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Aliases for PLPP7 Gene

Aliases for PLPP7 Gene

  • Phospholipid Phosphatase 7 (Inactive) 2 3 5
  • Phosphatidic Acid Phosphatase Type 2 Domain-Containing Protein 3 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain Containing 3 2 3
  • Nuclear Envelope Transmembrane Protein NET39 2 3
  • C9orf67 3 4
  • PPAPDC3 3 4
  • Probable Lipid Phosphate Phosphatase PPAPDC3 3
  • Chromosome 9 Open Reading Frame 67 2
  • EC 3.1.3 63
  • NET39 3

External Ids for PLPP7 Gene

Previous HGNC Symbols for PLPP7 Gene

  • C9orf67
  • PPAPDC3

Summaries for PLPP7 Gene

GeneCards Summary for PLPP7 Gene

PLPP7 (Phospholipid Phosphatase 7 (Inactive)) is a Protein Coding gene. An important paralog of this gene is PLPP6.

UniProtKB/Swiss-Prot for PLPP7 Gene

  • Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLPP7 Gene

Genomics for PLPP7 Gene

Regulatory Elements for PLPP7 Gene

Enhancers for PLPP7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLPP7 on UCSC Golden Path with GeneCards custom track

Promoters for PLPP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLPP7 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLPP7 Gene

Chromosome:
9
Start:
131,289,682 bp from pter
End:
131,309,262 bp from pter
Size:
19,581 bases
Orientation:
Plus strand

Genomic View for PLPP7 Gene

Genes around PLPP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP7 Gene

Proteins for PLPP7 Gene

  • Protein details for PLPP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBV4-PLPP7_HUMAN
    Recommended name:
    Inactive phospholipid phosphatase 7
    Protein Accession:
    Q8NBV4
    Secondary Accessions:
    • Q5T6P0
    • Q96SS7
    • Q9BRC3

    Protein attributes for PLPP7 Gene

    Size:
    271 amino acids
    Molecular mass:
    29448 Da
    Quaternary structure:
    • Homo and heterooligomer. Interacts with MTOR; controls MTOR-dependent IGF2 expression during myoblast differentiation (By similarity).
    SequenceCaution:
    • Sequence=CAI16274.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PLPP7 Gene

Proteomics data for PLPP7 Gene at MOPED

Selected DME Specific Peptides for PLPP7 Gene

Post-translational modifications for PLPP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLPP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PLPP7 Gene

Gene Families for PLPP7 Gene

Protein Domains for PLPP7 Gene

Suggested Antigen Peptide Sequences for PLPP7 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NBV4

UniProtKB/Swiss-Prot:

PLPP7_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP7: view

Function for PLPP7 Gene

Molecular function for PLPP7 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity).

Enzyme Numbers (IUBMB) for PLPP7 Gene

genes like me logo Genes that share phenotypes with PLPP7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLPP7

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLPP7 Gene

Localization for PLPP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP7 Gene

Nucleus envelope. Endoplasmic reticulum membrane. Membrane; Multi-pass membrane protein. Note=Both the N- and C-terminal are exposed to the cytoplasm/nucleoplasm. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for PLPP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPP7: view

No data available for Subcellular locations from COMPARTMENTS for PLPP7 Gene

Pathways & Interactions for PLPP7 Gene

SuperPathways for PLPP7 Gene

No Data Available

Interacting Proteins for PLPP7 Gene

Gene Ontology (GO) - Biological Process for PLPP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010832 negative regulation of myotube differentiation IEA --
genes like me logo Genes that share ontologies with PLPP7: view

No data available for Pathways by source and SIGNOR curated interactions for PLPP7 Gene

Drugs & Compounds for PLPP7 Gene

(12) Additional Compounds for PLPP7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
PA(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
PA(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
PA(16:0e/18:0)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with PLPP7: view

Transcripts for PLPP7 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP7 Gene

No ASD Table

Relevant External Links for PLPP7 Gene

GeneLoc Exon Structure for
PLPP7
ECgene alternative splicing isoforms for
PLPP7

Expression for PLPP7 Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PLPP7 Gene

Orthologs for PLPP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPP7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPAPDC3 35
  • 91.64 (n)
  • 94.46 (a)
PPAPDC3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPAPDC3 35
  • 92.37 (n)
  • 94.1 (a)
PPAPDC3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppapdc3 35
  • 89.42 (n)
  • 94.83 (a)
Plpp7 16
Ppapdc3 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPAPDC3 35
  • 94.65 (n)
  • 91.42 (a)
PPAPDC3 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppapdc3 35
  • 88.93 (n)
  • 94.1 (a)
oppossum
(Monodelphis domestica)
Mammalia PPAPDC3 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPAPDC3 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPAPDC3 35
  • 78.97 (n)
  • 81.92 (a)
PPAPDC3 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppapdc3 35
  • 68.4 (n)
  • 73.61 (a)
zebrafish
(Danio rerio)
Actinopterygii ppapdc3 35
  • 68.03 (n)
  • 68.03 (a)
ppapdc3 36
  • 63 (a)
OneToMany
PPAPDC3 (1 of 2) 36
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG31717 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T13C5.6 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for PLPP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLPP7 Gene

ENSEMBL:
Gene Tree for PLPP7 (if available)
TreeFam:
Gene Tree for PLPP7 (if available)

Paralogs for PLPP7 Gene

Paralogs for PLPP7 Gene

genes like me logo Genes that share paralogs with PLPP7: view

Variants for PLPP7 Gene

Sequence variations from dbSNP and Humsavar for PLPP7 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2966332 - 131,307,992(+) CGAGA(C/T)GAGCC reference, missense
rs11244366 - 131,308,270(+) AGATG(C/G)TCATC reference, missense
rs913217 -- 131,300,762(+) ACAGC(C/T)CATGC intron-variant
rs1191903 -- 131,306,316(+) gcaag(A/C)ggatc intron-variant
rs1191904 -- 131,306,513(+) gcctg(A/G)gcaac intron-variant

Variation tolerance for PLPP7 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLPP7 Gene

HapMap Linkage Disequilibrium report
PLPP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PLPP7 Gene

Disorders for PLPP7 Gene

Relevant External Links for PLPP7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPP7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPP7

No disorders were found for PLPP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLPP7 Gene

Publications for PLPP7 Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 67
  2. Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PMID: 12958361) Schirmer E.C. … Gerace L. (Science 2003) 2 3
  3. Regulation of myoblast differentiation by the nuclear envelope protein NET39. (PMID: 19704009) Liu G.H. … Gerace L. (Mol. Cell. Biol. 2009) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3

Products for PLPP7 Gene

Sources for PLPP7 Gene

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