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Aliases for PLPPR4 Gene

Aliases for PLPPR4 Gene

  • Phospholipid Phosphatase Related 4 2 3 5
  • Brain-Specific Phosphatidic Acid Phosphatase-Like Protein 1 3 4
  • Lipid Phosphate Phosphatase-Related Protein Type 4 3 4
  • Plasticity-Related Gene 1 Protein 3 4
  • EC 3.1.3.4 4 58
  • LPPR4 3 4
  • PRG-1 3 4
  • PRG1 3 4
  • PHP1 3 4
  • Phospholipid Phosphatase-Related Protein Type 4 3
  • Plasticity Related Gene-1 2
  • Plasticity Related Gene 1 3
  • KIAA0455 4
  • LPR4 3

External Ids for PLPPR4 Gene

Summaries for PLPPR4 Gene

Entrez Gene Summary for PLPPR4 Gene

  • The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

GeneCards Summary for PLPPR4 Gene

PLPPR4 (Phospholipid Phosphatase Related 4) is a Protein Coding gene. Among its related pathways are Lysosphingolipid and LPA receptors and Peptide ligand-binding receptors. An important paralog of this gene is PLPPR3.

UniProtKB/Swiss-Prot for PLPPR4 Gene

  • Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus.

Additional gene information for PLPPR4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLPPR4 Gene

Genomics for PLPPR4 Gene

Regulatory Elements for PLPPR4 Gene

Enhancers for PLPPR4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H099456 0.9 Ensembl ENCODE 10.4 +194.6 194613 2 CEBPB NR3C1 FOXA1 ZFHX2 JUND GATA3 POLR2A RCOR1 FOS TCF7L2 PLPPR4 ENSG00000233983 GC01M099214
GH01H099327 0.5 ENCODE 11.3 +64.5 64547 0 CTCF RFX1 MAX PLPPR4 GC01M099214 ENSG00000233983
GH01H099133 0.2 ENCODE 10.1 -128.8 -128784 0 PLPPR4 PLPPR5 ENSG00000227034
GH01H099469 0.3 FANTOM5 6 +206.9 206890 0 PLPPR4 PLPPR5 AGL ENSG00000233983 LINC01708
GH01H099264 0.9 Ensembl ENCODE 0.7 +1.6 1624 0 ZNF202 MXI1 SP3 L3MBTL2 SUZ12 REST RAD21 POLR2A EGR1 ZNF341 SASS6 TRMT13 PLPPR4 GC01M099214
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLPPR4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLPPR4 Gene

Chromosome:
1
Start:
99,262,953 bp from pter
End:
99,309,590 bp from pter
Size:
46,638 bases
Orientation:
Plus strand

Genomic View for PLPPR4 Gene

Genes around PLPPR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPPR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPPR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPPR4 Gene

Proteins for PLPPR4 Gene

  • Protein details for PLPPR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2D5-PLPR4_HUMAN
    Recommended name:
    Phospholipid phosphatase-related protein type 4
    Protein Accession:
    Q7Z2D5
    Secondary Accessions:
    • E7EPS1
    • O75043
    • Q5T9R9
    • Q86XQ5
    • Q8N3F1
    • Q96MP0

    Protein attributes for PLPPR4 Gene

    Size:
    763 amino acids
    Molecular mass:
    82983 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA32300.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI22799.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW72991.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PLPPR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLPPR4 Gene

Selected DME Specific Peptides for PLPPR4 Gene

Q7Z2D5:
  • PRSPMGKE
  • LVHIPEE
  • DRSLSMPY
  • FLTVCKP
  • MVTFSNTLPR

Post-translational modifications for PLPPR4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLPPR4 Gene

Domains & Families for PLPPR4 Gene

Gene Families for PLPPR4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for PLPPR4 Gene

Suggested Antigen Peptide Sequences for PLPPR4 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z2D5

UniProtKB/Swiss-Prot:

PLPR4_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPPR4: view

Function for PLPPR4 Gene

Molecular function for PLPPR4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus.

Enzyme Numbers (IUBMB) for PLPPR4 Gene

Phenotypes From GWAS Catalog for PLPPR4 Gene

Gene Ontology (GO) - Molecular Function for PLPPR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008195 phosphatidate phosphatase activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0042577 lipid phosphatase activity IEA,IBA --
genes like me logo Genes that share ontologies with PLPPR4: view
genes like me logo Genes that share phenotypes with PLPPR4: view

Animal Models for PLPPR4 Gene

MGI Knock Outs for PLPPR4:

Animal Model Products

miRNA for PLPPR4 Gene

miRTarBase miRNAs that target PLPPR4

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLPPR4 Gene

Localization for PLPPR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPPR4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPPR4 gene
Compartment Confidence
plasma membrane 4
nucleus 2

Gene Ontology (GO) - Cellular Components for PLPPR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPPR4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLPPR4 Gene

Pathways & Interactions for PLPPR4 Gene

genes like me logo Genes that share pathways with PLPPR4: view

Pathways by source for PLPPR4 Gene

Gene Ontology (GO) - Biological Process for PLPPR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IBA --
GO:0007165 signal transduction IBA --
GO:0007409 axonogenesis IEA,IBA --
GO:0046839 phospholipid dephosphorylation IBA --
GO:0048839 inner ear development IEA --
genes like me logo Genes that share ontologies with PLPPR4: view

No data available for SIGNOR curated interactions for PLPPR4 Gene

Drugs & Compounds for PLPPR4 Gene

(2) Drugs for PLPPR4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(23) Additional Compounds for PLPPR4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LPA(0:0/16:0)
  • 2-Hexadecanoyl-phosphatidic acid
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • LPA(16:0)
  • Lysophosphatidic acid(0:0/16:0)
LPA(0:0/18:0)
  • 2-Octadecanoyl-phosphatidic acid
  • 2-Stearoyl-glycero-3-phosphate
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
LPA(0:0/18:1(9Z))
  • 2-(9Z-Octadecenoyl)-phosphatidic acid
  • 2-Oleoyl-glycero-3-phosphate
  • LPA(0:0/18:1)
  • LPA(0:0/18:1n9)
  • LPA(0:0/18:1w9)
LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • 2-Linoleoyl-glycero-3-phosphate
  • LPA(0:0/18:2)
  • LPA(0:0/18:2n6)
  • LPA(0:0/18:2w6)
LPA(16:0/0:0)
  • 1-Hexadecanoyl-phosphatidic acid
  • 1-Palmitoyl lysophosphatidate
  • 1-Palmitoyl lysophosphatidic acid
  • 1-Palmitoyl-glycero-3-phosphate
  • 1-Palmitoylglycerol 3-phosphate
genes like me logo Genes that share compounds with PLPPR4: view

Transcripts for PLPPR4 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLPPR4 Gene

No ASD Table

Relevant External Links for PLPPR4 Gene

GeneLoc Exon Structure for
PLPPR4
ECgene alternative splicing isoforms for
PLPPR4

Expression for PLPPR4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLPPR4 Gene:

PLPPR4

mRNA Expression by UniProt/SwissProt for PLPPR4 Gene:

Q7Z2D5-PLPR4_HUMAN
Tissue specificity: Specifically expressed in neurons.

Evidence on tissue expression from TISSUES for PLPPR4 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with PLPPR4: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPPR4 Gene

Orthologs for PLPPR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPPR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
OneToOne
LOC469389 33
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 97 (a)
OneToOne
LOC513388 33
  • 91.79 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 97 (a)
OneToOne
LOC490146 33
  • 92.96 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D3Bwg0562e 34 33
  • 88.47 (n)
OneToOne
Plppr4 16
rat
(Rattus norvegicus)
Mammalia Lppr4 33
  • 87.68 (n)
chicken
(Gallus gallus)
Aves -- 34
  • 89 (a)
OneToOne
LPPR4 33
  • 80.32 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489346 33
  • 75.05 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34211 33
zebrafish
(Danio rerio)
Actinopterygii lppr4b 34
  • 71 (a)
OneToMany
lppr4a 33 34
  • 67.85 (n)
worm
(Caenorhabditis elegans)
Secernentea T06D8.3 34
  • 24 (a)
OneToMany
Species where no ortholog for PLPPR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLPPR4 Gene

ENSEMBL:
Gene Tree for PLPPR4 (if available)
TreeFam:
Gene Tree for PLPPR4 (if available)

Paralogs for PLPPR4 Gene

Paralogs for PLPPR4 Gene

genes like me logo Genes that share paralogs with PLPPR4: view

Variants for PLPPR4 Gene

Sequence variations from dbSNP and Humsavar for PLPPR4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000103229 -- 99,303,528(+) AATAA(A/G)CAAGT intron-variant
rs1000172515 -- 99,276,003(+) CTTTA(A/T)TTAAC intron-variant
rs1000181470 -- 99,280,677(+) AGAAG(A/G)TTTCA intron-variant
rs1000189052 -- 99,286,323(+) TTCAA(C/T)TATCT intron-variant
rs1000203556 -- 99,276,270(+) AGAGC(A/G)TTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLPPR4 Gene

Variant ID Type Subtype PubMed ID
nsv506950 OTHER sequence alteration 20534489

Variation tolerance for PLPPR4 Gene

Residual Variation Intolerance Score: 7.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLPPR4 Gene

Human Gene Mutation Database (HGMD)
PLPPR4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLPPR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLPPR4 Gene

Disorders for PLPPR4 Gene

Relevant External Links for PLPPR4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPPR4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPPR4

No disorders were found for PLPPR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLPPR4 Gene

Publications for PLPPR4 Gene

  1. A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. (PMID: 12730698) Bräuer AU … Nitsch R (Nature neuroscience 2003) 2 3 4 60
  2. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4 60
  3. Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease. (PMID: 23213074) Adams LA … Pennell CE (Hepatology (Baltimore, Md.) 2013) 3 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 60
  5. Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. (PMID: 19766573) Trimbuch T … Nitsch R (Cell 2009) 3 60

Products for PLPPR4 Gene

Sources for PLPPR4 Gene

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