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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLK5 Gene

protein-coding   GIFtS: 37
GCID: GC19P001525

Polo-Like Kinase 5

(Previous names: polo-like kinase 5 pseudogene, polo-like kinase 5, pseudogene)
(Previous symbol: PLK5P)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Polo-Like Kinase 51 2 3     Polo-Like Kinase 5 Pseudogene1
PLK5P1 2 3     SgK384ps2
Polo-Like Kinase 5, Pseudogene1 2     Inactive Serine/Threonine-Protein Kinase PLK52
PLK-52 3     

External Ids:    HGNC: 270011   Entrez Gene: 1265202   Ensembl: ENSG000001859887   UniProtKB: Q496M53   
ORGUL members:         
NONCODE14:n407145      

Export aliases for PLK5 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PLK5 Gene: 
PLK5 (polo-like kinase 5) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with PLK5 include glioblastoma, and neuronitis. GO annotations related to this gene include protein kinase activity and ATP binding. An important paralog of this gene is PLK4.

UniProtKB/Swiss-Prot: PLK5_HUMAN, Q496M5
Function: Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal
differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011255.14  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for PLK5
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLK5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

PLK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLK5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001525:  view genomic region     (about GC identifiers)

Start:
1,524,073 bp from pter      End:
1,535,455 bp from pter
Size:
11,383 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: PLK5_HUMAN, Q496M5 (See protein sequence)
Recommended Name: Inactive serine/threonine-protein kinase PLK5  
Size: 336 amino acids; 36329 Da
Subcellular location: Nucleus, nucleolus (By similarity). Cytoplasm
Secondary accessions: B3KNR4 Q1ZYM0
Alternative splicing: 2 isoforms:  Q496M5-1   Q496M5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PLK5: NX_Q496M5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q496M5

  • PLK5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001230008.1  
    ENSEMBL proteins: 
     ENSP00000468376   ENSP00000466248   ENSP00000465896  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA--

    PLK5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q496M5

    ProtoNet protein and cluster: Q496M5

    UniProtKB/Swiss-Prot: PLK5_HUMAN, Q496M5
    Domain: The truncated protein kinase domain is predicted to be catalytically inactive; has lost the main
    activatory autophosphorylation site and the conserved key residues involved in phospho-substrate. The C-terminus
    region (containing the POLO box domain) is sufficient for inducing cell cycle arrest
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily
    Similarity: Contains 1 POLO box domain
    Similarity: Contains 1 protein kinase domain


    PLK5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLK5_HUMAN, Q496M5
    Function: Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal
    differentiation
    Induction: Down-regulated in primary brain tumors

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    PLK5 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLK5

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002357defense response to tumor cell IDA--
    GO:0006468protein phosphorylation ----
    GO:0006927transformed cell apoptotic process IMP--
    GO:0007067mitosis IEA--
    GO:0010976positive regulation of neuron projection development IDA--

    PLK5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PLK5

    Search CenterWatch for drugs/clinical trials and news about PLK5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for PLK5 gene (2 alternative transcripts): 
    NM_001011716.1  NM_001243079.1  

    Unigene Cluster for PLK5:

    Polo-like kinase 5
    Hs.195352  [show with all ESTs]
    Unigene Representative Sequence: AK054808
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454744 ENST00000334770(uc002ltf.3 uc002ltg.1 uc010dsm.1)
    ENST00000588430 ENST00000588292
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    Additional mRNA sequence: 

    AK054808.1 BC100791.2 BC100792.1 BC100793.2 DQ424898.1 

    3 DOTS entries:

    DT.70101058  DT.101957799  DT.95218036 

    10 AceView cDNA sequences:

    BI827807 AI621045 AI651075 AK054808 AK122648 H52750 R15160 R41581 
    BG772641 BF364682 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLK5 expression in normal human tissues (normalized intensities)      PLK5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTTCAAC
    PLK5 Expression
    About this image


    PLK5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             retina   
     
     Choroid Plexus (Nervous System)
             Mature Choroid Plexus Cells Choroid Plexus
     
     Brain (Nervous System)
             Mature Choroid Plexus Cells Choroid Plexus

    Genevestigator expression for PLK5

    SOURCE GeneReport for Unigene cluster: Hs.195352

    UniProtKB/Swiss-Prot: PLK5_HUMAN, Q496M5
    Tissue specificity: Expressed in the brain, neurons and glial cells. Also expressed in highly differentiated
    cells, such as the serous acini in the parotid gland, distal and proximal tubules of the kidney, tubules of the
    seminal gland, Kupffer cells and some hepatocytes in the liver, and some cells in the germinal center of lymph
    nodes (at protein level)

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLK5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PLK5 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plk55 polo-like kinase 5 (Drosophila)   --   10 (39.72 cM) 80356459 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC56
    Polo-like kinase with multiple functions in mitosi...
    9(a)
    1 → many
    XIII(269019-271136)


    ENSEMBL Gene Tree for PLK5 (if available)
    TreeFam Gene Tree for PLK5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLK5 gene
    PLK42  PLK22  PLK12  PLK32  
    1 SIMAP similar gene for PLK5 using alignment to 2 protein entries:     PLK5_HUMAN (see all proteins):
    PLK1

    PLK5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/439 SNPs in PLK5 are shown (see all 439)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs767606101,2
    C,F--1522081(+) CACCTG/TCCTCA 1 -- us2k11Minor allele frequency- T:0.06NA 120
    rs1507185471,2
    C--1522187(+) CAGTCC/TGTTAA 1 -- us2k10--------
    rs1836968821,2
    --1522387(+) CAGGCA/GGGTCA 1 -- us2k10--------
    rs26684021,2
    C,H--1522489(+) GGTGGC/TGCATA 1 -- us2k15Minor allele frequency- T:0.11NA CSA 9
    rs351312511,2
    C,F--1522595(+) CAGCCT/CGGGTG 1 -- us2k17Minor allele frequency- C:0.23NA WA CSA 13
    rs608499591,2
    C,F--1522624(+) TCAAAC/AAAACA 1 -- us2k13Minor allele frequency- A:0.50WA NA CSA 6
    rs1429107641,2
    C--1522624(+) CAAAA-/AAAC  
            
    AAACA
    1 -- us2k10--------
    rs2020687491,2
    C--1522639(+) ACAAA-/CAAAAA 1 -- us2k10--------
    rs1917372921,2
    --1522640(+) ACAAAA/CAAAAA 1 -- us2k10--------
    rs1154519751,2
    F--1522712(+) ACACTC/AGGGCC 1 -- us2k11Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for PLK5 (1524073 - 1535455 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/27 variations for PLK5 (see all 27):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1284037CNV Deletion17803354
    esv2717845CNV Deletion23290073
    dgv3589n71CNV Loss21882294
    nsv470106CNV Loss18288195
    nsv910292CNV Loss21882294
    nsv910499CNV Loss21882294
    dgv3609n71CNV Loss21882294
    dgv3606n71CNV Loss21882294
    dgv3596n71CNV Loss21882294
    dgv3608n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for PLK5:    About MalaCards
    glioblastoma    neuronitis


    PLK5 for disorders           About GeneDecksing


    Export disorders for PLK5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLK5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with PLK5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Plk5, a polo box domain-only protein with specific ro les in neuron differentiation and glioblastoma suppression. (PubMed id 21245385)1, 2, 3 de CA!rcer G....Malumbres M. (2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The novel mouse Polo-like kinase 5 responds to DNA da mage and localizes in the nucleolus. (PubMed id 20100802)1 Andrysik Z....Bahassi e.l. .M. (2010)
    5. Identification and analysis of unitary pseudogenes: h istoric and contemporary gene losses in humans and other primates. (PubMed id 20210993)1 Zhang Z.D....Gerstein M. (2010)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 126520 HGNC: 27001 AceView: LOC126520 Ensembl:ENSG00000185988 euGenes: HUgn126520
    ECgene: PLK5 H-InvDB: PLK5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLK5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLK5 gene:
    Search GeneIP for patents involving PLK5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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