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Aliases for PLRG1 Gene

Aliases for PLRG1 Gene

  • Pleiotropic Regulator 1 2 3
  • Pleiotropic Regulator 1 (PRL1 Homolog, Arabidopsis) 2 3
  • Transport And Golgi Organization 4 Homolog (Drosophila) 2
  • Pleiotropic Regulator 1 (PRL1, Arabidopsis Homolog) 2
  • Transport And Golgi Organization 4 Homolog 3
  • PRPF46 3
  • TANGO4 3
  • PRP46 3
  • Cwc1 3
  • PRL1 3

External Ids for PLRG1 Gene

Previous GeneCards Identifiers for PLRG1 Gene

  • GC04M156305
  • GC04M155846
  • GC04M155922
  • GC04M156033
  • GC04M156035
  • GC04M155815
  • GC04M155675
  • GC04M155457
  • GC04M151198

Summaries for PLRG1 Gene

Entrez Gene Summary for PLRG1 Gene

  • This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for PLRG1 Gene

PLRG1 (Pleiotropic Regulator 1) is a Protein Coding gene. Diseases associated with PLRG1 include poikiloderma with neutropenia. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include signal transducer activity and transcription corepressor activity. An important paralog of this gene is FBXW10.

UniProtKB/Swiss-Prot for PLRG1 Gene

  • Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.

Gene Wiki entry for PLRG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLRG1 Gene

Genomics for PLRG1 Gene

Regulatory Elements for PLRG1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PLRG1 Gene

Chromosome:
4
Start:
154,534,997 bp from pter
End:
154,550,435 bp from pter
Size:
15,439 bases
Orientation:
Minus strand

Genomic View for PLRG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLRG1 Gene

Proteins for PLRG1 Gene

  • Protein details for PLRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43660-PLRG1_HUMAN
    Recommended name:
    Pleiotropic regulator 1
    Protein Accession:
    O43660
    Secondary Accessions:
    • B3KMK4
    • Q3KQY5
    • Q8WUD8

    Protein attributes for PLRG1 Gene

    Size:
    514 amino acids
    Molecular mass:
    57194 Da
    Quaternary structure:
    • Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts (via its WD40 repeat domain) directly with CDC5L (via its C-terminal); the interaction is required for mRNA splicing but not for spliceosome assembly. Also interacts directly in the complex with BCAS2 and PRPF19 (By similarity).

    Three dimensional structures from OCA and Proteopedia for PLRG1 Gene

    Alternative splice isoforms for PLRG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLRG1 Gene

Proteomics data for PLRG1 Gene at MOPED

Post-translational modifications for PLRG1 Gene

Antibody Products

No data available for DME Specific Peptides for PLRG1 Gene

Domains & Families for PLRG1 Gene

Gene Families for PLRG1 Gene

Suggested Antigen Peptide Sequences for PLRG1 Gene

Graphical View of Domain Structure for InterPro Entry

O43660

UniProtKB/Swiss-Prot:

PLRG1_HUMAN :
  • Belongs to the WD repeat PRL1/PRL2 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat PRL1/PRL2 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with PLRG1: view

Function for PLRG1 Gene

Molecular function for PLRG1 Gene

UniProtKB/Swiss-Prot Function:
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for PLRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20176811
genes like me logo Genes that share ontologies with PLRG1: view
genes like me logo Genes that share phenotypes with PLRG1: view

Animal Models for PLRG1 Gene

MGI Knock Outs for PLRG1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PLRG1 Gene

Localization for PLRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLRG1 Gene

Nucleus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLRG1 Gene COMPARTMENTS Subcellular localization image for PLRG1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for PLRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000974 Prp19 complex IBA --
GO:0005654 nucleoplasm TAS --
GO:0005662 colocalizes_with DNA replication factor A complex IDA 24332808
GO:0016607 nuclear speck IEA --
GO:0071011 precatalytic spliceosome IBA --
genes like me logo Genes that share ontologies with PLRG1: view

Pathways & Interactions for PLRG1 Gene

genes like me logo Genes that share pathways with PLRG1: view

Pathways by source for PLRG1 Gene

Gene Ontology (GO) - Biological Process for PLRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
GO:0034504 protein localization to nucleus IEA --
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle IEA --
genes like me logo Genes that share ontologies with PLRG1: view

No data available for SIGNOR curated interactions for PLRG1 Gene

Drugs & Compounds for PLRG1 Gene

No Compound Related Data Available

Transcripts for PLRG1 Gene

Unigene Clusters for PLRG1 Gene

Pleiotropic regulator 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLRG1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - -
SP6: - - -
SP7: - -
SP8:
SP9:
SP10:

ExUns: 14a · 14b ^ 15 ^ 16a · 16b ^ 17
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PLRG1 Gene

GeneLoc Exon Structure for
PLRG1
ECgene alternative splicing isoforms for
PLRG1

Expression for PLRG1 Gene

mRNA expression in normal human tissues for PLRG1 Gene

Protein differential expression in normal tissues from HIPED for PLRG1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.5), CD8 Tcells (8.0), Liver (7.8), and Fetal ovary (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLRG1 Gene



SOURCE GeneReport for Unigene cluster for PLRG1 Gene Hs.249996

genes like me logo Genes that share expression patterns with PLRG1: view

Protein tissue co-expression partners for PLRG1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PLRG1 Gene

Orthologs for PLRG1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLRG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLRG1 35
  • 91.6 (n)
  • 95.7 (a)
PLRG1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLRG1 35
  • 92.61 (n)
  • 95.91 (a)
PLRG1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plrg1 35
  • 88.95 (n)
  • 96.3 (a)
Plrg1 16
Plrg1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLRG1 35
  • 99.68 (n)
  • 99.81 (a)
PLRG1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plrg1 35
  • 89.56 (n)
  • 96.3 (a)
oppossum
(Monodelphis domestica)
Mammalia PLRG1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLRG1 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLRG1 35
  • 80.26 (n)
  • 88.71 (a)
PLRG1 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLRG1 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394977 35
plrg1 35
  • 76.44 (n)
  • 86.61 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.11443 35
plrg1 35
  • 71.19 (n)
  • 78.78 (a)
plrg1 36
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1796 37
  • 76 (a)
Tango4 35
  • 58.46 (n)
  • 64.3 (a)
Tango4 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005631 35
  • 58.28 (n)
  • 66.59 (a)
worm
(Caenorhabditis elegans)
Secernentea tag-135 35
  • 60.09 (n)
  • 60.09 (a)
plrg-1 36
  • 54 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR137W 35
  • 50.49 (n)
  • 47.48 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11231g 35
  • 55.52 (n)
  • 47.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP46 35
  • 56.27 (n)
  • 50.76 (a)
PRP46 36
  • 39 (a)
OneToMany
PRP46 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PRL1 35
  • 54.75 (n)
  • 50.11 (a)
rice
(Oryza sativa)
Liliopsida Os.46775 35
Os03g0339100 35
  • 57.81 (n)
  • 52.94 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.6105 35
corn
(Zea mays)
Liliopsida Zm.6454 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7383 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02966 35
  • 54.56 (n)
  • 58.81 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp5 35
  • 62.29 (n)
  • 63.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10484 36
  • 61 (a)
OneToOne
Species with no ortholog for PLRG1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PLRG1 Gene

ENSEMBL:
Gene Tree for PLRG1 (if available)
TreeFam:
Gene Tree for PLRG1 (if available)

Paralogs for PLRG1 Gene

Paralogs for PLRG1 Gene

genes like me logo Genes that share paralogs with PLRG1: view

Variants for PLRG1 Gene

Variation tolerance for PLRG1 Gene

Residual Variation Intolerance Score: 41.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLRG1 Gene

HapMap Linkage Disequilibrium report
PLRG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for PLRG1 Gene

Disorders for PLRG1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLRG1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
poikiloderma with neutropenia
  • clericuzio type poikiloderma with neutropenia
- elite association
Search PLRG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PLRG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLRG1
genes like me logo Genes that share disorders with PLRG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLRG1 Gene

Publications for PLRG1 Gene

  1. Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice. (PMID: 20467437) LlA"res D. … Lamond A.I. (EMBO Rep. 2010) 23 67
  2. The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links. (PMID: 16223718) Zhang N. … Legerski R.J. (J. Biol. Chem. 2005) 23 67
  3. A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing. (PMID: 11544257) Ajuh P. … Lamond A.I. (J. Biol. Chem. 2001) 23 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67

Products for PLRG1 Gene

Sources for PLRG1 Gene

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