PLK5 Gene
protein-coding GIFtS: 35
GCID: GC19P001525
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polo-like kinase 5(Previous names: polo-like kinase 5 pseudogene, polo-like kinase 5, pseudogene...)
(Previous symbol: PLK5P)
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Aliases
for PLK5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
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| Polo-Like Kinase 51 2 3 | | PLK-52 3 | | PLK5P1 2 3 | | Polo-Like Kinase 5 Pseudogene1 | | SgK384ps1 2 | | Inactive Serine/Threonine-Protein Kinase PLK52 | | Polo-Like Kinase 5, Pseudogene1 2 | | |
| External Ids: | HGNC: 270011 | Entrez Gene: 1265202 | Ensembl: ENSG000001859887 | UniProtKB: Q496M53 | | ORGUL members: | |
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| NONCODE:n407145 | |
Export aliases for PLK5 gene to outside databases
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Summaries
for PLK5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PLK5_HUMAN, Q496M5Function: Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronaldifferentiation
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Genomic Views
for PLK5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for PLK5
Other transcription factors
Search SABiosciences Chromatin IP Primers for PLK5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLK5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3PLK5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P001525: view genomic region
(about GC identifiers)
Start:
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1,524,073 bp from pter |
End:
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1,535,455 bp from pter |
Size:
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11,383 bases |
Orientation:
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plus strand |
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Proteins
for PLK5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PLK5_HUMAN, Q496M5 (See
protein sequence)Recommended Name: Inactive serine/threonine-protein kinase PLK5 Size: 336 amino acids; 36329 Da
Subcellular location: Nucleus, nucleolus (By similarity). Cytoplasm
Secondary accessions: B3KNR4 Q1ZYM0Alternative splicing: 2 isoforms: Q496M5-1 Q496M5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PLK5: NX_Q496M5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q496M5
PLK5 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001230008.1
ENSEMBL proteins: ENSP00000468376 ENSP00000466248 ENSP00000465896
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
PLK5 for ontologies About GeneDecksing
PLK5 Antibody Products:
Assay Products for PLK5: |
Protein
Domains /
Families
for PLK5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PLK5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q496M5ProtoNet protein and cluster: Q496M5 UniProtKB/Swiss-Prot: PLK5_HUMAN, Q496M5Domain: The truncated protein kinase domain is predicted to be catalytically inactive; has lost the main activatoryautophosphorylation site and the conserved key residues involved in phospho-substrate. The C-terminus region(containing the POLO box domain) is sufficient for inducing cell cycle arrestSimilarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamilySimilarity: Contains 1 POLO box domainSimilarity: Contains 1 protein kinase domain |
Function
for PLK5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: PLK5_HUMAN, Q496M5Function: Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronaldifferentiationInduction: Down-regulated in primary brain tumors
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLK5 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0004672 | protein kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
PLK5 for ontologies About GeneDecksing
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Pathways & Interactions
for PLK5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLK5
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0002357 | defense response to tumor cell |
IDA | -- | | GO:0006927 | transformed cell apoptotic process |
IMP | -- | | GO:0007067 | mitosis |
IEA | -- | | GO:0010976 | positive regulation of neuron projection development |
IDA | -- | | GO:0031572 | G2/M transition DNA damage checkpoint |
IMP | -- |
PLK5 for ontologies About GeneDecksing
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Drugs & Compounds
for PLK5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PLK5
Search CenterWatch for drugs/clinical trials and news about PLK5 
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Transcripts
for PLK5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PLK5 gene (2 alternative transcripts): NM_001011716.1 NM_001243079.1 Unigene Cluster for PLK5: Polo-like kinase 5 Hs.195352 [show with all ESTs]Unigene Representative Sequence: AK0548084 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000454744 ENST00000334770(uc002ltf.3 uc002ltg.1 uc010dsm.1)
ENST00000588430 ENST00000588292
Additional cDNA sequence: AK054808.1 BC100791.2 BC100792.1 BC100793.2 DQ424898.1 3 DOTS entries: DT.70101058 DT.101957799 DT.95218036 10 AceView cDNA sequences: BI827807 AI621045 AI651075 H52750 AK054808 AK122648 R15160 BF364682 BG772641 R41581
GeneLoc Exon Structure
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Expression
for PLK5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PLK5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGTTCAAC
About this image
Genevestigator expression for PLK5
SOURCE GeneReport for Unigene cluster: Hs.195352
UniProtKB/Swiss-Prot: PLK5_HUMAN, Q496M5Tissue specificity: Expressed in the brain, neurons and glial cells. Also expressed in highly differentiated cells,such as the serous acini in the parotid gland, distal and proximal tubules of the kidney, tubules of the seminalgland, Kupffer cells and some hepatocytes in the liver, and some cells in the germinal center of lymph nodes (atprotein level)
SABiosciences Custom PCR Arrays for PLK5
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PLK5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLK5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLK5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLK5 |
Orthologs
for PLK5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for PLK5 gene from 1/12 species (see all 12) About this table
ENSEMBL Gene Tree for PLK5 (if available)
TreeFam Gene Tree for PLK5 (if available) |
Paralogs
for PLK5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PLK5 gene
- PLK42 PLK22 PLK12 PLK32
1 SIMAP similar gene for PLK5 using alignment to 2 protein entries: PLK5_HUMAN (see all proteins):PLK1
PLK5 for paralogs About GeneDecksing
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Genomic Variants
for PLK5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for PLK5 (1524073 - 1535455 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PLK5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLK5 |
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Disorders
/ Diseases
for PLK5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PLK5 for disorders About GeneDecksing
2  diseases for PLK5: About MalaCardsglioblastoma neuronitis
Export disorders for PLK5 gene to outside databases
|
Publications
for PLK5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PLK5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PLK5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Plk5, a polo box domain-only protein with specific ro les in neuron differentiation and glioblastoma suppression. (PubMed id 21245385)1, 2, 3 de CA!rcer G....Malumbres M. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The novel mouse Polo-like kinase 5 responds to DNA da mage and localizes in the nucleolus. (PubMed id 20100802)1 Andrysik Z....Bahassi e.l. .M. (2010)
- Identification and analysis of unitary pseudogenes: h istoric and contemporary gene losses in humans and other primates. (PubMed id 20210993)1 Zhang Z.D....Gerstein M. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
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External Searches for PLK5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing PLK5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing PLK5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PLK5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for PLK5 gene:
Search GeneIP for patents involving PLK5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PLK5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PLK5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLK5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLK5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLK5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLK5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLK5 |
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 |  |  |  | |
| | | | Search Tocris compounds for PLK5 |
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 | | | PLK5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLK5 |
|  |  |  | | | | Search ThermoFisher Antibodies for PLK5 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PLK5 |
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