PLOD3 Gene
protein-coding GIFtS: 65
GCID: GC07M100849
|
|
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
| |
Aliases
for PLOD3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 31 2 | | Lysine Hydroxylase 32 | | LH31 2 3 | | Lysyl Hydroxlase 32 | | Lysyl Hydroxylase 32 3 | | Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 32 | | EC 1.14.11.43 8 | | |
Export aliases for PLOD3 gene to outside databasesPrevious GC identifers: GC07M099332 GC07M100395 GC07M100409 GC07M100442 GC07M100635 GC07M095442 |
Summaries
for PLOD3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PLOD3:
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the roughendoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues incollagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thusare critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB havedeficiencies in lysyl hydroxylase activity. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PLOD3_HUMAN, O60568Function: Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites ofattachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links
Gene Wiki entry for PLOD3
|
Genomic Views
for PLOD3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PLOD3 gene promoter:
p53 p300 NRSF form 1 HTF NRSF form 2 FOXL1 YY1 CREB deltaCREB Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for PLOD3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLOD3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1PLOD3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M100849: view genomic region
(about GC identifiers)
Start:
|
100,849,258 bp from pter |
End:
|
100,861,701 bp from pter |
Size:
|
12,444 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 100,207,645-100,219,398 |
|
Proteins
for PLOD3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PLOD3_HUMAN, O60568 (See
protein sequence)Recommended Name: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 precursor Size: 738 amino acids; 84785 Da
Cofactor: Iron
Cofactor: Ascorbate
Subunit: Homodimer
Subcellular location: Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side
Secondary accessions: B2R6W6 Q540C3Explore the universe of human proteins at neXtProt for PLOD3: NX_O60568
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60568
4/14 DME Specific Peptides for PLOD3 (O60568) (see all 14)
PLOD3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001075.1
ENSEMBL proteins: ENSP00000407555 ENSP00000223127 ENSP00000394045 ENSP00000407908 ENSP00000404799 ENSP00000407551 ENSP00000416070 Reactome Protein details: O60568
Human Recombinant Protein Products for PLOD3:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
PLOD3 for ontologies About GeneDecksing
PLOD3 Antibody Products:
Assay Products for PLOD3: |
Protein
Domains /
Families
for PLOD3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PLOD3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O60568ProtoNet protein and cluster: O60568 2 Blocks protein families: IPB001006 Procollagen-lysine 5-dioxygenase IPB006620 Prolyl 4-hydroxylase
UniProtKB/Swiss-Prot: PLOD3_HUMAN, O60568Similarity: Contains 1 Fe2OG dioxygenase domain |
Function
for PLOD3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PLOD3_HUMAN, O60568Function: Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites ofattachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-linksCatalytic activity: L-lysine-[procollagen] + 2-oxoglutarate + O(2) = (2S,5R)-5-hydroxy-L-lysine-[procollagen] +succinate + CO(2) Genatlas biochemistry entry for PLOD3:procollagen-lysine,2-oxoglutarate 5 dioxygenase 3,highly expressed in heart,placenta,pancreas
Enzyme Number (IUBMB): EC 1.14.11.41 2
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005506 | iron ion binding |
IEA | -- | | GO:0005515 | protein binding |
IPI | 16189514 | | GO:0008475 | procollagen-lysine 5-dioxygenase activity |
IEA | -- | | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
IEA | -- | | GO:0031418 | L-ascorbic acid binding |
IEA | -- |
PLOD3 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for PLOD3:
10 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Plod3):
PLOD3 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Plod3tm1Rmyl for PLOD3
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLOD3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLOD3 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PLOD3 (NM_001084) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PLOD3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLOD3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLOD3 |
|
Pathways & Interactions
for PLOD3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Collagen formation | | | 2 | Lysine degradation | | | 3 | Glucuronidation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for PLOD3
2 
Kegg Pathways (Kegg details for PLOD3):
PLOD3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLOD3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/99 Interacting proteins for PLOD3 (O605681, 2, 3 ENSP000002231274) via UniProtKB, MINT, STRING, and/or I2D (see all 99)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| RHOXF2 | Q9BQY41, 2, 3, ENSP000003604414 | EBI-741582,EBI-372094 MINT-66268 I2D:
score=6 STRING: ENSP00000360441 | | CCDC85B | Q158342, 3, ENSP000003116954 | MINT-66181 I2D:
score=5 STRING: ENSP00000311695 | | EHMT2 | Q96KQ72, 3, ENSP000003646874 | MINT-67128 I2D:
score=5 STRING: ENSP00000364687 | | DPPA2 | Q7Z7J52, 3 | MINT-68384 I2D:
score=4 | | MYC | P011063, ENSP000003672074 | I2D:
score=3 STRING: ENSP00000367207 |
About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
PLOD3 for ontologies About GeneDecksing
|
Drugs & Compounds
for PLOD3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PLOD3 for compounds About GeneDecksing
 Browse Tocris compounds for PLOD3
9 HMDB Compounds for PLOD3 About this table
2 DrugBank Compounds for PLOD3 About this table
2 Novoseek chemical compound relationships for PLOD3 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| pyridinoline |
59.9 |
1 |
15908192 (1) |
| lysine |
58.8 |
5 |
10457259 (1), 15523625 (1), 20470363 (1) |
Search CenterWatch for drugs/clinical trials and news about PLOD3
|
Transcripts
for PLOD3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PLOD3 gene: NM_001084.4 Unigene Cluster for PLOD3: Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 Hs.153357 [show with all ESTs]Unigene Representative Sequence: NM_00108416 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000454310 ENST00000223127(uc003uyd.3) ENST00000487563 ENST00000460132
ENST00000440925 ENST00000466881 ENST00000421736 ENST00000463479 ENST00000478082
ENST00000460475 ENST00000478264 ENST00000424135 ENST00000489927 ENST00000414785
ENST00000456079 ENST00000481461
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLOD3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLOD3 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PLOD3 (NM_001084) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PLOD3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLOD3 |
Additional cDNA sequence: AF046889.1 AF068229.1 AK075338.1 AK297559.1 AK298537.1 AK312743.1 AL049952.1 AY220458.1 BC011674.2 BC018946.2 24 DOTS entries: DT.446678 DT.97860330 DT.95282626 DT.91761063 DT.121126449 DT.100038114 DT.100788312 DT.121126473 DT.121126568 DT.97842928 DT.100038113 DT.95260306 DT.100791405 DT.317183 DT.91764386 DT.95252861 DT.121126511 DT.91764384 DT.91764387 DT.95161326 DT.100788310 DT.100841654 DT.121126500 DT.91649100 24/432 AceView cDNA sequences (see all 432): BQ278638 CA489284 CA941851 BM928353 BM755939 AI365391 BU858096 BG059942 AI092891 BM759640 BM762504 BM829528 BM762600 BM851151 AV720827 BM128324 CF131926 BU538608 BM796391 BM842756 CA420695 AI266246 BU151410 BG180459
GeneLoc Exon Structure
|
Expression
for PLOD3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PLOD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCGCGTGC
About this image
See PLOD3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLOD3
SOURCE GeneReport for Unigene cluster: Hs.153357
SABiosciences Expression via Pathway-Focused PCR Array including PLOD3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLOD3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PLOD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLOD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLOD3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLOD3 |
Orthologs
for PLOD3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PLOD3 gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
PLOD36 |
-- |
74(a) |
1 ↔ 1 |
GL343466.1(15211-31548) |
African clawed frog
(Xenopus laevis) |
Amphibia |
plod-prov2 |
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 |
75.26(n) |
|
BC043893.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufa10a052 |
wufa10a05 |
77.49(n) |
|
334935 BU808678.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG61993
Plod1 |
procollagen-lysine 5-dioxygenase3
procollagen lysyl hydroxylase1 |
46(a)3
55.14(n)1
47.03(a)1 |
|
68B13
392651 NM_140194.11 NP_648451.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
let-2681 , 3 |
procollagen-lysine,2-oxoglutarate
5-dioxygenase more3
Protein LET-2681 |
46(a)3
51.66(n)1
47.69(a)1 |
|
II(10033358-10038027)3
1745641 NM_063769.21 NP_496170.11 |
ENSEMBL Gene Tree for PLOD3 (if available)
TreeFam Gene Tree for PLOD3 (if available) |
Paralogs
for PLOD3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PLOD3 gene
- GLT25D12 GLT25D22 PLOD22 CERCAM2 PLOD12
4 SIMAP similar genes for PLOD3 using alignment to 7 protein entries: PLOD3_HUMAN (see all proteins):DKFZp564O1822 PLOD2 PLOD1 GLT25D2
PLOD3 for paralogs About GeneDecksing
|
Genomic Variants
for PLOD3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PLOD3 (100849258 - 100861701 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PLOD3
3 CNVs: 5244 8576 5245
Human Gene Mutation Database (HGMD): PLOD3
Locus Specific Mutation Databases (LSDB): PLOD3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLOD3 |
|
Disorders
/ Diseases
for PLOD3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PLOD3 for disorders About GeneDecksing
OMIM gene information: 603066
OMIM disorders: 612394
UniProtKB/Swiss-Prot: PLOD3_HUMAN, O60568
Defects in PLOD3 are the cause of lysyl hydroxylase 3 deficiency (LH3 deficiency) [MIM:612394]; also known asbone fragility with contractures arterial rupture and deafness. LH3 deficiency is a connective tissue disorder. Thesyndrome is characterized by congenital malformations severely affecting many tissues and organs and revealingfeatures of several collagen disorders, most of them involving COL2A1 (type II collagen). The findings suggest thatthe failure of lysyl hydroxylation and hydroxylysyl carbohydrate addition, which affects many collagens, is themolecular basis of this syndrome
7  diseases for PLOD3: About MalaCardsehlers-danlos syndrome lysyl hydroxylase 3 deficiency ullrich congenital muscular dystrophy congenital muscular dystrophy
muscular dystrophy pharyngitis fibrosis
2 diseases from the University of Copenhagen DISEASES database for PLOD3:Ehlers-Danlos syndrome Ullrich congenital muscular dystrophy 1 Novoseek disease relationship for PLOD3 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ehlers-danlos syndrome |
70.4 |
1 |
9724729 (1) |
Human Genome Epidemiology (HuGE) Navigator: PLOD3 (1 document)
Export disorders for PLOD3 gene to outside databases
|
Publications
for PLOD3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PLOD3 gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with PLOD3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Primary structure, tissue distribution, and chromosomal localization of a novel isoform of lysyl hydroxylase (lysyl hydroxylase 3). (PubMed id 9582318)1, 2, 3, 9 Valtavaara M.... Myllylae R. (1998)
- Cloning and characterization of a third human lysyl hydroxylase isoform. (PubMed id 9724729)1, 2, 3, 9 Passoja K.... Kivirikko K.I. (1998)
- Complete exon-intron organization of the gene for human lysyl hydroxylase 3 (LH3). (PubMed id 10686427)1, 2, 9 Rautavuoma K.... Kivirikko K.I. (2000)
- A connective tissue disorder caused by mutations of the lysyl hydroxylase 3 gene. (PubMed id 18834968)1, 2, 9 Salo A.M.... Myllylae R. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- The glycosyltransferase activities of lysyl hydroxylase 3 (LH3) in the extracellular space are important for cell growth and viability. (PubMed id 18298658)1, 9 Wang C....MyllylAo R. (2009)
- Lysyl hydroxylase 3 is a multifunctional protein possessing collagen glucosyltransferase activity. (PubMed id 10934207)1, 9 Heikkinen J....Myllyla R. (2000)
- The third activity for lysyl hydroxylase 3: galactosylation of hydroxylysyl residues in collagens in vitro. (PubMed id 12475640)1, 9 Wang C....Myllyla R. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
|
External Searches for PLOD3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PLOD3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PLOD3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PLOD3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PLOD3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PLOD3 gene:
Search GeneIP for patents involving PLOD3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PLOD3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PLOD3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLOD3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLOD3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PLOD3 | | OriGene 3'-UTR Clone for PLOD3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLOD3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLOD3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PLOD3 | | OriGene Custom Protein Services for PLOD3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PLOD3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLOD3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLOD3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLOD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLOD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLOD3 |
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| | | | Search Tocris compounds for PLOD3 |
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 | | | PLOD3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLOD3 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for PLOD3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLOD3 |
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