Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLS1 Gene

Aliases for PLS1 Gene

  • Plastin 1 2 3 5
  • Intestine-Specific Plastin 3 4
  • Intestine Specific Plastin 3
  • Plastin 1 (I Isoform) 2
  • I Plastin 3
  • Plastin-1 3
  • I-Plastin 4
  • Fimbrin 3

External Ids for PLS1 Gene

Previous GeneCards Identifiers for PLS1 Gene

  • GC03P139303
  • GC03P143171
  • GC03P143623
  • GC03P143663
  • GC03P143825
  • GC03P142315
  • GC03P139687

Summaries for PLS1 Gene

Entrez Gene Summary for PLS1 Gene

  • Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010]

GeneCards Summary for PLS1 Gene

PLS1 (Plastin 1) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include calcium ion binding and actin filament binding. An important paralog of this gene is PLS3.

UniProtKB/Swiss-Prot for PLS1 Gene

  • Actin-bundling protein in the absence of calcium.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLS1 Gene

Genomics for PLS1 Gene

Regulatory Elements for PLS1 Gene

Enhancers for PLS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PLS1 on UCSC Golden Path with GeneCards custom track

Promoters for PLS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PLS1 Gene

Chromosome:
3
Start:
142,596,387 bp from pter
End:
142,713,664 bp from pter
Size:
117,278 bases
Orientation:
Plus strand

Genomic View for PLS1 Gene

Genes around PLS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLS1 Gene

Proteins for PLS1 Gene

  • Protein details for PLS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14651-PLSI_HUMAN
    Recommended name:
    Plastin-1
    Protein Accession:
    Q14651
    Secondary Accessions:
    • A8K2Q1
    • D3DNG3
    • Q8NEG6

    Protein attributes for PLS1 Gene

    Size:
    629 amino acids
    Molecular mass:
    70253 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for PLS1 Gene

Post-translational modifications for PLS1 Gene

No data available for DME Specific Peptides for PLS1 Gene

Domains & Families for PLS1 Gene

Gene Families for PLS1 Gene

Suggested Antigen Peptide Sequences for PLS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14651

UniProtKB/Swiss-Prot:

PLSI_HUMAN :
  • Contains 2 actin-binding domains.
Domain:
  • Contains 2 actin-binding domains.
  • Contains 4 CH (calponin-homology) domains.
  • Contains 2 EF-hand domains.
genes like me logo Genes that share domains with PLS1: view

Function for PLS1 Gene

Molecular function for PLS1 Gene

GENATLAS Biochemistry:
plastin 1,I isoform,68kDa,actin binding protein,expressed in the brush border of small intestine and colon
UniProtKB/Swiss-Prot Function:
Actin-bundling protein in the absence of calcium.

Gene Ontology (GO) - Molecular Function for PLS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton TAS 8139549
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IEA --
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with PLS1: view
genes like me logo Genes that share phenotypes with PLS1: view

Animal Models for PLS1 Gene

MGI Knock Outs for PLS1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PLS1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLS1 Gene

Localization for PLS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLS1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLS1 Gene COMPARTMENTS Subcellular localization image for PLS1 gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for PLS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005903 brush border ISS --
GO:0070062 extracellular exosome IDA 19056867
GO:1990357 terminal web IEA --
genes like me logo Genes that share ontologies with PLS1: view

Pathways & Interactions for PLS1 Gene

genes like me logo Genes that share pathways with PLS1: view

Pathways by source for PLS1 Gene

Gene Ontology (GO) - Biological Process for PLS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001951 intestinal D-glucose absorption IEA --
GO:0032532 regulation of microvillus length IEA --
GO:0040018 positive regulation of multicellular organism growth IEA --
GO:0090004 positive regulation of establishment of protein localization to plasma membrane ISS --
GO:1902896 terminal web assembly IEA --
genes like me logo Genes that share ontologies with PLS1: view

No data available for SIGNOR curated interactions for PLS1 Gene

Drugs & Compounds for PLS1 Gene

(1) Drugs for PLS1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with PLS1: view

Transcripts for PLS1 Gene

Unigene Clusters for PLS1 Gene

Plastin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PLS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - -
SP2:
SP3: - -
SP4: -

Relevant External Links for PLS1 Gene

GeneLoc Exon Structure for
PLS1
ECgene alternative splicing isoforms for
PLS1

Expression for PLS1 Gene

mRNA expression in normal human tissues for PLS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLS1 Gene

This gene is overexpressed in Colon - Transverse (x16.2) and Small Intestine - Terminal Ileum (x10.3).

Protein differential expression in normal tissues from HIPED for PLS1 Gene

This gene is overexpressed in Pancreatic juice (18.9), Cervix (8.6), Rectum (7.5), Islet of Langerhans (6.8), and Colon (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLS1 Gene



NURSA nuclear receptor signaling pathways regulating expression of PLS1 Gene:

PLS1

SOURCE GeneReport for Unigene cluster for PLS1 Gene:

Hs.203637

mRNA Expression by UniProt/SwissProt for PLS1 Gene:

Q14651-PLSI_HUMAN
Tissue specificity: In small intestine, colon, and kidney; relatively lower levels of expression are detected in the lung and stomach.
genes like me logo Genes that share expression patterns with PLS1: view

Primer Products

No data available for Protein tissue co-expression partners for PLS1 Gene

Orthologs for PLS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLS1 34
  • 93.22 (n)
  • 94.75 (a)
PLS1 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLS1 34
  • 93.42 (n)
  • 94.11 (a)
PLS1 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pls1 34
  • 87.02 (n)
  • 94.44 (a)
Pls1 16
Pls1 35
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLS1 34
  • 99.79 (n)
  • 100 (a)
PLS1 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLS1 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLS1 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLS1 34
  • 80.07 (n)
  • 86.49 (a)
PLS1 35
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLS1 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pls1 34
  • 72.81 (n)
  • 76.28 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 34
pls1 34
  • 68.37 (n)
  • 73.28 (a)
pls1 35
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Fim 36
  • 52 (a)
Fim 35
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y104H12BL.1 36
  • 51 (a)
Y104H12BR.1 36
  • 56 (a)
Y73B3B.1 36
  • 55 (a)
plst-1 35
  • 51 (a)
ManyToMany
Y73B3B.1 35
  • 33 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAC6 35
  • 38 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons FIM1 34
  • 51.55 (n)
  • 40.27 (a)
rice
(Oryza sativa)
Liliopsida Os.23544 34
Os02g0719100 34
  • 50.51 (n)
  • 42.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8022 35
  • 46 (a)
OneToMany
Species where no ortholog for PLS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLS1 Gene

ENSEMBL:
Gene Tree for PLS1 (if available)
TreeFam:
Gene Tree for PLS1 (if available)

Paralogs for PLS1 Gene

Paralogs for PLS1 Gene

(4) SIMAP similar genes for PLS1 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for PLS1 Gene

genes like me logo Genes that share paralogs with PLS1: view

Variants for PLS1 Gene

Sequence variations from dbSNP and Humsavar for PLS1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs35710125 - 142,676,230(-) ATGGG(C/T)ATAAG reference, missense
rs35435507 - 142,684,073(-) GATCT(A/G)ATGCA reference, missense
rs953641 -- 142,708,894(+) TTAGA(A/G)ACTTA intron-variant
rs1042095 -- 142,711,554(+) ATTGC(A/G)CCAAA reference, synonymous-codon
rs4594656 -- 142,661,666(+) TATAA(A/G)AGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLS1 Gene

Variant ID Type Subtype PubMed ID
dgv300n21 CNV gain 19592680
esv2564720 CNV deletion 19546169
nsv520533 CNV gain 19592680
nsv591920 CNV loss 21841781

Variation tolerance for PLS1 Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLS1 Gene

Disorders for PLS1 Gene

Relevant External Links for PLS1

Genetic Association Database (GAD)
PLS1
Human Genome Epidemiology (HuGE) Navigator
PLS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLS1

No disorders were found for PLS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLS1 Gene

Publications for PLS1 Gene

  1. Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney. (PMID: 8139549) Lin C.-S. … Matsudaira P. (Mol. Cell. Biol. 1994) 2 3 4 22 65
  2. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X. … Tai E.S. (PLoS Genet. 2011) 3 46 65
  3. Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells. (PMID: 2111166) Zu Y. … Namba Y. (Biochemistry 1990) 3 22 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 65

Products for PLS1 Gene

Sources for PLS1 Gene

Content
Loading form....