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Aliases for PLPP1 Gene

Aliases for PLPP1 Gene

  • Phospholipid Phosphatase 1 2 3 5
  • Phosphatidate Phosphohydrolase Type 2a 3 4
  • Phosphatidic Acid Phosphatase Type 2A 2 3
  • Phosphatidic Acid Phosphatase 2a 3 4
  • EC 3.1.3.4 4 58
  • PPAP2A 3 4
  • PAP-2a 3 4
  • LPP1 3 4
  • Phosphatidic Acid Phosphohydrolase Type 2a 3
  • Type-2 Phosphatidic Acid Phosphatase Alpha 3
  • Lipid Phosphate Phosphohydrolase 1a 3
  • Lipid Phosphate Phosphohydrolase 1 4
  • PAP2-Alpha 4
  • LLP1a 3
  • PAP2a 4
  • PAP2 3

External Ids for PLPP1 Gene

Previous HGNC Symbols for PLPP1 Gene

  • PPAP2A

Summaries for PLPP1 Gene

Entrez Gene Summary for PLPP1 Gene

  • The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for PLPP1 Gene

PLPP1 (Phospholipid Phosphatase 1) is a Protein Coding gene. Among its related pathways are Metabolism and triacylglycerol biosynthesis. An important paralog of this gene is PLPP2.

UniProtKB/Swiss-Prot for PLPP1 Gene

  • Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. Its down-regulation may contribute to the development of colon adenocarcinoma.

Gene Wiki entry for PLPP1 Gene

Additional gene information for PLPP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLPP1 Gene

Genomics for PLPP1 Gene

Regulatory Elements for PLPP1 Gene

Enhancers for PLPP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H055436 1.4 Ensembl ENCODE dbSUPER 11.4 +96.5 96480 4 NFIB INSM2 KLF17 SIN3A ZEB1 EGR1 RCOR1 FOS EGR2 SP3 RNF138P1 SKIV2L2 PLPP1 DHX29 CCNO GC05M055421 ENSG00000279883
GH05H055632 1.2 Ensembl ENCODE dbSUPER 11.1 -100.4 -100373 6 MAX RAD21 RFX5 YY1 GATA3 POLR2A ZNF350 RCOR1 RUNX3 NR3C1 PLPP1 RNF138P1 SKIV2L2 DHX29 SLC38A9 DDX4 GC05P055648 LOC105378975
GH05H055623 1 Ensembl ENCODE dbSUPER 11.1 -90.1 -90084 3 CEBPA CEBPB RCOR1 CEBPG PLPP1 RNF138P1 SLC38A9 DDX4 LOC105378975 GC05P055648
GH05H055508 0.8 ENCODE dbSUPER 12 +25.4 25401 2 OSR2 CTCF SCRT1 HNF4A PRDM1 NR2F2 RNF138P1 PLPP1 MIR5687
GH05H055494 0.7 ENCODE dbSUPER 12.3 +40.5 40512 0 HNF4A RAD21 RNF138P1 PLPP1 ENSG00000279883 MIR5687
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLPP1 on UCSC Golden Path with GeneCards custom track

Promoters for PLPP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000180761 1070 2201 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 KLF7 RUNX3 SP3 SP5

Genomic Location for PLPP1 Gene

Chromosome:
5
Start:
55,424,842 bp from pter
End:
55,535,370 bp from pter
Size:
110,529 bases
Orientation:
Minus strand

Genomic View for PLPP1 Gene

Genes around PLPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP1 Gene

Proteins for PLPP1 Gene

  • Protein details for PLPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14494-PLPP1_HUMAN
    Recommended name:
    Phospholipid phosphatase 1
    Protein Accession:
    O14494
    Secondary Accessions:
    • B7ZKN8
    • G3XA95
    • O60457
    • O60463
    • Q17RZ4

    Protein attributes for PLPP1 Gene

    Size:
    284 amino acids
    Molecular mass:
    32156 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for PLPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLPP1 Gene

Selected DME Specific Peptides for PLPP1 Gene

O14494:
  • DESIKYP
  • RLSFYSGHSSF
  • SIGRLRPHF
  • HTTLHET
  • ALYLQARM
  • GTFLFGAA
  • SIYVGLSR

Post-translational modifications for PLPP1 Gene

Other Protein References for PLPP1 Gene

Domains & Families for PLPP1 Gene

Gene Families for PLPP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for PLPP1 Gene

Suggested Antigen Peptide Sequences for PLPP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14494

UniProtKB/Swiss-Prot:

PLPP1_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP1: view

Function for PLPP1 Gene

Molecular function for PLPP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sphingosine, zinc ions and propanolol. Not inhibited by N-ethylmaleimide treatment.
UniProtKB/Swiss-Prot Function:
Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. Its down-regulation may contribute to the development of colon adenocarcinoma.
UniProtKB/Swiss-Prot Induction:
By androgens.

Enzyme Numbers (IUBMB) for PLPP1 Gene

Gene Ontology (GO) - Molecular Function for PLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008195 phosphatidate phosphatase activity NAS,IEA 9570154
GO:0016787 hydrolase activity IEA --
GO:0042392 sphingosine-1-phosphate phosphatase activity TAS --
GO:0042577 lipid phosphatase activity IBA --
genes like me logo Genes that share ontologies with PLPP1: view
genes like me logo Genes that share phenotypes with PLPP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLPP1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PLPP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLPP1 Gene

Localization for PLPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPP1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA,NAS 9705349
GO:0016020 membrane IDA,IEA 9468526
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PLPP1: view

Pathways & Interactions for PLPP1 Gene

genes like me logo Genes that share pathways with PLPP1: view

Gene Ontology (GO) - Biological Process for PLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0006629 lipid metabolic process IEA,NAS 9705349
GO:0006644 phospholipid metabolic process IBA --
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway TAS 9468526
GO:0008285 negative regulation of cell proliferation NAS 9468526
genes like me logo Genes that share ontologies with PLPP1: view

No data available for SIGNOR curated interactions for PLPP1 Gene

Drugs & Compounds for PLPP1 Gene

(6) Drugs for PLPP1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
sphingosine 1-phosphate Pharma Full agonist, Agonist 0

(37) Additional Compounds for PLPP1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cer(d18:1/26:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • Ceramide (d18:1/24:1(15Z))
104404-17-3
Ceramide (d18:1/12:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • N-Acylsphingosine
104404-17-3
Ceramide (d18:1/16:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • N-Acylsphingosine
104404-17-3
Ceramide (d18:1/20:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • N-Acylsphingosine
104404-17-3
Ceramide (d18:1/24:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • N-Acylsphingosine
104404-17-3
genes like me logo Genes that share compounds with PLPP1: view

Transcripts for PLPP1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PLPP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP1 Gene

No ASD Table

Relevant External Links for PLPP1 Gene

GeneLoc Exon Structure for
PLPP1
ECgene alternative splicing isoforms for
PLPP1

Expression for PLPP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLPP1 Gene:

PLPP1

mRNA Expression by UniProt/SwissProt for PLPP1 Gene:

O14494-PLPP1_HUMAN
Tissue specificity: Ubiquitously expressed with highest expression found in prostate. Isoform 1 is predominant in kidney, lung, placenta and liver. Isoform 2 is predominant in heart and pancreas. Found to be down-regulated in colon adenocarcinomas.

Evidence on tissue expression from TISSUES for PLPP1 Gene

  • Nervous system(4.7)
  • Lung(4.4)
  • Liver(2.6)
  • Gall bladder(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with PLPP1: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPP1 Gene

Orthologs for PLPP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPAP2A 33 34
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia PPAP2A 34
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPAP2A 34
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppap2a 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPAP2A 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPAP2A 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPAP2A 34
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPAP2A 34
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29191 33
zebrafish
(Danio rerio)
Actinopterygii LOC569053 33
  • 63.65 (n)
PPAP2A 34
  • 54 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9193 33
fruit fly
(Drosophila melanogaster)
Insecta wun 33 34
  • 51 (n)
CG11425 34
  • 31 (a)
ManyToMany
CG11426 34
  • 29 (a)
ManyToMany
CG11437 34
  • 28 (a)
ManyToMany
CG11438 34
  • 27 (a)
ManyToMany
laza 34
  • 27 (a)
ManyToMany
wun2 34
  • 27 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012445 33
  • 50.15 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_F53C3.13 33
  • 49.27 (n)
F53C3.13 34
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
OneToMany
Species where no ortholog for PLPP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLPP1 Gene

ENSEMBL:
Gene Tree for PLPP1 (if available)
TreeFam:
Gene Tree for PLPP1 (if available)

Paralogs for PLPP1 Gene

genes like me logo Genes that share paralogs with PLPP1: view

Variants for PLPP1 Gene

Sequence variations from dbSNP and Humsavar for PLPP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000020056 -- 55,430,902(+) GATAT(-/A)AAAAA intron-variant
rs1000073884 -- 55,478,302(+) TTCAT(G/T)TGGGC intron-variant
rs1000075842 -- 55,436,288(+) CATGT(C/T)GTGGG intron-variant
rs1000129336 -- 55,485,135(+) CTGAC(-/AG)AGTCA intron-variant
rs1000131458 -- 55,524,265(+) AGCTT(A/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLPP1 Gene

Variant ID Type Subtype PubMed ID
dgv3090n106 CNV deletion 24896259
esv1622290 CNV insertion 17803354
esv1648958 CNV insertion 17803354
esv1709723 CNV deletion 17803354
esv2436029 CNV insertion 19546169
esv2675371 CNV deletion 23128226
esv2730190 CNV deletion 23290073
esv3565929 CNV deletion 23714750
nsv1074296 CNV deletion 25765185
nsv328978 CNV deletion 16902084
nsv4834 CNV insertion 18451855
nsv830304 CNV gain+loss 17160897

Variation tolerance for PLPP1 Gene

Residual Variation Intolerance Score: 21.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLPP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLPP1 Gene

Disorders for PLPP1 Gene

Relevant External Links for PLPP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPP1

No disorders were found for PLPP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLPP1 Gene

Publications for PLPP1 Gene

  1. Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity. (PMID: 12909631) Smyth SS … Morris AJ (The Journal of biological chemistry 2003) 3 4 22 60
  2. Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. (PMID: 9705349) Roberts R … Morris AJ (The Journal of biological chemistry 1998) 3 4 22 60
  3. Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells. (PMID: 9570154) Leung DW … White T (DNA and cell biology 1998) 3 4 22 60
  4. Identification of the phosphatidic acid phosphatase type 2a isozyme as an androgen-regulated gene in the human prostatic adenocarcinoma cell line LNCaP. (PMID: 9468526) Ulrix W … Verhoeven G (The Journal of biological chemistry 1998) 3 4 22 60
  5. Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase. (PMID: 9305923) Kai M … Kanoh H (The Journal of biological chemistry 1997) 2 3 4 60

Products for PLPP1 Gene

Sources for PLPP1 Gene

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