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Aliases for PLPP5 Gene

Aliases for PLPP5 Gene

  • Phospholipid Phosphatase 5 2 3 5
  • Phosphatidic Acid Phosphatase Type 2 Domain-Containing Protein 1B 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain Containing 1B 2 3
  • Diacylglycerol Pyrophosphate Phosphatase-Like 1 2 3
  • PPAPDC1B 3 4
  • DPPL1 3 4
  • HTPAP 3 4
  • Diacylglycerol Pyrophosphate Like 1 3
  • Phosphatidate Phosphatase PPAPDC1B 3
  • Testicular Secretory Protein Li 38 3
  • EC 3.1.3.4 4

External Ids for PLPP5 Gene

Previous HGNC Symbols for PLPP5 Gene

  • PPAPDC1B

Summaries for PLPP5 Gene

GeneCards Summary for PLPP5 Gene

PLPP5 (Phospholipid Phosphatase 5) is a Protein Coding gene. Diseases associated with PLPP5 include Hepatocellular Carcinoma. Among its related pathways are Role of phospholipids in phagocytosis and Innate Immune System. An important paralog of this gene is PLPP4.

UniProtKB/Swiss-Prot for PLPP5 Gene

  • Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLPP5 Gene

Genomics for PLPP5 Gene

Regulatory Elements for PLPP5 Gene

Enhancers for PLPP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G038267 1.3 ENCODE dbSUPER 0.7 +0.6 606 3.6 HDGF FOXA2 AGO1 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 YY1 DDHD2 LETM2 ENSG00000254898 FGFR1 PLPP5
GH08G038230 1.1 ENCODE 0.3 +37.6 37556 2.7 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 LETM2 DDHD2 PLPP5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLPP5 on UCSC Golden Path with GeneCards custom track

Promoters for PLPP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000223646 437 1201 HDGF ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 FOS DEK ZNF263

Genomic Location for PLPP5 Gene

Chromosome:
8
Start:
38,261,790 bp from pter
End:
38,269,437 bp from pter
Size:
7,648 bases
Orientation:
Minus strand

Genomic View for PLPP5 Gene

Genes around PLPP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP5 Gene

Proteins for PLPP5 Gene

  • Protein details for PLPP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEB5-PLPP5_HUMAN
    Recommended name:
    Phospholipid phosphatase 5
    Protein Accession:
    Q8NEB5
    Secondary Accessions:
    • C9JKF5
    • Q3KQX6
    • Q9BY45

    Protein attributes for PLPP5 Gene

    Size:
    264 amino acids
    Molecular mass:
    29484 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI06015.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK14924.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PLPP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLPP5 Gene

Post-translational modifications for PLPP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLPP5 Gene

Domains & Families for PLPP5 Gene

Gene Families for PLPP5 Gene

Protein Domains for PLPP5 Gene

Suggested Antigen Peptide Sequences for PLPP5 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEB5

UniProtKB/Swiss-Prot:

PLPP5_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP5: view

Function for PLPP5 Gene

Molecular function for PLPP5 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=41 uM for diacylglycerol pyrophosphate {ECO:0000269 PubMed:17590538}; KM=277 uM for phosphatidate {ECO:0000269 PubMed:17590538}; KM=295 uM for lysophosphatidate {ECO:0000269 PubMed:17590538};
UniProtKB/Swiss-Prot CatalyticActivity:
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethylmaleimide.
UniProtKB/Swiss-Prot Function:
Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma.

Enzyme Numbers (IUBMB) for PLPP5 Gene

Gene Ontology (GO) - Molecular Function for PLPP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008195 phosphatidate phosphatase activity IEA,IDA 17590538
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLPP5: view
genes like me logo Genes that share phenotypes with PLPP5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLPP5

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLPP5 Gene

Localization for PLPP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPP5 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PLPP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 21219541
GO:0005886 plasma membrane TAS 21219541
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPP5: view

Pathways & Interactions for PLPP5 Gene

genes like me logo Genes that share pathways with PLPP5: view

Interacting Proteins for PLPP5 Gene

Gene Ontology (GO) - Biological Process for PLPP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IBA --
GO:0007165 signal transduction IBA --
GO:0046839 phospholipid dephosphorylation IDA 17590538
genes like me logo Genes that share ontologies with PLPP5: view

No data available for SIGNOR curated interactions for PLPP5 Gene

Drugs & Compounds for PLPP5 Gene

(2) Drugs for PLPP5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(12) Additional Compounds for PLPP5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
PA(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
PA(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
PA(16:0e/18:0)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with PLPP5: view

Transcripts for PLPP5 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP5 Gene

No ASD Table

Relevant External Links for PLPP5 Gene

GeneLoc Exon Structure for
PLPP5
ECgene alternative splicing isoforms for
PLPP5

Expression for PLPP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PLPP5 Gene:

PLPP5

mRNA Expression by UniProt/SwissProt for PLPP5 Gene:

Q8NEB5-PLPP5_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for PLPP5 Gene

  • Lung(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with PLPP5: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPP5 Gene

Orthologs for PLPP5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLPP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPAPDC1B 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia PPAPDC1B 34 35
  • 87.66 (n)
mouse
(Mus musculus)
Mammalia Ppapdc1b 34 35
  • 85.85 (n)
Plpp5 16
rat
(Rattus norvegicus)
Mammalia Ppapdc1b 34
  • 85.05 (n)
cow
(Bos Taurus)
Mammalia LOC616337 34
  • 83.47 (n)
PPAPDC1B 35
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPAPDC1B 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPAPDC1B 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPAPDC1B 34 35
  • 66.53 (n)
lizard
(Anolis carolinensis)
Reptilia PPAPDC1B 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppapdc1b 34
  • 66.12 (n)
zebrafish
(Danio rerio)
Actinopterygii ppapdc1b 34 35
  • 63.23 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta CG12746 34 35
  • 55.81 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DPP1 35
  • 29 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons LPP3 34
  • 48.68 (n)
rice
(Oryza sativa)
Liliopsida Os01g0139600 34
  • 48.99 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToMany
Species where no ortholog for PLPP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLPP5 Gene

ENSEMBL:
Gene Tree for PLPP5 (if available)
TreeFam:
Gene Tree for PLPP5 (if available)

Paralogs for PLPP5 Gene

Paralogs for PLPP5 Gene

genes like me logo Genes that share paralogs with PLPP5: view

Variants for PLPP5 Gene

Sequence variations from dbSNP and Humsavar for PLPP5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000058844 -- 38,270,782(+) ATTCT(A/G)TTTTC intron-variant, upstream-variant-2KB
rs1000366334 -- 38,270,423(+) CAAAT(A/C)TACAC intron-variant, upstream-variant-2KB
rs1000431558 -- 38,270,684(+) AGGGG(A/T)GCAGT intron-variant, upstream-variant-2KB
rs1000864322 -- 38,264,224(+) CTCAC(A/T)GGAAC intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000895238 -- 38,264,430(+) GCCCG(C/G)CCAGA intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PLPP5 Gene

Variant ID Type Subtype PubMed ID
dgv7164n100 CNV gain 25217958

Variation tolerance for PLPP5 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLPP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLPP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLPP5 Gene

Disorders for PLPP5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLPP5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search PLPP5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PLPP5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPP5
genes like me logo Genes that share disorders with PLPP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLPP5 Gene

Publications for PLPP5 Gene

  1. Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase. (PMID: 17590538) Takeuchi M. … Kamatani N. (Gene 2007) 2 3 4 64
  2. HTPAP gene on chromosome 8p is a candidate metastasis suppressor for human hepatocellular carcinoma. (PMID: 16261160) Wu X. … Qin L.-X. (Oncogene 2006) 3 4 64
  3. Genomic aberrations in the HTPAP promoter affect tumor metastasis and clinical prognosis of hepatocellular carcinoma. (PMID: 24603412) Wu J.C. … Ren N. (PLoS ONE 2014) 3 64
  4. PPAPDC1B and WHSC1L1 are common drivers of the 8p11-12 amplicon, not only in breast tumors but also in pancreatic adenocarcinomas and lung tumors. (PMID: 24051013) Mahmood S.F. … Bernard-Pierrot I. (Am. J. Pathol. 2013) 3 64
  5. Downregulation of HTPAP transcript variant 1 correlates with tumor metastasis and poor survival in patients with hepatocellular carcinoma. (PMID: 21219541) Dai C. … Qin L.X. (Cancer Sci. 2011) 3 64

Products for PLPP5 Gene

Sources for PLPP5 Gene

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