Aliases for PLK4 Gene
Aliases for PLK4 Gene
External Ids for PLK4 Gene
- HGNC: 11397
- Entrez Gene: 10733
- Ensembl: ENSG00000142731
- OMIM: 605031
- UniProtKB: O00444
Previous HGNC Symbols for PLK4 Gene
- STK18
Previous GeneCards Identifiers for PLK4 Gene
- GC04P129260
- GC04P129159
- GC04P129021
- GC04P128802
- GC04P124529
Summaries for PLK4 Gene
-
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
GeneCards Summary for PLK4 Gene
PLK4 (Polo Like Kinase 4) is a Protein Coding gene. Diseases associated with PLK4 include Microcephaly And Chorioretinopathy, Autosomal Recessive, 2 and Autosomal Recessive Chorioretinopathy-Microcephaly Syndrome. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is PLK3.
UniProtKB/Swiss-Prot for PLK4 Gene
-
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates Ser-151 of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124).
Additional gene information for PLK4 Gene
- Monarch Initiative
- Search for PLK4 at DataMed
- Search for PLK4 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLK4 Gene
Genomics for PLK4 Gene
GeneHancer (GH) Regulatory Elements for PLK4 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH04I127879 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 550.8 | 0.0 | -1 | 2.5 | HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 | PLK4 HSPA4L ABHD18 ENSG00000261668 | |
GH04I127856 | Enhancer | 0.9 | Ensembl ENCODE | 11.3 | -23.9 | -23916 | 1.7 | MEIS2 PKNOX1 SMAD1 BACH1 EBF1 BMI1 BATF IRF4 POLR2A NFATC1 | PLK4 RNU6-583P INTU ABHD18 ENSG00000261668 | |
GH04I127846 | Enhancer | 0.7 | ENCODE | 12.1 | -34.5 | -34540 | 0.2 | TEAD4 TAL1 CHAMP1 TCF12 ZNF316 NCOR1 CBFA2T2 NFE2 TRIM24 MAFK | PLK4 RNU6-583P ENSG00000261668 | |
GH04I127966 | Enhancer | 0.7 | Ensembl ENCODE | 11.5 | +86.5 | 86493 | 1.1 | BCOR KLF1 ZNF362 ZNF384 ZBTB33 CHAMP1 | MFSD8 RNU6-583P PLK4 ABHD18 GC04M128059 | |
GH04I126898 | Enhancer | 0.5 | Ensembl ENCODE | 4 | -981.1 | -981077 | 2.8 | JUND | PLK4 ENSG00000199862 GC04M127030 RBM48P1 |
Regulatory Element Products
Genomic Locations for PLK4 Gene
- chr4:127,880,861-127,899,224
- (GRCh38/hg38)
- Size:
- 18,364 bases
- Orientation:
- Plus strand
- chr4:128,802,016-128,820,379
- (GRCh37/hg19)
Genomic View for PLK4 Gene
- Cytogenetic band:
-
- 4q28.1 by Ensembl
- 4q28.1 by Entrez Gene
- 4q28.1 by HGNC


RefSeq DNA sequence for PLK4 Gene
Proteins for PLK4 Gene
-
Protein details for PLK4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00444-PLK4_HUMAN
- Recommended name:
- Serine/threonine-protein kinase PLK4
- Protein Accession:
- O00444
- B2RAL0
- B7Z837
- B7Z8G7
- Q8IYF0
- Q96Q95
- Q9UD84
- Q9UDE2
Protein attributes for PLK4 Gene
- Size:
- 970 amino acids
- Molecular mass:
- 108972 Da
- Quaternary structure:
-
- Homodimer (By similarity). Interacts with CEP152 (via N-terminus). Interacts with CEP78; this interaction may be important for proper PLK4 localization to the centriole and PLK4-induced overduplication of centrioles (PubMed:27246242).
Three dimensional structures from OCA and Proteopedia for PLK4 Gene
Protein Expression for PLK4 Gene
Post-translational modifications for PLK4 Gene
- Tyrosine-phosphorylated by TEC.
- Ubiquitinated; leading to its degradation by the proteasome.
Other Protein References for PLK4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PLK4
-
Abcam antibodies for PLK4
- Invitrogen Antibodies for PLK4
- GeneTex PLK4 antibody for PLK4
-
Santa Cruz Biotechnology (SCBT) Antibodies for PLK4
- Sino Biological Antibodies for PLK4
Protein Products
-
OriGene Purified Proteins for PLK4
- Search Origene for MassSpec and Protein Over-expression Lysates for PLK4
- Origene Custom Protein Services for PLK4
- Search GeneTex for Proteins for PLK4
-
Abcam proteins for PLK4
Assay Products
- antibodies-online: Search results for available PLK4 related products ranked by validation data
No data available for DME Specific Peptides for PLK4 Gene
Domains & Families for PLK4 Gene
Gene Families for PLK4 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for PLK4 Gene
Suggested Antigen Peptide Sequences for PLK4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O00444UniProtKB/Swiss-Prot:
PLK4_HUMAN :- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
Function for PLK4 Gene
Molecular function for PLK4 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates Ser-151 of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124).
- UniProtKB/Swiss-Prot Induction:
- Down-regulated in HCT 116 colorectal cancer cells, leading to aberrant centrioles composed of disorganized cylindrical microtubules and displaced appendages. Down-regulated by p53/TP53.
Enzyme Numbers (IUBMB) for PLK4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | ISS,IEA | -- |
GO:0005515 | protein binding | IPI | 16189514 |
GO:0005524 | ATP binding | IEA | -- |
Phenotypes for PLK4 Gene
- MGI mutant phenotypes for PLK4:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for PLK4:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Effect on mitosis
- Decreased viability
- Decreased substrate adherent cell growth
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased cell migration
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Increased mitotic index
- Increased Nanog expression
- Decreased centriole number
- Decreased Cdk9 T-loop phosphorylation
- Reduced beta-catenin activity and colon cancer cell proliferation
Animal Models for PLK4 Gene
- MGI Knock Outs for PLK4:
-
- Plk4 tm1Jwd
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for PLK4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PLK4 gene
- Search ViGene Biosciences for PLK4
CRISPR Products
-
OriGene CRISPR knockouts for PLK4
- genomics-online: gRNA clones - Search results for available PLK4 gene related products
- Applied Biological Materials CRISPR for PLK4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLK4
- GenScript: Design CRISPR guide RNA sequences for PLK4
miRNA for PLK4 Gene
- miRTarBase miRNAs that target PLK4
miRNA Products
- Search ViGene Biosciences for PLK4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PLK4
- Browse OriGene Inhibitory RNA Products For PLK4
- genomics-online: shRNA clones - Search results for available PLK4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PLK4 gene
Clone Products
-
OriGene ORF clones in human for PLK4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PLK4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PLK4
- genomics-online: cdna clones - Search results for available PLK4 gene related products
- orf clones - Search results for available PLK4 gene related products
- Applied Biological Materials Clones for PLK4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PLK4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PLK4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PLK4 gene
No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for PLK4 Gene
Localization for PLK4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PLK4 Gene
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus, nucleolus. Cleavage furrow. Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows.
- Centrosome (3)
- Cytosol (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001741 | XY body | IEA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005730 | nucleolus | ISS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005813 | centrosome | IDA | 21399614 |
Pathways & Interactions for PLK4 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of PLK1 Activity at G2/M Transition |
.49
|
|
2 | FoxO signaling pathway | ||
3 | Cell Cycle, Mitotic |
.83
|
|
4 | Organelle biogenesis and maintenance |
.56
|
|
5 | Sweet Taste Signaling |
.37
|
Pathways by source for PLK4 Gene
3 BioSystems pathways for PLK4 Gene
13 Reactome pathways for PLK4 Gene
1 KEGG pathway for PLK4 Gene
1 Qiagen pathway for PLK4 Gene
Interacting Proteins for PLK4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0007099 | centriole replication | IEA,IMP | 21725316 |
GO:0010389 | regulation of G2/M transition of mitotic cell cycle | TAS | -- |
GO:0016310 | phosphorylation | IEA | -- |
Drugs & Compounds for PLK4 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
ATP | Investigational | Nutra | Agonist | 0 | ||
GSK461364 | Pharma | Plk1 inhibitor, Kinase Inhibitors, Polo-like kinase inhibitor | 0 | |||
HMN-214 | Pharma | Plk inhibitor,broad-spectrum anti-tumor agent | 0 | |||
MLN0905 | Pharma | Potent PLK1 inhibitor | 0 | |||
NMS-1286937 | Pharma | Kinase Inhibitors | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(4) ApexBio Compounds for PLK4 Gene
Compound | Action | Cas Number |
---|---|---|
GSK461364 | Plk1 inhibitor | 929095-18-1 |
HMN-214 | Plk inhibitor,broad-spectrum anti-tumor agent | 173529-46-9 |
MLN0905 | Potent PLK1 inhibitor | 1228960-69-7 |
NMS-1286937 | 1034616-18-6 |
Transcripts for PLK4 Gene
mRNA/cDNA for PLK4 Gene
- (6) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (79) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PLK4
- genomics-online: gRNA clones - Search results for available PLK4 gene related products
- Applied Biological Materials CRISPR for PLK4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLK4
- GenScript: Design CRISPR guide RNA sequences for PLK4
miRNA Products
- Search ViGene Biosciences for PLK4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PLK4
- Browse OriGene Inhibitory RNA Products For PLK4
- genomics-online: shRNA clones - Search results for available PLK4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PLK4 gene
Clone Products
-
OriGene ORF clones in human for PLK4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PLK4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PLK4
- genomics-online: cdna clones - Search results for available PLK4 gene related products
- orf clones - Search results for available PLK4 gene related products
- Applied Biological Materials Clones for PLK4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - |
Expression for PLK4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Zeugopod
- Rib
-
Limb (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Zeugopod
-
Brain (Nervous System)
- Choroid Plexus Progenitor Cells Choroid Plexus
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for PLK4 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLK4 Gene
NURSA nuclear receptor signaling pathways regulating expression of PLK4 Gene:
PLK4SOURCE GeneReport for Unigene cluster for PLK4 Gene:
Hs.172052Evidence on tissue expression from TISSUES for PLK4 Gene
- Blood(4.3)
- Lung(4.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PLK4 Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
- brain
- cerebellum
- cheek
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- larynx
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- skull
- tongue
- tooth
- vocal cord
- chest wall
- clavicle
- heart
- heart valve
- lung
- rib
- rib cage
- scapula
- sternum
- kidney
- pelvis
- penis
- testicle
- urethra
- vagina
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
- blood
- bone marrow
- coagulation system
- hair
- peripheral nervous system
- red blood cell
- skin
- spinal column
- spinal cord
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for PLK4
-
OriGene qPCR primer pairs and template standards for PLK4
- genomics-online: primer clones - Search results for available PLK4 gene related products
No data available for mRNA Expression by UniProt/SwissProt for PLK4 Gene
Orthologs for PLK4 Gene
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PLK4 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | PLK4 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | PLK4 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Plk4 33 |
|
||
mouse (Mus musculus) |
Mammalia | Plk4 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | PLK4 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | PLK4 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | LOC422497 33 |
|
||
PLK4 34 |
|
OneToOne | |||
lizard (Anolis carolinensis) |
Reptilia | PLK4 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | plk4 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | MGC68791 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | plk4 33 34 |
|
||
Dr.11503 33 |
|
||||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9557 33 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012499 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | SAK 33 34 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC5 34 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3490 34 |
|
OneToOne |
- Species where no ortholog for PLK4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PLK4 Gene
(58) SIMAP similar genes for PLK4 Gene using alignment to 4 proteins:
- Plk-1 delta
- RPS6KA2
- MKNK1
- AURKA
- AURKC
- RPS6KA3
- PKN2
- AURKB
- STK36
- PkB-like 1
- NUAK1
- STK33
- STK32A
- PRKAA1
- PDPK2
- MYO3A
- KIN27
- KIAA0999
- HUNK
- DKFZp564L2416
- BRAF
- PRKACA
- MARK4
- MAPK8
- DAPK1
- TRIB2
- STK17A
- STK11
- PRKACG
- PAK2
- DAPK2
- CCRK
- PRKACB
- MARK3
- CAMK1
- STK25
- PRKY
- PNCK
- PHKG1
- CHEK2
- CAMK2B
- NEK6
- NEK3
- CDK10
- TSSK3
- TRIB1
- PRKG2
- PAK4
- MST094
- CAMK2D
- SGK2
- PIM2
- NEK7
- CDK7
- CDC2
- CAMK1D
- MAPK14
- CDK4
Pseudogenes.org Pseudogenes for PLK4 Gene
Variants for PLK4 Gene
SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs724159995 | pathogenic, Microcephaly and chorioretinopathy, autosomal recessive, 2 | 127,898,434(+) | C/G | intron_variant | |
rs724159996 | pathogenic, Microcephaly and chorioretinopathy, autosomal recessive, 2 | 127,886,669(+) | TAAAG/ | coding_sequence_variant, frameshift, intron_variant | |
rs199771668 | likely-benign, not specified | 127,883,297(+) | A/C/G | coding_sequence_variant, intron_variant, synonymous_variant | |
rs879255691 | uncertain-significance, not provided | 127,883,335(+) | TGAAACATCCTTCT/T | coding_sequence_variant, frameshift, intron_variant | |
rs141081905 | uncertain-significance, not specified | 127,890,181(+) | C/G/T | coding_sequence_variant, missense_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv5385n100 | CNV | gain | 25217958 |
nsv1019193 | CNV | loss | 25217958 |
Additional Variant Information for PLK4 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLK4 Gene
Disorders for PLK4 Gene

(5) MalaCards diseases for PLK4 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
microcephaly and chorioretinopathy, autosomal recessive, 2 |
|
|
autosomal recessive chorioretinopathy-microcephaly syndrome |
|
|
seckel syndrome |
|
|
dwarfism |
|
|
microcephaly |
|
|
UniProtKB/Swiss-Prot
PLK4_HUMAN- Microcephaly and chorioretinopathy, autosomal recessive, 2 (MCCRP2) [MIM:616171]: A severe disorder characterized by microcephaly, delayed psychomotor development, growth retardation with dwarfism, and ocular abnormalities. {ECO:0000269 PubMed:25344692}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for PLK4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for PLK4 Gene
Publications for PLK4 Gene
- SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing. (PMID: 15967108) Li J … Sun Y (Neoplasia (New York, N.Y.) 2005) 3 4 22 58
- SAK/PLK4 is required for centriole duplication and flagella development. (PMID: 16326102) Bettencourt-Dias M … Glover DM (Current biology : CB 2005) 3 4 22 58
- Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase. (PMID: 11489907) Yamashita Y … Mano H (The Journal of biological chemistry 2001) 3 4 22 58
- Cep78 is a new centriolar protein involved in Plk4-induced centriole overduplication. (PMID: 27246242) Brunk K … Hoffmann I (Journal of cell science 2016) 3 4 58
- Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. (PMID: 25344692) Martin CA … Jackson AP (Nature genetics 2014) 3 4 58
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