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PLP2 Gene

protein-coding   GIFtS: 58
GCID: GC0XP049037

Proteolipid Protein 2 (Colonic Epithelium-Enriched)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proteolipid Protein 2 (Colonic Epithelium-Enriched)1 2     A42 3
A4 Differentiation-Dependent Protein1 2     A4LSB2
Differentiation-Dependent Protein A42 3     Proteolipid Protein 22
Intestinal Membrane A4 Protein2 3     

External Ids:    HGNC: 90871   Entrez Gene: 53552   Ensembl: ENSG000001020077   OMIM: 3001125   UniProtKB: Q049413   

Export aliases for PLP2 gene to outside databases

Previous GC identifers: GC0XP047811 GC0XP047269 GC0XP048054 GC0XP048784 GC0XP048915 GC0XP046685


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLP2 Gene:
This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial
cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of
this gene may be linked to an increased risk of X-linked mental retardation. A pseudogene of this gene is found
on chromosome 5. (provided by RefSeq, Jan 2010)

GeneCards Summary for PLP2 Gene:
PLP2 (proteolipid protein 2 (colonic epithelium-enriched)) is a protein-coding gene. GO annotations related to this gene include chemokine binding and ion transmembrane transporter activity. An important paralog of this gene is CMTM5.

UniProtKB/Swiss-Prot: PLP2_HUMAN, Q04941
Function: May play a role in cell differentiation in the intestinal epithelium

Gene Wiki entry for PLP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_079573.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLP2 gene promoter:
         Bach1   ER-alpha   Tal-1   Tal-1beta   YY1   E47   RORalpha1   HEN1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLP2 promoter sequence
   Search Chromatin IP Primers for PLP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

PLP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLP2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP049037:  view genomic region     (about GC identifiers)

Start:
49,028,184 bp from pter      End:
49,031,588 bp from pter
Size:
3,405 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PLP2_HUMAN, Q04941 (See protein sequence)
Recommended Name: Proteolipid protein 2  
Size: 152 amino acids; 16691 Da
Secondary accessions: A6NDT7 Q32MM8
Alternative splicing: 2 isoforms:  Q04941-1   Q04941-2   

Explore the universe of human proteins at neXtProt for PLP2: NX_Q04941

Explore proteomics data for PLP2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn18, Asn108, Thr141, Thr145
  • Modification sites at PhosphoSitePlus

  • See PLP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002659.1  
    ENSEMBL proteins: 
     ENSP00000365500   ENSP00000365505  

    PLP2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PLP2

     
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    antibodies-online proteins for PLP2 (2 products) 

     
    antibodies-online peptides for PLP2

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    antibodies-online antibodies for PLP2 (5 products) 

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    antibodies-online kits for PLP2 (11 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008253 Marvel

    Graphical View of Domain Structure for InterPro Entry Q04941

    ProtoNet protein and cluster: Q04941

    1 Blocks protein domain: IPB008253 Marvel

    UniProtKB/Swiss-Prot: PLP2_HUMAN, Q04941
    Similarity: Contains 1 MARVEL domain


    Find genes that share domains with PLP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLP2_HUMAN, Q04941
    Function: May play a role in cell differentiation in the intestinal epithelium

         Genatlas biochemistry entry for PLP2:
    proteolipid protein 2,50kDa,differentially expressed in colonic epithelial cell lines

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15474493
    GO:0015075ion transmembrane transporter activity TAS9124532
    GO:0019956chemokine binding IPI15474493
         
    Find genes that share ontologies with PLP2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PLP2:
     G0/1 arrest  Increased G1 DNA content 

         1 MGI phenotypic allele for Plp2 (no phenotypes)

    Find genes that share phenotypes with PLP2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLP2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLP2

    miRNA
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    miRTarBase miRNAs that target PLP2:
    hsa-mir-124-3p (MIRT002655), hsa-mir-221-3p (MIRT046849)

    Block miRNA regulation of human, mouse, rat PLP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLP2 (see all 10):
    hsa-miR-3678-3p hsa-miR-588 hsa-miR-765 hsa-miR-7 hsa-miR-3159 hsa-miR-664 hsa-miR-124 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidPLP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PLP2

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    GenScript: all cDNA clones in your preferred vector (see all 4): PLP2 (NM_001142276)
    Sino Biological Human cDNA Clone for PLP2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLP2_HUMAN, Q04941: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum4
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS9124532
    GO:0005789endoplasmic reticulum membrane TAS9124532
    GO:0005886plasma membrane IDA15474493
    GO:0016020membrane TAS9124532
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PLP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLP2
    Interactions:

        GeneGlobe Interaction Network for PLP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for PLP2 (Q049411, 2, 3 ENSP000003655054) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCR1P322461, 3, ENSP000002961404EBI-608347,EBI-608322 I2D: score=4 STRING: ENSP00000296140
    BCAP31P515723, ENSP000003923304I2D: score=1 STRING: ENSP00000392330
    SHBGP042783, ENSP000003698164I2D: score=3 STRING: ENSP00000369816
    IKBKAPO951633, ENSP000003637794I2D: score=4 STRING: ENSP00000363779
    PRKAB1Q9Y4783, ENSP000002293284I2D: score=1 STRING: ENSP00000229328
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS9124532
    GO:0006935chemotaxis NAS15474493
    GO:0019221cytokine-mediated signaling pathway NAS15474493
    GO:0034220ion transmembrane transport TAS9124532

    Find genes that share ontologies with PLP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PLP2

    1 Novoseek inferred chemical compound relationship for PLP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 8.92 2 10803608 (1), 10686543 (1)



    Find genes that share compounds with PLP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLP2 gene: 
    NM_002668.2  

    Unigene Cluster for PLP2:

    Proteolipid protein 2 (colonic epithelium-enriched)
    Hs.77422  [show with all ESTs]
    Unigene Representative Sequence: BF214130
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376322 ENST00000376327(uc004dmx.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat PLP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLP2 (see all 10):
    hsa-miR-3678-3p hsa-miR-588 hsa-miR-765 hsa-miR-7 hsa-miR-3159 hsa-miR-664 hsa-miR-124 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidPLP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PLP2
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    GenScript: all cDNA clones in your preferred vector (see all 4): PLP2 (NM_001142276)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLP2
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    OriGene qPCR primer pairs and template standards for PLP2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLP2
      QuantiTect SYBR Green Assays in human, mouse, rat PLP2
      QuantiFast Probe-based Assays in human, mouse, rat PLP2

    Additional mRNA sequence: 

    BC109066.2 L09604.1 

    14 DOTS entries:

    DT.92420263  DT.100804052  DT.100030701  DT.95269870  DT.100804053  DT.92451792  DT.100711406  DT.102822518 
    DT.86836943  DT.92451754  DT.95269875  DT.95269876  DT.100770022  DT.95269871 

    Selected AceView cDNA sequences (see all 474):

    BF971130 BQ574511 CA488812 AA430526 BQ430177 BM789726 AW328355 BQ128117 
    AW001996 CD742701 BU621686 AA285059 CA455118 BQ084286 CA305972 BX280119 
    BQ021320 BQ944039 CA437193 BU158556 AW304217 BM824229 BM541251 CR607707 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PLP2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b
    SP1:                                -     -                     
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            


    ECgene alternative splicing isoforms for PLP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCCACCTA
    PLP2 Expression
    About this image


    PLP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Peripheral Nervous System (Nervous System)
             Immature Schwann Cells Peripheral Nerve Domain
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
    PLP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.77422

    UniProtKB/Swiss-Prot: PLP2_HUMAN, Q04941
    Tissue specificity: Enriched in colonic mucosa. The expression of A4 follows a gradient along the crypto-villus
    axis with the most abundant message occurring in the lower half of the crypt

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PLP2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plp21 , 5 proteolipid protein 21, 5 84.33(n)1
    80.13(a)1
      X (3.45 cM)5
    188241  NM_019755.41  NP_062729.11 
     76679415 
    lizard
    (Anolis carolinensis)
    Reptilia PLP26
    proteolipid protein 2 (colonic epithelium-enriched...
    44(a)
    1 ↔ 1
    1(205832723-205877236)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia plp21 proteolipid protein 2 (colonic epithelium-enriched) 53.11(n)
    42.67(a)
      733483  NM_001044427.1  NP_001037892.1 
    zebrafish
    (Danio rerio)
    Actinopterygii plp21 proteolipid protein 2 55.78(n)
    46.26(a)
      798079  NM_001161445.1  NP_001154917.1 


    ENSEMBL Gene Tree for PLP2 (if available)
    TreeFam Gene Tree for PLP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLP2 gene
    CMTM52  CMTM32  

    Find genes that share paralogs with PLP2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for PLP2
    PGOHUM00000244348 PGOHUM00000235484


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLP2 (see all 92)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1443417841,2
    --46683478(+) TTGAGA/GTCAGG 1 -- us2k10--------
    rs1886070521,2
    --48945858(+) CACCCC/TAGGAG 1 -- us2k10--------
    rs736342141,2
    C,F--48945927(+) TGTGCT/CGACTG 1 -- us2k11Minor allele frequency- C:0.00WA 2
    rs1929624061,2
    --48946060(+) TTTTTA/TAAATA 1 -- us2k10--------
    rs1856673601,2
    --48946231(+) ACTCAA/GTGCTC 1 -- us2k10--------
    rs1905396861,2
    --48946363(+) TTTTCC/TCACAA 1 -- us2k10--------
    rs1912546461,2
    --48946584(+) GGCACA/GTGCCA 1 -- us2k10--------
    rs1837767411,2
    --48946591(+) GCCACC/TATGCC 1 -- us2k10--------
    rs776980001,2
    C--48946747(+) CCTGAC/TTAGCT 1 -- us2k10--------
    rs759141741,2
    C--48947334(+) TGTTTC/TTCCAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PLP2 (49028184 - 49031588 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PLP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv528292CNV Gain19592680
    esv32909CNV Gain+Loss17666407
    nsv7442OTHER Inversion18451855
    nsv205OTHER Inversion15895083

    Human Gene Mutation Database (HGMD): PLP2
    Locus Specific Mutation Databases (LSDB): PLP2

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300112    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for PLP2:
    Severe acute respiratory syndrome

    Find genes that share disorders with PLP2           About GenesLikeMe


    Export disorders for PLP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for PLP2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with PLP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a differentiation-dependent gene in the human colonic cell line HT29-18. (PubMed id 8470895)1, 2, 3 Oliva M.M.... Yang V.W. (Arch. Biochem. Biophys. 1993)
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1, 2 Kimura K.... Sugano S. (Genome Res. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp. (PubMed id 9344658)1, 2 Fisher S.E.... Craig I.W. (Genomics 1997)
    5. Promoter regulation of a differentially expressed gene in the human colonic epithelial cell lines HT29-18 and HT29-18-C1. (PubMed id 7622043)1, 3 Oliva M.M....Yang V.W. (Gene 1995)
    6. Colonic epithelium-enriched protein A4 is a proteolipid that exhibits ion channel characteristics. (PubMed id 9124532)1, 9 Breitwieser G.E....Yang V.W. (Am. J. Physiol. 1997)
    7. PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells. (PubMed id 15474493)1, 9 Lee S.M....Kim J. (Biochem. Biophys. Res. Commun. 2004)
    8. Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. (PubMed id 23142642)1 Passantino R....Guarneri P. (Biochim. Biophys. Acta 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Viral immune modulators perturb the human molecular network by common and unique strategies. (PubMed id 22810585)1 Pichlmair A....Superti-Furga G. (Nature 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5355 HGNC: 9087 AceView: PLP2 Ensembl:ENSG00000102007 euGenes: HUgn5355
    ECgene: PLP2 H-InvDB: PLP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PLP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLP2 gene:
    Search GeneIP for patents involving PLP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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