PLK4 Gene
protein-coding GIFtS : 61 GCID: GC04 P128802
polo-like kinase 4 serine/threonine kinase 18, polo-like kinase 4 (Drosophila)... STK18 )
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Aliasesfor PLK4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Polo-Like Kinase 4 1 2 3 Sak1 STK181 2 3 5 Polo-Like Kinase 4 (Drosophila)1 SAK2 3 5 Serine/Threonine Protein Kinase SAK2 Serine/Threonine Kinase 181 2 Serine/Threonine-Protein Kinase PLK42 Serine/Threonine-Protein Kinase 182 3 Snk Akin Kinase2 Serine/Threonine-Protein Kinase Sak2 3 EC 2.7.11.213 PLK-42 3
Export aliases for PLK4 gene to outside databases Previous GC identifers: GC04P129260 GC04P129159 GC04P129021 GC04P124529
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Summariesfor PLK4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for PLK4 : This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. (provided by RefSeq, Jun 2010) UniProtKB/Swiss-Prot: PLK4_HUMAN, O00444 Function : Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to triggerprocentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2 Gene Wiki entry for PLK4
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Genomic Viewsfor PLK4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_016354.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the PLK4 gene promoter:C/EBPbeta AML1a Sp1 NF-E2 p45 CREB deltaCREB Pax-4a NF-E2 Other transcription factors Search SABiosciences Chromatin IP Primers for PLK4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q28 Ensembl cytogenetic band: 4q28.2 HGNC cytogenetic band: 4q27-q28 PLK4 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P128802: view genomic region
(about GC identifiers )
Start: 128,802,016 bp from pter End:
128,820,379 bp from pter
Size: 18,364 bases Orientation:
plus strand
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Proteinsfor PLK4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: PLK4_HUMAN, O00444 See
protein sequence )Recommended Name: Size : 970 amino acids; 108972 DaSubunit : Homodimer (By similarity). Interacts with CEP152 (via N-terminus)Subcellular location : Cytoplasm, cytoskeleton, centrosome, centriole. Nucleus, nucleolus (By similarity). Cleavagefurrow. Note=Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows
1 PDB 3D structure from :3COK (3D) Secondary accessions : B2RAL0 B7Z837 B7Z8G7 Q8IYF0 Q96Q95 Q9UD84 Q9UDE2Alternative splicing : 3 isoforms : O00444-1 O00444-2 O00444-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PLK4: NX_O00444 Post-translational modifications:
Ubiquitinated; leading to its degradation by the proteasome (By similarity)1 Tyrosine-phosphorylated by TEC1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O00444 PLK4 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (3 alternative transcripts): NP_001177728.1 NP_001177730.1 NP_055079.3 ENSEMBL proteins: ENSP00000270861 ENSP00000421774 ENSP00000427554 ENSP00000423412 ENSP00000423582 ENSP00000427568 Reactome Protein details: O00444 Human Recombinant Protein Products: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing PLK4 Antibody Products: Assay Products for PLK4:
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Protein
Domains /for PLK4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry O00444 ProtoNet protein and cluster: O00444
1 Blocks protein family : IPB008266 UniProtKB/Swiss-Prot: PLK4_HUMAN, O00444 Similarity : Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamilySimilarity : Contains 1 POLO box domainSimilarity : Contains 1 protein kinase domain
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Functionfor PLK4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: PLK4_HUMAN, O00444 Function : Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to triggerprocentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2 Catalytic activity : ATP + a protein = ADP + a phosphoproteinInduction : Down-regulated in HCT 116 colorectal cancer cells, leading to aberrant centrioles composed of disorganizedcylindrical microtubules and displaced appendages. Down-regulated by p53/TP53 Enzyme Number (IUBMB): EC 2.7.11.21 1
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): PLK4 (NM_014264 ) Sino Biological Human cDNA Clone for PLK4 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PLK4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PLK4
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLK4
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing 3 GenomeRNAi human phenotypes for PLK4 :Animal Models: Plk4 tm1Jwd for PLK48 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Plk4) :About GeneDecksing
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Pathways & Interactionsfor PLK4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/6 super-pathways (see all 6 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Recruitment of mitotic centrosome proteins and complexes 2 Cell Cycle 3 PLK2 and PLK4 events 4 Cell Cycle / Checkpoint Control 5 Selected targets of p53
Pathway sources See GeneCards unified pathways Show all pathways 1 1 1 2 5/8 (see all 8 )About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PLK4 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/90 Interacting proteins for PLK4 (O00444 1 , 2 , 3 ENSP00000270861 4 via UniProtKB, MINT, STRING , and/or I2D (see all 90 )About this table Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing
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Drugs & Compoundsfor PLK4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for PLK4 2 HMDB Compounds for PLK4 About this table 4 Novoseek chemical compound relationships for PLK4 gene About this table PLK4
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Transcriptsfor PLK4 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for PLK4 gene (3 alternative transcripts): NM_001190799.1 NM_001190801.1 NM_014264.4 Unigene Cluster for PLK4:
Polo-like kinase 4 Hs.172052 [show with all ESTs ] Unigene Representative Sequence: NM_014264 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000270861 (uc003ifo.3 uc011cgs.2 uc011cgt.2 ) ENST00000511942 ENST00000503914 ENST00000515069 ENST00000513090 ENST00000507249 ENST00000514379 ENST00000510605 ENST00000507454 ENST00000508113 ENST00000510192 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): PLK4 (NM_014264 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PLK4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PLK4
Additional cDNA sequence: AB006972.1 AK302858.1 AK303399.1 AK314238.1 BC036023.1 Y13115.1 Z25433.1
5 DOTS entries : DT.313781 DT.100680216
DT.86845924 DT.100021202 DT.97818382 24/79 AceView cDNA sequences (see all 79 ):
AU130274 AA732873 Z45951 AW274701 BC036023 Z41568 BU633758 AA599731 AI380324 BI829311 AI189463 AA825821 F09138 BU431553 AI088969 BQ012426 BM759840 AA328593 BM830522 AI561148 CK299126 AA761923 BP351757 F11476 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PLK4 (see all 6 ) About this scheme ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 SP1 : SP2 : SP3 : - SP4 : - SP5 :
ECgene alternative splicing isoforms for PLK4
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Expression for PLK4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section PLK4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TATATTTGTT
About this image PLK4 expression in embryonic tissues and stem cells About this table 1 LifeMap In Vivo Development Anatomical Compartment/CellTissue Category (developmental path) Bone Thoracic Rib Bone Expression: Experimental details:
In-situ hybridization
Stem Cell Differentiation: 2 LifeMap Cells Name Category PureStem™ progenitor E44 (Embryonic Progenitor Cell)PureStem™ progenitor F15 (Embryonic Progenitor Cell)
See PLK4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for PLK4 SOURCE GeneReport for Unigene cluster: Hs.172052 SABiosciences Expression via Pathway-Focused PCR Array including PLK4 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLK4
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Orthologsfor PLK4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for PLK4 gene from 5/22 species (see all 22 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves PLK46
Uncharacterized protein
67(a)
1 ↔ 1
4(35480293-35495573)
lizard Reptilia PLK46
--
65(a)
1 ↔ 1
5(136382434-136403939)
African clawed frog Amphibia MGC687912
hypothetical protein MGC68791
75.75(n)
BC060363.1
zebrafish Actinopterygii Dr.115032
Danio rerio, Similar to serine/threonine kinase 18, more
73.8(n)
BC045337.1
fruit fly Insecta SAK1
Sak kinase
51.26(n) 46.53(a)
40384 NM_141067.2 NP_649324.1
ENSEMBL Gene Tree for PLK4 (if available)TreeFam Gene Tree for PLK4 (if available)
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Paralogsfor PLK4 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for PLK4 gene PLK2 2 PLK1 2 PLK5 2 PLK3 2 18/60 SIMAP similar genes for PLK4 using alignment to 4 protein entries: PLK4_HUMAN (see all proteins )
(see all similar genes ):Plk-1 delta AURKA MKNK1 RPS6KA2 AURKC RPS6KA3 AURKB PKN2 NUAK1 PkB-like 1 STK36 STK33 BRAF DKFZp564L2416 HUNK KIAA0999 KIN27 MYO3A About GeneDecksing 1 Pseudogenes.org Pseudogene for PLK4 PGOHUM00000249627
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Genomic Variantsfor PLK4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor PLK4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 605031
OMIM disorders : --7 : About MalaCards acute myocardial infarction myocardial infarction colorectal cancer breast cancer pneumonia tuberculosis mycobacterium tuberculosis 4 Novoseek disease relationships for PLK4 gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
acute myocardial infarction
5.22
1
8902993 (1)
stroke
0
1
10769618 (1)
tumors
0
4
15967108 (2), 20348415 (1)
cancer
0
1
16652354 (1)
Human Genome Epidemiology (HuGE) Navigator: PLK4 (3 documents) Export disorders for PLK4 gene to outside databases
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Publicationsfor PLK4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for PLK4 gene, integrated from 9 sources (see all 81 ):(articles sorted by number of sources associating them with PLK4) Utopia : connect your pdf to the dynamic
SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing. (PubMed id 15967108) 1 , 2 , 9(2005) Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase. (PubMed id 11489907) 1 , 2 , 9(2001) SAK/PLK4 is required for centriole duplication and flagella development. (PubMed id 16326102) 1 , 2 , 9(2005) The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication. (PubMed id 21725316) 1 , 2 (2011) Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome. (PubMed id 21059844) 1 , 2 (2010) Gamma-tubulin-containing abnormal centrioles are induced by insufficient Plk4 in human HCT116 colorectal cancer cells. (PubMed id 19454482) 1 , 2 (2009) Human Plk4 phosphorylates Cdc25C. (PubMed id 18239451) 1 , 2 (2008) Plk4-induced centriole biogenesis in human cells. (PubMed id 17681131) 1 , 2 (2007) The Polo kinase Plk4 functions in centriole duplication. (PubMed id 16244668) 1 , 2 (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004)
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External Searches for PLK4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing PLK4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing PLK4 gene
(According to HUGE )
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Specialized Databases showing PLK4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for PLK4 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for PLK4 gene: PLK4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor PLK4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for PLK4 OriGene shRNA RFP for PLK4 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for PLK4 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for PLK4 OriGene 3'-UTR Clone for PLK4 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for PLK4 OriGene Custom Protein Services for PLK4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PLK4 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for PLK4
Search Tocris compounds for PLK4
PLK4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLK4
ThermoFisher Antibody for PLK4
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PLK4
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and Proteopedia 
for PLK4:
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
Microarrays
