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Aliases for PLK5 Gene

Aliases for PLK5 Gene

  • Polo Like Kinase 5 2 3 5
  • Polo-Like Kinase 5, Pseudogene 2 3
  • Polo-Like Kinase 5 2 4
  • PLK5P 3 4
  • PLK-5 3 4
  • Inactive Serine/Threonine-Protein Kinase PLK5 3
  • Polo-Like Kinase 5 Pseudogene 2
  • SgK384ps 3

External Ids for PLK5 Gene

Previous HGNC Symbols for PLK5 Gene

  • PLK5P

Summaries for PLK5 Gene

GeneCards Summary for PLK5 Gene

PLK5 (Polo Like Kinase 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein kinase activity. An important paralog of this gene is PLK3.

UniProtKB/Swiss-Prot for PLK5 Gene

  • Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation.

Additional gene information for PLK5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLK5 Gene

Genomics for PLK5 Gene

GeneHancer (GH) Regulatory Elements for PLK5 Gene

Promoters and enhancers for PLK5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I001524 Promoter 0.8 EPDnew 550.8 0.0 -16 0.1 FOXM1 ZBTB6 L3MBTL2 POLR2A EZH2 PLK5 ADAMTSL5
GH19I001526 Promoter 0.7 EPDnew 550.8 +2.1 2078 0.1 ZEB2 ZEB1 PLK5 GC19M001551
GH19I001522 Enhancer 0.5 FANTOM5 561.1 -1.1 -1077 0.2 NFIL3 ZNF3 HLF KDM1A ZBTB8A EZH2 PLK5 MUM1 ADAMTSL5
GH19I001382 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 21.4 -140.0 -140048 2.2 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NDUFS7 PIR43938 PIR60227 TRF-GAA1-6 TRN-GTT2-6 CIRBP SF3A2 TMEM259 MUM1 TCF3
GH19I001019 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 21.3 -502.9 -502867 4.4 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 TMEM259 GC19P001025 RNU6-2 TCF3 LOC100288123 DAZAP1 GRIN3B PTBP1 CIRBP MED16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLK5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PLK5 Gene

Genomic Locations for PLK5 Gene
chr19:1,524,074-1,535,456
(GRCh38/hg38)
Size:
11,383 bases
Orientation:
Plus strand
chr19:1,524,073-1,535,455
(GRCh37/hg19)

Genomic View for PLK5 Gene

Genes around PLK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLK5 Gene

Proteins for PLK5 Gene

  • Protein details for PLK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q496M5-PLK5_HUMAN
    Recommended name:
    Inactive serine/threonine-protein kinase PLK5
    Protein Accession:
    Q496M5
    Secondary Accessions:
    • B3KNR4
    • Q1ZYM0

    Protein attributes for PLK5 Gene

    Size:
    336 amino acids
    Molecular mass:
    36329 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLK5 Gene

Post-translational modifications for PLK5 Gene

No Post-translational modifications

Other Protein References for PLK5 Gene

No data available for DME Specific Peptides for PLK5 Gene

Domains & Families for PLK5 Gene

Gene Families for PLK5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PLK5 Gene

Suggested Antigen Peptide Sequences for PLK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q496M5

UniProtKB/Swiss-Prot:

PLK5_HUMAN :
  • The truncated protein kinase domain is predicted to be catalytically inactive; has lost the main activatory autophosphorylation site and the conserved key residues involved in phospho-substrate. The C-terminal region (containing the POLO box domain) is sufficient for inducing cell cycle arrest.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
Domain:
  • The truncated protein kinase domain is predicted to be catalytically inactive; has lost the main activatory autophosphorylation site and the conserved key residues involved in phospho-substrate. The C-terminal region (containing the POLO box domain) is sufficient for inducing cell cycle arrest.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
genes like me logo Genes that share domains with PLK5: view

Function for PLK5 Gene

Molecular function for PLK5 Gene

UniProtKB/Swiss-Prot Function:
Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation.
UniProtKB/Swiss-Prot Induction:
Down-regulated in primary brain tumors.

Phenotypes From GWAS Catalog for PLK5 Gene

Gene Ontology (GO) - Molecular Function for PLK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PLK5: view

Phenotypes for PLK5 Gene

genes like me logo Genes that share phenotypes with PLK5: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLK5 Gene

Localization for PLK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLK5 Gene

Nucleus, nucleolus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLK5 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA,IDA 21245385
genes like me logo Genes that share ontologies with PLK5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLK5 Gene

Pathways & Interactions for PLK5 Gene

No Data Available

Interacting Proteins for PLK5 Gene

Gene Ontology (GO) - Biological Process for PLK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002357 defense response to tumor cell IDA 21245385
GO:0006468 protein phosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0010976 positive regulation of neuron projection development IDA 21245385
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with PLK5: view

No data available for Pathways by source and SIGNOR curated interactions for PLK5 Gene

Drugs & Compounds for PLK5 Gene

No Compound Related Data Available

Transcripts for PLK5 Gene

mRNA/cDNA for PLK5 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLK5 Gene

Polo-like kinase 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLK5 Gene

No ASD Table

Relevant External Links for PLK5 Gene

GeneLoc Exon Structure for
PLK5
ECgene alternative splicing isoforms for
PLK5

Expression for PLK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLK5 Gene

This gene is overexpressed in Brain - Cerebellum (x12.6) and Brain - Cerebellar Hemisphere (x12.3).

NURSA nuclear receptor signaling pathways regulating expression of PLK5 Gene:

PLK5

SOURCE GeneReport for Unigene cluster for PLK5 Gene:

Hs.195352

mRNA Expression by UniProt/SwissProt for PLK5 Gene:

Q496M5-PLK5_HUMAN
Tissue specificity: Expressed in the brain, neurons and glial cells. Also expressed in highly differentiated cells, such as the serous acini in the parotid gland, distal and proximal tubules of the kidney, tubules of the seminal gland, Kupffer cells and some hepatocytes in the liver, and some cells in the germinal center of lymph nodes (at protein level).

Evidence on tissue expression from TISSUES for PLK5 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PLK5: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLK5 Gene

Orthologs for PLK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PLK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLK5 33
  • 93.37 (n)
dog
(Canis familiaris)
Mammalia PLK5 34 33
  • 77.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PLK5 33 34
  • 77.34 (n)
mouse
(Mus musculus)
Mammalia Plk5 16 34 33
  • 71.89 (n)
rat
(Rattus norvegicus)
Mammalia Plk5 33
  • 71.08 (n)
oppossum
(Monodelphis domestica)
Mammalia PLK5 34
  • 28 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLK5 34
  • 26 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii plk2b 34
  • 16 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC5 34
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8152 34
  • 11 (a)
OneToMany
Species where no ortholog for PLK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLK5 Gene

ENSEMBL:
Gene Tree for PLK5 (if available)
TreeFam:
Gene Tree for PLK5 (if available)

Paralogs for PLK5 Gene

Paralogs for PLK5 Gene

(1) SIMAP similar genes for PLK5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLK5: view

Variants for PLK5 Gene

Sequence variations from dbSNP and Humsavar for PLK5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000179276 -- 1,531,020(+) G/A/C intron_variant
rs1000182542 -- 1,528,844(+) C/A/T intron_variant
rs1000276567 -- 1,535,055(+) C/A/T intron_variant
rs1000366546 -- 1,533,280(+) G/A intron_variant
rs1000383397 -- 1,534,664(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLK5 Gene

Variant ID Type Subtype PubMed ID
esv1284037 CNV deletion 17803354
esv2717845 CNV deletion 23290073
esv2758743 CNV gain+loss 17122850
esv32942 CNV gain+loss 17666407
esv3398090 CNV duplication 20981092
esv3643402 CNV loss 21293372
nsv1126500 CNV deletion 24896259
nsv458324 CNV loss 19166990
nsv470105 CNV gain 18288195
nsv470106 CNV loss 18288195
nsv578279 CNV gain 21841781
nsv578295 CNV gain 21841781
nsv578297 CNV loss 21841781
nsv833705 CNV loss 17160897
nsv953942 CNV deletion 24416366

Variation tolerance for PLK5 Gene

Gene Damage Index Score: 24.52; 99.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLK5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLK5 Gene

Disorders for PLK5 Gene

Additional Disease Information for PLK5

No disorders were found for PLK5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLK5 Gene

Publications for PLK5 Gene

  1. Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. (PMID: 21245385) de Cárcer G … Malumbres M (Molecular and cellular biology 2011) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Genetic mutations associated with metastatic clear cell renal cell carcinoma. (PMID: 26908440) Li Z … Zhong JF (Oncotarget 2016) 3 58
  5. The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus. (PMID: 20100802) Andrysik Z … Bahassi el M (Nucleic acids research 2010) 3 58

Products for PLK5 Gene

Sources for PLK5 Gene

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