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Aliases for PLSCR3 Gene

Aliases for PLSCR3 Gene

  • Phospholipid Scramblase 3 2 3
  • Ca(2+)-Dependent Phospholipid Scramblase 3 4
  • TMEM256-PLSCR3 Readthrough (NMD Candidate) 5
  • PL Scramblase 3 4
  • TMEM256-PLSCR3 5

External Ids for PLSCR3 Gene

Previous GeneCards Identifiers for PLSCR3 Gene

  • GC16P055602
  • GC17M008022
  • GC17M007235
  • GC17M007493
  • GC17M007233
  • GC17M007294

Summaries for PLSCR3 Gene

GeneCards Summary for PLSCR3 Gene

PLSCR3 (Phospholipid Scramblase 3) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is PLSCR1.

UniProtKB/Swiss-Prot for PLSCR3 Gene

  • May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.

Gene Wiki entry for PLSCR3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLSCR3 Gene

Genomics for PLSCR3 Gene

Regulatory Elements for PLSCR3 Gene

Enhancers for PLSCR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F007474 1.6 FANTOM5 ENCODE 11 -85.7 -85747 12.5 CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DVL2 SNORD10 SNORA48 CHRNB1 PFAS LOC105371523 KCTD11 CTC1 CNTROB MIR6883
GH17F007465 1 Ensembl ENCODE 11.1 -72.2 -72185 2.2 HDAC1 ESRRA ZNF175 BCL11B YY1 HIC1 NCOR1 POLR2A RCOR1 NR2F6 CHRNB1 FGF11 TMEM102 C17orf74 SPEM1 TNFSF12 TNFSF12-TNFSF13 NLGN2 TMEM256 TMEM256-PLSCR3
GH17F007454 1 ENCODE 10.8 -61.1 -61138 2.0 HDGF ATF1 PKNOX1 CREB3L1 ZNF493 ZFP64 SIN3A FEZF1 ETS1 YY1 DVL2 PFAS CNTROB CTC1 LOC105371523 CHRNB1 NLGN2 SNORA48 SNORD10 NEURL4
GH17F007471 0.7 Ensembl 11 -77.3 -77258 0.6 ZNF202 ZFP64 ZBTB11 ZNF140 ZNF266 ZBTB8A ZNF623 ZNF518A ZNF781 ZNF101 PFAS LOC105371523 DVL2 CNTROB CHRNB1 CTC1 NLGN2 SNORD10 SNORA48 CYB5D1
GH17F007460 0.5 ENCODE 10.7 -66.2 -66154 0.2 JUND PRDM10 PRDM1 ZNF652 C17orf74 SPEM1 TNFSF12 TNFSF12-TNFSF13 NLGN2 TMEM256 TMEM256-PLSCR3 PLSCR3 ACAP1 PIR46408
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLSCR3 on UCSC Golden Path with GeneCards custom track

Promoters for PLSCR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001340188 343 1801 HDGF ATF1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 GLIS2
ENSR00001804781 1543 201 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 ZNF121 GLIS2 ELK1

Genomic Location for PLSCR3 Gene

Chromosome:
17
Start:
7,389,727 bp from pter
End:
7,394,843 bp from pter
Size:
5,117 bases
Orientation:
Minus strand

Genomic View for PLSCR3 Gene

Genes around PLSCR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLSCR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLSCR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLSCR3 Gene

Proteins for PLSCR3 Gene

  • Protein details for PLSCR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRY6-PLS3_HUMAN
    Recommended name:
    Phospholipid scramblase 3
    Protein Accession:
    Q9NRY6
    Secondary Accessions:
    • A8K252
    • Q567U0
    • Q8NBW6
    • Q96F13

    Protein attributes for PLSCR3 Gene

    Size:
    295 amino acids
    Molecular mass:
    31648 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with PDCD6 in a calcium-dependent manner.
    • Interacts with PDCD6 in a calcium-dependent manner.

neXtProt entry for PLSCR3 Gene

Post-translational modifications for PLSCR3 Gene

  • Phosphorylation at Thr-21 by PKC/PRKCD upon apoptotic stimuli enhances flip-flop activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for PLSCR3
  • Santa Cruz Biotechnology (SCBT) Antibodies for PLSCR3

No data available for DME Specific Peptides for PLSCR3 Gene

Domains & Families for PLSCR3 Gene

Gene Families for PLSCR3 Gene

Protein Domains for PLSCR3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PLSCR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRY6

UniProtKB/Swiss-Prot:

PLS3_HUMAN :
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
  • Belongs to the phospholipid scramblase family.
Domain:
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
Family:
  • Belongs to the phospholipid scramblase family.
genes like me logo Genes that share domains with PLSCR3: view

Function for PLSCR3 Gene

Molecular function for PLSCR3 Gene

UniProtKB/Swiss-Prot Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.

Gene Ontology (GO) - Molecular Function for PLSCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 10930526
GO:0005515 protein binding IPI 16189514
GO:0017124 SH3 domain binding IEA --
GO:0017128 phospholipid scramblase activity NAS 10930526
GO:0048306 calcium-dependent protein binding IPI 18256029
genes like me logo Genes that share ontologies with PLSCR3: view
genes like me logo Genes that share phenotypes with PLSCR3: view

Animal Models for PLSCR3 Gene

MGI Knock Outs for PLSCR3:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLSCR3

miRNA for PLSCR3 Gene

miRTarBase miRNAs that target PLSCR3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLSCR3 Gene

Localization for PLSCR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLSCR3 Gene

Mitochondrion membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLSCR3 gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
extracellular 2
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for PLSCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005886 plasma membrane NAS 10930526
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with PLSCR3: view

Pathways & Interactions for PLSCR3 Gene

SuperPathways for PLSCR3 Gene

No Data Available

SIGNOR curated interactions for PLSCR3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PLSCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0017121 phospholipid scrambling NAS 10930526
GO:0042593 glucose homeostasis IEA --
GO:0042632 cholesterol homeostasis IEA --
GO:0071222 cellular response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with PLSCR3: view

No data available for Pathways by source for PLSCR3 Gene

Drugs & Compounds for PLSCR3 Gene

(2) Drugs for PLSCR3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(514) Additional Compounds for PLSCR3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
PE(P-16:0e/16:0)
  • 2-Hexadecanoyl-1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine
PEP-16:0/18:1(11Z))
  • 1-(1-Enyl-palmitoyl)-2-vaccenoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:1)
  • GPEtn(16:0/18:1n7)
  • GPEtn(16:0/18:1w7)
  • GPEtn(34:1)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-Trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
68737-67-7
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-stearidonoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/18:4)
  • GPCho(16:0/18:4n3)
  • GPCho(16:0/18:4w3)
  • GPCho(34:4)
88542-95-4
genes like me logo Genes that share compounds with PLSCR3: view

Transcripts for PLSCR3 Gene

Unigene Clusters for PLSCR3 Gene

Phospholipid scramblase 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLSCR3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ·
SP1: - - - - -
SP2: - -
SP3: - -
SP4: - - - -
SP5: - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - - - - -
SP9: - - - -
SP10: - - - - -
SP11: - - - -
SP12: -
SP13: - - - - - - - -
SP14: - - - - - - -
SP15: - -
SP16:
SP17: - - - - - - - - -
SP18: - - -
SP19: - - - - - - -
SP20: - - - - -
SP21: - - -
SP22: -
SP23: - - -
SP24: -
SP25: -
SP26:

ExUns: 12c ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b · 16c ^ 17
SP1: -
SP2: -
SP3: -
SP4: - -
SP5:
SP6: -
SP7: - -
SP8: - -
SP9: - -
SP10: -
SP11: -
SP12: - -
SP13:
SP14: -
SP15: -
SP16: - - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23: - -
SP24:
SP25:
SP26:

Relevant External Links for PLSCR3 Gene

GeneLoc Exon Structure for
PLSCR3
ECgene alternative splicing isoforms for
PLSCR3

Expression for PLSCR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLSCR3 Gene

Protein differential expression in normal tissues from HIPED for PLSCR3 Gene

This gene is overexpressed in Bone (13.8) and Peripheral blood mononuclear cells (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLSCR3 Gene



Protein tissue co-expression partners for PLSCR3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLSCR3 Gene:

PLSCR3

SOURCE GeneReport for Unigene cluster for PLSCR3 Gene:

Hs.534591

mRNA Expression by UniProt/SwissProt for PLSCR3 Gene:

Q9NRY6-PLS3_HUMAN
Tissue specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine and peripheral blood lymphocytes. Not detected in testis, brain and liver.
genes like me logo Genes that share expression patterns with PLSCR3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PLSCR3 Gene

Orthologs for PLSCR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLSCR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLSCR3 34
  • 99.55 (n)
TMEM256-PLSCR3 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLSCR3 34 35
  • 90.28 (n)
dog
(Canis familiaris)
Mammalia PLSCR3 34
  • 88.89 (n)
TMEM256-PLSCR3 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plscr3 34
  • 87.12 (n)
mouse
(Mus musculus)
Mammalia Plscr3 34 16 35
  • 86.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM256-PLSCR3 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM256-PLSCR3 35
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM256-PLSCR3 35
  • 46 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2011 34
zebrafish
(Danio rerio)
Actinopterygii plscr3a 35
  • 48 (a)
OneToMany
plscr3b 35
  • 45 (a)
OneToMany
CR848032.2 35
  • 23 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4717 34
fruit fly
(Drosophila melanogaster)
Insecta scramb2 34 35
  • 52.4 (n)
scramb1 35
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ZK1053.5 36
  • 40 (a)
scrm-3 35
  • 34 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2436 35
  • 53 (a)
OneToMany
Species where no ortholog for PLSCR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLSCR3 Gene

ENSEMBL:
Gene Tree for PLSCR3 (if available)
TreeFam:
Gene Tree for PLSCR3 (if available)

Paralogs for PLSCR3 Gene

Paralogs for PLSCR3 Gene

(5) SIMAP similar genes for PLSCR3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLSCR3: view

Variants for PLSCR3 Gene

Sequence variations from dbSNP and Humsavar for PLSCR3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1113978 -- 7,390,919(-) CATTA(A/G)AGGGG intron-variant
rs111545310 -- 7,396,775(+) TGTTT(A/G)TTGAG intron-variant, upstream-variant-2KB
rs112604439 -- 7,389,770(+) AACAT(A/G)TAAAG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs112819055 -- 7,390,907(+) TCAGT(A/G)AATCT intron-variant
rs113255803 -- 7,392,536(+) TTAGA(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLSCR3 Gene

Variant ID Type Subtype PubMed ID
nsv952118 CNV deletion 24416366
nsv574322 CNV loss 21841781
nsv523672 CNV loss 19592680
nsv470575 CNV loss 18288195
nsv457659 CNV loss 19166990
esv2422288 CNV deletion 17116639
esv1007381 CNV deletion 20482838

Variation tolerance for PLSCR3 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLSCR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLSCR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLSCR3 Gene

Disorders for PLSCR3 Gene

Relevant External Links for PLSCR3

Genetic Association Database (GAD)
PLSCR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLSCR3

No disorders were found for PLSCR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLSCR3 Gene

Publications for PLSCR3 Gene