Aliases for PLPPR4 Gene
The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
GeneCards Summary for PLPPR4 Gene
PLPPR4 (Phospholipid Phosphatase Related 4) is a Protein Coding gene. Diseases associated with PLPPR4 include Cenani-Lenz Syndrome. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. An important paralog of this gene is PLPP1.
UniProtKB/Swiss-Prot for PLPPR4 Gene
Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus.