Aliases for PLRG1 Gene
External Ids for PLRG1 Gene
Previous GeneCards Identifiers for PLRG1 Gene
This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for PLRG1 Gene
PLRG1 (Pleiotropic Regulator 1) is a Protein Coding gene. Diseases associated with PLRG1 include Poikiloderma With Neutropenia. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include signal transducer activity and transcription corepressor activity. An important paralog of this gene is WDR83.
UniProtKB/Swiss-Prot for PLRG1 Gene
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.