000571541
    ENST00000573774 ENST00000576201 ENST00000574401(uc002ggn.2 uc002ggo.2 uc002ggm.2)
    ENST00000575543 ENST00000576362 ENST00000575434 ENST00000571078 ENST00000571802
    ENST00000573213 ENST00000535512
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    Selected qRT-PCR Assays for microRNAs that regulate PLSCR3 (see all 13):
    hsa-miR-3910 hsa-miR-1226 hsa-miR-520d-5p hsa-miR-561 hsa-miR-29a hsa-miR-29c hsa-miR-548s hsa-miR-9
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      QuantiTect SYBR Green Assays in human, mouse, rat PLSCR3
      QuantiFast Probe-based Assays in human, mouse, rat PLSCR3

    Additional mRNA sequence: 

    AF159442.1 AF289602.1 AK075188.1 AK314643.1 BC011735.2 BC093026.1 NR_037719.1 

    16 DOTS entries:

    DT.109741  DT.311656  DT.100848931  DT.95377291  DT.120936155  DT.120936182  DT.120936184  DT.75145079 
    DT.91727652  DT.100710536  DT.95320862  DT.100710480  DT.100710529  DT.100853647  DT.102829020  DT.100045904 

    Selected AceView cDNA sequences (see all 267):

    AI493480 CR621218 BC030270 BM509910 BP353698 BQ069307 BF589809 BG122341 
    CA413589 AK075188 BM685213 AA355059 BM828829 BI870394 BM782439 AA641443 
    CR600989 BM685125 CR618924 AW872903 AI570736 BP351210 CR597400 BP355937 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PLSCR3 (see all 26)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ·
    SP1:                                                                          -     -     -                       -                             -               
    SP2:                                                                                                              -                             -               
    SP3:                                                                                                              -                             -               
    SP4:                                                                                                              -                             -     -     -   
    SP5:                                                                                                              -                             -     -         

    ExUns: 12c ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b · 16c ^ 17
    SP1:        -                                                               
    SP2:        -                                                               
    SP3:        -                                                               
    SP4:  -     -                                                               
    SP5:                                                                        


    ECgene alternative splicing isoforms for PLSCR3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLSCR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACTTTGAG
    PLSCR3 Expression
    About this image

    PLSCR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLSCR3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534591

    UniProtKB/Swiss-Prot: PLS3_HUMAN, Q9NRY6
    Tissue specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus,
    prostate, uterus, small intestine and peripheral blood lymphocytes. Not detected in testis, brain and liver

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLSCR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PLSCR3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plscr31 , 5 phospholipid scramblase 31, 5 86.44(n)1
    93.22(a)1
      11 (42.90 cM)5
    703101  NM_001168497.11  NP_001161969.11 
     698463765 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM256-PLSCR36
    TMEM256-PLSCR3 readthrough (NMD candidate)
    46(a)
    1 ↔ 1
    GL344753.1(2548-6587)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.20112 Xenopus laevis transcribed sequence with weak similarity more 73.33(n)    CD519846.1 
    zebrafish
    (Danio rerio)
    Actinopterygii plscr3a6
    plscr3b6
    (see all 3)
    phospholipid scramblase 3b
    (see all 3)
    48(a)
    45(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    5(25903401-25907668) ENSDARG00000093078
    7(27707513-27729338) ENSDARG00000069432
    fruit fly
    (Drosophila melanogaster)
    Insecta scramb21 scramblase 2 52.4(n)
    45.12(a)
      38362  NM_139504.3  NP_647761.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK1053.53   -- 40(a)   I(13243237-13244647)   --


    ENSEMBL Gene Tree for PLSCR3 (if available)
    TreeFam Gene Tree for PLSCR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLSCR3 gene
    PLSCR12  PLSCR22  PLSCR52  PLSCR42  
    5 SIMAP similar genes for PLSCR3 using alignment to 1 protein entry:     PLS3_HUMAN:
    TMEM256-PLSCR3    PLSCR2    PLSCR1    PLSCR5    PLSCR4

    Find genes that share paralogs with PLSCR3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for PLSCR3    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37445491,2,4
    ----see VAR_0155682 mis40--------

    HapMap Linkage Disequilibrium report for PLSCR3 (7293046 - 7307416 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PLSCR3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1007381CNV Deletion20482838
    esv2422288CNV Deletion17116639
    dgv3054n71CNV Loss21882294
    dgv3055n71CNV Loss21882294
    nsv457659CNV Loss19166990
    nsv523672CNV Loss19592680
    nsv907645CNV Loss21882294
    nsv470575CNV Loss18288195
    nsv907644CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLSCR3
    DNA2.0 Custom Variant and Variant Library Synthesis for PLSCR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607611    OMIM disorders: --


    Find genes that share disorders with PLSCR3           About GenesLikeMe

    Genetic Association Database (GAD): PLSCR3

    Export disorders for PLSCR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLSCR3 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with PLSCR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of three new members of the phospholipid scramblase gene family. (PubMed id 10930526)1, 2, 3 Wiedmer T.... Sims P.J. (Biochim. Biophys. Acta 2000)
    2. Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants. (PubMed id 18256029)1, 2, 9 Shibata H....Maki M. (J. Biol. Chem. 2008)
    3. Phosphorylation of mitochondrial phospholipid scramblase 3 by protein kinase C-delta induces its activation and facilitates mitochondrial targeting of tBid. (PubMed id 17226776)1, 2, 9 He Y.... Lee R.M. (J. Cell. Biochem. 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Phospholipid scramblase-3 regulates cardiolipin de novo biosynthesis and its resynthesis in growing HeLa cells. (PubMed id 16939411)1, 9 Van Q....Hatch G.M. (Biochem. J. 2007)
    7. Phospholipid scramblase 3 is the mitochondrial target of protein kinase C delta-induced apoptosis. (PubMed id 12649167)1, 9 Liu J....Lee R.M. (Cancer Res. 2003)
    8. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced mitochondrial pathway to apoptosis and caspase activation is potentiated by phospholipid scramblase-3. (PubMed id 18491232)1, 9 Ndebele K....Khosravi-Far R. (Apoptosis 2008)
    9. Phospholipid scramblase 3 controls mitochondrial structure, function, and apoptotic response. (PubMed id 14573790)1, 9 Liu J....Lee R.M. (Mol. Cancer Res. 2003)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57048 HGNC: 16495 AceView: PLSCR3andMGC40107 Ensembl:ENSG00000187838 euGenes: HUgn57048
    ECgene: PLSCR3 H-InvDB: PLSCR3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PLSCR3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PLSCR3 gene:
    Search GeneIP for patents involving PLSCR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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