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Aliases for PLPP1 Gene

Aliases for PLPP1 Gene

  • Phospholipid Phosphatase 1 2 3 5
  • Phosphatidate Phosphohydrolase Type 2a 3 4
  • Phosphatidic Acid Phosphatase Type 2A 2 3
  • Phosphatidic Acid Phosphatase 2a 3 4
  • EC 3.1.3.4 4 63
  • PPAP2A 3 4
  • PAP-2a 3 4
  • LPP1 3 4
  • Phosphatidic Acid Phosphohydrolase Type 2a 3
  • Type-2 Phosphatidic Acid Phosphatase Alpha 3
  • Lipid Phosphate Phosphohydrolase 1a 3
  • Lipid Phosphate Phosphohydrolase 1 4
  • PAP2-Alpha 4
  • LLP1a 3
  • PAP2a 4
  • PAP2 3

External Ids for PLPP1 Gene

Previous HGNC Symbols for PLPP1 Gene

  • PPAP2A

Summaries for PLPP1 Gene

Entrez Gene Summary for PLPP1 Gene

  • The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for PLPP1 Gene

PLPP1 (Phospholipid Phosphatase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Fat digestion and absorption. An important paralog of this gene is PLPPR4.

UniProtKB/Swiss-Prot for PLPP1 Gene

  • Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. Its down-regulation may contribute to the development of colon adenocarcinoma.

Gene Wiki entry for PLPP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLPP1 Gene

Genomics for PLPP1 Gene

Regulatory Elements for PLPP1 Gene

Promoters for PLPP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLPP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLPP1 Gene

Chromosome:
5
Start:
55,424,842 bp from pter
End:
55,535,370 bp from pter
Size:
110,529 bases
Orientation:
Minus strand

Genomic View for PLPP1 Gene

Genes around PLPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP1 Gene

Proteins for PLPP1 Gene

  • Protein details for PLPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14494-PLPP1_HUMAN
    Recommended name:
    Phospholipid phosphatase 1
    Protein Accession:
    O14494
    Secondary Accessions:
    • B7ZKN8
    • G3XA95
    • O60457
    • O60463
    • Q17RZ4

    Protein attributes for PLPP1 Gene

    Size:
    284 amino acids
    Molecular mass:
    32156 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for PLPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLPP1 Gene

Proteomics data for PLPP1 Gene at MOPED

Selected DME Specific Peptides for PLPP1 Gene

Post-translational modifications for PLPP1 Gene

Other Protein References for PLPP1 Gene

Domains & Families for PLPP1 Gene

Gene Families for PLPP1 Gene

Protein Domains for PLPP1 Gene

Suggested Antigen Peptide Sequences for PLPP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14494

UniProtKB/Swiss-Prot:

PLPP1_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP1: view

Function for PLPP1 Gene

Molecular function for PLPP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sphingosine, zinc ions and propanolol. Not inhibited by N-ethylmaleimide treatment.
UniProtKB/Swiss-Prot Function:
Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. Its down-regulation may contribute to the development of colon adenocarcinoma.
UniProtKB/Swiss-Prot Induction:
By androgens.

Enzyme Numbers (IUBMB) for PLPP1 Gene

Gene Ontology (GO) - Molecular Function for PLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042577 lipid phosphatase activity IBA --
genes like me logo Genes that share ontologies with PLPP1: view
genes like me logo Genes that share phenotypes with PLPP1: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLPP1 Gene

Localization for PLPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP1 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for PLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 9468526
genes like me logo Genes that share ontologies with PLPP1: view

No data available for Subcellular locations from COMPARTMENTS for PLPP1 Gene

Pathways & Interactions for PLPP1 Gene

genes like me logo Genes that share pathways with PLPP1: view

Gene Ontology (GO) - Biological Process for PLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0006629 lipid metabolic process IEA,NAS 9705349
GO:0006665 sphingolipid metabolic process TAS --
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway TAS 9468526
GO:0008354 germ cell migration TAS 9305923
genes like me logo Genes that share ontologies with PLPP1: view

No data available for SIGNOR curated interactions for PLPP1 Gene

Drugs & Compounds for PLPP1 Gene

(4) Drugs for PLPP1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist Endogenous agonist at S1P1-5 0

(39) Additional Compounds for PLPP1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cer(d18:1/26:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • Ceramide (d18:1/24:1(15Z))
104404-17-3
Ceramide (d18:1/12:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • N-Acylsphingosine
104404-17-3
Ceramide (d18:1/16:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • N-Acylsphingosine
104404-17-3
Ceramide (d18:1/20:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • N-Acylsphingosine
104404-17-3
Ceramide (d18:1/24:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • N-Acylsphingosine
104404-17-3
genes like me logo Genes that share compounds with PLPP1: view

Transcripts for PLPP1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP1 Gene

No ASD Table

Relevant External Links for PLPP1 Gene

GeneLoc Exon Structure for
PLPP1
ECgene alternative splicing isoforms for
PLPP1

Expression for PLPP1 Gene

mRNA Expression by UniProt/SwissProt for PLPP1 Gene

O14494-PLPP1_HUMAN
Tissue specificity: Ubiquitously expressed with highest expression found in prostate. Isoform 1 is predominant in kidney, lung, placenta and liver. Isoform 2 is predominant in heart and pancreas. Found to be down-regulated in colon adenocarcinomas.
genes like me logo Genes that share expression patterns with PLPP1: view

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PLPP1 Gene

Orthologs for PLPP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPAP2A 35
  • 99.77 (n)
  • 99.65 (a)
PPAP2A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPAP2A 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPAP2A 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPAP2A 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppap2a 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPAP2A 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPAP2A 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPAP2A 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29191 35
zebrafish
(Danio rerio)
Actinopterygii LOC569053 35
  • 63.65 (n)
  • 64.86 (a)
PPAP2A 36
  • 54 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9193 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012445 35
  • 50.15 (n)
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta wun 35
  • 51 (n)
  • 49 (a)
CG11425 36
  • 31 (a)
ManyToMany
CG11426 36
  • 29 (a)
ManyToMany
CG11437 36
  • 28 (a)
ManyToMany
CG11438 36
  • 27 (a)
ManyToMany
laza 36
  • 27 (a)
ManyToMany
wun 36
  • 31 (a)
ManyToMany
wun2 36
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_F53C3.13 35
  • 49.27 (n)
  • 45.02 (a)
F53C3.13 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for PLPP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLPP1 Gene

ENSEMBL:
Gene Tree for PLPP1 (if available)
TreeFam:
Gene Tree for PLPP1 (if available)

Paralogs for PLPP1 Gene

Paralogs for PLPP1 Gene

genes like me logo Genes that share paralogs with PLPP1: view

Variants for PLPP1 Gene

Sequence variations from dbSNP and Humsavar for PLPP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs189122 -- 55,426,608(-) CAACA(C/T)AGTGA intron-variant
rs230737 -- 55,431,833(-) atttc(A/G)tttat intron-variant
rs230738 -- 55,431,610(-) ttgtt(G/T)ttggg intron-variant
rs230739 -- 55,430,078(-) tggtg(A/G)tagca intron-variant
rs230740 -- 55,429,609(-) gactc(A/G)ggggg intron-variant

Variation tolerance for PLPP1 Gene

Residual Variation Intolerance Score: 21.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLPP1 Gene

HapMap Linkage Disequilibrium report
PLPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PLPP1 Gene

Disorders for PLPP1 Gene

Relevant External Links for PLPP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPP1

No disorders were found for PLPP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLPP1 Gene

Publications for PLPP1 Gene

  1. Cloning and characterization of two human isozymes of Mg2+- independent phosphatidic acid phosphatase. (PMID: 9305923) Kai M. … Kanoh H. (J. Biol. Chem. 1997) 2 3 4 67
  2. A splicing isoform of LPP1, LPP1a, exhibits high phosphatase activity toward FTY720 phosphate. (PMID: 18755152) Yamanaka M. … Kihara A. (Biochem. Biophys. Res. Commun. 2008) 3 23
  3. The expression of phosphatidic acid phosphatase 2a, which hydrolyzes lipids to generate diacylglycerol, is regulated by p73, a member of the p53 family. (PMID: 17169329) Ishida T. … Shimotohno K. (Biochem. Biophys. Res. Commun. 2007) 3 23
  4. Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity. (PMID: 12909631) Smyth S.S. … Morris A.J. (J. Biol. Chem. 2003) 3 23
  5. Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer. (PMID: 14506139) Tanyi J.L. … Mills G.B. (Clin. Cancer Res. 2003) 3 23

Products for PLPP1 Gene

Sources for PLPP1 Gene

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