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Aliases for PLK5 Gene

Aliases for PLK5 Gene

  • Polo Like Kinase 5 2 3 5
  • Polo-Like Kinase 5, Pseudogene 2 3
  • Polo-Like Kinase 5 2 4
  • PLK5P 3 4
  • PLK-5 3 4
  • Inactive Serine/Threonine-Protein Kinase PLK5 3
  • Polo-Like Kinase 5 Pseudogene 2
  • SgK384ps 3

External Ids for PLK5 Gene

Previous HGNC Symbols for PLK5 Gene

  • PLK5P

Summaries for PLK5 Gene

GeneCards Summary for PLK5 Gene

PLK5 (Polo Like Kinase 5) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein kinase activity. An important paralog of this gene is PLK3.

UniProtKB/Swiss-Prot for PLK5 Gene

  • Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLK5 Gene

Genomics for PLK5 Gene

Regulatory Elements for PLK5 Gene

Enhancers for PLK5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F001382 1.2 ENCODE 12.2 -140.0 -140049 2.2 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SF3A2 TMEM259 CIRBP LOC100288123 ENSG00000267317 GRIN3B ENSG00000261526 ENSG00000266990 RNA5SP462 CFD
GH19F001019 1.2 ENCODE 12.1 -502.9 -502867 4.4 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SP3 LOC100288123 TMEM259 ENSG00000267317 GRIN3B MIER2 ABCA7 ENSG00000261526 CIRBP WDR18 ENSG00000266990
GH19F001097 1.6 FANTOM5 ENCODE 5 -421.2 -421244 10.5 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SSRP1 GLIS1 TMEM259 GPX4 LOC100288123 CIRBP GRIN3B SCAMP4 RPS15 POLR2E ABCA7 PLK5
GH19F001522 0.6 FANTOM5 11.1 -1.1 -1078 0.2 NFIL3 HLF USF2 ZBTB8A KDM1A PLK5 MUM1 ADAMTSL5
GH19F001546 1.2 Ensembl ENCODE 0.3 +22.3 22284 0.5 HDAC1 KLF17 ZNF2 RAD21 ZEB1 SCRT2 ZNF143 ZNF391 CREM ZNF654 ATP8B3 MIR1909 REXO1 TCF3 PCSK4 REEP6 C19orf25 RNU6-1223P DAZAP1 GAMT
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLK5 on UCSC Golden Path with GeneCards custom track

Promoters for PLK5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001815170 26 201 TFDP1 L3MBTL2 POLR2A ZBTB7A

Genomic Location for PLK5 Gene

Chromosome:
19
Start:
1,524,074 bp from pter
End:
1,535,456 bp from pter
Size:
11,383 bases
Orientation:
Plus strand

Genomic View for PLK5 Gene

Genes around PLK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLK5 Gene

Proteins for PLK5 Gene

  • Protein details for PLK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q496M5-PLK5_HUMAN
    Recommended name:
    Inactive serine/threonine-protein kinase PLK5
    Protein Accession:
    Q496M5
    Secondary Accessions:
    • B3KNR4
    • Q1ZYM0

    Protein attributes for PLK5 Gene

    Size:
    336 amino acids
    Molecular mass:
    36329 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLK5 Gene

Post-translational modifications for PLK5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLK5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLK5 Gene

Domains & Families for PLK5 Gene

Protein Domains for PLK5 Gene

Suggested Antigen Peptide Sequences for PLK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q496M5

UniProtKB/Swiss-Prot:

PLK5_HUMAN :
  • The truncated protein kinase domain is predicted to be catalytically inactive; has lost the main activatory autophosphorylation site and the conserved key residues involved in phospho-substrate. The C-terminal region (containing the POLO box domain) is sufficient for inducing cell cycle arrest.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
Domain:
  • The truncated protein kinase domain is predicted to be catalytically inactive; has lost the main activatory autophosphorylation site and the conserved key residues involved in phospho-substrate. The C-terminal region (containing the POLO box domain) is sufficient for inducing cell cycle arrest.
  • Contains 1 POLO box domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
genes like me logo Genes that share domains with PLK5: view

No data available for Gene Families for PLK5 Gene

Function for PLK5 Gene

Molecular function for PLK5 Gene

UniProtKB/Swiss-Prot Function:
Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation.
UniProtKB/Swiss-Prot Induction:
Down-regulated in primary brain tumors.

Gene Ontology (GO) - Molecular Function for PLK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PLK5: view

Phenotypes for PLK5 Gene

genes like me logo Genes that share phenotypes with PLK5: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLK5 Gene

Localization for PLK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLK5 Gene

Nucleus, nucleolus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLK5 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA,IDA 21245385
genes like me logo Genes that share ontologies with PLK5: view

Pathways & Interactions for PLK5 Gene

No Data Available

Interacting Proteins for PLK5 Gene

Gene Ontology (GO) - Biological Process for PLK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002357 defense response to tumor cell IDA 21245385
GO:0006468 protein phosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0010976 positive regulation of neuron projection development IDA 21245385
genes like me logo Genes that share ontologies with PLK5: view

No data available for Pathways by source and SIGNOR curated interactions for PLK5 Gene

Transcripts for PLK5 Gene

mRNA/cDNA for PLK5 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLK5 Gene

Polo-like kinase 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLK5 Gene

No ASD Table

Relevant External Links for PLK5 Gene

GeneLoc Exon Structure for
PLK5
ECgene alternative splicing isoforms for
PLK5

Expression for PLK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLK5 Gene

This gene is overexpressed in Brain - Cerebellum (x12.6) and Brain - Cerebellar Hemisphere (x12.3).

NURSA nuclear receptor signaling pathways regulating expression of PLK5 Gene:

PLK5

SOURCE GeneReport for Unigene cluster for PLK5 Gene:

Hs.195352

mRNA Expression by UniProt/SwissProt for PLK5 Gene:

Q496M5-PLK5_HUMAN
Tissue specificity: Expressed in the brain, neurons and glial cells. Also expressed in highly differentiated cells, such as the serous acini in the parotid gland, distal and proximal tubules of the kidney, tubules of the seminal gland, Kupffer cells and some hepatocytes in the liver, and some cells in the germinal center of lymph nodes (at protein level).
genes like me logo Genes that share expression patterns with PLK5: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PLK5 Gene

Orthologs for PLK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PLK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLK5 34
  • 93.37 (n)
dog
(Canis familiaris)
Mammalia PLK5 34 35
  • 77.88 (n)
cow
(Bos Taurus)
Mammalia PLK5 34 35
  • 77.34 (n)
mouse
(Mus musculus)
Mammalia Plk5 34 16 35
  • 71.89 (n)
rat
(Rattus norvegicus)
Mammalia Plk5 34
  • 71.08 (n)
oppossum
(Monodelphis domestica)
Mammalia PLK5 35
  • 28 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLK5 35
  • 26 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii plk2b 35
  • 16 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC5 35
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8152 35
  • 11 (a)
OneToMany
Species where no ortholog for PLK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLK5 Gene

ENSEMBL:
Gene Tree for PLK5 (if available)
TreeFam:
Gene Tree for PLK5 (if available)

Paralogs for PLK5 Gene

Paralogs for PLK5 Gene

(1) SIMAP similar genes for PLK5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLK5: view

Variants for PLK5 Gene

Sequence variations from dbSNP and Humsavar for PLK5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10406566 -- 1,534,060(+) TCAAA(A/C)TCGGG intron-variant
rs10408052 -- 1,529,424(+) CGAAA(A/G)AGGTT reference, missense
rs10411643 -- 1,526,265(+) GGTGC(A/G)GGGCC intron-variant
rs10425440 -- 1,533,835(+) GCGGC(A/G)GCGGC intron-variant
rs10545181 -- 1,532,522(+) TCTTC(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLK5 Gene

Variant ID Type Subtype PubMed ID
nsv953942 CNV deletion 24416366
nsv833705 CNV loss 17160897
nsv578297 CNV loss 21841781
nsv578295 CNV gain 21841781
nsv578279 CNV gain 21841781
nsv470106 CNV loss 18288195
nsv470105 CNV gain 18288195
nsv458324 CNV loss 19166990
nsv1126500 CNV deletion 24896259
esv3643402 CNV loss 21293372
esv3398090 CNV duplication 20981092
esv32942 CNV gain+loss 17666407
esv2758743 CNV gain+loss 17122850
esv2717845 CNV deletion 23290073
esv1284037 CNV deletion 17803354

Variation tolerance for PLK5 Gene

Gene Damage Index Score: 24.52; 99.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLK5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLK5 Gene

Disorders for PLK5 Gene

Relevant External Links for PLK5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLK5

No disorders were found for PLK5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLK5 Gene

Publications for PLK5 Gene

  1. Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. (PMID: 21245385) de Carcer G. … Malumbres M. (Mol. Cell. Biol. 2011) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus. (PMID: 20100802) Andrysik Z. … Bahassi e.l. .M. (Nucleic Acids Res. 2010) 3 64
  5. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. (PMID: 20210993) Zhang Z.D. … Gerstein M. (Genome Biol. 2010) 3 64

Products for PLK5 Gene

Sources for PLK5 Gene

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