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Aliases for PLS1 Gene

Aliases for PLS1 Gene

  • Plastin 1 2 3 5
  • Intestine Specific Plastin 3
  • Intestine-Specific Plastin 4
  • Plastin 1 (I Isoform) 2
  • I Plastin 3
  • Plastin-1 3
  • I-Plastin 4
  • Fimbrin 3

External Ids for PLS1 Gene

Previous GeneCards Identifiers for PLS1 Gene

  • GC03P139303
  • GC03P143171
  • GC03P143623
  • GC03P143663
  • GC03P143825
  • GC03P142315
  • GC03P139687

Summaries for PLS1 Gene

Entrez Gene Summary for PLS1 Gene

  • Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010]

GeneCards Summary for PLS1 Gene

PLS1 (Plastin 1) is a Protein Coding gene. Diseases associated with PLS1 include Retinitis Pigmentosa 18. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include calcium ion binding and actin filament binding. An important paralog of this gene is PLS3.

UniProtKB/Swiss-Prot for PLS1 Gene

  • Actin-bundling protein in the absence of calcium.

Additional gene information for PLS1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLS1 Gene

Genomics for PLS1 Gene

GeneHancer (GH) Regulatory Elements for PLS1 Gene

Promoters and enhancers for PLS1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I142594 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 556.4 +0.4 431 3.8 FOXA2 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 IRF4 PLS1 ATR XRN1 PLS1-AS1 LOC105374136
GH03I142623 Promoter 0.7 EPDnew 561.6 +27.0 27018 0.1 GATA3 CEBPB PLS1 RNA5SP143 LOC105374136 PLS1-AS1
GH03I142656 Promoter 0.7 EPDnew 550.2 +60.5 60487 0.1 MEIS2 IKZF1 LOC105374136 PLS1-AS1 PLS1
GH03I142646 Promoter 0.5 EPDnew 560.7 +50.5 50456 0.1 PLS1 RNA5SP143 PLS1-AS1 LOC105374136
GH03I142997 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.4 +404.0 404034 6.2 MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZNF610 U2SURP LOC100289361 XRN1 PBX2P1 ATR ST13P15 PAQR9 PAQR9-AS1 TFDP2 LOC100507389
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLS1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLS1 gene promoter:

Genomic Locations for PLS1 Gene

Genomic Locations for PLS1 Gene
117,278 bases
Plus strand

Genomic View for PLS1 Gene

Genes around PLS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLS1 Gene

Proteins for PLS1 Gene

  • Protein details for PLS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K2Q1
    • D3DNG3
    • Q8NEG6

    Protein attributes for PLS1 Gene

    629 amino acids
    Molecular mass:
    70253 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for PLS1 Gene

Post-translational modifications for PLS1 Gene

No data available for DME Specific Peptides for PLS1 Gene

Domains & Families for PLS1 Gene

Gene Families for PLS1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PLS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLS1: view

No data available for UniProtKB/Swiss-Prot for PLS1 Gene

Function for PLS1 Gene

Molecular function for PLS1 Gene

GENATLAS Biochemistry:
plastin 1,I isoform,68kDa,actin binding protein,expressed in the brush border of small intestine and colon
UniProtKB/Swiss-Prot Function:
Actin-bundling protein in the absence of calcium.

Phenotypes From GWAS Catalog for PLS1 Gene

Gene Ontology (GO) - Molecular Function for PLS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005200 structural constituent of cytoskeleton TAS 8139549
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0051015 actin filament binding IBA,TAS --
genes like me logo Genes that share ontologies with PLS1: view
genes like me logo Genes that share phenotypes with PLS1: view

Animal Models for PLS1 Gene

MGI Knock Outs for PLS1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PLS1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLS1 Gene

Localization for PLS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLS1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLS1 gene
Compartment Confidence
extracellular 5
cytoskeleton 4
cytosol 3
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PLS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005884 actin filament IBA --
GO:0005903 brush border ISS --
GO:0032432 actin filament bundle IBA --
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with PLS1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLS1 Gene

Pathways & Interactions for PLS1 Gene

genes like me logo Genes that share pathways with PLS1: view

Pathways by source for PLS1 Gene

Gene Ontology (GO) - Biological Process for PLS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001951 intestinal D-glucose absorption IEA --
GO:0032532 regulation of microvillus length IEA --
GO:0040018 positive regulation of multicellular organism growth IEA --
GO:0051017 actin filament bundle assembly IBA --
GO:0051639 actin filament network formation IBA --
genes like me logo Genes that share ontologies with PLS1: view

No data available for SIGNOR curated interactions for PLS1 Gene

Drugs & Compounds for PLS1 Gene

(1) Drugs for PLS1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with PLS1: view

Transcripts for PLS1 Gene

Unigene Clusters for PLS1 Gene

Plastin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PLS1

Alternative Splicing Database (ASD) splice patterns (SP) for PLS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - -
SP3: - -
SP4: -

Relevant External Links for PLS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLS1 Gene

This gene is overexpressed in Colon - Transverse (x16.2) and Small Intestine - Terminal Ileum (x10.3).

Protein differential expression in normal tissues from HIPED for PLS1 Gene

This gene is overexpressed in Pancreatic juice (18.9), Cervix (8.6), Rectum (7.5), Islet of Langerhans (6.8), and Colon (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLS1 Gene:


SOURCE GeneReport for Unigene cluster for PLS1 Gene:


mRNA Expression by UniProt/SwissProt for PLS1 Gene:

Tissue specificity: In small intestine, colon, and kidney; relatively lower levels of expression are detected in the lung and stomach.

Evidence on tissue expression from TISSUES for PLS1 Gene

  • Intestine(4.5)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with PLS1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLS1 Gene

Orthologs for PLS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLS1 34 33
  • 99.79 (n)
(Canis familiaris)
Mammalia PLS1 34 33
  • 93.42 (n)
(Bos Taurus)
Mammalia PLS1 34 33
  • 93.22 (n)
(Monodelphis domestica)
Mammalia PLS1 34
  • 93 (a)
(Mus musculus)
Mammalia Pls1 33 16 34
  • 87.02 (n)
(Ornithorhynchus anatinus)
Mammalia PLS1 34
  • 72 (a)
(Gallus gallus)
Aves PLS1 34 33
  • 80.07 (n)
(Anolis carolinensis)
Reptilia PLS1 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pls1 33
  • 72.81 (n)
(Danio rerio)
Actinopterygii pls1 34 33
  • 68.37 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta Fim 35 34
  • 52 (a)
(Caenorhabditis elegans)
Secernentea Y104H12BR.1 35
  • 56 (a)
Y73B3B.1 35 34
  • 55 (a)
Y104H12BL.1 35
  • 51 (a)
plst-1 34
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAC6 34
  • 38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons FIM1 33
  • 51.55 (n)
(Oryza sativa)
Liliopsida Os02g0719100 33
  • 50.51 (n)
Os.23544 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8022 34
  • 46 (a)
Species where no ortholog for PLS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLS1 Gene

Gene Tree for PLS1 (if available)
Gene Tree for PLS1 (if available)

Paralogs for PLS1 Gene

Paralogs for PLS1 Gene

(4) SIMAP similar genes for PLS1 Gene using alignment to 8 proteins: Pseudogenes for PLS1 Gene

genes like me logo Genes that share paralogs with PLS1: view

Variants for PLS1 Gene

Sequence variations from dbSNP and Humsavar for PLS1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000026003 -- 142,621,498(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000026927 -- 142,629,570(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000073259 -- 142,638,604(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000082631 -- 142,629,322(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000130607 -- 142,674,441(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLS1 Gene

Variant ID Type Subtype PubMed ID
dgv300n21 CNV gain 19592680
esv2564720 CNV deletion 19546169
nsv520533 CNV gain 19592680
nsv591920 CNV loss 21841781

Variation tolerance for PLS1 Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLS1 Gene

Disorders for PLS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLS1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 18
  • rp18
- elite association - COSMIC cancer census association via MalaCards
Search PLS1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PLS1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PLS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLS1 Gene

Publications for PLS1 Gene

  1. Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney. (PMID: 8139549) Lin CS … Matsudaira P (Molecular and cellular biology 1994) 2 3 4 22 58
  2. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X … Tai ES (PLoS genetics 2011) 3 44 58
  3. Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells. (PMID: 2111166) Zu Y … Namba Y (Biochemistry 1990) 3 22 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The Roles of Actin-Binding Domains 1 and 2 in the Calcium-Dependent Regulation of Actin Filament Bundling by Human Plastins. (PMID: 28694070) Schwebach CL … Kudryashov DS (Journal of molecular biology 2017) 3 58

Products for PLS1 Gene

Sources for PLS1 Gene

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