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Aliases for PLK5 Gene

Aliases for PLK5 Gene

  • Polo-Like Kinase 5 2 3 4
  • Polo-Like Kinase 5, Pseudogene 2 3
  • PLK5P 3 4
  • PLK-5 3 4
  • Inactive Serine/Threonine-Protein Kinase PLK5 3
  • Polo-Like Kinase 5 Pseudogene 2
  • SgK384ps 3

External Ids for PLK5 Gene

Previous HGNC Symbols for PLK5 Gene

  • PLK5P

Summaries for PLK5 Gene

GeneCards Summary for PLK5 Gene

PLK5 (Polo-Like Kinase 5) is a Protein Coding gene. GO annotations related to this gene include protein kinase activity. An important paralog of this gene is PLK4.

UniProtKB/Swiss-Prot for PLK5 Gene

  • Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLK5 Gene

Genomics for PLK5 Gene

Genomic Location for PLK5 Gene

Start:
1,524,074 bp from pter
End:
1,535,456 bp from pter
Size:
11,383 bases
Orientation:
Plus strand

Genomic View for PLK5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLK5 Gene

No data available for Regulatory Elements for PLK5 Gene

Proteins for PLK5 Gene

  • Protein details for PLK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q496M5-PLK5_HUMAN
    Recommended name:
    Inactive serine/threonine-protein kinase PLK5
    Protein Accession:
    Q496M5
    Secondary Accessions:
    • B3KNR4
    • Q1ZYM0

    Protein attributes for PLK5 Gene

    Size:
    336 amino acids
    Molecular mass:
    36329 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLK5 Gene

Proteomics data for PLK5 Gene at MOPED

Post-translational modifications for PLK5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLK5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLK5 Gene

Domains for PLK5 Gene

Protein Domains for PLK5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q496M5

UniProtKB/Swiss-Prot:

PLK5_HUMAN :
  • Q496M5
Domain:
  • The truncated protein kinase domain is predicted to be catalytically inactive; has lost the main activatory autophosphorylation site and the conserved key residues involved in phospho-substrate. The C-terminal region (containing the POLO box domain) is sufficient for inducing cell cycle arrest
  • Contains 1 POLO box domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
genes like me logo Genes that share domains with PLK5: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for PLK5 Gene

Function for PLK5 Gene

Molecular function for PLK5 Gene

UniProtKB/Swiss-Prot Function: Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation.
UniProtKB/Swiss-Prot Induction: Down-regulated in primary brain tumors.

Gene Ontology (GO) - Molecular Function for PLK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with PLK5: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PLK5 Gene

Localization for PLK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLK5 Gene

Nucleus, nucleolus. Cytoplasm.

Gene Ontology (GO) - Cellular Components for PLK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA 21245385
genes like me logo Genes that share ontologies with PLK5: view

No data available for Subcellular locations from COMPARTMENTS for PLK5 Gene

Pathways for PLK5 Gene

SuperPathways for PLK5 Gene

No Data Available

Interacting Proteins for PLK5 Gene

Gene Ontology (GO) - Biological Process for PLK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002357 defense response to tumor cell IDA 21245385
GO:0006468 protein phosphorylation IEA --
GO:0006927 transformed cell apoptotic process IMP 21245385
GO:0007067 mitotic nuclear division IEA --
GO:0010976 positive regulation of neuron projection development IDA 21245385
genes like me logo Genes that share ontologies with PLK5: view

No data available for Pathways by source for PLK5 Gene

Compounds for PLK5 Gene

(8) ApexBio Compounds for PLK5 Gene

Compound Action Cas Number
BI 2536 PLK1 inhibitor [755038-02-9]
BI6727 (Volasertib) highly potent Polo-like kinase inhibitor. [755038-65-4]
GSK461364 inhibits purified Plk1. [929095-18-1]
GW843682X selective inhibitor of PLK1 and PLK3 [660868-91-7]
HMN-214 potent inhibitor of Polo-like kinase (Plk) [173529-46-9]
MLN0905 small-molecule PLK1 inhibitor. [1228960-69-7]
Poloxin non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor [321688-88-4]
Rigosertib (ON-01910) PLK1 Inhibitor [1225497-78-8]
genes like me logo Genes that share compounds with PLK5: view

Transcripts for PLK5 Gene

mRNA/cDNA for PLK5 Gene

(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLK5 Gene

Polo-like kinase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLK5 Gene

No ASD Table

Relevant External Links for PLK5 Gene

GeneLoc Exon Structure for
PLK5
ECgene alternative splicing isoforms for
PLK5

Expression for PLK5 Gene

mRNA expression in normal human tissues for PLK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLK5 Gene

This gene is overexpressed in Brain - Cerebellum (12.6) and Brain - Cerebellar Hemisphere (12.3).

SOURCE GeneReport for Unigene cluster for PLK5 Gene Hs.195352

mRNA Expression by UniProt/SwissProt for PLK5 Gene

Q496M5-PLK5_HUMAN
Tissue specificity: Expressed in the brain, neurons and glial cells. Also expressed in highly differentiated cells, such as the serous acini in the parotid gland, distal and proximal tubules of the kidney, tubules of the seminal gland, Kupffer cells and some hepatocytes in the liver, and some cells in the germinal center of lymph nodes (at protein level).
genes like me logo Genes that share expressions with PLK5: view

No data available for Protein expression for PLK5 Gene

Orthologs for PLK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PLK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLK5 35
  • 93.37 (n)
  • 91.24 (a)
cow
(Bos Taurus)
Mammalia PLK5 35
  • 77.34 (n)
  • 72.26 (a)
PLK5 36
  • 37 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLK5 35
  • 77.88 (n)
  • 69.64 (a)
PLK5 36
  • 29 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plk5 35
  • 71.89 (n)
  • 66.87 (a)
Plk5 16
Plk5 36
  • 37 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLK5 36
  • 28 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLK5 36
  • 26 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plk5 35
  • 71.08 (n)
  • 65.06 (a)
zebrafish
(Danio rerio)
Actinopterygii plk2b 36
  • 16 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC5 36
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8152 36
  • 11 (a)
OneToMany
Species with no ortholog for PLK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLK5 Gene

ENSEMBL:
Gene Tree for PLK5 (if available)
TreeFam:
Gene Tree for PLK5 (if available)

Paralogs for PLK5 Gene

Paralogs for PLK5 Gene

Selected SIMAP similar genes for PLK5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLK5: view

Variants for PLK5 Gene

Sequence variations from dbSNP and Humsavar for PLK5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs265281 -- 1,535,350(+) GGGAG(A/G)GCTGG utr-variant-3-prime
rs265282 -- 1,535,206(+) CCACC(C/G)GACAG missense, reference
rs265283 -- 1,535,148(+) GGGTC(C/T)CCTGG reference, synonymous-codon
rs265284 -- 1,534,686(+) gtggc(C/G)ggcgc intron-variant
rs265285 -- 1,534,677(+) ccggg(C/T)gtggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLK5 Gene

Variant ID Type Subtype PubMed ID
nsv910292 CNV Loss 21882294
dgv1055e1 CNV Complex 17122850
dgv3580n71 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3589n71 CNV Loss 21882294
dgv3596n71 CNV Loss 21882294
esv32942 CNV Gain+Loss 17666407
dgv3598n71 CNV Loss 21882294
dgv3599n71 CNV Loss 21882294
essv18235 CNV CNV 17122850
nsv833705 CNV Loss 17160897
nsv910499 CNV Loss 21882294
dgv3600n71 CNV Loss 21882294
dgv3601n71 CNV Loss 21882294
dgv3602n71 CNV Loss 21882294
dgv3603n71 CNV Loss 21882294
nsv470105 CNV Gain 18288195
dgv3604n71 CNV Gain+Loss 21882294
nsv470106 CNV Loss 18288195
nsv910521 CNV Loss 21882294
dgv3606n71 CNV Loss 21882294
dgv3607n71 CNV Loss 21882294
dgv3608n71 CNV Loss 21882294
dgv3609n71 CNV Loss 21882294
nsv458324 CNV Loss 19166990
esv2717845 CNV Deletion 23290073
esv1284037 CNV Deletion 17803354

Relevant External Links for PLK5 Gene

HapMap Linkage Disequilibrium report
PLK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLK5 Gene

Disorders for PLK5 Gene

No disorders were found for PLK5 Gene.

No data available for UniProtKB/Swiss-Prot for PLK5 Gene

Publications for PLK5 Gene

  1. Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. (PMID: 21245385) de Carcer G. … Malumbres M. (Mol. Cell. Biol. 2011) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus. (PMID: 20100802) Andrysik Z. … Bahassi e.l. .M. (Nucleic Acids Res. 2010) 3

Products for PLK5 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate PLK5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PLK5
    • Block miRNA regulation of PLK5 using miScript Target Protectors

    Sources for PLK5 Gene

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