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Aliases for PLPPR3 Gene

Aliases for PLPPR3 Gene

  • Phospholipid Phosphatase Related 3 2 3 5
  • Lipid Phosphate Phosphatase-Related Protein Type 3 3 4
  • Plasticity-Related Gene 2 Protein 3 4
  • PAP-2-Like Protein 2 3 4
  • EC 3.1.3.4 4 58
  • LPPR3 3 4
  • PRG-2 3 4
  • PRG2 3 4
  • Phospholipid Phosphatase-Related Protein Type 3 3
  • EC 3.1.3 58
  • LPR3 3
  • PHP2 4

External Ids for PLPPR3 Gene

Summaries for PLPPR3 Gene

Entrez Gene Summary for PLPPR3 Gene

  • The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PLPPR3 Gene

PLPPR3 (Phospholipid Phosphatase Related 3) is a Protein Coding gene. Among its related pathways are Lysosphingolipid and LPA receptors and Peptide ligand-binding receptors. An important paralog of this gene is PLPPR4.

Additional gene information for PLPPR3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLPPR3 Gene

Genomics for PLPPR3 Gene

Regulatory Elements for PLPPR3 Gene

Enhancers for PLPPR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H000823 1.3 FANTOM5 ENCODE 12.9 +0.5 531 0 HDAC1 TBP ATF1 RB1 NFRKB ZNF766 ELK1 ATF7 CREM ZBTB2 AZU1 PLPPR3 PRTN3 ELANE PRSS57 BSG PTBP1 GC19P000823
GH19H000479 1.5 Ensembl ENCODE dbSUPER 9.7 +344.0 343958 0 HDGF PKNOX1 ATF1 ARNT ZNF133 ARID4B SIN3A YBX1 ZNF2 TCF12 DAZAP1 TMEM259 PTBP1 ENSG00000267317 MIER2 GRIN3B MED16 RPS15 CIRBP CNN2
GH19H000824 0.6 ENCODE 0.7 -0.2 -181 0 HDAC1 ZNF766 E2F5 ZNF175 ZBTB33 CUX1 ZNF644 ZFX ZNF592 AZU1 PLPPR3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLPPR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLPPR3 Gene

Chromosome:
19
Start:
812,488 bp from pter
End:
824,243 bp from pter
Size:
11,756 bases
Orientation:
Minus strand

Genomic View for PLPPR3 Gene

Genes around PLPPR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPPR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPPR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPPR3 Gene

Proteins for PLPPR3 Gene

  • Protein details for PLPPR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6T4P5-PLPR3_HUMAN
    Recommended name:
    Phospholipid phosphatase-related protein type 3
    Protein Accession:
    Q6T4P5
    Secondary Accessions:
    • Q86XQ4
    • Q96EH1
    • Q9BQF9
    • Q9HAJ4

    Protein attributes for PLPPR3 Gene

    Size:
    718 amino acids
    Molecular mass:
    76037 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLPPR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLPPR3 Gene

Selected DME Specific Peptides for PLPPR3 Gene

Q6T4P5:
  • EGLPPLG
  • LVHIPEE
  • ARKTFPS
  • FLTVCKP

Post-translational modifications for PLPPR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLPPR3 Gene

Domains & Families for PLPPR3 Gene

Gene Families for PLPPR3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for PLPPR3 Gene

Suggested Antigen Peptide Sequences for PLPPR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6T4P5

UniProtKB/Swiss-Prot:

PLPR3_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPPR3: view

Function for PLPPR3 Gene

Molecular function for PLPPR3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.

Enzyme Numbers (IUBMB) for PLPPR3 Gene

Gene Ontology (GO) - Molecular Function for PLPPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008195 phosphatidate phosphatase activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0042577 lipid phosphatase activity IBA --
genes like me logo Genes that share ontologies with PLPPR3: view
genes like me logo Genes that share phenotypes with PLPPR3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLPPR3

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLPPR3 Gene

Localization for PLPPR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPPR3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPPR3 gene
Compartment Confidence
plasma membrane 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLPPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPPR3: view

Pathways & Interactions for PLPPR3 Gene

genes like me logo Genes that share pathways with PLPPR3: view

Pathways by source for PLPPR3 Gene

Interacting Proteins for PLPPR3 Gene

Gene Ontology (GO) - Biological Process for PLPPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IBA --
GO:0007165 signal transduction IBA --
GO:0046839 phospholipid dephosphorylation IBA --
genes like me logo Genes that share ontologies with PLPPR3: view

No data available for SIGNOR curated interactions for PLPPR3 Gene

Drugs & Compounds for PLPPR3 Gene

(2) Drugs for PLPPR3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for PLPPR3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with PLPPR3: view

Transcripts for PLPPR3 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLPPR3 Gene

No ASD Table

Relevant External Links for PLPPR3 Gene

GeneLoc Exon Structure for
PLPPR3
ECgene alternative splicing isoforms for
PLPPR3

Expression for PLPPR3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLPPR3 Gene:

PLPPR3

Evidence on tissue expression from TISSUES for PLPPR3 Gene

  • Nervous system(4.2)
  • Eye(4)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPPR3 Gene

Orthologs for PLPPR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPPR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPPR3 33
  • 89.97 (n)
-- 34
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC005764 33 34
  • 80.74 (n)
Plppr3 16
rat
(Rattus norvegicus)
Mammalia Lppr3 33
  • 80.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858410 33
  • 79.09 (n)
-- 34
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lppr3 33
  • 62.98 (n)
Str.10644 33
zebrafish
(Danio rerio)
Actinopterygii lppr3a 33
  • 67.12 (n)
lppr3b 34
  • 59 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T06D8.3 34
  • 23 (a)
OneToMany
Species where no ortholog for PLPPR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLPPR3 Gene

ENSEMBL:
Gene Tree for PLPPR3 (if available)
TreeFam:
Gene Tree for PLPPR3 (if available)

Paralogs for PLPPR3 Gene

Paralogs for PLPPR3 Gene

genes like me logo Genes that share paralogs with PLPPR3: view

Variants for PLPPR3 Gene

Sequence variations from dbSNP and Humsavar for PLPPR3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000037722 -- 822,050(+) CCAGA(C/G)GCCGC intron-variant, upstream-variant-2KB
rs1000050520 -- 813,986(+) GGACC(-/G)GGGGT intron-variant, downstream-variant-500B
rs1000106016 -- 822,831(+) AAATC(A/G)GTTTT intron-variant, upstream-variant-2KB
rs1000134201 -- 825,696(+) CCCTG(G/T)ACTCT upstream-variant-2KB
rs1000187086 -- 825,590(+) GAGAT(G/T)ACAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLPPR3 Gene

Variant ID Type Subtype PubMed ID
dgv134n111 CNV deletion 26073780
dgv1678n106 CNV deletion 24896259
dgv566n67 CNV gain 20364138
dgv6176n54 CNV loss 21841781
esv26343 CNV gain 19812545
esv2675158 CNV deletion 23128226
esv2717790 CNV deletion 23290073
esv2717791 CNV deletion 23290073
esv2717792 CNV deletion 23290073
esv2717793 CNV deletion 23290073
esv2743119 CNV deletion 23290073
esv3555827 CNV deletion 23714750
nsv1072291 CNV deletion 25765185
nsv1072292 CNV deletion 25765185
nsv1144848 CNV deletion 24896259
nsv1147444 CNV deletion 26484159
nsv458321 CNV loss 19166990
nsv470101 CNV loss 18288195
nsv578167 CNV loss 21841781
nsv578172 CNV loss 21841781
nsv828354 CNV gain 20364138
nsv828357 CNV loss 20364138
nsv953938 CNV deletion 24416366
nsv954615 CNV deletion 24416366

Variation tolerance for PLPPR3 Gene

Gene Damage Index Score: 9.00; 87.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLPPR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLPPR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLPPR3 Gene

Disorders for PLPPR3 Gene

Relevant External Links for PLPPR3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPPR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPPR3

No disorders were found for PLPPR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLPPR3 Gene

Publications for PLPPR3 Gene

  1. A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. (PMID: 12730698) Bräuer AU … Nitsch R (Nature neuroscience 2003) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for PLPPR3 Gene

Sources for PLPPR3 Gene

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