Aliases for PLK4 Gene
Aliases for PLK4 Gene
External Ids for PLK4 Gene
- HGNC: 11397
- Entrez Gene: 10733
- Ensembl: ENSG00000142731
- OMIM: 605031
- UniProtKB: O00444
Previous HGNC Symbols for PLK4 Gene
- STK18
Previous GeneCards Identifiers for PLK4 Gene
- GC04P129260
- GC04P129159
- GC04P129021
- GC04P128802
- GC04P124529
Summaries for PLK4 Gene
-
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
GeneCards Summary for PLK4 Gene
PLK4 (Polo Like Kinase 4) is a Protein Coding gene. Diseases associated with PLK4 include Microcephaly And Chorioretinopathy, Autosomal Recessive, 2 and Seckel Syndrome. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Sweet Taste Signaling. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is PLK3.
UniProtKB/Swiss-Prot for PLK4 Gene
-
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates Ser-151 of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLK4 Gene
Genomics for PLK4 Gene
Regulatory Elements for PLK4 Gene
Enhancers for PLK4 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH04G127856 | 1 | Ensembl ENCODE | 11.3 | -23.9 | -23917 | 1.7 | TBP PKNOX1 BACH1 SIN3A BMI1 EBF1 ZBTB40 ARID3A CBX5 POLR2A | PLK4 RNU6-583P INTU ABHD18 ENSG00000261668 |
| GH04G127966 | 0.9 | Ensembl ENCODE | 11.5 | +86.5 | 86493 | 1.1 | BCOR ESRRA KLF1 ZNF362 NR2F1 HLF ZBTB33 ZNF384 | RNU6-583P PLK4 MFSD8 GC04M128059 |
| GH04G127846 | 0.7 | ENCODE | 12.1 | -34.5 | -34541 | 0.2 | TAL1 MAFG DPF2 CHAMP1 TCF12 ARID1B ZNF316 NCOR1 IKZF1 NFE2 | PLK4 RNU6-583P ENSG00000261668 |
| GH04G126898 | 0.7 | Ensembl ENCODE | 4 | -981.1 | -981077 | 2.8 | JUND TCF7L2 | PLK4 ENSG00000199862 GC04M127030 RBM48P1 |
| GH04G127879 | 1.1 | ENCODE | 0.7 | 0.0 | -1 | 2.5 | HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 | MFSD8 HSPA4L ABHD18 PLK4 ENSG00000261668 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around PLK4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PLK4 gene promoter:
Regulatory Element Products
Genomic Location for PLK4 Gene
- Chromosome:
- 4
- Start:
- 127,880,861 bp from pter
- End:
- 127,899,224 bp from pter
- Size:
- 18,364 bases
- Orientation:
- Plus strand
Genomic View for PLK4 Gene
Genes around PLK4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q28.1 by Ensembl
- 4q28.1 by Entrez Gene
- 4q28.1 by HGNC
PLK4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLK4 Gene
Proteins for PLK4 Gene
-
Protein details for PLK4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00444-PLK4_HUMAN
- Recommended name:
- Serine/threonine-protein kinase PLK4
- Protein Accession:
- O00444
- B2RAL0
- B7Z837
- B7Z8G7
- Q8IYF0
- Q96Q95
- Q9UD84
- Q9UDE2
Protein attributes for PLK4 Gene
- Size:
- 970 amino acids
- Molecular mass:
- 108972 Da
- Quaternary structure:
-
- Homodimer (By similarity). Interacts with CEP152 (via N-terminus). Interacts with CEP78; this interaction may be important for proper PLK4 localization to the centriole and PLK4-induced overduplication of centrioles (PubMed:27246242).
Three dimensional structures from OCA and Proteopedia for PLK4 Gene
Protein Expression for PLK4 Gene
Post-translational modifications for PLK4 Gene
- Tyrosine-phosphorylated by TEC.
- Ubiquitinated; leading to its degradation by the proteasome.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PLK4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for PLK4
- Cell Signaling Technology (CST) Antibodies for PLK4 (PLK4)
- Novus Biologicals Antibodies for PLK4
-
Abcam antibodies for PLK4
- Invitrogen Antibodies for PLK4
- antibodies-online Antibodies for PLK4: See all 29
- GeneTex PLK4 antibody for PLK4
-
Santa Cruz Biotechnology (SCBT) Antibodies for PLK4
Protein Products
-
OriGene Purified Proteins for PLK4
- Search Origene for MassSpec and Protein Over-expression Lysates for PLK4
- Origene Custom Protein Services for PLK4
- antibodies-online Proteins for PLK4: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for PLK4
-
Abcam proteins for PLK4
Assay Products
No data available for DME Specific Peptides for PLK4 Gene
Domains & Families for PLK4 Gene
Gene Families for PLK4 Gene
- IUPHAR :
Protein Domains for PLK4 Gene
Suggested Antigen Peptide Sequences for PLK4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O00444UniProtKB/Swiss-Prot:
PLK4_HUMAN :- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
Function for PLK4 Gene
Molecular function for PLK4 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates Ser-151 of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124).
- UniProtKB/Swiss-Prot Induction:
- Down-regulated in HCT 116 colorectal cancer cells, leading to aberrant centrioles composed of disorganized cylindrical microtubules and displaced appendages. Down-regulated by p53/TP53.
Enzyme Numbers (IUBMB) for PLK4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | ISS,IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for PLK4 Gene
- MGI mutant phenotypes for PLK4:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for PLK4:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Effect on mitosis
- Decreased viability
- Decreased substrate adherent cell growth
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased cell migration
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Increased mitotic index
- Increased Nanog expression
- Decreased centriole number
- Decreased Cdk9 T-loop phosphorylation
- Reduced beta-catenin activity and colon cancer cell proliferation
Animal Models for PLK4 Gene
- MGI Knock Outs for PLK4:
-
- Plk4 tm1Jwd
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PLK4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PLK4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PLK4 gene
- Search ViGene Biosciences for PLK4
CRISPR Products
-
OriGene CRISPR knockouts for PLK4
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLK4
- GenScript: Design CRISPR guide RNA sequences for PLK4
miRNA for PLK4 Gene
- miRTarBase miRNAs that target PLK4
miRNA Products
- Search ViGene Biosciences for PLK4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PLK4
- Browse OriGene Inhibitory RNA Products For PLK4
-
ViGene Biosciences ready-to-package AAV shRNAs for PLK4 gene
Clone Products
- Sino Biological Human cDNA Clone for PLK4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PLK4
- VectorBuilder custom plasmid, inducible vectors for PLK4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PLK4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PLK4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PLK4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PLK4 gene
Flow Cytometry Products
No data available for Transcription Factor Targets and HOMER Transcription for PLK4 Gene
Localization for PLK4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PLK4 Gene
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus, nucleolus. Cleavage furrow. Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001741 | XY body | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005730 | nucleolus | ISS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IDA | 21399614 |
Pathways & Interactions for PLK4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of PLK1 Activity at G2/M Transition |
.49
|
|
| 2 | FoxO signaling pathway | ||
| 3 | Cell Cycle, Mitotic |
.83
|
|
| 4 | Organelle biogenesis and maintenance |
.56
|
|
| 5 | DNA Damage | ||
Pathways by source for PLK4 Gene
1 Cell Signaling Technology pathway for PLK4 Gene
3 BioSystems pathways for PLK4 Gene
13 Reactome pathways for PLK4 Gene
1 KEGG pathway for PLK4 Gene
1 Qiagen pathway for PLK4 Gene
Interacting Proteins for PLK4 Gene
Selected Interacting proteins:
ENSP00000270861
O00444-PLK4_HUMAN
for PLK4 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0007099 | centriole replication | IMP,IEA | 21725316 |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0046601 | positive regulation of centriole replication | IMP | 16244668 |
Drugs & Compounds for PLK4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adenosine triphosphate | Approved | Nutra | 0 | |||
| GSK461364 | Pharma | Plk1 inhibitor, Kinase Inhibitors, Polo-like kinase inhibitor | 0 | |||
| HMN-214 | Pharma | Plk inhibitor,broad-spectrum anti-tumor agent | 0 | |||
| MLN0905 | Pharma | Potent PLK1 inhibitor | 0 | |||
| NMS-1286937 | Pharma | Kinase Inhibitors | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(4) ApexBio Compounds for PLK4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| GSK461364 | Plk1 inhibitor | 929095-18-1 |
| HMN-214 | Plk inhibitor,broad-spectrum anti-tumor agent | 173529-46-9 |
| MLN0905 | Potent PLK1 inhibitor | 1228960-69-7 |
| NMS-1286937 | 1034616-18-6 |
Drug Products
- ApexBio compounds for PLK4
Transcripts for PLK4 Gene
mRNA/cDNA for PLK4 Gene
- (6) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (79) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PLK4
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLK4
- GenScript: Design CRISPR guide RNA sequences for PLK4
miRNA Products
- Search ViGene Biosciences for PLK4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PLK4
- Browse OriGene Inhibitory RNA Products For PLK4
-
ViGene Biosciences ready-to-package AAV shRNAs for PLK4 gene
Clone Products
- Sino Biological Human cDNA Clone for PLK4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PLK4
- VectorBuilder custom plasmid, inducible vectors for PLK4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PLK4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - |
Expression for PLK4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Zeugopod
- Rib
-
Limb (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Zeugopod
-
Brain (Nervous System)
- Choroid Plexus Progenitor Cells Choroid Plexus
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for PLK4 Gene
This gene is overexpressed in Testis (x8.1).
This gene is overexpressed in Breast (30.3), Cervix (27.7), and Pancreatic juice (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLK4 Gene
NURSA nuclear receptor signaling pathways regulating expression of PLK4 Gene:
PLK4SOURCE GeneReport for Unigene cluster for PLK4 Gene:
Hs.172052Evidence on tissue expression from TISSUES for PLK4 Gene
- Blood(4.3)
- Lung(4.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PLK4 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Organs:
Head and neck:
- brain
- cerebellum
- cheek
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- larynx
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- skull
- tongue
- tooth
- vocal cord
Thorax:
- chest wall
- clavicle
- heart
- heart valve
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- kidney
Pelvis:
- pelvis
- penis
- testicle
- urethra
- vagina
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- bone marrow
- coagulation system
- hair
- peripheral nervous system
- red blood cell
- skin
- spinal column
- spinal cord
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for PLK4
-
OriGene qPCR primer pairs and template standards for PLK4
No data available for mRNA Expression by UniProt/SwissProt for PLK4 Gene
Orthologs for PLK4 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PLK4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | PLK4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | PLK4 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Plk4 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Plk4 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PLK4 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PLK4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LOC422497 34 |
|
||
| PLK4 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | PLK4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | plk4 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68791 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | plk4 34 35 |
|
||
| Dr.11503 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9557 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012499 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | SAK 34 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC5 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3490 35 |
|
OneToOne |
- Species where no ortholog for PLK4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PLK4 Gene
(58) SIMAP similar genes for PLK4 Gene using alignment to 4 proteins:
- Plk-1 delta
- RPS6KA2
- MKNK1
- AURKA
- AURKC
- RPS6KA3
- PKN2
- AURKB
- STK36
- PkB-like 1
- NUAK1
- STK33
- STK32A
- PRKAA1
- PDPK2
- MYO3A
- KIN27
- KIAA0999
- HUNK
- DKFZp564L2416
- BRAF
- PRKACA
- MARK4
- MAPK8
- DAPK1
- TRIB2
- STK17A
- STK11
- PRKACG
- PAK2
- DAPK2
- CCRK
- PRKACB
- MARK3
- CAMK1
- STK25
- PRKY
- PNCK
- PHKG1
- CHEK2
- CAMK2B
- NEK6
- NEK3
- CDK10
- TSSK3
- TRIB1
- PRKG2
- PAK4
- MST094
- CAMK2D
- SGK2
- PIM2
- NEK7
- CDK7
- CDC2
- CAMK1D
- MAPK14
- CDK4
Pseudogenes.org Pseudogenes for PLK4 Gene
Variants for PLK4 Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs724159995 | Pathogenic | 127,898,434(+) | CTTCA(C/G)TTAGG | intron-variant | |
| rs724159996 | Pathogenic | 127,886,669(+) | TTCTT(-/TAAAG)AAAAG | intron-variant, reference, frameshift-variant | |
| rs56414190 | Uncertain significance | 127,891,202(+) | GTAAT(A/G)TGTAG | intron-variant | |
| rs879255691 | Uncertain significance | 127,883,336(+) | CAATT(-/GAAACATCCTTCT)ATCTT | intron-variant, reference, frameshift-variant | |
| rs1000149678 | -- | 127,888,032(+) | AAAAT(C/T)AGCTG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5385n100 | CNV | gain | 25217958 |
| nsv1019193 | CNV | loss | 25217958 |
Residual Variation Intolerance Score:
25.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.08;
38.06% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PLK4 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLK4 Gene
Disorders for PLK4 Gene
(4) MalaCards diseases for PLK4 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| microcephaly and chorioretinopathy, autosomal recessive, 2 |
|
|
| seckel syndrome |
|
|
| carotid artery thrombosis |
|
|
| sertoli cell-only syndrome |
|
|
Search PLK4 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PLK4_HUMAN- Microcephaly and chorioretinopathy, autosomal recessive, 2 (MCCRP2) [MIM:616171]: A severe disorder characterized by microcephaly, delayed psychomotor development, growth retardation with dwarfism, and ocular abnormalities. {ECO:0000269 PubMed:25344692}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for PLK4
No data available for Genatlas for PLK4 Gene
Publications for PLK4 Gene
- SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing. (PMID: 15967108) Li J. … Sun Y. (Neoplasia 2005) 3 4 22 64
- SAK/PLK4 is required for centriole duplication and flagella development. (PMID: 16326102) Bettencourt-Dias M. … Glover D.M. (Curr. Biol. 2005) 3 4 22 64
- Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase. (PMID: 11489907) Yamashita Y. … Mano H. (J. Biol. Chem. 2001) 3 4 22 64
- Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. (PMID: 25344692) Martin C.A. … Jackson A.P. (Nat. Genet. 2014) 3 4 64
- Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
Products for PLK4 Gene
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