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PLK4 Gene(Protein Coding)

Polo Like Kinase 4

GCID:
GC04P127880
GIFtS:
55
Genes Participants
UDN Logo

Aliases for PLK4 Gene

Aliases for PLK4 Gene

  • Polo Like Kinase 4 2 3 5
  • Serine/Threonine-Protein Kinase Sak 3 4
  • Serine/Threonine-Protein Kinase 18 3 4
  • Polo-Like Kinase 4 2 4
  • STK18 3 4
  • SAK 3 4
  • Serine/Threonine-Protein Kinase PLK4 3
  • Polo-Like Kinase 4 (Drosophila) 2
  • Serine/Threonine Kinase 18 2
  • Snk Akin Kinase 3
  • EC 2.7.11.21 4
  • MCCRP2 3
  • PLK-4 4

External Ids for PLK4 Gene

Previous HGNC Symbols for PLK4 Gene

  • STK18

Previous GeneCards Identifiers for PLK4 Gene

  • GC04P129260
  • GC04P129159
  • GC04P129021
  • GC04P128802
  • GC04P124529

Summaries for PLK4 Gene

Entrez Gene Summary for PLK4 Gene

  • This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for PLK4 Gene

PLK4 (Polo Like Kinase 4) is a Protein Coding gene. Diseases associated with PLK4 include Microcephaly And Chorioretinopathy, Autosomal Recessive, 2 and Autosomal Recessive Chorioretinopathy-Microcephaly Syndrome. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is PLK3.

UniProtKB/Swiss-Prot for PLK4 Gene

  • Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates Ser-151 of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124).

Gene Wiki entry for PLK4 Gene

Additional gene information for PLK4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLK4 Gene

Genomics for PLK4 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for PLK4 Gene

Promoters and enhancers for PLK4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04I127879 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 0.0 -1 2.5 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 PLK4 HSPA4L ABHD18 ENSG00000261668
GH04I127856 Enhancer 0.9 Ensembl ENCODE 11.3 -23.9 -23916 1.7 MEIS2 PKNOX1 SMAD1 BACH1 EBF1 BMI1 BATF IRF4 POLR2A NFATC1 PLK4 RNU6-583P INTU ABHD18 ENSG00000261668
GH04I127846 Enhancer 0.7 ENCODE 12.1 -34.5 -34540 0.2 TEAD4 TAL1 CHAMP1 TCF12 ZNF316 NCOR1 CBFA2T2 NFE2 TRIM24 MAFK PLK4 RNU6-583P ENSG00000261668
GH04I127966 Enhancer 0.7 Ensembl ENCODE 11.5 +86.5 86493 1.1 BCOR KLF1 ZNF362 ZNF384 ZBTB33 CHAMP1 MFSD8 RNU6-583P PLK4 ABHD18 GC04M128059
GH04I126898 Enhancer 0.5 Ensembl ENCODE 4 -981.1 -981077 2.8 JUND PLK4 ENSG00000199862 GC04M127030 RBM48P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLK4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLK4 gene promoter:

Genomic Locations for PLK4 Gene

Genomic Locations for PLK4 Gene
chr4:127,880,861-127,899,224
(GRCh38/hg38)
Size:
18,364 bases
Orientation:
Plus strand
chr4:128,802,016-128,820,379
(GRCh37/hg19)

Genomic View for PLK4 Gene

Genes around PLK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLK4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PLK4 Gene

Proteins for PLK4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PLK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00444-PLK4_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PLK4
    Protein Accession:
    O00444
    Secondary Accessions:
    • B2RAL0
    • B7Z837
    • B7Z8G7
    • Q8IYF0
    • Q96Q95
    • Q9UD84
    • Q9UDE2

    Protein attributes for PLK4 Gene

    Size:
    970 amino acids
    Molecular mass:
    108972 Da
    Quaternary structure:
    • Homodimer (By similarity). Interacts with CEP152 (via N-terminus). Interacts with CEP78; this interaction may be important for proper PLK4 localization to the centriole and PLK4-induced overduplication of centrioles (PubMed:27246242).

    Three dimensional structures from OCA and Proteopedia for PLK4 Gene

    Alternative splice isoforms for PLK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLK4 Gene

Protein Expression for PLK4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PLK4 Gene

Other Protein References for PLK4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLK4 Gene

Domains & Families for PLK4 Gene

Gene Families for PLK4 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for PLK4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PLK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00444

UniProtKB/Swiss-Prot:

PLK4_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
genes like me logo Genes that share domains with PLK4: view

Function for PLK4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for PLK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates Ser-151 of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124).
UniProtKB/Swiss-Prot Induction:
Down-regulated in HCT 116 colorectal cancer cells, leading to aberrant centrioles composed of disorganized cylindrical microtubules and displaced appendages. Down-regulated by p53/TP53.

Enzyme Numbers (IUBMB) for PLK4 Gene

Gene Ontology (GO) - Molecular Function for PLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity ISS,IEA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PLK4: view
genes like me logo Genes that share phenotypes with PLK4: view

Human Phenotype Ontology for PLK4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PLK4 Gene

MGI Knock Outs for PLK4:

CRISPR Products

miRNA for PLK4 Gene

miRTarBase miRNAs that target PLK4

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for PLK4 Gene

Localization for PLK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLK4 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus, nucleolus. Cleavage furrow. Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLK4 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001741 XY body IEA --
GO:0005634 nucleus IEA --
GO:0005730 nucleolus ISS --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with PLK4: view

Pathways & Interactions for PLK4 Gene

genes like me logo Genes that share pathways with PLK4: view

Pathways by source for PLK4 Gene

1 KEGG pathway for PLK4 Gene
1 Qiagen pathway for PLK4 Gene

SIGNOR curated interactions for PLK4 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006468 protein phosphorylation IEA --
GO:0007099 centriole replication IEA,IMP 21725316
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with PLK4: view

Drugs & Compounds for PLK4 Gene

Products:

  1. Drug

(7) Drugs for PLK4 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist 0
GSK461364 Pharma Plk1 inhibitor, Kinase Inhibitors, Polo-like kinase inhibitor 0
HMN-214 Pharma Plk inhibitor,broad-spectrum anti-tumor agent 0
MLN0905 Pharma Potent PLK1 inhibitor 0
NMS-1286937 Pharma Kinase Inhibitors 0

(3) Additional Compounds for PLK4 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0

(4) ApexBio Compounds for PLK4 Gene

Compound Action Cas Number
GSK461364 Plk1 inhibitor 929095-18-1
HMN-214 Plk inhibitor,broad-spectrum anti-tumor agent 173529-46-9
MLN0905 Potent PLK1 inhibitor 1228960-69-7
NMS-1286937 1034616-18-6
genes like me logo Genes that share compounds with PLK4: view

Drug Products

Transcripts for PLK4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for PLK4 Gene

(6) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(79) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLK4 Gene

Polo-like kinase 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLK4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3: -
SP4: -
SP5:
SP6: -

Relevant External Links for PLK4 Gene

GeneLoc Exon Structure for
PLK4
ECgene alternative splicing isoforms for
PLK4

Expression for PLK4 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLK4 Gene

mRNA expression in normal human tissues for PLK4 Gene
mRNA expression by GTEx for PLK4 GenemRNA expression by BioGPS for PLK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLK4 Gene

This gene is overexpressed in Testis (x8.1).

Protein differential expression in normal tissues from HIPED for PLK4 Gene

This gene is overexpressed in Breast (30.3), Cervix (27.7), and Pancreatic juice (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLK4 Gene



Protein tissue co-expression partners for PLK4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLK4 Gene:

PLK4

SOURCE GeneReport for Unigene cluster for PLK4 Gene:

Hs.172052

Evidence on tissue expression from TISSUES for PLK4 Gene

  • Blood(4.3)
  • Lung(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PLK4 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cerebellum
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • larynx
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • outer ear
  • skull
  • tongue
  • tooth
  • vocal cord
Thorax:
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • kidney
Pelvis:
  • pelvis
  • penis
  • testicle
  • urethra
  • vagina
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • bone marrow
  • coagulation system
  • hair
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • spinal cord
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with PLK4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PLK4 Gene

Orthologs for PLK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PLK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia PLK4 33 34
  • 99.6 (n)
dog
(Canis familiaris)
 Mammalia PLK4 33 34
  • 91.96 (n)
cow
(Bos Taurus)
 Mammalia PLK4 33 34
  • 91.59 (n)
rat
(Rattus norvegicus)
 Mammalia Plk4 33
  • 85.33 (n)
mouse
(Mus musculus)
 Mammalia Plk4 33 16 34
  • 85.25 (n)
oppossum
(Monodelphis domestica)
 Mammalia PLK4 34
  • 70 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia PLK4 34
  • 50 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves LOC422497 33
  • 71.24 (n)
PLK4 34
  • 67 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia PLK4 34
  • 64 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia plk4 33
  • 66.31 (n)
African clawed frog
(Xenopus laevis)
 Amphibia MGC68791 33
zebrafish
(Danio rerio)
 Actinopterygii plk4 33 34
  • 58.55 (n)
Dr.11503 33
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.9557 33
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP012499 33
  • 55.34 (n)
fruit fly
(Drosophila melanogaster)
 Insecta SAK 33 34
  • 52 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes CDC5 34
  • 20 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.3490 34
  • 37 (a)
 OneToOne
Species where no ortholog for PLK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLK4 Gene

ENSEMBL:
Gene Tree for PLK4 (if available)
TreeFam:
Gene Tree for PLK4 (if available)

Paralogs for PLK4 Gene

Variants for PLK4 Gene

Sequence variations from dbSNP and Humsavar for PLK4 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs724159995 pathogenic, Microcephaly and chorioretinopathy, autosomal recessive, 2 127,898,434(+) C/G intron_variant
rs724159996 pathogenic, Microcephaly and chorioretinopathy, autosomal recessive, 2 127,886,669(+) TAAAG/ coding_sequence_variant, frameshift, intron_variant
rs199771668 likely-benign, not specified 127,883,297(+) A/C/G coding_sequence_variant, intron_variant, synonymous_variant
rs879255691 uncertain-significance, not provided 127,883,335(+) TGAAACATCCTTCT/T coding_sequence_variant, frameshift, intron_variant
rs141081905 uncertain-significance, not specified 127,890,181(+) C/G/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for PLK4 Gene

Variant ID Type Subtype PubMed ID
dgv5385n100 CNV gain 25217958
nsv1019193 CNV loss 25217958

Variation tolerance for PLK4 Gene

Residual Variation Intolerance Score: 25.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLK4 Gene

Human Gene Mutation Database (HGMD)
PLK4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLK4 Gene

Disorders for PLK4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PLK4 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PLK4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PLK4_HUMAN
  • Microcephaly and chorioretinopathy, autosomal recessive, 2 (MCCRP2) [MIM:616171]: A severe disorder characterized by microcephaly, delayed psychomotor development, growth retardation with dwarfism, and ocular abnormalities. {ECO:0000269 PubMed:25344692}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for PLK4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PLK4: view

No data available for Genatlas for PLK4 Gene

Publications for PLK4 Gene

  1. SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing. (PMID: 15967108) Li J … Sun Y (Neoplasia (New York, N.Y.) 2005) 3 4 22 58
  2. SAK/PLK4 is required for centriole duplication and flagella development. (PMID: 16326102) Bettencourt-Dias M … Glover DM (Current biology : CB 2005) 3 4 22 58
  3. Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase. (PMID: 11489907) Yamashita Y … Mano H (The Journal of biological chemistry 2001) 3 4 22 58
  4. Cep78 is a new centriolar protein involved in Plk4-induced centriole overduplication. (PMID: 27246242) Brunk K … Hoffmann I (Journal of cell science 2016) 3 4 58
  5. Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. (PMID: 25344692) Martin CA … Jackson AP (Nature genetics 2014) 3 4 58

Products for PLK4 Gene

  • Addgene plasmids for PLK4

Sources for PLK4 Gene

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