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Aliases for PLPP2 Gene

Aliases for PLPP2 Gene

  • Phospholipid Phosphatase 2 2 3 5
  • Phosphatidate Phosphohydrolase Type 2c 3 4
  • Phosphatidic Acid Phosphatase Type 2C 2 3
  • Lipid Phosphate Phosphohydrolase 2 3 4
  • Phosphatidic Acid Phosphatase 2c 3 4
  • PAP2-Gamma 3 4
  • EC 3.1.3.4 4 63
  • PAP2-G 3 4
  • PPAP2C 3 4
  • PAP-2c 3 4
  • PAP2c 3 4
  • LPP2 3 4
  • Phosphatidic Acid Phosphohydrolase Type 2c 3
  • Type-2 Phosphatidic Acid Phosphatase-Gamma 3

External Ids for PLPP2 Gene

Previous HGNC Symbols for PLPP2 Gene

  • PPAP2C

Summaries for PLPP2 Gene

Entrez Gene Summary for PLPP2 Gene

  • The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLPP2 Gene

PLPP2 (Phospholipid Phosphatase 2) is a Protein Coding gene. Among its related pathways are triacylglycerol biosynthesis and Metabolism. An important paralog of this gene is PLPPR4.

UniProtKB/Swiss-Prot for PLPP2 Gene

  • Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.

Gene Wiki entry for PLPP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLPP2 Gene

Genomics for PLPP2 Gene

Regulatory Elements for PLPP2 Gene

Enhancers for PLPP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLPP2 on UCSC Golden Path with GeneCards custom track

Promoters for PLPP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLPP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLPP2 Gene

Chromosome:
19
Start:
281,040 bp from pter
End:
291,504 bp from pter
Size:
10,465 bases
Orientation:
Minus strand

Genomic View for PLPP2 Gene

Genes around PLPP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP2 Gene

Proteins for PLPP2 Gene

  • Protein details for PLPP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43688-PLPP2_HUMAN
    Recommended name:
    Phospholipid phosphatase 2
    Protein Accession:
    O43688
    Secondary Accessions:
    • A6NLV0
    • E9PAY8

    Protein attributes for PLPP2 Gene

    Size:
    288 amino acids
    Molecular mass:
    32574 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for PLPP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLPP2 Gene

Proteomics data for PLPP2 Gene at MOPED

Selected DME Specific Peptides for PLPP2 Gene

Post-translational modifications for PLPP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLPP2 Gene

Domains & Families for PLPP2 Gene

Gene Families for PLPP2 Gene

Protein Domains for PLPP2 Gene

Suggested Antigen Peptide Sequences for PLPP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43688

UniProtKB/Swiss-Prot:

PLPP2_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP2: view

Function for PLPP2 Gene

Molecular function for PLPP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sphingosine, zinc ions and propanolol.
UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.

Enzyme Numbers (IUBMB) for PLPP2 Gene

Gene Ontology (GO) - Molecular Function for PLPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity TAS 9607309
GO:0005515 protein binding IPI 25416956
GO:0042577 lipid phosphatase activity IBA --
genes like me logo Genes that share ontologies with PLPP2: view
genes like me logo Genes that share phenotypes with PLPP2: view

Animal Models for PLPP2 Gene

MGI Knock Outs for PLPP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLPP2

miRNA for PLPP2 Gene

miRTarBase miRNAs that target PLPP2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLPP2 Gene

Localization for PLPP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP2 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for PLPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 9607309
genes like me logo Genes that share ontologies with PLPP2: view

No data available for Subcellular locations from COMPARTMENTS for PLPP2 Gene

Pathways & Interactions for PLPP2 Gene

genes like me logo Genes that share pathways with PLPP2: view

Gene Ontology (GO) - Biological Process for PLPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS 9607309
GO:0006665 sphingolipid metabolic process TAS --
GO:0007165 signal transduction IBA --
GO:0030148 sphingolipid biosynthetic process TAS --
genes like me logo Genes that share ontologies with PLPP2: view

No data available for SIGNOR curated interactions for PLPP2 Gene

Drugs & Compounds for PLPP2 Gene

(3) Drugs for PLPP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist Endogenous agonist at S1P1-5 0

(35) Additional Compounds for PLPP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cer(d18:1/26:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • Ceramide (d18:1/24:1(15Z))
104404-17-3
Ceramide (d18:1/12:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • N-Acylsphingosine
104404-17-3
Ceramide (d18:1/16:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • N-Acylsphingosine
104404-17-3
Ceramide (d18:1/20:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • N-Acylsphingosine
104404-17-3
Ceramide (d18:1/24:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • N-Acylsphingosine
104404-17-3
genes like me logo Genes that share compounds with PLPP2: view

Transcripts for PLPP2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP2 Gene

No ASD Table

Relevant External Links for PLPP2 Gene

GeneLoc Exon Structure for
PLPP2
ECgene alternative splicing isoforms for
PLPP2

Expression for PLPP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA Expression by UniProt/SwissProt for PLPP2 Gene

O43688-PLPP2_HUMAN
Tissue specificity: Found mainly in brain, pancreas and placenta.
genes like me logo Genes that share expression patterns with PLPP2: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PLPP2 Gene

Orthologs for PLPP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPAP2C 35
  • 86.17 (n)
  • 90.74 (a)
PPAP2C 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPAP2C 35
  • 87.58 (n)
  • 92.99 (a)
PPAP2C 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppap2c 35
  • 83.91 (n)
  • 90.35 (a)
Plpp2 16
Ppap2c 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPAP2C 35
  • 93.64 (n)
  • 93.2 (a)
PPAP2C 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppap2c 35
  • 83.78 (n)
  • 91.12 (a)
oppossum
(Monodelphis domestica)
Mammalia PPAP2C 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPAP2C 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858471 35
  • 75.12 (n)
  • 76.43 (a)
PPAP2C 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPAP2C 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75849 35
ppap2c 35
  • 70.26 (n)
  • 77.31 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29343 35
zebrafish
(Danio rerio)
Actinopterygii LOC563806 35
  • 69.38 (n)
  • 70.93 (a)
wufj16e10 35
ppap2c 36
  • 62 (a)
OneToMany
PPAP2C (1 of 2) 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11425 36
  • 27 (a)
ManyToMany
CG11426 36
  • 27 (a)
ManyToMany
CG11437 36
  • 27 (a)
ManyToMany
CG11438 36
  • 26 (a)
ManyToMany
laza 36
  • 25 (a)
ManyToMany
wun 36
  • 26 (a)
ManyToMany
wun2 36
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F53C3.13 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for PLPP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLPP2 Gene

ENSEMBL:
Gene Tree for PLPP2 (if available)
TreeFam:
Gene Tree for PLPP2 (if available)

Paralogs for PLPP2 Gene

Paralogs for PLPP2 Gene

genes like me logo Genes that share paralogs with PLPP2: view

Variants for PLPP2 Gene

Sequence variations from dbSNP and Humsavar for PLPP2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1138439 - 282,753(-) CTTGG(A/C/G/T)GGTGA reference, missense
rs12976715 -- 288,367(+) CTGCC(C/T)CTCAC intron-variant
rs12977046 -- 289,589(+) tccca(A/G)ctcct intron-variant
rs12977298 -- 289,630(+) ctcag(A/G)aggca intron-variant
rs12977301 -- 289,636(+) aggca(A/G)aggtt intron-variant

Variation tolerance for PLPP2 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.78; 83.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for PLPP2 Gene

Disorders for PLPP2 Gene

Relevant External Links for PLPP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPP2

No disorders were found for PLPP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLPP2 Gene

Publications for PLPP2 Gene

  1. Identification of a novel human phosphatidic acid phosphatase type 2 isoform. (PMID: 9607309) Hooks S.B. … Lynch K.R. (FEBS Lett. 1998) 2 3 4 23 67
  2. Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function. (PMID: 18215144) Long J.S. … Pyne S. (Biochem. J. 2008) 3 23
  3. Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells. (PMID: 9570154) Leung D.W. … White T. (DNA Cell Biol. 1998) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for PLPP2 Gene

Sources for PLPP2 Gene

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