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Aliases for PLPPR4 Gene

Aliases for PLPPR4 Gene

  • Phospholipid Phosphatase Related 4 2 3 5
  • Brain-Specific Phosphatidic Acid Phosphatase-Like Protein 1 3 4
  • Lipid Phosphate Phosphatase-Related Protein Type 4 3 4
  • Plasticity-Related Gene 1 Protein 3 4
  • Plasticity Related Gene-1 2 3
  • EC 3.1.3.4 4 63
  • LPPR4 3 4
  • PRG-1 3 4
  • PRG1 3 4
  • PHP1 3 4
  • Plasticity Related Gene 1 3
  • KIAA0455 4
  • LPR4 3

External Ids for PLPPR4 Gene

Summaries for PLPPR4 Gene

Entrez Gene Summary for PLPPR4 Gene

  • The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

GeneCards Summary for PLPPR4 Gene

PLPPR4 (Phospholipid Phosphatase Related 4) is a Protein Coding gene. Diseases associated with PLPPR4 include cenani-lenz syndrome. Among its related pathways are Peptide ligand-binding receptors and Lysosphingolipid and LPA receptors. An important paralog of this gene is PLPP1.

UniProtKB/Swiss-Prot for PLPPR4 Gene

  • Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLPPR4 Gene

Genomics for PLPPR4 Gene

Regulatory Elements for PLPPR4 Gene

Enhancers for PLPPR4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLPPR4 on UCSC Golden Path with GeneCards custom track

Promoters for PLPPR4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLPPR4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLPPR4 Gene

Chromosome:
1
Start:
99,262,953 bp from pter
End:
99,309,590 bp from pter
Size:
46,638 bases
Orientation:
Plus strand

Genomic View for PLPPR4 Gene

Genes around PLPPR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPPR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPPR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPPR4 Gene

Proteins for PLPPR4 Gene

  • Protein details for PLPPR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2D5-PLPR4_HUMAN
    Recommended name:
    Phospholipid phosphatase-related protein type 4
    Protein Accession:
    Q7Z2D5
    Secondary Accessions:
    • E7EPS1
    • O75043
    • Q5T9R9
    • Q86XQ5
    • Q8N3F1
    • Q96MP0

    Protein attributes for PLPPR4 Gene

    Size:
    763 amino acids
    Molecular mass:
    82983 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA32300.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI22799.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW72991.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PLPPR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLPPR4 Gene

Proteomics data for PLPPR4 Gene at MOPED

Selected DME Specific Peptides for PLPPR4 Gene

Post-translational modifications for PLPPR4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLPPR4 Gene

Domains & Families for PLPPR4 Gene

Gene Families for PLPPR4 Gene

Protein Domains for PLPPR4 Gene

Suggested Antigen Peptide Sequences for PLPPR4 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z2D5

UniProtKB/Swiss-Prot:

PLPR4_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPPR4: view

Function for PLPPR4 Gene

Molecular function for PLPPR4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus.

Enzyme Numbers (IUBMB) for PLPPR4 Gene

Gene Ontology (GO) - Molecular Function for PLPPR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042577 lipid phosphatase activity IEA,IBA --
genes like me logo Genes that share ontologies with PLPPR4: view
genes like me logo Genes that share phenotypes with PLPPR4: view

Animal Models for PLPPR4 Gene

MGI Knock Outs for PLPPR4:

Animal Model Products

miRNA for PLPPR4 Gene

miRTarBase miRNAs that target PLPPR4

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLPPR4 Gene

Localization for PLPPR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPPR4 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for PLPPR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with PLPPR4: view

No data available for Subcellular locations from COMPARTMENTS for PLPPR4 Gene

Pathways & Interactions for PLPPR4 Gene

genes like me logo Genes that share pathways with PLPPR4: view

Pathways by source for PLPPR4 Gene

Interacting Proteins for PLPPR4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359204%0d%0a9606.ENSP00000293831%0d%0a
Selected Interacting proteins: Q7Z2D5-PLPR4_HUMAN ENSP00000359204 for PLPPR4 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for PLPPR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007409 axonogenesis IEA,IBA --
GO:0048839 inner ear development IEA --
genes like me logo Genes that share ontologies with PLPPR4: view

No data available for SIGNOR curated interactions for PLPPR4 Gene

Drugs & Compounds for PLPPR4 Gene

(25) Additional Compounds for PLPPR4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LPA(0:0/16:0)
  • 2-Hexadecanoyl-phosphatidic acid
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • LPA(16:0)
  • Lysophosphatidic acid(0:0/16:0)
LPA(0:0/18:0)
  • 2-Octadecanoyl-phosphatidic acid
  • 2-Stearoyl-glycero-3-phosphate
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
LPA(0:0/18:1(9Z))
  • 2-(9Z-Octadecenoyl)-phosphatidic acid
  • 2-Oleoyl-glycero-3-phosphate
  • LPA(0:0/18:1)
  • LPA(0:0/18:1n9)
  • LPA(0:0/18:1w9)
LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • 2-Linoleoyl-glycero-3-phosphate
  • LPA(0:0/18:2)
  • LPA(0:0/18:2n6)
  • LPA(0:0/18:2w6)
LPA(16:0/0:0)
  • 1-Hexadecanoyl-phosphatidic acid
  • 1-Palmitoyl lysophosphatidate
  • 1-Palmitoyl lysophosphatidic acid
  • 1-Palmitoyl-glycero-3-phosphate
  • 1-Palmitoylglycerol 3-phosphate
genes like me logo Genes that share compounds with PLPPR4: view

Transcripts for PLPPR4 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PLPPR4 Gene

No ASD Table

Relevant External Links for PLPPR4 Gene

GeneLoc Exon Structure for
PLPPR4
ECgene alternative splicing isoforms for
PLPPR4

Expression for PLPPR4 Gene

mRNA Expression by UniProt/SwissProt for PLPPR4 Gene

Q7Z2D5-PLPR4_HUMAN
Tissue specificity: Specifically expressed in neurons.
genes like me logo Genes that share expression patterns with PLPPR4: view

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PLPPR4 Gene

Orthologs for PLPPR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPPR4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC513388 35
  • 91.79 (n)
  • 97.9 (a)
-- 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC490146 35
  • 92.96 (n)
  • 98.74 (a)
-- 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D3Bwg0562e 35
  • 88.47 (n)
  • 96.07 (a)
Plppr4 16
D3Bwg0562e 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC469389 35
  • 99.65 (n)
  • 99.87 (a)
-- 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lppr4 35
  • 87.68 (n)
  • 95.54 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 89 (a)
OneToOne
LPPR4 35
  • 80.32 (n)
  • 90.18 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489346 35
  • 75.05 (n)
  • 85.25 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34211 35
zebrafish
(Danio rerio)
Actinopterygii lppr4a 35
  • 67.85 (n)
  • 73.83 (a)
lppr4a 36
  • 66 (a)
OneToMany
lppr4b 36
  • 71 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T06D8.3 36
  • 24 (a)
OneToMany
Species with no ortholog for PLPPR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLPPR4 Gene

ENSEMBL:
Gene Tree for PLPPR4 (if available)
TreeFam:
Gene Tree for PLPPR4 (if available)

Paralogs for PLPPR4 Gene

Paralogs for PLPPR4 Gene

genes like me logo Genes that share paralogs with PLPPR4: view

Variants for PLPPR4 Gene

Sequence variations from dbSNP and Humsavar for PLPPR4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs712896 - 99,264,453(-) GCGCT(A/G/T)CATGC intron-variant, reference, missense
rs35285687 - 99,264,544(-) GCACA(A/G)CGCAG intron-variant, reference, missense
rs712879 -- 99,293,869(+) ATATA(G/T)TTCCT intron-variant
rs712880 -- 99,293,775(+) TTTTT(C/G)TTGTT intron-variant
rs712881 -- 99,292,747(+) CCAAA(A/C)ATATA intron-variant

Variation tolerance for PLPPR4 Gene

Residual Variation Intolerance Score: 7.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLPPR4 Gene

HapMap Linkage Disequilibrium report
PLPPR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PLPPR4 Gene

Disorders for PLPPR4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLPPR4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cenani-lenz syndrome
  • syndactyly cenani lenz type
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLPPR4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPPR4
genes like me logo Genes that share disorders with PLPPR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLPPR4 Gene

Publications for PLPPR4 Gene

  1. A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. (PMID: 12730698) Braeuer A.U. … Nitsch R. (Nat. Neurosci. 2003) 2 3 4 67
  2. Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease. (PMID: 23213074) Adams L.A. … Pennell C.E. (Hepatology 2013) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. LRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome. (PMID: 20381006) Li Y. … Wollnik B. (Am. J. Hum. Genet. 2010) 3
  5. Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. (PMID: 19766573) Trimbuch T. … Nitsch R. (Cell 2009) 3

Products for PLPPR4 Gene

Sources for PLPPR4 Gene

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