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Aliases for PLS1 Gene

Aliases for PLS1 Gene

  • Plastin 1 2 3 5
  • Intestine Specific Plastin 3
  • Intestine-Specific Plastin 4
  • Plastin 1 (I Isoform) 2
  • I Plastin 3
  • Plastin-1 3
  • I-Plastin 4
  • Fimbrin 3

External Ids for PLS1 Gene

Previous GeneCards Identifiers for PLS1 Gene

  • GC03P139303
  • GC03P143171
  • GC03P143623
  • GC03P143663
  • GC03P143825
  • GC03P142315
  • GC03P139687

Summaries for PLS1 Gene

Entrez Gene Summary for PLS1 Gene

  • Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010]

GeneCards Summary for PLS1 Gene

PLS1 (Plastin 1) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include calcium ion binding and actin filament binding. An important paralog of this gene is PLS3.

UniProtKB/Swiss-Prot for PLS1 Gene

  • Actin-bundling protein in the absence of calcium.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLS1 Gene

Genomics for PLS1 Gene

Regulatory Elements for PLS1 Gene

Enhancers for PLS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F142618 0.9 ENCODE 17.7 +22.7 22662 1.6 HDAC1 TBL1XR1 CHAMP1 GATA2 FOS CREM ZBTB11 NCOA1 ZNF589 KLF16 PLS1 RNA5SP143 ATR XRN1 PLS1-AS1
GH03F142997 1.2 ENCODE 10.4 +404.0 404035 6.2 HDGF PKNOX1 ARNT MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 XRN1 ST13P15 PAQR9 PAQR9-AS1 PBX2P1 LOC100507389 RNA5SP143 PLS1 U2SURP LOC100289361
GH03F142993 1.1 Ensembl ENCODE 10.4 +397.9 397914 1.0 ARID4B ZNF2 RAD21 SCRT2 ZNF143 MIXL1 THAP11 ZNF654 CEBPB REST PAQR9 PAQR9-AS1 LOC100507389 PLS1 RNA5SP143 LOC100289361 U2SURP
GH03F142645 1 Ensembl ENCODE 11.3 +49.5 49467 1.5 SAP130 JUN ZNF600 ZNF652 HMG20B HLF MXD4 HMG20A NFIL3 JUND PLS1 RNA5SP143 PLS1-AS1
GH03F142904 1 Ensembl ENCODE 10.6 +308.6 308610 0.8 SCRT1 CTCF ZNF654 REST RAD21 RELA ARID1B GATA3 JUND ATF3 PLS1 RNA5SP143 PCOLCE2 LOC100507389
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLS1 on UCSC Golden Path with GeneCards custom track

Promoters for PLS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PLS1 Gene

142,596,387 bp from pter
142,713,664 bp from pter
117,278 bases
Plus strand

Genomic View for PLS1 Gene

Genes around PLS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLS1 Gene

Proteins for PLS1 Gene

  • Protein details for PLS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K2Q1
    • D3DNG3
    • Q8NEG6

    Protein attributes for PLS1 Gene

    629 amino acids
    Molecular mass:
    70253 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for PLS1 Gene

Post-translational modifications for PLS1 Gene

No data available for DME Specific Peptides for PLS1 Gene

Domains & Families for PLS1 Gene

Gene Families for PLS1 Gene

Suggested Antigen Peptide Sequences for PLS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 actin-binding domains.
  • Contains 2 actin-binding domains.
  • Contains 4 CH (calponin-homology) domains.
  • Contains 2 EF-hand domains.
genes like me logo Genes that share domains with PLS1: view

Function for PLS1 Gene

Molecular function for PLS1 Gene

GENATLAS Biochemistry:
plastin 1,I isoform,68kDa,actin binding protein,expressed in the brush border of small intestine and colon
UniProtKB/Swiss-Prot Function:
Actin-bundling protein in the absence of calcium.

Gene Ontology (GO) - Molecular Function for PLS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005200 structural constituent of cytoskeleton TAS 8139549
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0051015 actin filament binding IEA,TAS --
genes like me logo Genes that share ontologies with PLS1: view
genes like me logo Genes that share phenotypes with PLS1: view

Animal Models for PLS1 Gene

MGI Knock Outs for PLS1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLS1 Gene

Localization for PLS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLS1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLS1 gene
Compartment Confidence
extracellular 5
cytoskeleton 4
cytosol 3
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PLS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IBA --
GO:0005884 actin filament IBA --
GO:0005903 brush border ISS --
GO:0032432 actin filament bundle IBA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PLS1: view

Pathways & Interactions for PLS1 Gene

genes like me logo Genes that share pathways with PLS1: view

Pathways by source for PLS1 Gene

Gene Ontology (GO) - Biological Process for PLS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001951 intestinal D-glucose absorption IEA --
GO:0032532 regulation of microvillus length IEA --
GO:0040018 positive regulation of multicellular organism growth IEA --
GO:0051017 actin filament bundle assembly IBA --
GO:0051639 actin filament network formation IBA --
genes like me logo Genes that share ontologies with PLS1: view

No data available for SIGNOR curated interactions for PLS1 Gene

Drugs & Compounds for PLS1 Gene

(1) Drugs for PLS1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with PLS1: view

Transcripts for PLS1 Gene

Unigene Clusters for PLS1 Gene

Plastin 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - -
SP3: - -
SP4: -

Relevant External Links for PLS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLS1 Gene

This gene is overexpressed in Colon - Transverse (x16.2) and Small Intestine - Terminal Ileum (x10.3).

Protein differential expression in normal tissues from HIPED for PLS1 Gene

This gene is overexpressed in Pancreatic juice (18.9), Cervix (8.6), Rectum (7.5), Islet of Langerhans (6.8), and Colon (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLS1 Gene:


SOURCE GeneReport for Unigene cluster for PLS1 Gene:


mRNA Expression by UniProt/SwissProt for PLS1 Gene:

Tissue specificity: In small intestine, colon, and kidney; relatively lower levels of expression are detected in the lung and stomach.
genes like me logo Genes that share expression patterns with PLS1: view

Primer Products

No data available for Protein tissue co-expression partners for PLS1 Gene

Orthologs for PLS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLS1 34 35
  • 99.79 (n)
(Canis familiaris)
Mammalia PLS1 34 35
  • 93.42 (n)
(Bos Taurus)
Mammalia PLS1 34 35
  • 93.22 (n)
(Monodelphis domestica)
Mammalia PLS1 35
  • 93 (a)
(Mus musculus)
Mammalia Pls1 34 16 35
  • 87.02 (n)
(Ornithorhynchus anatinus)
Mammalia PLS1 35
  • 72 (a)
(Gallus gallus)
Aves PLS1 34 35
  • 80.07 (n)
(Anolis carolinensis)
Reptilia PLS1 35
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pls1 34
  • 72.81 (n)
(Danio rerio)
Actinopterygii pls1 34 35
  • 68.37 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Fim 36 35
  • 52 (a)
(Caenorhabditis elegans)
Secernentea Y104H12BR.1 36
  • 56 (a)
Y73B3B.1 36 35
  • 55 (a)
Y104H12BL.1 36
  • 51 (a)
plst-1 35
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAC6 35
  • 38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons FIM1 34
  • 51.55 (n)
(Oryza sativa)
Liliopsida Os02g0719100 34
  • 50.51 (n)
Os.23544 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8022 35
  • 46 (a)
Species where no ortholog for PLS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLS1 Gene

Gene Tree for PLS1 (if available)
Gene Tree for PLS1 (if available)

Paralogs for PLS1 Gene

Paralogs for PLS1 Gene

(4) SIMAP similar genes for PLS1 Gene using alignment to 8 proteins: Pseudogenes for PLS1 Gene

genes like me logo Genes that share paralogs with PLS1: view

Variants for PLS1 Gene

Sequence variations from dbSNP and Humsavar for PLS1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1042095 -- 142,711,554(+) ATTGC(A/G)CCAAA reference, synonymous-codon
rs10537624 -- 142,669,688(+) GATGA(-/TGA)CAATA intron-variant
rs10598043 -- 142,694,120(+) AAACA(-/TT)TTGTT intron-variant
rs10631186 -- 142,704,646(+) TTTTT(-/TTTT)GGAGA intron-variant
rs10683463 -- 142,696,721(+) TAATA(-/AAT/ATA)CCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLS1 Gene

Variant ID Type Subtype PubMed ID
nsv591920 CNV loss 21841781
nsv520533 CNV gain 19592680
esv2564720 CNV deletion 19546169
dgv300n21 CNV gain 19592680

Variation tolerance for PLS1 Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLS1 Gene

Disorders for PLS1 Gene

Relevant External Links for PLS1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PLS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLS1 Gene

Publications for PLS1 Gene

  1. Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney. (PMID: 8139549) Lin C.-S. … Matsudaira P. (Mol. Cell. Biol. 1994) 2 3 4 22 64
  2. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X. … Tai E.S. (PLoS Genet. 2011) 3 46 64
  3. Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells. (PMID: 2111166) Zu Y. … Namba Y. (Biochemistry 1990) 3 22 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for PLS1 Gene

Sources for PLS1 Gene

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