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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLN Gene

protein-coding   GIFtS: 62
GCID: GC06P118869

Phospholamban


(Previous symbol: PLB)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
phospholamban1 2
PLB1 2 3 5
CMD1P2 5
CMH182
Cardiac Phospholamban2

External Ids:    HGNC: 90801   Entrez Gene: 53502   Ensembl: ENSG000001985237   OMIM: 1724055   UniProtKB: P266783   

Export aliases for PLN gene to outside databases

Previous GC identifers: GC06P118715 GC06P118892 GC06P118915 GC06P118976 GC06P116451


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLN Gene:
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein
kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum
Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The
subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the
inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac
diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory
congestive heart failure. (provided by RefSeq, Jul 2008)

GeneCards Summary for PLN Gene: 
PLN (phospholamban) is a protein-coding gene. Diseases associated with PLN include pln-related familial hypertrophic cardiomyopathy, and pln-related dilated cardiomyopathy, and among its related super-pathways are Activation of cAMP-Dependent PKA and Hypertrophic cardiomyopathy (HCM). GO annotations related to this gene include ATPase binding and identical protein binding.

UniProtKB/Swiss-Prot: PPLA_HUMAN, P26678
Function: Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic
reticulum

Gene Wiki entry for PLN (Phospholamban) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLN gene promoter:
         CREB   MEF-2A   AP-1   ATF-2   deltaCREB   c-Jun   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLN promoter sequence
   Search SABiosciences Chromatin IP Primers for PLN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.1   Ensembl cytogenetic band:  6q22.31   HGNC cytogenetic band: 6q22.1

PLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLN gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P118869:  view genomic region     (about GC identifiers)

Start:
118,869,442 bp from pter      End:
118,881,893 bp from pter
Size:
12,452 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PPLA_HUMAN, P26678 (See protein sequence)
Recommended Name: Cardiac phospholamban  
Size: 52 amino acids; 6109 Da
Subunit: Homopentamer. Interacts with HAX1
Subcellular location: Mitochondrion membrane; Single-pass membrane protein. Sarcoplasmic reticulum (By similarity)
6/7 PDB 3D structures from and Proteopedia for PLN (see all 7):
1K9N (3D)        1KCH (3D)        1PLN (3D)        1PLP (3D)        1PSL (3D)        1ZLL (3D)    

Explore the universe of human proteins at neXtProt for PLN: NX_P26678

Explore proteomics data for PLN at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may
    stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P26678

  • PLN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLN Protein Expression
    REFSEQ proteins: NP_002658.1  
    ENSEMBL proteins: 
     ENSP00000350132  

    Human Recombinant Protein Products for PLN: 
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    OriGene Protein Over-expression Lysate for PLN
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    OriGene Custom Protein Services for PLN
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    Novus Biologicals PLN Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PLN 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ISS--
    GO:0016020membrane IDA19708671
    GO:0016021integral to membrane IEA--
    GO:0016529sarcoplasmic reticulum ----
    GO:0031966mitochondrial membrane IEA--

    PLN for ontologies           About GeneDecksing



    PLN Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PLN
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    Novus Biologicals PLN Antibodies
    Abcam antibodies for PLN
    Cloud-Clone Corp. Antibodies for PLN 
    ThermoFisher Antibody for PLN
    LSBio Antibodies in human, mouse, rat for PLN 

    Assay Products for PLN: 
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    Cloud-Clone Corp. CLIAs for PLN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR005984 P_lamban

    Graphical View of Domain Structure for InterPro Entry P26678

    ProtoNet protein and cluster: P26678

    1 Blocks protein domain: IPB005984 Phospholamban

    UniProtKB/Swiss-Prot: PPLA_HUMAN, P26678
    Similarity: Belongs to the phospholamban family


    PLN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPLA_HUMAN, P26678
    Function: Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic
    reticulum

         Genatlas biochemistry entry for PLN:
    phospholamban,6.1kDa,mainly expressed in cardiac muscle,also expressed in smooth muscle,phosphoregulated by
    cAMP-dependent and other protein kinases,regulating the activity of the sarcoplasmic Ca++ ATPase (ATP2A2) isoform
    a,regulator of the kinetics of cardiac contraction (diastolic function)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity ISS12032137
    GO:0005246calcium channel regulator activity IEA--
    GO:0005515protein binding IPI15598648
    GO:0042030ATPase inhibitor activity ISS--
    GO:0042802identical protein binding ISS--
         
    PLN for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pln):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  mortality/aging  muscle 

    PLN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Plntm1Egk for PLN

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PLN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PLN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLN 
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    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate PLN (see all 9):
    hsa-miR-433 hsa-miR-579 hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-3122 hsa-miR-3913-5p hsa-miR-573 hsa-miR-3915
    SwitchGear 3'UTR luciferase reporter plasmidPLN 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PLN About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2Hypertrophic cardiomyopathy (HCM)
    Dilated cardiomyopathy0.75
    3Signal transduction cAMP signaling
    Signal transduction cAMP signaling0.44
    4Calcium Regulation in the Cardiac Cell
    Calcium Regulation in the Cardiac Cell0.43
    5Erythropoietin Pathway
    Beta-Adrenergic Signaling0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for PLN
        Signal transduction Calcium signaling
    Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLN
        Activation of PKA through GPCR
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA
    Beta-Adrenergic Signaling

    2 Cell Signaling Technology (CST) Pathways for PLN
        Ca, cAMP and Lipid Signaling
    Angiogenesis

    3 GeneGo (Thomson Reuters) Pathways for PLN
        Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Signal transduction Calcium signaling

    2 BioSystems Pathways for PLN
        Calcium Regulation in the Cardiac Cell
    Integrated Pancreatic Cancer Pathway

    1 PharmGKB Pathway for PLN
        Antiarrhythmic Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for PLN):
        Calcium signaling pathway
    Dilated cardiomyopathy


    PLN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PLN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/14 Interacting proteins for PLN (P266781, 3 ENSP000003501324) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DMPKQ090131, 3, ENSP000003459974EBI-692836,EBI-692774 I2D: score=2 STRING: ENSP00000345997
    PRKACAP176123, ENSP000003095914I2D: score=1 STRING: ENSP00000309591
    S100A1P232973, ENSP000002921694I2D: score=1 STRING: ENSP00000292169
    ATP2A1O149833, ENSP000003495954I2D: score=2 STRING: ENSP00000349595
    SLNO006313, ENSP000003047074I2D: score=2 STRING: ENSP00000304707
    About this table

    Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002026regulation of the force of heart contraction IC19708671
    GO:0006816calcium ion transport IEA--
    GO:0006874cellular calcium ion homeostasis ----
    GO:0008015blood circulation NAS8406504
    GO:0008016regulation of heart contraction IMP16432188

    PLN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PLN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PLN (PPLA)

    1 HMDB Compound for PLN    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for PLN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 36 16 15049694 (6), 8406504 (1), 15640069 (1), 15358683 (1) (see all 6)
    lipid 0 5 9062126 (4)

    Search CenterWatch for drugs/clinical trials and news about PLN / PPLA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLN gene: 
    NM_002667.3  

    Unigene Cluster for PLN:

    Phospholamban
    Hs.170839  [show with all ESTs]
    Unigene Representative Sequence: NM_002667
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000357525(uc003pye.3)
    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate PLN (see all 9):
    hsa-miR-433 hsa-miR-579 hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-3122 hsa-miR-3913-5p hsa-miR-573 hsa-miR-3915
    SwitchGear 3'UTR luciferase reporter plasmidPLN 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK311799.1 BC005269.1 M60411.1 M63603.1 

    7 DOTS entries:

    DT.450591  DT.100792140  DT.121381779  DT.102828292  DT.100792141  DT.95268199  DT.121381742 

    24/341 AceView cDNA sequences (see all 341):

    BE221753 AI969945 M63603 T29219 M60411 AL601171 AL600027 AI810312 
    AL600531 AA470416 AL601164 BQ880927 AW013864 NM_002667 AA399005 CB963226 
    AU121180 AJ709272 CB045392 R58598 AI668637 AL600559 AI129671 BI819558 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLN expression in normal human tissues (normalized intensities)      PLN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGTTAGGG
    PLN Expression
    About this image


    PLN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 6 entries
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...
             heart/ventricle   
     
     Lower Urinary Tract (Urinary System)
             visceral organ   
     
     Oral Cavity (Gastrointestinal Tract)
             TONGUE   
     
     Placenta (Extraembryonic Tissues)
             Decidua-derived mesenchymal cells
     
     Blood (Cardiovascular System)
             mouse/organ system/cardiovascular system   

    See PLN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLN

    SOURCE GeneReport for Unigene cluster: Hs.170839

    UniProtKB/Swiss-Prot: PPLA_HUMAN, P26678
    Tissue specificity: Heart

        SABiosciences Expression via Pathway-Focused PCR Arrays including PLN: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cardiotoxicity in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PLN gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pln1 , 5 phospholamban1, 5 87.82(n)1
    98.08(a)1
      10 (27.11 cM)5
    188211  NM_001141927.11  NP_001135399.11 
     533376865 
    chicken
    (Gallus gallus)
    Aves PLN6
    cardiac phospholamban
    85(a)
    1 ↔ 1
    3(62380777-62388473)
    lizard
    (Anolis carolinensis)
    Reptilia PLN6
    Uncharacterized protein
    85(a)
    1 ↔ 1
    1(184997977-184998132)


    ENSEMBL Gene Tree for PLN (if available)
    TreeFam Gene Tree for PLN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in PLN are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0259894
    Cardiomyopathy, dilated 1P (CMD1P)4--see VAR_0259892 R C mis40--------

    HapMap Linkage Disequilibrium report for PLN (118869442 - 118881893 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PLN:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv274179CNV Insertion20981092
    esv275552CNV Loss21479260
    nsv525179CNV Gain19592680


    Human Gene Mutation Database (HGMD): PLN
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PLN
    DNA2.0 Custom Variant and Variant Library Synthesis for PLN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 172405   
    OMIM disorders: 609909  
    UniProtKB/Swiss-Prot: PPLA_HUMAN, P26678
  • Cardiomyopathy, dilated 1P (CMD1P) [MIM:609909]: A disorder characterized by ventricular dilation and
    impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of
    premature death. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Cardiomyopathy, familial hypertrophic 18 (CMH18) [MIM:613874]: A hereditary heart disorder characterized
    by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The
    symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by
    exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high
    risk of cardiac failure and sudden cardiac death. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 15 diseases for PLN:    About MalaCards
    pln-related familial hypertrophic cardiomyopathy    pln-related dilated cardiomyopathy    congestive heart failure    dilated cardiomyopathy
    achalasia    familial hypertrophic cardiomyopathy    hypertrophic cardiomyopathy    resting heart rate
    congenital heart defect    syncope    myotonic dystrophy    vascular disease
    myopathy    pancreatic cancer    pancreatitis

    3 diseases from the University of Copenhagen DISEASES database for PLN:
    Heart disease     Vascular disease     Familial hypertrophic cardiomyopathy

    PLN for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for PLN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dilated cardiomyopathy 60.9 6 12639993 (1), 14507721 (1), 15640069 (1), 16235537 (1) (see all 5)
    heart failure 54.3 5 9790566 (1), 12639993 (1), 14507721 (1), 15582584 (1)
    hypertrophy 27 1 17517351 (1)
    cardiomyopathy 22.8 2 16382369 (1), 16829191 (1)

    GeneTests: PLN
    GeneReviews: PLN
    Genetic Association Database (GAD): PLN
    Human Genome Epidemiology (HuGE) Navigator: PLN (18 documents)

    Export disorders for PLN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLN gene, integrated from 9 sources (see all 100):
    (articles sorted by number of sources associating them with PLN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy. (PubMed id 12705874)1, 2, 4 Minamisawa S....Matsuoka R. (2003)
    2. Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6. (PubMed id 1828805)1, 2, 3 Fujii J.... Maclennan D.H. (1991)
    3. [Association between mutation of phospholamban gene and dilated cardiomyopathy.] (PubMed id 15640069)1, 4, 9 Zhao C.X....Wang D.W. (2004)
    4. [Association between phospholamban gene mutation and dilated cardiomyopathy in the Chengdu area] (PubMed id 16235537)1, 4, 9 Chen X.Y....Wang B. (2005)
    5. Phospholamban gene mutations are not associated with hypertrophic cardiomyopathy in a Northern Greek population. (PubMed id 16382369)1, 4, 9 Kalemi T....Louridas G. (2005)
    6. PLN-encoded phospholamban mutation in a large cohort of hypertrophic cardiomyopathy cases: summary of the literature and implication s for genetic testing. (PubMed id 21167350)1, 4 Landstrom A.P....Ackerman M.J. (2011)
    7. A novel custom resequencing array for dilated cardiom yopathy. (PubMed id 20474083)1, 4 Zimmerman R.S....Funke B.H. (2010)
    8. No evidence for an association between the -36A>C phospholamban gene polymorphism and a worse prognosis in heart failure. (PubMed id 19638213)1, 4 Santos D.G....Pereira A.C. (2009)
    9. Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide a ssociation studies. (PubMed id 19587794)1, 4 Nolte I.M....Jamshidi Y. (2009)
    10. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. (PubMed id 19305409)1, 4 Pfeufer A....Chakravarti A. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5350 HGNC: 9080 AceView: PLN Ensembl:ENSG00000198523 euGenes: HUgn5350
    ECgene: PLN Kegg: 5350 H-InvDB: PLN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLN Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PLN

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLN gene:
    Search GeneIP for patents involving PLN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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