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Aliases for PLS3 Gene

Aliases for PLS3 Gene

  • Plastin 3 2 3 5
  • T-Plastin 3 4
  • Plastin 3 (T Isoform) 2
  • T Fimbrin 3
  • T Plastin 3
  • Plastin-3 3
  • BMND18 3

External Ids for PLS3 Gene

Previous GeneCards Identifiers for PLS3 Gene

  • GC0XP109814
  • GC0XP111920
  • GC0XP112831
  • GC0XP113559
  • GC0XP114618
  • GC0XP114795
  • GC0XP104379

Summaries for PLS3 Gene

Entrez Gene Summary for PLS3 Gene

  • Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

GeneCards Summary for PLS3 Gene

PLS3 (Plastin 3) is a Protein Coding gene. Diseases associated with PLS3 include Bone Mineral Density Qtl18, Osteoporosis and Sezary's Disease. GO annotations related to this gene include calcium ion binding and actin binding. An important paralog of this gene is LCP1.

UniProtKB/Swiss-Prot for PLS3 Gene

  • Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development.

Gene Wiki entry for PLS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLS3 Gene

Genomics for PLS3 Gene

Regulatory Elements for PLS3 Gene

Enhancers for PLS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF115559 0.2 ENCODE 15.1 +1.2 1170 5.7 PKNOX1 ARID4B SIN3A FEZF1 YY1 GLIS2 FOS ZNF263 SP3 NFYC PLS3 PLS3-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PLS3 on UCSC Golden Path with GeneCards custom track

Promoters for PLS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000481308 1350 3201 PKNOX1 ARID4B FEZF1 YY1 GLIS2 FOS ZNF263 SP3 NFYC TSHZ1

Genomic Location for PLS3 Gene

115,560,850 bp from pter
115,650,861 bp from pter
90,012 bases
Plus strand

Genomic View for PLS3 Gene

Genes around PLS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLS3 Gene

Proteins for PLS3 Gene

  • Protein details for PLS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K579
    • B1AQ09
    • B4DGB4
    • B7Z6M1
    • Q86YI6

    Protein attributes for PLS3 Gene

    630 amino acids
    Molecular mass:
    70811 Da
    Quaternary structure:
    • Monomer.
    • Sequence=CAI39884.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLS3 Gene

    Alternative splice isoforms for PLS3 Gene


neXtProt entry for PLS3 Gene

Post-translational modifications for PLS3 Gene

  • Ubiquitination at Lys 52, Lys 59, Lys 100, Lys 168, Lys 300, Lys 382, and Lys 437
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PLS3 Gene

Domains & Families for PLS3 Gene

Gene Families for PLS3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 actin-binding domains.
  • Contains 2 actin-binding domains.
  • Contains 4 CH (calponin-homology) domains.
  • Contains 2 EF-hand domains.
genes like me logo Genes that share domains with PLS3: view

Function for PLS3 Gene

Molecular function for PLS3 Gene

UniProtKB/Swiss-Prot Function:
Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development.

Gene Ontology (GO) - Molecular Function for PLS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with PLS3: view
genes like me logo Genes that share phenotypes with PLS3: view

Human Phenotype Ontology for PLS3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PLS3 Gene

MGI Knock Outs for PLS3:
  • Pls3 tm1a(EUCOMM)Wtsi

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PLS3 Gene

Localization for PLS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLS3 Gene


Subcellular locations from

Jensen Localization Image for PLS3 Gene COMPARTMENTS Subcellular localization image for PLS3 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
peroxisome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PLS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005884 actin filament IBA --
GO:0032432 actin filament bundle IBA --
genes like me logo Genes that share ontologies with PLS3: view

Pathways & Interactions for PLS3 Gene

SuperPathways for PLS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051017 actin filament bundle assembly IBA --
GO:0051639 actin filament network formation IBA --
GO:0051764 actin crosslink formation IBA --
GO:0060348 bone development IMP 24088043
genes like me logo Genes that share ontologies with PLS3: view

No data available for Pathways by source and SIGNOR curated interactions for PLS3 Gene

Transcripts for PLS3 Gene

Unigene Clusters for PLS3 Gene

Plastin 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLS3 Gene

No ASD Table

Relevant External Links for PLS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLS3 Gene

This gene is overexpressed in Artery - Aorta (x6.3) and Artery - Tibial (x5.0).

Protein differential expression in normal tissues from HIPED for PLS3 Gene

This gene is overexpressed in Amniocyte (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLS3 Gene

Protein tissue co-expression partners for PLS3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PLS3 Gene:


SOURCE GeneReport for Unigene cluster for PLS3 Gene:


mRNA Expression by UniProt/SwissProt for PLS3 Gene:

Tissue specificity: Expressed in a variety of organs, including muscle, brain, uterus and esophagus.
genes like me logo Genes that share expression patterns with PLS3: view

Primer Products

Orthologs for PLS3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLS3 34 35
  • 99.61 (n)
(Monodelphis domestica)
Mammalia PLS3 35
  • 95 (a)
(Bos Taurus)
Mammalia PLS3 34 35
  • 94.71 (n)
(Canis familiaris)
Mammalia PLS3 34 35
  • 93.54 (n)
(Rattus norvegicus)
Mammalia Pls3 34
  • 91.22 (n)
(Mus musculus)
Mammalia Pls3 34 16 35
  • 90.79 (n)
(Ornithorhynchus anatinus)
Mammalia PLS3 35
  • 84 (a)
(Gallus gallus)
Aves PLS3 34 35
  • 82.11 (n)
(Anolis carolinensis)
Reptilia PLS3 35
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pls3 34
  • 79.09 (n)
Str.17623 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68681 34
(Danio rerio)
Actinopterygii pls3 34 35
  • 74.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta Fim 36 35
  • 54 (a)
(Caenorhabditis elegans)
Secernentea Y104H12BR.1 36
  • 59 (a)
Y73B3B.1 36 35
  • 59 (a)
plst-1 35
  • 52 (a)
Y104H12BL.1 36
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAC6 35 37
  • 38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G48460 34
  • 53.58 (n)
(Oryza sativa)
Liliopsida Os01g0514600 34
  • 50.69 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8022 35
  • 49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4644 34
Species where no ortholog for PLS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLS3 Gene

Gene Tree for PLS3 (if available)
Gene Tree for PLS3 (if available)

Paralogs for PLS3 Gene

Paralogs for PLS3 Gene

(2) SIMAP similar genes for PLS3 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with PLS3: view

Variants for PLS3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PLS3 Gene

Genetic variations in PLS3 define the bone mineral density quantitative trait locus 18 (BMND18) [MIM:300910]. Variance in bone mineral density influences bone mass, contributes to size determination in the general population, and is a susceptibility factor for osteoporotic fractures.

Sequence variations from dbSNP and Humsavar for PLS3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_035462 A breast cancer sample
rs140121121 other 115,629,281(+) CTGGG(A/T)GGAAC reference, synonymous-codon
rs397518421 other 115,646,495(+) GGAAC(C/T)AAACC reference, stop-gained
rs397518463 other 115,622,407(+) TTGTT(-/T)ATGTA intron-variant, reference, frameshift-variant
rs10081864 -- 115,589,124(+) cacca(C/T)gccca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLS3 Gene

Variant ID Type Subtype PubMed ID
esv2666518 CNV deletion 23128226
esv33994 CNV gain+loss 17666407
esv3559212 CNV deletion 23714750
esv3577051 CNV gain 25503493

Variation tolerance for PLS3 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 13.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLS3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for PLS3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PLS3 Gene - From: OMIM, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bone mineral density qtl18, osteoporosis
  • bone mineral density quantitative trait locus 18
sezary's disease
  • sezary disease
  • osteoporosis, postmenopausal, susceptibility
spinal muscular atrophy
  • kugelberg-welander disease
- elite association - COSMIC cancer census association via MalaCards
Search PLS3 in MalaCards View complete list of genes associated with diseases


  • Osteoporosis (OSTEOP) [MIM:166710]: A systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs. {ECO:0000269 PubMed:24088043}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for PLS3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PLS3: view

No data available for Genatlas for PLS3 Gene

Publications for PLS3 Gene

  1. Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells. (PMID: 8428952) Lin C.-S. … Leavitt J. (J. Biol. Chem. 1993) 2 3 4 64
  2. Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain. (PMID: 2378651) Lin C.-S. … Leavitt J. (Mol. Cell. Biol. 1990) 3 4 22 64
  3. PLS3 mutations in X-linked osteoporosis with fractures. (PMID: 24088043) van Dijk F.S. … Pals G. (N. Engl. J. Med. 2013) 3 4 64
  4. Expression of T-plastin, FoxP3 and other tumor-associated markers by leukemic T-cells of cutaneous T-cell lymphoma. (PMID: 18569641) Capriotti E. … Hess A.D. (Leuk. Lymphoma 2008) 3 22 64
  5. Actin-filament cross-linking protein T-plastin increases Arp2/3-mediated actin-based movement. (PMID: 15741236) Giganti A. … Friederich E. (J. Cell. Sci. 2005) 3 22 64

Products for PLS3 Gene

Sources for PLS3 Gene

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