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PLN Gene

protein-coding   GIFtS: 61
GCID: GC06P118869

Phospholamban


(Previous symbol: PLB)
  See PLN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
phospholamban1 2
PLB1 2 3 5
CMD1P2 5
CMH182 5
Cardiac Phospholamban2

External Ids:    HGNC: 90801   Entrez Gene: 53502   Ensembl: ENSG000001985237   OMIM: 1724055   UniProtKB: P266783   

Export aliases for PLN gene to outside databases

Previous GC identifers: GC06P118715 GC06P118892 GC06P118915 GC06P118976 GC06P116451


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLN Gene:
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein
kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum
Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The
subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the
inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac
diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory
congestive heart failure. (provided by RefSeq, Jul 2008)

GeneCards Summary for PLN Gene:
PLN (phospholamban) is a protein-coding gene. Diseases associated with PLN include cardiomyopathy, dilated, 1p, and pln-related familial hypertrophic cardiomyopathy. GO annotations related to this gene include ATPase binding and identical protein binding.

UniProtKB/Swiss-Prot: PPLA_HUMAN, P26678
Function: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent
affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological
stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important
role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state
of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation

Gene Wiki entry for PLN (Phospholamban) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLN gene promoter:
         CREB   MEF-2A   AP-1   ATF-2   deltaCREB   c-Jun   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLN promoter sequence
   Search Chromatin IP Primers for PLN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.1   Ensembl cytogenetic band:  6q22.31   HGNC cytogenetic band: 6q22.1

PLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLN gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P118869:  view genomic region     (about GC identifiers)

Start:
118,869,442 bp from pter      End:
118,881,893 bp from pter
Size:
12,452 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PPLA_HUMAN, P26678 (See protein sequence)
Recommended Name: Cardiac phospholamban  
Size: 52 amino acids; 6109 Da
Subunit: Homopentamer. Interacts with HAX1 and ATP2A2
Miscellaneous: For practical reasons, PLN activity is most often studied with ATP2A1 instead of ATP2A2
Selected PDB 3D structures from and Proteopedia for PLN (see all 7):
1K9N (3D)        1KCH (3D)        1PLN (3D)        1PLP (3D)        1PSL (3D)        1ZLL (3D)    

Explore the universe of human proteins at neXtProt for PLN: NX_P26678

Explore proteomics data for PLN at MOPED

Post-translational modifications: 

  • Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by
    CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic
    reticulum calcium uptake in cardiomyocytes1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PLN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002658.1  
    ENSEMBL proteins: 
     ENSP00000350132  

    PLN Human Recombinant Protein Products:

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    Novus Biologicals PLN Protein
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    Cloud-Clone Corp. Proteins for PLN

     
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    antibodies-online proteins for PLN (3 products) 

     
    antibodies-online peptides for PLN

    PLN Antibody Products:

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    PLN Assay Products:

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    antibodies-online kits for PLN (37 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005984 P_lamban

    Graphical View of Domain Structure for InterPro Entry P26678

    ProtoNet protein and cluster: P26678

    1 Blocks protein domain: IPB005984 Phospholamban

    UniProtKB/Swiss-Prot: PPLA_HUMAN, P26678
    Similarity: Belongs to the phospholamban family


    Find genes that share domains with PLN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPLA_HUMAN, P26678
    Function: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent
    affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological
    stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important
    role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state
    of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation

         Genatlas biochemistry entry for PLN:
    phospholamban,6.1kDa,mainly expressed in cardiac muscle,also expressed in smooth muscle,phosphoregulated by
    cAMP-dependent and other protein kinases,regulating the activity of the sarcoplasmic Ca++ ATPase (ATP2A2) isoform
    a,regulator of the kinetics of cardiac contraction (diastolic function)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity ISS12032137
    GO:0005246calcium channel regulator activity IEA--
    GO:0005515protein binding IPI15598648
    GO:0042030ATPase inhibitor activity ISS--
    GO:0042802identical protein binding ISS--
         
    Find genes that share ontologies with PLN           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pln):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  mortality/aging  muscle 

    Find genes that share phenotypes with PLN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Plntm1Egk for PLN

       genOway: Develop your customized and physiologically relevant rodent model for PLN

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PLN (see all 9):
    hsa-miR-433 hsa-miR-579 hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-3122 hsa-miR-3913-5p hsa-miR-573 hsa-miR-3915
    SwitchGear 3'UTR luciferase reporter plasmidPLN 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPLA_HUMAN, P26678: Sarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane;
    Single-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    endoplasmic reticulum4
    cytoskeleton2
    extracellular2
    plasma membrane2
    cytosol1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005783endoplasmic reticulum ISS--
    GO:0016020membrane IDA19708671
    GO:0016021integral component of membrane ----
    GO:0016529sarcoplasmic reticulum ----

    Find genes that share ontologies with PLN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLN About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2Ca-dependent events
    Signal transduction Calcium signaling0.35
    Development Beta adrenergic receptors signaling via cAMP0.32
    3Hypertrophic cardiomyopathy (HCM)
    Dilated cardiomyopathy0.75
    4G Protein Signaling Pathways
    Signal transduction cAMP signaling0.44
    5Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell0.43


    Find genes that share SuperPaths with PLN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PLN
        Activation of PKA through GPCR
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA
    Beta-Adrenergic Signaling

    2 Cell Signaling Technology (CST) Pathways for PLN
        Ca, cAMP and Lipid Signaling
    Angiogenesis

    3 GeneGo (Thomson Reuters) Pathways for PLN
        Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Signal transduction Calcium signaling

    2 BioSystems Pathways for PLN
        Calcium Regulation in the Cardiac Cell
    Integrated Pancreatic Cancer Pathway

    1 PharmGKB Pathway for PLN
        Antiarrhythmic Pathway, Pharmacodynamics

    4 Kegg Pathways  (Kegg details for PLN):
        Calcium signaling pathway
    Adrenergic signaling in cardiomyocytes
    Thyroid hormone signaling pathway
    Dilated cardiomyopathy

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PLN: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PLN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for PLN (P266781, 3 ENSP000003501324) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DMPKQ090131, 3, ENSP000003459974EBI-692836,EBI-692774 I2D: score=2 STRING: ENSP00000345997
    PRKACAP176123, ENSP000003095914I2D: score=1 STRING: ENSP00000309591
    S100A1P232973, ENSP000002921694I2D: score=1 STRING: ENSP00000292169
    ATP2A1O149833, ENSP000003495954I2D: score=2 STRING: ENSP00000349595
    SLNO006313, ENSP000003047074I2D: score=2 STRING: ENSP00000304707
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002026regulation of the force of heart contraction IC19708671
    GO:0006816calcium ion transport IEA--
    GO:0006874cellular calcium ion homeostasis ----
    GO:0008015blood circulation NAS8406504
    GO:0008016regulation of heart contraction IMP16432188

    Find genes that share ontologies with PLN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PLN (PPLA)

    1 HMDB Compound for PLN    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for PLN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 36 16 15049694 (6), 8406504 (1), 15640069 (1), 15358683 (1) (see all 6)
    lipid 0 5 9062126 (4)



    Find genes that share compounds with PLN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLN gene: 
    NM_002667.3  

    Unigene Cluster for PLN:

    Phospholamban
    Hs.170839  [show with all ESTs]
    Unigene Representative Sequence: NM_002667
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000357525(uc003pye.3)
    miRNA
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    hsa-miR-433 hsa-miR-579 hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-3122 hsa-miR-3913-5p hsa-miR-573 hsa-miR-3915
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    Additional mRNA sequence: 

    AK311799.1 BC005269.1 M60411.1 M63603.1 

    7 DOTS entries:

    DT.450591  DT.100792140  DT.121381779  DT.102828292  DT.100792141  DT.95268199  DT.121381742 

    Selected AceView cDNA sequences (see all 341):

    BE044545 AL599452 BE221753 AI684716 AI969945 M63603 T29219 M60411 
    AL601171 AL600027 AU121180 BQ880927 CB045392 R58598 AI668637 AL600559 
    AI129671 BI819558 AI376536 C05636 AA045423 NM_002667 AA909648 AL601344 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGTTAGGG
    PLN Expression
    About this image


    PLN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Cardiomyocyte-like progenitor cells
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Cardiomyocyte precursor cells
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
    PLN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.170839

    UniProtKB/Swiss-Prot: PPLA_HUMAN, P26678
    Tissue specificity: Heart muscle (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PLN: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cardiotoxicity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PLN gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pln5 phospholamban   --   10 (27.11 cM) 53337686 
    chicken
    (Gallus gallus)
    Aves PLN6
    Gallus gallus phospholamban (PLN), mRNA.
    85(a)
    1 ↔ 1
    3(62380777-62388473)
    lizard
    (Anolis carolinensis)
    Reptilia PLN6
    phospholamban
    85(a)
    1 ↔ 1
    1(184997977-184998132)


    ENSEMBL Gene Tree for PLN (if available)
    TreeFam Gene Tree for PLN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for PLN    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0259894
    Cardiomyopathy, dilated 1P (CMD1P)4--see VAR_0259892 R C mis40--------

    HapMap Linkage Disequilibrium report for PLN (118869442 - 118881893 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PLN:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv274179CNV Insertion20981092
    esv275552CNV Loss21479260
    nsv525179CNV Gain19592680

    Human Gene Mutation Database (HGMD): PLN
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 172405   
    OMIM disorders: 609909  613874  
    UniProtKB/Swiss-Prot: PPLA_HUMAN, P26678
  • Cardiomyopathy, dilated 1P (CMD1P) [MIM:609909]: A disorder characterized by ventricular dilation and
    impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of
    premature death. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Cardiomyopathy, familial hypertrophic 18 (CMH18) [MIM:613874]: A hereditary heart disorder characterized
    by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The
    symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by
    exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high
    risk of cardiac failure and sudden cardiac death. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 10 diseases for PLN:    
    About MalaCards
    cardiomyopathy, dilated, 1p    pln-related familial hypertrophic cardiomyopathy    pln-related dilated cardiomyopathy    cardiomyopathy, familial hypertrophic, 18
    congestive heart failure    fructosuria    dilated cardiomyopathy    cardiomyopathy, dilated, 1w
    septic shock    familial hypertrophic cardiomyopathy

    3 diseases from the University of Copenhagen DISEASES database for PLN:
    Heart disease     Vascular disease     Familial hypertrophic cardiomyopathy

    Find genes that share disorders with PLN           About GenesLikeMe

    4 Novoseek inferred disease relationships for PLN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dilated cardiomyopathy 60.9 6 12639993 (1), 14507721 (1), 15640069 (1), 16235537 (1) (see all 5)
    heart failure 54.3 5 9790566 (1), 12639993 (1), 14507721 (1), 15582584 (1)
    hypertrophy 27 1 17517351 (1)
    cardiomyopathy 22.8 2 16382369 (1), 16829191 (1)

    GeneTests: PLN
    GeneReviews: PLN
    Genetic Association Database (GAD): PLN
    Human Genome Epidemiology (HuGE) Navigator: PLN (18 documents)

    Export disorders for PLN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLN gene, integrated from 10 sources (see all 104):
    (articles sorted by number of sources associating them with PLN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy. (PubMed id 12705874)1, 2, 4 Minamisawa S.... Matsuoka R. (Biochem. Biophys. Res. Commun. 2003)
    2. Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6. (PubMed id 1828805)1, 2, 3 Fujii J.... Maclennan D.H. (J. Biol. Chem. 1991)
    3. [Association between mutation of phospholamban gene and dilated cardiomyopathy]. (PubMed id 15640069)1, 4, 9 Zhao C.X....Wang D.W. (Yi Chuan 2004)
    4. [Association between phospholamban gene mutation and dilated cardiomyopathy in the Chengdu area]. (PubMed id 16235537)1, 4, 9 Chen X.Y....Wang B. (Sichuan Da Xue Xue Bao Yi Xue Ban 2005)
    5. Phospholamban gene mutations are not associated with hypertrophic cardiomyopathy in a Northern Greek population. (PubMed id 16382369)1, 4, 9 Kalemi T....Louridas G. (Biochem. Genet. 2005)
    6. Hydrophobic imbalance in the cytoplasmic domain of phospholamban is a determinant for lethal dilated cardiomyopathy. (PubMed id 22427649)1, 2 Ceholski D.K....Young H.S. (J. Biol. Chem. 2012)
    7. PLN-encoded phospholamban mutation in a large cohort of hypertrophic cardiomyopathy cases: summary of the literature and implications for genetic testing. (PubMed id 21167350)1, 4 Landstrom A.P....Ackerman M.J. (Am. Heart J. 2011)
    8. A novel custom resequencing array for dilated cardiomyopathy. (PubMed id 20474083)1, 4 Zimmerman R.S....Funke B.H. (Genet. Med. 2010)
    9. No evidence for an association between the -36A&gt;C phospholamban gene polymorphism and a worse prognosis in heart failure. (PubMed id 19638213)1, 4 Santos D.G....Pereira A.C. (BMC Cardiovasc Disord 2009)
    10. Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. (PubMed id 19587794)1, 4 Nolte I.M....Jamshidi Y. (PLoS ONE 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5350 HGNC: 9080 AceView: PLN Ensembl:ENSG00000198523 euGenes: HUgn5350
    ECgene: PLN Kegg: 5350 H-InvDB: PLN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PLN Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=PLN[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLN gene:
    Search GeneIP for patents involving PLN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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