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Aliases for PLPP7 Gene

Aliases for PLPP7 Gene

  • Phospholipid Phosphatase 7 (Inactive) 2 3 5
  • Phosphatidic Acid Phosphatase Type 2 Domain-Containing Protein 3 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain Containing 3 2 3
  • Nuclear Envelope Transmembrane Protein NET39 2 3
  • C9orf67 3 4
  • PPAPDC3 3 4
  • Probable Lipid Phosphate Phosphatase PPAPDC3 3
  • Inactive Phospholipid Phosphatase 7 3
  • Chromosome 9 Open Reading Frame 67 2
  • EC 3.1.3 61
  • NET39 3

External Ids for PLPP7 Gene

Previous HGNC Symbols for PLPP7 Gene

  • C9orf67

Summaries for PLPP7 Gene

GeneCards Summary for PLPP7 Gene

PLPP7 (Phospholipid Phosphatase 7 (Inactive)) is a Protein Coding gene. An important paralog of this gene is PLPP6.

UniProtKB/Swiss-Prot for PLPP7 Gene

  • Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLPP7 Gene

Genomics for PLPP7 Gene

Regulatory Elements for PLPP7 Gene

Enhancers for PLPP7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G131330 1.6 Ensembl ENCODE dbSUPER 17.2 +41.5 41476 1.7 HDGF PKNOX1 CREB3L1 ARNT ZNF766 ZNF263 REST ZNF592 MEF2D SMARCA4 PLPP7 ENSG00000246851 NUP214 POMT1 ENSG00000176868 LOC105376299
GH09G131263 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13 -18.0 -18003 15.8 HDGF PKNOX1 MLX WRNIP1 SIN3A ARID4B DMAP1 ETS1 ZNF207 ZNF143 PLPP7 NUP214 ENSG00000246851 FAM78A QRFP RAPGEF1 GC09P131253
GH09G131287 1.4 ENCODE dbSUPER 14.3 -0.5 -458 4.4 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 PLPP7 ENSG00000246851 NUP214 FAM78A
GH09G131349 1.5 Ensembl ENCODE dbSUPER 11.1 +60.5 60521 1.2 PKNOX1 SIN3A ARID4B ZNF2 ZNF48 ZBTB7B YY1 ETS1 GLIS2 ELK1 PRRC2B PLPP7 FAM78A ENSG00000176868 POMT1 LOC105376300 LOC105376299
GH09G131310 1.3 Ensembl ENCODE dbSUPER 12.4 +21.3 21325 0.8 ELF3 PKNOX1 RAD21 YY1 RARA RELB IKZF2 CEBPB GATAD2B REST PLPP7 FAM78A ENSG00000246851 NUP214 ENSG00000176868 POMT1 LOC105376299
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLPP7 on UCSC Golden Path with GeneCards custom track

Promoters for PLPP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PLPP7 Gene

131,289,682 bp from pter
131,309,262 bp from pter
19,581 bases
Plus strand

Genomic View for PLPP7 Gene

Genes around PLPP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP7 Gene

Proteins for PLPP7 Gene

  • Protein details for PLPP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive phospholipid phosphatase 7
    Protein Accession:
    Secondary Accessions:
    • Q5T6P0
    • Q96SS7
    • Q9BRC3

    Protein attributes for PLPP7 Gene

    271 amino acids
    Molecular mass:
    29448 Da
    Quaternary structure:
    • Homo and heterooligomer. Interacts with MTOR; controls MTOR-dependent IGF2 expression during myoblast differentiation (By similarity).
    • Sequence=CAI16274.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PLPP7 Gene

Selected DME Specific Peptides for PLPP7 Gene


Post-translational modifications for PLPP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLPP7 Gene

Domains & Families for PLPP7 Gene

Gene Families for PLPP7 Gene

Protein Domains for PLPP7 Gene

Suggested Antigen Peptide Sequences for PLPP7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PA-phosphatase related phosphoesterase family.
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP7: view

Function for PLPP7 Gene

Molecular function for PLPP7 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity).

Enzyme Numbers (IUBMB) for PLPP7 Gene

genes like me logo Genes that share phenotypes with PLPP7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLPP7

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLPP7 Gene

Localization for PLPP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP7 Gene

Nucleus envelope. Endoplasmic reticulum membrane. Membrane; Multi-pass membrane protein. Note=Both the N- and C-terminal are exposed to the cytoplasm/nucleoplasm. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPP7 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
plasma membrane 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLPP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPP7: view

Pathways & Interactions for PLPP7 Gene

SuperPathways for PLPP7 Gene

No Data Available

Interacting Proteins for PLPP7 Gene

Gene Ontology (GO) - Biological Process for PLPP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010832 negative regulation of myotube differentiation IEA --
genes like me logo Genes that share ontologies with PLPP7: view

No data available for Pathways by source and SIGNOR curated interactions for PLPP7 Gene

Drugs & Compounds for PLPP7 Gene

(12) Additional Compounds for PLPP7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with PLPP7: view

Transcripts for PLPP7 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP7 Gene

No ASD Table

Relevant External Links for PLPP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLPP7 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLPP7 Gene:


Evidence on tissue expression from TISSUES for PLPP7 Gene

  • Nervous system(4.7)
  • Heart(3.3)
  • Muscle(2.2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPP7 Gene

Orthologs for PLPP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPAPDC3 34 35
  • 94.65 (n)
(Canis familiaris)
Mammalia PPAPDC3 34 35
  • 92.37 (n)
(Bos Taurus)
Mammalia PPAPDC3 34 35
  • 91.64 (n)
(Mus musculus)
Mammalia Ppapdc3 34 35
  • 89.42 (n)
Plpp7 16
(Rattus norvegicus)
Mammalia Ppapdc3 34
  • 88.93 (n)
(Monodelphis domestica)
Mammalia PPAPDC3 35
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia PPAPDC3 35
  • 87 (a)
(Gallus gallus)
Aves PPAPDC3 34 35
  • 78.97 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppapdc3 34
  • 68.4 (n)
(Danio rerio)
Actinopterygii ppapdc3 34 35
  • 68.03 (n)
PPAPDC3 (1 of 2) 35
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31717 35
  • 27 (a)
(Caenorhabditis elegans)
Secernentea T13C5.6 35
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
Species where no ortholog for PLPP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLPP7 Gene

Gene Tree for PLPP7 (if available)
Gene Tree for PLPP7 (if available)

Paralogs for PLPP7 Gene

Paralogs for PLPP7 Gene

genes like me logo Genes that share paralogs with PLPP7: view

Variants for PLPP7 Gene

Sequence variations from dbSNP and Humsavar for PLPP7 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000035008 -- 131,305,919(+) CCACC(A/G)TGCCC intron-variant
rs1000086827 -- 131,306,186(+) GAGCC(A/G)AGATG intron-variant
rs1000437345 -- 131,295,992(+) GCCCC(C/T)GCTTT intron-variant
rs1000529509 -- 131,301,763(+) ACCAC(C/T)CTTGC intron-variant
rs1000542952 -- 131,306,164(+) CCCAG(A/G)AGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLPP7 Gene

Variant ID Type Subtype PubMed ID
nsv1124483 CNV deletion 24896259
nsv466602 CNV loss 19166990
nsv509327 CNV insertion 20534489
nsv615535 CNV loss 21841781
nsv615536 CNV loss 21841781
nsv831739 CNV loss 17160897

Variation tolerance for PLPP7 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLPP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLPP7 Gene

Disorders for PLPP7 Gene

Relevant External Links for PLPP7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PLPP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLPP7 Gene

Publications for PLPP7 Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PMID: 12958361) Schirmer E.C. … Gerace L. (Science 2003) 2 3 64

Products for PLPP7 Gene

Sources for PLPP7 Gene

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