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Aliases for PLS3 Gene

Aliases for PLS3 Gene

  • Plastin 3 2 3 5
  • T-Plastin 3 4
  • Plastin 3 (T Isoform) 2
  • T Fimbrin 3
  • T Plastin 3
  • BMND18 3

External Ids for PLS3 Gene

Previous GeneCards Identifiers for PLS3 Gene

  • GC0XP109814
  • GC0XP111920
  • GC0XP112831
  • GC0XP113559
  • GC0XP114618
  • GC0XP114795
  • GC0XP104379

Summaries for PLS3 Gene

Entrez Gene Summary for PLS3 Gene

  • Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

GeneCards Summary for PLS3 Gene

PLS3 (Plastin 3) is a Protein Coding gene. Diseases associated with PLS3 include bone mineral density qtl18, osteoporosis and x-linked osteoporosis with fractures. GO annotations related to this gene include calcium ion binding and actin binding. An important paralog of this gene is PLS1.

UniProtKB/Swiss-Prot for PLS3 Gene

  • Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development.

Gene Wiki entry for PLS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLS3 Gene

Genomics for PLS3 Gene

Regulatory Elements for PLS3 Gene

Promoters for PLS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLS3 Gene

Chromosome:
X
Start:
115,560,850 bp from pter
End:
115,650,861 bp from pter
Size:
90,012 bases
Orientation:
Plus strand

Genomic View for PLS3 Gene

Genes around PLS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLS3 Gene

Proteins for PLS3 Gene

  • Protein details for PLS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13797-PLST_HUMAN
    Recommended name:
    Plastin-3
    Protein Accession:
    P13797
    Secondary Accessions:
    • A8K579
    • B1AQ09
    • B4DGB4
    • B7Z6M1
    • Q86YI6

    Protein attributes for PLS3 Gene

    Size:
    630 amino acids
    Molecular mass:
    70811 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=CAI39884.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLS3 Gene

    Alternative splice isoforms for PLS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLS3 Gene

Proteomics data for PLS3 Gene at MOPED

Post-translational modifications for PLS3 Gene

  • Ubiquitination at Lys 52, Lys 59, Lys 100, Lys 168, Lys 300, Lys 382, and Lys 437
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for PLS3 Gene

Domains & Families for PLS3 Gene

Gene Families for PLS3 Gene

Graphical View of Domain Structure for InterPro Entry

P13797

UniProtKB/Swiss-Prot:

PLST_HUMAN :
  • Contains 2 actin-binding domains.
Domain:
  • Contains 2 actin-binding domains.
  • Contains 4 CH (calponin-homology) domains.
  • Contains 2 EF-hand domains.
genes like me logo Genes that share domains with PLS3: view

Function for PLS3 Gene

Molecular function for PLS3 Gene

UniProtKB/Swiss-Prot Function:
Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development.

Gene Ontology (GO) - Molecular Function for PLS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with PLS3: view
genes like me logo Genes that share phenotypes with PLS3: view

Human Phenotype Ontology for PLS3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PLS3 Gene

MGI Knock Outs for PLS3:
  • Pls3 tm1a(EUCOMM)Wtsi

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PLS3 Gene

Localization for PLS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLS3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLS3 Gene COMPARTMENTS Subcellular localization image for PLS3 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
peroxisome 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for PLS3 Gene

Pathways & Interactions for PLS3 Gene

SuperPathways for PLS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042491 auditory receptor cell differentiation IEA --
genes like me logo Genes that share ontologies with PLS3: view

No data available for Pathways by source and SIGNOR curated interactions for PLS3 Gene

Drugs & Compounds for PLS3 Gene

No Compound Related Data Available

Transcripts for PLS3 Gene

Unigene Clusters for PLS3 Gene

Plastin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLS3 Gene

No ASD Table

Relevant External Links for PLS3 Gene

GeneLoc Exon Structure for
PLS3
ECgene alternative splicing isoforms for
PLS3

Expression for PLS3 Gene

mRNA expression in normal human tissues for PLS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLS3 Gene

This gene is overexpressed in Artery - Aorta (x6.3) and Artery - Tibial (x5.0).

Protein differential expression in normal tissues from HIPED for PLS3 Gene

This gene is overexpressed in Amniocyte (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLS3 Gene



SOURCE GeneReport for Unigene cluster for PLS3 Gene Hs.496622

mRNA Expression by UniProt/SwissProt for PLS3 Gene

P13797-PLST_HUMAN
Tissue specificity: Expressed in a variety of organs, including muscle, brain, uterus and esophagus.
genes like me logo Genes that share expression patterns with PLS3: view

Protein tissue co-expression partners for PLS3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PLS3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLS3 35
  • 99.61 (n)
  • 99.67 (a)
PLS3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLS3 36
  • 98 (a)
OneToOne
PLS3 35
  • 94.71 (n)
  • 99.37 (a)
dog
(Canis familiaris)
Mammalia PLS3 35
  • 93.54 (n)
  • 99.52 (a)
PLS3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pls3 36
  • 99 (a)
OneToOne
Pls3 16
Pls3 35
  • 90.79 (n)
  • 99.05 (a)
oppossum
(Monodelphis domestica)
Mammalia PLS3 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLS3 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pls3 35
  • 91.22 (n)
  • 98.1 (a)
chicken
(Gallus gallus)
Aves PLS3 36
  • 94 (a)
OneToOne
PLS3 35
  • 82.11 (n)
  • 94.57 (a)
lizard
(Anolis carolinensis)
Reptilia PLS3 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68681 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pls3 35
  • 79.09 (n)
  • 88.64 (a)
Str.17623 35
zebrafish
(Danio rerio)
Actinopterygii pls3 36
  • 87 (a)
OneToOne
pls3 35
  • 74.85 (n)
  • 87.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fim 36
  • 52 (a)
OneToMany
Fim 37
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea Y104H12BL.1 37
  • 51 (a)
Y104H12BR.1 37
  • 59 (a)
Y73B3B.1 37
  • 59 (a)
plst-1 36
  • 52 (a)
ManyToMany
Y73B3B.1 36
  • 35 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAC6 36
  • 38 (a)
OneToMany
SAC6 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G48460 35
  • 53.58 (n)
  • 43.72 (a)
rice
(Oryza sativa)
Liliopsida Os01g0514600 35
  • 50.69 (n)
  • 42.91 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4644 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8022 36
  • 49 (a)
OneToMany
Species with no ortholog for PLS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLS3 Gene

ENSEMBL:
Gene Tree for PLS3 (if available)
TreeFam:
Gene Tree for PLS3 (if available)

Paralogs for PLS3 Gene

Paralogs for PLS3 Gene

(2) SIMAP similar genes for PLS3 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with PLS3: view

Variants for PLS3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PLS3 Gene

P13797-PLST_HUMAN
Genetic variations in PLS3 define the bone mineral density quantitative trait locus 18 (BMND18) [MIM:300910]. Variance in bone mineral density influences bone mass, contributes to size determination in the general population, and is a susceptibility factor for osteoporotic fractures.

Sequence variations from dbSNP and Humsavar for PLS3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_035462 A breast cancer sample
rs2301951 -- 115,646,617(+) GTGGA(C/T)ATGTC intron-variant
rs2843606 -- 115,647,289(-) cgccc(A/G)gctaa intron-variant
rs2895155 -- 115,644,003(+) TAGTC(A/G)AGTCG intron-variant
rs2522177 -- 115,570,323(+) ATAAT(A/C)CACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLS3 Gene

Variant ID Type Subtype PubMed ID
esv33994 CNV Gain+Loss 17666407
esv2666518 CNV Deletion 23128226

Variation tolerance for PLS3 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 13.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLS3 Gene

HapMap Linkage Disequilibrium report
PLS3
Human Gene Mutation Database (HGMD)
PLS3

Disorders for PLS3 Gene

MalaCards: The human disease database

(7) MalaCards diseases for PLS3 Gene - From: OMIM, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
bone mineral density qtl18, osteoporosis
  • osteoporosis and osteoporotic fractures, susceptibility to
x-linked osteoporosis with fractures
mycosis fungoides
  • mf
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
sezary's disease
  • sezary disease
- elite association - COSMIC cancer census association via MalaCards
Search PLS3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PLST_HUMAN
  • Osteoporosis (OSTEOP) [MIM:166710]: A systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs. {ECO:0000269 PubMed:24088043}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for PLS3

Genetic Association Database (GAD)
PLS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLS3
genes like me logo Genes that share disorders with PLS3: view

No data available for Genatlas for PLS3 Gene

Publications for PLS3 Gene

  1. Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells. (PMID: 8428952) Lin C.-S. … Leavitt J. (J. Biol. Chem. 1993) 2 3 4 67
  2. Expression of T-plastin, FoxP3 and other tumor-associated markers by leukemic T-cells of cutaneous T-cell lymphoma. (PMID: 18569641) Capriotti E. … Hess A.D. (Leuk. Lymphoma 2008) 3 23
  3. Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways. (PMID: 16115810) Ralser M. … Krobitsch S. (Hum. Mol. Genet. 2005) 3 23
  4. Actin-filament cross-linking protein T-plastin increases Arp2/3-mediated actin-based movement. (PMID: 15741236) Giganti A. … Friederich E. (J. Cell. Sci. 2005) 3 23
  5. Changes in T-plastin expression with human trophoblast differentiation. (PMID: 14567899) Rao R.M. … Rao A.J. (Reprod. Biomed. Online 2003) 3 23

Products for PLS3 Gene

Sources for PLS3 Gene

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