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Aliases for PLPP6 Gene

Aliases for PLPP6 Gene

  • Phospholipid Phosphatase 6 2 3 5
  • Presqualene Diphosphate Phosphatase 2 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain-Containing Protein 2 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain Containing 2 2 3
  • Polyisoprenoid Diphosphate Phosphatase Type 1 2 3
  • PPAP2 Domain-Containing Protein 2 3 4
  • PPAPDC2 3 4
  • EC 3.1.3.- 4
  • BA6J24.6 3
  • EC 3.1.3 61
  • PDP1 3
  • PSDP 3

External Ids for PLPP6 Gene

Previous HGNC Symbols for PLPP6 Gene

  • PPAPDC2

Summaries for PLPP6 Gene

GeneCards Summary for PLPP6 Gene

PLPP6 (Phospholipid Phosphatase 6) is a Protein Coding gene. Among its related pathways are Immune response CCR3 signaling in eosinophils and DAG and IP3 signaling. An important paralog of this gene is PLPP7.

UniProtKB/Swiss-Prot for PLPP6 Gene

  • Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLPP6 Gene

Genomics for PLPP6 Gene

Regulatory Elements for PLPP6 Gene

Enhancers for PLPP6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G004738 1.6 Ensembl ENCODE dbSUPER 10.5 +79.1 79130 5.1 HDGF PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 AK3 RIC1 CDC37L1 JAK2 PLPP6 MTND5P14 GC09P004695
GH09G004661 1.1 ENCODE 9.9 +1.9 1892 5.8 HDGF PKNOX1 FOXA2 MLX WRNIP1 ARID4B SIN3A DMAP1 FEZF1 YY1 SPATA6L RIC1 AK3 PLPP6 CDC37L1-AS1
GH09G004595 1 Ensembl ENCODE 10.8 -66.1 -66099 1.9 TAF1 MAX RAD21 YY1 ZFHX2 GATA2 HNF4G MAFK EGR2 MAFG SPATA6L PLPP6 CDC37L1 PIR55745 RPS6P11
GH09G004291 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.9 -365.1 -365077 12.0 PKNOX1 ARID4B SIN3A BRCA1 ZNF2 ZNF48 YY1 GLIS2 GATA2 FOS GLIS3 MTND4P14 ENSG00000228322 PLPP6 GC09M004258
GH09G004619 0.5 ENCODE 11.6 -41.3 -41323 2.0 JUND JUN MAX MYC ATF2 PLPP6 SPATA6L RPS6P11 PIR55745
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLPP6 on UCSC Golden Path with GeneCards custom track

Promoters for PLPP6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000334183 206 1001 HDGF MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 DEK

Genomic Location for PLPP6 Gene

Chromosome:
9
Start:
4,662,294 bp from pter
End:
4,665,274 bp from pter
Size:
2,981 bases
Orientation:
Plus strand

Genomic View for PLPP6 Gene

Genes around PLPP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP6 Gene

Proteins for PLPP6 Gene

  • Protein details for PLPP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY26-PLPP6_HUMAN
    Recommended name:
    Phospholipid phosphatase 6
    Protein Accession:
    Q8IY26
    Secondary Accessions:
    • B3KY05
    • Q5JVJ6
    • Q8NCK9

    Protein attributes for PLPP6 Gene

    Size:
    295 amino acids
    Molecular mass:
    32194 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK074672; Type=Frameshift; Positions=267; Evidence={ECO:0000305};

neXtProt entry for PLPP6 Gene

Selected DME Specific Peptides for PLPP6 Gene

Q8IY26:
  • LGRHNVTDVAFGFF
  • SGHGIPWL
  • SLLAIDLWLSK
  • YSFPSGHATRAA
  • VRRRRPAHN
  • RSDSWAGREVLMNLLFALLLDLLLV
  • LNHLVLA

Post-translational modifications for PLPP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLPP6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PLPP6 Gene

Gene Families for PLPP6 Gene

Protein Domains for PLPP6 Gene

Suggested Antigen Peptide Sequences for PLPP6 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IY26

UniProtKB/Swiss-Prot:

PLPP6_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP6: view

Function for PLPP6 Gene

Molecular function for PLPP6 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7-8. {ECO:0000269 PubMed:16464866};
UniProtKB/Swiss-Prot Function:
Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid.

Enzyme Numbers (IUBMB) for PLPP6 Gene

Gene Ontology (GO) - Molecular Function for PLPP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA,TAS --
genes like me logo Genes that share ontologies with PLPP6: view
genes like me logo Genes that share phenotypes with PLPP6: view

Animal Models for PLPP6 Gene

MGI Knock Outs for PLPP6:

Animal Model Products

CRISPR Products

miRNA for PLPP6 Gene

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLPP6 Gene

Localization for PLPP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPP6 gene
Compartment Confidence
plasma membrane 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PLPP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPP6: view

Pathways & Interactions for PLPP6 Gene

genes like me logo Genes that share pathways with PLPP6: view

Interacting Proteins for PLPP6 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000371307%0d%0a9606.ENSP00000341327%0d%0a9606.ENSP00000253680%0d%0a
Selected Interacting proteins: ENSP00000371307 Q8IY26-PLPP6_HUMAN for PLPP6 Gene via STRING IID

Gene Ontology (GO) - Biological Process for PLPP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006695 cholesterol biosynthetic process TAS --
genes like me logo Genes that share ontologies with PLPP6: view

No data available for SIGNOR curated interactions for PLPP6 Gene

Drugs & Compounds for PLPP6 Gene

(12) Additional Compounds for PLPP6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
PA(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
PA(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
PA(16:0e/18:0)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with PLPP6: view

Transcripts for PLPP6 Gene

mRNA/cDNA for PLPP6 Gene

(1) REFSEQ mRNAs :
(71) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP6 Gene

No ASD Table

Relevant External Links for PLPP6 Gene

GeneLoc Exon Structure for
PLPP6
ECgene alternative splicing isoforms for
PLPP6

Expression for PLPP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PLPP6 Gene:

PLPP6

mRNA Expression by UniProt/SwissProt for PLPP6 Gene:

Q8IY26-PLPP6_HUMAN
Tissue specificity: Widely expressed. Expressed in most organs, in particular gastrointestinal organs, spleen, placenta, kidney, thymus and brain.

Evidence on tissue expression from TISSUES for PLPP6 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with PLPP6: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPP6 Gene

Orthologs for PLPP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPAPDC2 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia PPAPDC2 34 35
  • 89.32 (n)
cow
(Bos Taurus)
Mammalia PPAPDC2 34 35
  • 89.24 (n)
rat
(Rattus norvegicus)
Mammalia Ppapdc2 34
  • 87.51 (n)
mouse
(Mus musculus)
Mammalia Ppapdc2 34 35
  • 87.4 (n)
Plpp6 16
oppossum
(Monodelphis domestica)
Mammalia PPAPDC2 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPAPDC2 34 35
  • 76.95 (n)
lizard
(Anolis carolinensis)
Reptilia PPAPDC2 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppapdc2 34
  • 65.88 (n)
zebrafish
(Danio rerio)
Actinopterygii ppapdc2 35
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005824 34
  • 50.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31717 34 35
  • 50.19 (n)
worm
(Caenorhabditis elegans)
Secernentea T13C5.6 35
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToMany
Species where no ortholog for PLPP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLPP6 Gene

ENSEMBL:
Gene Tree for PLPP6 (if available)
TreeFam:
Gene Tree for PLPP6 (if available)

Paralogs for PLPP6 Gene

Paralogs for PLPP6 Gene

genes like me logo Genes that share paralogs with PLPP6: view

Variants for PLPP6 Gene

Sequence variations from dbSNP and Humsavar for PLPP6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000112166 -- 4,661,002(+) CAGGG(C/T)GGGGA intron-variant, upstream-variant-2KB
rs1000441433 -- 4,660,851(+) CAGCC(A/G)TAAAA intron-variant, upstream-variant-2KB
rs1000956267 -- 4,661,112(+) TGTGC(A/C)TATGT intron-variant, upstream-variant-2KB
rs1001437537 -- 4,664,736(+) GGTTC(A/G)GAACC intron-variant, utr-variant-3-prime
rs1001537336 -- 4,660,688(+) ATATA(A/C)CCAAA intron-variant, upstream-variant-2KB

Variation tolerance for PLPP6 Gene

Residual Variation Intolerance Score: 35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.99; 74.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLPP6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLPP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PLPP6 Gene

Disorders for PLPP6 Gene

Relevant External Links for PLPP6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPP6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPP6

No disorders were found for PLPP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLPP6 Gene

Publications for PLPP6 Gene

  1. Identification and functional characterization of a presqualene diphosphate phosphatase. (PMID: 16464866) Fukunaga K. … Levy B.D. (J. Biol. Chem. 2006) 2 3 4 64
  2. Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells. (PMID: 20110354) Miriyala S. … Morris A.J. (J. Biol. Chem. 2010) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PLPP6 Gene

Sources for PLPP6 Gene

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