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Aliases for PLK3 Gene

Aliases for PLK3 Gene

  • Polo-Like Kinase 3 2 3 4
  • Cytokine-Inducible Serine/Threonine-Protein Kinase 3 4
  • Proliferation-Related Kinase 3 4
  • FGF-Inducible Kinase 3 4
  • EC 2.7.11.21 4 63
  • PLK-3 3 4
  • CNK 3 4
  • FNK 3 4
  • PRK 3 4
  • Polo-Like Kinase 3 (Drosophila) 2
  • Cytokine-Inducible Kinase 2
  • EC 2.7.11 63

External Ids for PLK3 Gene

Previous HGNC Symbols for PLK3 Gene

  • CNK

Previous GeneCards Identifiers for PLK3 Gene

  • GC01P044679
  • GC01P044934
  • GC01P045038
  • GC01P045265
  • GC01P043379

Summaries for PLK3 Gene

Entrez Gene Summary for PLK3 Gene

  • The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis. [provided by RefSeq, Sep 2015]

GeneCards Summary for PLK3 Gene

PLK3 (Polo-Like Kinase 3) is a Protein Coding gene. Among its related pathways are DNA Damage and Integrated Breast Cancer Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PLK4.

UniProtKB/Swiss-Prot for PLK3 Gene

  • Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.

Tocris Summary for PLK3 Gene

  • Polo-like kinases (PLKs) are a family of four serine/threonine protein kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. PLK1, -2 and -3 are ubiquitously expressed, whereas PLK4 is restricted to a few tissues.

Gene Wiki entry for PLK3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLK3 Gene

Genomics for PLK3 Gene

Regulatory Elements for PLK3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PLK3 Gene

Chromosome:
1
Start:
44,799,952 bp from pter
End:
44,805,995 bp from pter
Size:
6,044 bases
Orientation:
Plus strand

Genomic View for PLK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLK3 Gene

Proteins for PLK3 Gene

  • Protein details for PLK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4B4-PLK3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PLK3
    Protein Accession:
    Q9H4B4
    Secondary Accessions:
    • Q15767
    • Q5JR99
    • Q96CV1

    Protein attributes for PLK3 Gene

    Size:
    646 amino acids
    Molecular mass:
    71629 Da
    Quaternary structure:
    • Interacts (via the POLO-box domain) with CIB1; leading to inhibit PLK3 kinase activity. Interacts with GOLGB1.
    SequenceCaution:
    • Sequence=AAC50637.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLK3 Gene

neXtProt entry for PLK3 Gene

Proteomics data for PLK3 Gene at MOPED

Post-translational modifications for PLK3 Gene

  • Phosphorylated in an ATM-dependent manner following DNA damage. Phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PLK3 (PLK3)

Domains & Families for PLK3 Gene

Gene Families for PLK3 Gene

Suggested Antigen Peptide Sequences for PLK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H4B4

UniProtKB/Swiss-Prot:

PLK3_HUMAN :
  • The POLO box domains act as phosphopeptide-binding module that recognize and bind serine-[phosphothreonine/phosphoserine]-(proline/X) motifs. PLK3 recognizes and binds docking proteins that are already phosphorylated on these motifs, and then phosphorylates them (By similarity). The POLO box domains mediates localization to the centrosome.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
Domain:
  • The POLO box domains act as phosphopeptide-binding module that recognize and bind serine-[phosphothreonine/phosphoserine]-(proline/X) motifs. PLK3 recognizes and binds docking proteins that are already phosphorylated on these motifs, and then phosphorylates them (By similarity). The POLO box domains mediates localization to the centrosome.
  • Contains 2 POLO box domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
genes like me logo Genes that share domains with PLK3: view

Function for PLK3 Gene

Molecular function for PLK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.
UniProtKB/Swiss-Prot Induction:
Cytokine and cellular adhesion trigger induction. Down-regulated in a majority of lung carcinoma samples.

Enzyme Numbers (IUBMB) for PLK3 Gene

Gene Ontology (GO) - Molecular Function for PLK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IDA 11447225
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 11447225
GO:0005515 protein binding IPI 14968113
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PLK3: view
genes like me logo Genes that share phenotypes with PLK3: view

Animal Models for PLK3 Gene

MGI Knock Outs for PLK3:

Animal Model Products

miRNA for PLK3 Gene

miRTarBase miRNAs that target PLK3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLK3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PLK3 Gene

Localization for PLK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLK3 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Translocates to the nucleus upon cisplatin treatment. Localizes to the Golgi apparatus during interphase. According to a report, PLK3 localizes only in the nucleolus and not in the centrosome, or in any other location in the cytoplasm (PubMed:17264206). The discrepancies in results may be explained by the PLK3 antibody specificity, by cell line-specific expression or post-translational modifications. {ECO:0000269 PubMed:17264206}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLK3 Gene COMPARTMENTS Subcellular localization image for PLK3 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for PLK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005634 nucleus IDA 19490146
GO:0005730 nucleolus IDA 17264206
GO:0005737 cytoplasm IDA 19490146
GO:0005795 Golgi stack IDA 14980500
genes like me logo Genes that share ontologies with PLK3: view

Pathways & Interactions for PLK3 Gene

genes like me logo Genes that share pathways with PLK3: view

Pathways by source for PLK3 Gene

1 Cell Signaling Technology pathway for PLK3 Gene
2 KEGG pathways for PLK3 Gene
1 GeneGo (Thomson Reuters) pathway for PLK3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for PLK3 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for PLK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IMP 17264206
GO:0000086 G2/M transition of mitotic cell cycle TAS 16481012
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 19490146
GO:0000302 response to reactive oxygen species IDA 11447225
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with PLK3: view

Drugs & Compounds for PLK3 Gene

(8) Drugs for PLK3 Gene - From: HMDB, ApexBio, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
GSK461364 Pharma Plk1 inhibitor, Kinase Inhibitors, Polo-like kinase inhibitor 0
HMN-214 Pharma Plk inhibitor,broad-spectrum anti-tumor agent 0
MLN0905 Pharma Potent PLK1 inhibitor 0
NMS-1286937 Pharma Kinase Inhibitors 0

(5) Additional Compounds for PLK3 Gene - From: HMDB, NovoSeek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
Cyclapolin 9
40533-25-3
SBE 13 hydrochloride
1052532-15-6
TC-S 7005
1082739-92-1
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
genes like me logo Genes that share compounds with PLK3: view

Transcripts for PLK3 Gene

Unigene Clusters for PLK3 Gene

Polo-like kinase 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLK3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLK3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for PLK3 Gene

GeneLoc Exon Structure for
PLK3
ECgene alternative splicing isoforms for
PLK3

Expression for PLK3 Gene

mRNA expression in normal human tissues for PLK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLK3 Gene

This gene is overexpressed in Whole Blood (x6.8).

SOURCE GeneReport for Unigene cluster for PLK3 Gene Hs.632415

mRNA Expression by UniProt/SwissProt for PLK3 Gene

Q9H4B4-PLK3_HUMAN
Tissue specificity: Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. May have a short half-live. In cells of hematopoietic origin, strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor
genes like me logo Genes that share expression patterns with PLK3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PLK3 Gene

Orthologs for PLK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PLK3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLK3 35
  • 90.61 (n)
  • 92.26 (a)
PLK3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLK3 35
  • 90.47 (n)
  • 93.23 (a)
PLK3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plk3 35
  • 88.38 (n)
  • 93.47 (a)
Plk3 16
Plk3 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plk3 35
  • 88.16 (n)
  • 93.63 (a)
oppossum
(Monodelphis domestica)
Mammalia PLK3 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLK3 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLK3 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLK3 35
  • 70.29 (n)
  • 68.45 (a)
PLK3 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLK3 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plk3 35
  • 64.54 (n)
  • 67.36 (a)
Str.19671 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19981 35
zebrafish
(Danio rerio)
Actinopterygii plk3 35
  • 61.94 (n)
  • 61.42 (a)
plk3 36
  • 56 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC5 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8152 36
  • 38 (a)
OneToMany
Species with no ortholog for PLK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLK3 Gene

ENSEMBL:
Gene Tree for PLK3 (if available)
TreeFam:
Gene Tree for PLK3 (if available)

Paralogs for PLK3 Gene

Paralogs for PLK3 Gene

(12) SIMAP similar genes for PLK3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLK3: view

Variants for PLK3 Gene

Sequence variations from dbSNP and Humsavar for PLK3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1804641 -- 44,804,172(+) TGAAG(A/T)AGGTC reference, missense, nc-transcript-variant
rs3795716 -- 44,802,026(+) CTGAT(C/G)TGTGC intron-variant
rs4520451 -- 44,805,061(+) ATGGC(G/T)CACCA intron-variant
rs6676749 -- 44,798,873(+) TAAAG(G/T)AGGCT upstream-variant-2KB
rs11211035 -- 44,799,568(+) AAAAA(A/G)AAAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLK3 Gene

Variant ID Type Subtype PubMed ID
nsv461406 CNV Loss 19166990
nsv870815 CNV Loss 21882294
nsv871320 CNV Loss 21882294
nsv870773 CNV Loss 21882294
nsv870876 CNV Loss 21882294

Variation tolerance for PLK3 Gene

Residual Variation Intolerance Score: 19.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLK3 Gene

HapMap Linkage Disequilibrium report
PLK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLK3 Gene

Disorders for PLK3 Gene

Relevant External Links for PLK3

Genetic Association Database (GAD)
PLK3
Human Genome Epidemiology (HuGE) Navigator
PLK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLK3
genes like me logo Genes that share disorders with PLK3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLK3 Gene

Publications for PLK3 Gene

  1. Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas. (PMID: 8702627) Li B. … Dai W. (J. Biol. Chem. 1996) 2 23 67
  2. Development of high-throughput assays based on fluorescence polarization for inhibitors of the polo-box domains of polo-like kinases 2 and 3. (PMID: 19716361) Reindl W. … Berg T. (Anal. Biochem. 2009) 23 67
  3. GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers. (PMID: 18167338) Kang T. … Piwnica-Worms H. (Cancer Cell 2008) 23 67
  4. In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1. (PMID: 17267659) Lansing T.J. … Cheung M. (Mol. Cancer Ther. 2007) 23 67
  5. Polo-like kinase 3 is required for entry into S phase. (PMID: 17264206) Zimmerman W.C. … Erikson R.L. (Proc. Natl. Acad. Sci. U.S.A. 2007) 23 67

Products for PLK3 Gene

  • Addgene plasmids for PLK3

Sources for PLK3 Gene

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