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Aliases for PLSCR1 Gene

Aliases for PLSCR1 Gene

  • Phospholipid Scramblase 1 2 3 5
  • Ca(2+)-Dependent Phospholipid Scramblase 1 3 4
  • Erythrocyte Phospholipid Scramblase 3 4
  • PL Scramblase 1 3 4
  • MMTRA1B 3 4

External Ids for PLSCR1 Gene

Previous GeneCards Identifiers for PLSCR1 Gene

  • GC03M143025
  • GC03M147108
  • GC03M147514
  • GC03M147553
  • GC03M147715
  • GC03M146232
  • GC03M143612

Summaries for PLSCR1 Gene

GeneCards Summary for PLSCR1 Gene

PLSCR1 (Phospholipid Scramblase 1) is a Protein Coding gene. Diseases associated with PLSCR1 include scott syndrome. Among its related pathways are EGFR1 Signaling Pathway. GO annotations related to this gene include calcium ion binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is PLSCR4.

UniProtKB/Swiss-Prot for PLSCR1 Gene

  • May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.

  • May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.

Gene Wiki entry for PLSCR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLSCR1 Gene

Genomics for PLSCR1 Gene

Regulatory Elements for PLSCR1 Gene

Enhancers for PLSCR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLSCR1 on UCSC Golden Path with GeneCards custom track

Promoters for PLSCR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLSCR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLSCR1 Gene

Chromosome:
3
Start:
146,515,178 bp from pter
End:
146,544,864 bp from pter
Size:
29,687 bases
Orientation:
Minus strand

Genomic View for PLSCR1 Gene

Genes around PLSCR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLSCR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLSCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLSCR1 Gene

Proteins for PLSCR1 Gene

  • Protein details for PLSCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15162-PLS1_HUMAN
    Recommended name:
    Phospholipid scramblase 1
    Protein Accession:
    O15162
    Secondary Accessions:
    • B2R8H8
    • B4DTE8

    Protein attributes for PLSCR1 Gene

    Size:
    318 amino acids
    Molecular mass:
    35049 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with ABL.

    Three dimensional structures from OCA and Proteopedia for PLSCR1 Gene

    Alternative splice isoforms for PLSCR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLSCR1 Gene

Proteomics data for PLSCR1 Gene at MOPED

Post-translational modifications for PLSCR1 Gene

  • Ubiquitination at Lys 261
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PLSCR1 (Phospholipid Scramblase 1/PLSCR1)

No data available for DME Specific Peptides for PLSCR1 Gene

Domains & Families for PLSCR1 Gene

Gene Families for PLSCR1 Gene

Protein Domains for PLSCR1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PLSCR1 Gene

Graphical View of Domain Structure for InterPro Entry

O15162

UniProtKB/Swiss-Prot:

PLS1_HUMAN :
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
  • Belongs to the phospholipid scramblase family.
Domain:
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
Family:
  • Belongs to the phospholipid scramblase family.
genes like me logo Genes that share domains with PLSCR1: view

Function for PLSCR1 Gene

Molecular function for PLSCR1 Gene

UniProtKB/Swiss-Prot Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
UniProtKB/Swiss-Prot Function:
May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.
UniProtKB/Swiss-Prot Induction:
By phosphorylation by PKC. Induced by IFNB1/IFN-beta in response to a viral infection.

Gene Ontology (GO) - Molecular Function for PLSCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017128 phospholipid scramblase activity IDA 9218461
genes like me logo Genes that share ontologies with PLSCR1: view
genes like me logo Genes that share phenotypes with PLSCR1: view

Animal Models for PLSCR1 Gene

MGI Knock Outs for PLSCR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLSCR1

miRNA for PLSCR1 Gene

miRTarBase miRNAs that target PLSCR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLSCR1 Gene

Localization for PLSCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLSCR1 Gene

Cell membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor; Cytoplasmic side. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLSCR1 Gene COMPARTMENTS Subcellular localization image for PLSCR1 gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 5
nucleus 5
plasma membrane 5
endosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLSCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 17712045
GO:0005886 plasma membrane IDA 17712045
genes like me logo Genes that share ontologies with PLSCR1: view

Pathways & Interactions for PLSCR1 Gene

SuperPathways for PLSCR1 Gene

Superpath Contained pathways
1 EGFR1 Signaling Pathway
genes like me logo Genes that share pathways with PLSCR1: view

Pathways by source for PLSCR1 Gene

1 BioSystems pathway for PLSCR1 Gene

SIGNOR curated interactions for PLSCR1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PLSCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IDA 10770950
GO:0017121 phospholipid scrambling IDA 9218461
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 16091359
GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity IDA 17567603
genes like me logo Genes that share ontologies with PLSCR1: view

Drugs & Compounds for PLSCR1 Gene

(3) Drugs for PLSCR1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(515) Additional Compounds for PLSCR1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
PE(P-16:0e/16:0)
  • 2-Hexadecanoyl-1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine
PEP-16:0/18:1(11Z))
  • 1-(1-Enyl-palmitoyl)-2-vaccenoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:1)
  • GPEtn(16:0/18:1n7)
  • GPEtn(16:0/18:1w7)
  • GPEtn(34:1)
Phosphatidylcholines Group A
  • (R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-Trioxa-4-phosphapentacosan-1-aminium 4-oxide hydroxide inner salt
  • (R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-Trioxa-4-phosphapentacosan-1-aminium 4-oxide inner salt
  • 1,2-Bis(hexadecanoyl)-sn-glycero-3-phosphocholine
  • 1,2-Bis(palmitoyl)-sn-glycero-3-phosphocholine
  • 1,2-Dihexadecanoyl-sn-glycerol-3-phosphorylcholine
63-89-8, 68737-67-7
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-stearidonoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/18:4)
  • GPCho(16:0/18:4n3)
  • GPCho(16:0/18:4w3)
  • GPCho(34:4)
88542-95-4
genes like me logo Genes that share compounds with PLSCR1: view

Transcripts for PLSCR1 Gene

Unigene Clusters for PLSCR1 Gene

Phospholipid scramblase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLSCR1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - - - - -
SP2: - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - -
SP11: - - -
SP12: - - -
SP13: - - - -
SP14: - - - - -
SP15:

Relevant External Links for PLSCR1 Gene

GeneLoc Exon Structure for
PLSCR1
ECgene alternative splicing isoforms for
PLSCR1

Expression for PLSCR1 Gene

mRNA expression in normal human tissues for PLSCR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLSCR1 Gene

This gene is overexpressed in Whole Blood (x5.9).

Protein differential expression in normal tissues from HIPED for PLSCR1 Gene

This gene is overexpressed in Urine (12.1) and Fetal gut (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLSCR1 Gene



SOURCE GeneReport for Unigene cluster for PLSCR1 Gene Hs.130759

mRNA Expression by UniProt/SwissProt for PLSCR1 Gene

O15162-PLS1_HUMAN
Tissue specificity: Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.
genes like me logo Genes that share expression patterns with PLSCR1: view

Protein tissue co-expression partners for PLSCR1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PLSCR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PLSCR1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC611500 35
  • 86 (n)
  • 83.65 (a)
-- 36
  • 80 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PLSCR1 35
  • 99.79 (n)
  • 99.69 (a)
PLSCR1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plscr1 16
1700057G04Rik 36
  • 68 (a)
ManyToMany
Plscr1 36
  • 74 (a)
ManyToMany
Plscr2 36
  • 68 (a)
ManyToMany
Plscr1 35
  • 80.72 (n)
  • 79.23 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PLSCR2 36
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Plscr1 35
  • 80.07 (n)
  • 81.12 (a)
chicken
(Gallus gallus)
Aves PLSCR1 35
  • 70.1 (n)
  • 71.13 (a)
-- 36
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489273 35
  • 70.01 (n)
  • 69.87 (a)
Str.951 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16684 35
FP245465.1 36
  • 41 (a)
ManyToMany
si:ch211-71m22.1 36
  • 59 (a)
ManyToMany
si:ch211-71m22.3 36
  • 37 (a)
ManyToMany
si:ch211-71m22.5 36
  • 61 (a)
ManyToMany
si:ch73-206p6.1 36
  • 62 (a)
ManyToMany
plscr3b 35
  • 58.53 (n)
  • 62.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1893 37
  • 51 (a)
scramb1 35
  • 54.67 (n)
  • 58.91 (a)
scramb1 36
  • 39 (a)
ManyToMany
scramb2 36
  • 47 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005504 35
  • 57.78 (n)
  • 58.6 (a)
worm
(Caenorhabditis elegans)
Secernentea C04E12.7 37
  • 35 (a)
ZK1053.5 37
  • 42 (a)
scrm-2 36
  • 39 (a)
ManyToMany
scrm-1 35
  • 50.6 (n)
  • 44.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AIM25 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10381 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7036 36
  • 46 (a)
ManyToMany
Species with no ortholog for PLSCR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLSCR1 Gene

ENSEMBL:
Gene Tree for PLSCR1 (if available)
TreeFam:
Gene Tree for PLSCR1 (if available)

Paralogs for PLSCR1 Gene

Paralogs for PLSCR1 Gene

Pseudogenes.org Pseudogenes for PLSCR1 Gene

genes like me logo Genes that share paralogs with PLSCR1: view

Variants for PLSCR1 Gene

Sequence variations from dbSNP and Humsavar for PLSCR1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs343320 - 146,517,122(-) CCAAG(C/T)ACTGG reference, missense
rs343310 -- 146,526,111(-) ctgcc(G/T)cctgg intron-variant
rs343311 -- 146,523,688(-) TCCCA(C/T)GGTCT intron-variant
rs343312 -- 146,522,970(-) aaaca(C/T)gtgaa intron-variant
rs343313 -- 146,522,903(-) atata(A/C)ataaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLSCR1 Gene

Variant ID Type Subtype PubMed ID
nsv877606 CNV Gain 21882294
esv2496437 CNV Deletion 19546169
esv2726024 CNV Deletion 23290073
nsv822282 CNV Gain 20364138

Variation tolerance for PLSCR1 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLSCR1 Gene

HapMap Linkage Disequilibrium report
PLSCR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLSCR1 Gene

Disorders for PLSCR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLSCR1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
scott syndrome
  • platelet factor x receptor deficiency
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLSCR1

Human Genome Epidemiology (HuGE) Navigator
PLSCR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLSCR1
genes like me logo Genes that share disorders with PLSCR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLSCR1 Gene

Publications for PLSCR1 Gene

  1. Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids. (PMID: 9218461) Zhou Q. … Sims P.J. (J. Biol. Chem. 1997) 2 3 4 67
  2. The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane. (PMID: 19333378) Py B. … Benichou S. (PLoS ONE 2009) 3 23
  3. Calcium binding studies of peptides of human phospholipid scramblases 1 to 4 suggest that scramblases are new class of calcium binding proteins in the cell. (PMID: 19540310) Sahu S.K. … Gummadi S.N. (Biochim. Biophys. Acta 2009) 3 23
  4. Phospholipid scramblase 1 modulates a selected set of IgE receptor-mediated mast cell responses through LAT-dependent pathway. (PMID: 18579528) Amir-Moazami O. … Benhamou M. (J. Biol. Chem. 2008) 3 23
  5. Over-expression of recombinant human phospholipid scramblase 1 in E. coli and its purification from inclusion bodies. (PMID: 18629440) Sahu S.K. … Gummadi S.N. (Biotechnol. Lett. 2008) 3 23

Products for PLSCR1 Gene

Sources for PLSCR1 Gene

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