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Aliases for PLSCR1 Gene

Aliases for PLSCR1 Gene

  • Phospholipid Scramblase 1 2 3
  • MMTRA1B 3 4 6
  • Ca(2+)-Dependent Phospholipid Scramblase 1 3 4
  • Erythrocyte Phospholipid Scramblase 3 4
  • PL Scramblase 1 3 4

External Ids for PLSCR1 Gene

Summaries for PLSCR1 Gene

GeneCards Summary for PLSCR1 Gene

PLSCR1 (Phospholipid Scramblase 1) is a Protein Coding gene. Diseases associated with PLSCR1 include scott syndrome. Among its related pathways are EGFR1 Signaling Pathway. GO annotations related to this gene include calcium ion binding and SH3 domain binding. An important paralog of this gene is PLSCR4.

UniProtKB/Swiss-Prot for PLSCR1 Gene

  • May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system

  • May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation

Gene Wiki entry for PLSCR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLSCR1 Gene

Genomics for PLSCR1 Gene

Genomic Location for PLSCR1 Gene

Start:
146,515,180 bp from pter
End:
146,544,864 bp from pter
Size:
29,685 bases
Orientation:
Minus strand

Genomic View for PLSCR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLSCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLSCR1 Gene

Regulatory Elements for PLSCR1 Gene

Proteins for PLSCR1 Gene

  • Protein details for PLSCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15162-PLS1_HUMAN
    Recommended name:
    Phospholipid scramblase 1
    Protein Accession:
    O15162
    Secondary Accessions:
    • B2R8H8
    • B4DTE8

    Protein attributes for PLSCR1 Gene

    Size:
    318 amino acids
    Molecular mass:
    35049 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with ABL.

    Three dimensional structures from OCA and Proteopedia for PLSCR1 Gene

    Alternative splice isoforms for PLSCR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLSCR1 Gene

Proteomics data for PLSCR1 Gene at MOPED

Post-translational modifications for PLSCR1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys261

No data available for DME Specific Peptides for PLSCR1 Gene

Domains for PLSCR1 Gene

Protein Domains for PLSCR1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

PLS1_HUMAN
Domain:
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity:
    • O15162
Family:
  • Belongs to the phospholipid scramblase family.:
    • O15162
genes like me logo Genes that share domains with PLSCR1: view

No data available for Gene Families for PLSCR1 Gene

Function for PLSCR1 Gene

Molecular function for PLSCR1 Gene

UniProtKB/Swiss-Prot Function: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system
UniProtKB/Swiss-Prot Function: May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation
UniProtKB/Swiss-Prot Induction: By phosphorylation by PKC. Induced by IFNB1/IFN-beta in response to a viral infection.

Gene Ontology (GO) - Molecular Function for PLSCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 16091359
GO:0003677 DNA binding IEA --
GO:0005154 epidermal growth factor receptor binding IPI 12009895
GO:0005509 calcium ion binding NAS 9218461
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with PLSCR1: view
genes like me logo Genes that share phenotypes with PLSCR1: view

Animal Models for PLSCR1 Gene

MGI Knock Outs for PLSCR1:

miRNA for PLSCR1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PLSCR1 Gene

Localization for PLSCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLSCR1 Gene

Cell membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor; Cytoplasmic side. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLSCR1 Gene COMPARTMENTS Subcellular localization image for PLSCR1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 5
plasma membrane 5
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLSCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20870722
GO:0005730 nucleolus IDA 17567603
GO:0005794 Golgi apparatus IDA 12586838
GO:0005829 cytosol IDA 17712045
GO:0005886 plasma membrane IDA 17712045
genes like me logo Genes that share ontologies with PLSCR1: view

Pathways for PLSCR1 Gene

SuperPathways for PLSCR1 Gene

Superpath Contained pathways
1 EGFR1 Signaling Pathway
genes like me logo Genes that share pathways with PLSCR1: view

Pathways by source for PLSCR1 Gene

1 BioSystems pathway for PLSCR1 Gene

Gene Ontology (GO) - Biological Process for PLSCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006659 phosphatidylserine biosynthetic process ISS --
GO:0006915 apoptotic process IDA 10770950
GO:0006953 acute-phase response ISS --
GO:0010628 positive regulation of gene expression IMP 15308695
GO:0017121 phospholipid scrambling IDA 10770950
genes like me logo Genes that share ontologies with PLSCR1: view

Compounds for PLSCR1 Gene

(2714) HMDB Compounds for PLSCR1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
PC(14:0/14:0)
  • Phosphatidylcholine(14:0/14:0)
Not Available
PC(14:0/14:1(9Z))
  • Phosphatidylcholine(14:0/14:1)
Not Available
PC(14:0/15:0)
  • GPCho(14:0/15:0)
Not Available
PC(14:0/16:0)
  • GPCho(30:0)
Not Available

(7) Novoseek inferred chemical compound relationships for PLSCR1 Gene

Compound -log(P) Hits PubMed IDs
phospholipid 79.4 45
phosphatidylserine 65.2 5
rottlerin 61.5 2
inositol 1,4,5 trisphosphate 28.5 3
retinoic acid 27.4 7
genes like me logo Genes that share compounds with PLSCR1: view

Transcripts for PLSCR1 Gene

Unigene Clusters for PLSCR1 Gene

Phospholipid scramblase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLSCR1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - - - - -
SP2: - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - -
SP11: - - -
SP12: - - -
SP13: - - - -
SP14: - - - - -
SP15:

Relevant External Links for PLSCR1 Gene

GeneLoc Exon Structure for
PLSCR1
ECgene alternative splicing isoforms for
PLSCR1

Expression for PLSCR1 Gene

mRNA expression in normal human tissues for PLSCR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLSCR1 Gene

This gene is overexpressed in Whole Blood (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLSCR1 Gene

SOURCE GeneReport for Unigene cluster for PLSCR1 Gene Hs.130759

mRNA Expression by UniProt/SwissProt for PLSCR1 Gene

O15162-PLS1_HUMAN
Tissue specificity: Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle
genes like me logo Genes that share expressions with PLSCR1: view

Orthologs for PLSCR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PLSCR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLSCR1 36
  • 99.79 (n)
  • 99.69 (a)
PLSCR1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLSCR2 37
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 80 (a)
OneToMany
LOC611500 36
  • 86 (n)
  • 83.65 (a)
mouse
(Mus musculus)
Mammalia 1700057G04Rik 37
  • 68 (a)
ManyToMany
Plscr1 36
  • 80.72 (n)
  • 79.23 (a)
Plscr1 16
Plscr1 37
  • 74 (a)
ManyToMany
Plscr2 37
  • 68 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Plscr1 36
  • 80.07 (n)
  • 81.12 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 67 (a)
OneToMany
PLSCR1 36
  • 70.1 (n)
  • 71.13 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 59 (a)
ManyToMany
-- 37
  • 48 (a)
ManyToMany
-- 37
  • 62 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489273 36
  • 70.01 (n)
  • 69.87 (a)
Str.951 36
zebrafish
(Danio rerio)
Actinopterygii Dr.16684 36
FP245465.1 37
  • 41 (a)
ManyToMany
plscr3b 36
  • 58.53 (n)
  • 62.89 (a)
si:ch211-71m22.1 37
  • 59 (a)
ManyToMany
si:ch211-71m22.3 37
  • 37 (a)
ManyToMany
si:ch211-71m22.5 37
  • 61 (a)
ManyToMany
si:ch73-206p6.1 37
  • 62 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005504 36
  • 57.78 (n)
  • 58.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta scramb1 36
  • 54.67 (n)
  • 58.91 (a)
scramb1 37
  • 39 (a)
ManyToMany
scramb2 37
  • 47 (a)
ManyToMany
CG1893 38
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea scrm-1 36
  • 50.6 (n)
  • 44.22 (a)
scrm-2 37
  • 39 (a)
ManyToMany
C04E12.7 38
  • 35 (a)
ZK1053.5 38
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AIM25 39
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10381 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7036 37
  • 46 (a)
ManyToMany
Species with no ortholog for PLSCR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLSCR1 Gene

ENSEMBL:
Gene Tree for PLSCR1 (if available)
TreeFam:
Gene Tree for PLSCR1 (if available)

Paralogs for PLSCR1 Gene

Paralogs for PLSCR1 Gene

Pseudogenes.org Pseudogenes for PLSCR1 Gene

genes like me logo Genes that share paralogs with PLSCR1: view

Variants for PLSCR1 Gene

Sequence variations from dbSNP and Humsavar for PLSCR1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs173150 -- 146,520,256(-) TTTCA(A/T)CTGGC intron-variant
rs186910 -- 146,520,241(-) TTTCT(C/T)GATGG intron-variant
rs343310 -- 146,526,111(-) ctgcc(G/T)cctgg intron-variant
rs343311 -- 146,523,688(-) TCCCA(C/T)GGTCT intron-variant
rs343312 -- 146,522,970(-) aaaca(C/T)gtgaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLSCR1 Gene

Variant ID Type Subtype PubMed ID
nsv877606 CNV Gain 21882294
esv2496437 CNV Deletion 19546169
esv2726024 CNV Deletion 23290073
nsv822282 CNV Gain 20364138

Relevant External Links for PLSCR1 Gene

HapMap Linkage Disequilibrium report
PLSCR1

Disorders for PLSCR1 Gene

(1) MalaCards Diseases for PLSCR1 Gene

Search for PLSCR1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for PLSCR1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 3

Relevant External Links for PLSCR1

Human Genome Epidemiology (HuGE) Navigator
PLSCR1
genes like me logo Genes that share disorders with PLSCR1: view

No data available for UniProtKB/Swiss-Prot for PLSCR1 Gene

Publications for PLSCR1 Gene

  1. Identification of three new members of the phospholipid scramblase gene family. (PMID: 10930526) Wiedmer T. … Sims P.J. (Biochim. Biophys. Acta 2000) 3 4 23
  2. Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane. (PMID: 12564925) Wiedmer T. … Sims P.J. (Biochemistry 2003) 3 4 23
  3. Phospholipid scramblase 1 potentiates the antiviral activity of interferon. (PMID: 15308695) Dong B. … Silverman R.H. (J. Virol. 2004) 3 4 23
  4. Phospholipid scramblase 1 contains a nonclassical nuclear localization signal with unique binding site in importin alpha. (PMID: 15611084) Chen M.H. … Cingolani G. (J. Biol. Chem. 2005) 3 4 23
  5. Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression. (PMID: 16091359) Zhou Q. … Sims P.J. (J. Biol. Chem. 2005) 3 4 23

Products for PLSCR1 Gene

Sources for PLSCR1 Gene

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