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Aliases for PLSCR2 Gene

Aliases for PLSCR2 Gene

  • Phospholipid Scramblase 2 2 3 5
  • Ca(2+)-Dependent Phospholipid Scramblase 2 4
  • PL Scramblase 2 4

External Ids for PLSCR2 Gene

Previous GeneCards Identifiers for PLSCR2 Gene

  • GC03M142944
  • GC03M147028
  • GC03M147390
  • GC03M147471
  • GC03M147633
  • GC03M146110
  • GC03M143527

Summaries for PLSCR2 Gene

Entrez Gene Summary for PLSCR2 Gene

  • This gene encodes a member of the phospholipid scramblase family. Phospholipid scramblases are membrane proteins that mediate calcium-dependent, non-specific movement of plasma membrane phospholipids and phosphatidylserine exposure. The encoded protein contains a low affinity calcium binding motif and may play a role in blood coagulation and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for PLSCR2 Gene

PLSCR2 (Phospholipid Scramblase 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and phospholipid scramblase activity. An important paralog of this gene is PLSCR1.

UniProtKB/Swiss-Prot for PLSCR2 Gene

  • May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.

  • Isoform 1 has no prospholipid scramblase activity, due to the lack of a N-terminal proline-rich domain.

Gene Wiki entry for PLSCR2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLSCR2 Gene

Genomics for PLSCR2 Gene

Regulatory Elements for PLSCR2 Gene

Enhancers for PLSCR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G146467 1.4 Ensembl ENCODE dbSUPER 18.3 +26.6 26641 3.2 HDAC1 TBP ATF1 RB1 SIN3A RAD21 EGR1 CREM ZNF654 SMAD5 PLSCR2 PLSCR1 ENSG00000241358
GH03G146541 1.7 FANTOM5 ENCODE dbSUPER 9.7 -47.4 -47420 4.3 HDGF FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 PLSCR1 PLSCR2 ENSG00000279320
GH03G146550 1.3 FANTOM5 Ensembl ENCODE 9.6 -55.3 -55281 1.1 PKNOX1 HLF JUN BHLHE40 JUNB FOSL1 JUND RAD51 ATF3 SIRT6 PLSCR1 PLSCR4 PLSCR2 GC03P146572
GH03G146390 0.4 ENCODE 23.5 +104.9 104852 1.1 ATF3 NR2F2 PLSCR2 PLSCR4 PLSCR1 GC03P146374 ENSG00000241358
GH03G146313 1.2 FANTOM5 Ensembl ENCODE 6.7 +181.8 181836 2.2 JUN MAX CEBPB NR3C1 EP300 RFX5 ZKSCAN1 JUND GATA2 FOS PLSCR4 PLSCR1 PLSCR2 LOC100419967
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLSCR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLSCR2 Gene

Chromosome:
3
Start:
146,391,363 bp from pter
End:
146,496,012 bp from pter
Size:
104,650 bases
Orientation:
Minus strand

Genomic View for PLSCR2 Gene

Genes around PLSCR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLSCR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLSCR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLSCR2 Gene

Proteins for PLSCR2 Gene

  • Protein details for PLSCR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRY7-PLS2_HUMAN
    Recommended name:
    Phospholipid scramblase 2
    Protein Accession:
    Q9NRY7
    Secondary Accessions:
    • B4DXC3
    • J3KR76
    • Q0VAQ1
    • Q6NSW9
    • Q7Z4L7

    Protein attributes for PLSCR2 Gene

    Size:
    297 amino acids
    Molecular mass:
    33504 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH55415.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PLSCR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLSCR2 Gene

Post-translational modifications for PLSCR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLSCR2 Gene

Domains & Families for PLSCR2 Gene

Gene Families for PLSCR2 Gene

Protein Domains for PLSCR2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PLSCR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NRY7

UniProtKB/Swiss-Prot:

PLS2_HUMAN :
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
  • Belongs to the phospholipid scramblase family.
Domain:
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
Family:
  • Belongs to the phospholipid scramblase family.
genes like me logo Genes that share domains with PLSCR2: view

Function for PLSCR2 Gene

Molecular function for PLSCR2 Gene

UniProtKB/Swiss-Prot Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
UniProtKB/Swiss-Prot Function:
Isoform 1 has no prospholipid scramblase activity, due to the lack of a N-terminal proline-rich domain.

Gene Ontology (GO) - Molecular Function for PLSCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 10930526
GO:0017128 phospholipid scramblase activity NAS 10930526
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PLSCR2: view
genes like me logo Genes that share phenotypes with PLSCR2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLSCR2 Gene

Localization for PLSCR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLSCR2 Gene

Membrane; Single-pass type II membrane protein.
Isoform 1: Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLSCR2 gene
Compartment Confidence
plasma membrane 4
nucleus 4
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PLSCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane NAS 10930526
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLSCR2: view

Pathways & Interactions for PLSCR2 Gene

SuperPathways for PLSCR2 Gene

No Data Available

Interacting Proteins for PLSCR2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000420132%0d%0a9606.ENSP00000280527%0d%0a9606.ENSP00000339404%0d%0a9606.ENSP00000368401%0d%0a9606.ENSP00000364524%0d%0a9606.ENSP00000375921%0d%0a
Selected Interacting proteins: ENSP00000420132 Q9NRY7-PLS2_HUMAN for PLSCR2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for PLSCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017121 phospholipid scrambling NAS 10930526
genes like me logo Genes that share ontologies with PLSCR2: view

No data available for Pathways by source and SIGNOR curated interactions for PLSCR2 Gene

Drugs & Compounds for PLSCR2 Gene

(1) Drugs for PLSCR2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(511) Additional Compounds for PLSCR2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
PE(P-16:0e/16:0)
  • 2-Hexadecanoyl-1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine
PEP-16:0/18:1(11Z))
  • 1-(1-Enyl-palmitoyl)-2-vaccenoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:1)
  • GPEtn(16:0/18:1n7)
  • GPEtn(16:0/18:1w7)
  • GPEtn(34:1)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-Trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
68737-67-7
Phosphatidylcholines Group B
  • 1-(1-Enyl-vaccenoyl)-2-stearidonoyl-sn-glycero-3-phosphocholine
  • GPCho(18:1/18:4)
  • GPCho(18:1n7/18:4n3)
  • GPCho(18:1w7/18:4w3)
  • GPCho(36:5)
88542-95-4
genes like me logo Genes that share compounds with PLSCR2: view

Transcripts for PLSCR2 Gene

Unigene Clusters for PLSCR2 Gene

Phospholipid scramblase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLSCR2 Gene

No ASD Table

Relevant External Links for PLSCR2 Gene

GeneLoc Exon Structure for
PLSCR2
ECgene alternative splicing isoforms for
PLSCR2

Expression for PLSCR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLSCR2 Gene

mRNA differential expression in normal tissues according to GTEx for PLSCR2 Gene

This gene is overexpressed in Testis (x34.9).

Protein differential expression in normal tissues from HIPED for PLSCR2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLSCR2 Gene



Protein tissue co-expression partners for PLSCR2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PLSCR2 Gene:

PLSCR2

SOURCE GeneReport for Unigene cluster for PLSCR2 Gene:

Hs.744414

mRNA Expression by UniProt/SwissProt for PLSCR2 Gene:

Q9NRY7-PLS2_HUMAN
Tissue specificity: Expression of isoform 1 seems restricted to testis.
genes like me logo Genes that share expression patterns with PLSCR2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLSCR2 Gene

Orthologs for PLSCR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLSCR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLSCR2 34 35
  • 98.65 (n)
cow
(Bos Taurus)
Mammalia PLSCR2 35
  • 69 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 68 (a)
OneToMany
mouse
(Mus musculus)
Mammalia 1700057G04Rik 35
  • 63 (a)
ManyToMany
Plscr1 35
  • 63 (a)
ManyToMany
Plscr2 35
  • 57 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 56 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 54 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-71m22.5 35
  • 56 (a)
ManyToMany
si:ch73-206p6.1 35
  • 55 (a)
ManyToMany
si:ch211-71m22.1 35
  • 51 (a)
ManyToMany
FP245465.1 35
  • 37 (a)
ManyToMany
si:ch211-71m22.3 35
  • 35 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1893 36
  • 46 (a)
scramb2 35
  • 42 (a)
ManyToMany
scramb1 35
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ZK1053.5 36
  • 40 (a)
K08D10.18 35
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6170 35
  • 39 (a)
ManyToMany
Species where no ortholog for PLSCR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLSCR2 Gene

ENSEMBL:
Gene Tree for PLSCR2 (if available)
TreeFam:
Gene Tree for PLSCR2 (if available)

Paralogs for PLSCR2 Gene

Paralogs for PLSCR2 Gene

(5) SIMAP similar genes for PLSCR2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PLSCR2: view

Variants for PLSCR2 Gene

Sequence variations from dbSNP and Humsavar for PLSCR2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000008046 -- 146,426,129(+) ACATT(C/G)TATTT intron-variant
rs1000020408 -- 146,436,023(+) ATTTA(A/G)TAGGG intron-variant
rs1000078391 -- 146,411,924(+) AATTG(A/C)GGATA intron-variant
rs1000090602 -- 146,440,432(+) TTTGA(C/G)CTTCT intron-variant, downstream-variant-500B
rs1000092130 -- 146,434,816(+) GTGCA(C/T)AATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLSCR2 Gene

Variant ID Type Subtype PubMed ID
esv2496437 CNV deletion 19546169
esv2726024 CNV deletion 23290073
esv3562677 CNV deletion 23714750

Variation tolerance for PLSCR2 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLSCR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLSCR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLSCR2 Gene

Disorders for PLSCR2 Gene

Relevant External Links for PLSCR2

Genetic Association Database (GAD)
PLSCR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLSCR2

No disorders were found for PLSCR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLSCR2 Gene

Publications for PLSCR2 Gene

  1. Identification of three new members of the phospholipid scramblase gene family. (PMID: 10930526) Wiedmer T. … Sims P.J. (Biochim. Biophys. Acta 2000) 2 3 4 64
  2. N-terminal proline-rich domain is required for scrambling activity of human phospholipid scramblases. (PMID: 24648509) Rayala S. … Gummadi S.N. (J. Biol. Chem. 2014) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64
  5. Calcium binding studies of peptides of human phospholipid scramblases 1 to 4 suggest that scramblases are new class of calcium binding proteins in the cell. (PMID: 19540310) Sahu S.K. … Gummadi S.N. (Biochim. Biophys. Acta 2009) 3 64

Products for PLSCR2 Gene

Sources for PLSCR2 Gene

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