Aliases for PLK2 Gene
Aliases for PLK2 Gene
External Ids for PLK2 Gene
- HGNC: 19699
- Entrez Gene: 10769
- Ensembl: ENSG00000145632
- OMIM: 607023
- UniProtKB: Q9NYY3
Previous GeneCards Identifiers for PLK2 Gene
- GC05M057765
- GC05M057785
- GC05M057749
- GC05M054706
Summaries for PLK2 Gene
-
The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for PLK2 Gene
PLK2 (Polo Like Kinase 2) is a Protein Coding gene. Diseases associated with PLK2 include Kummell's Disease. Among its related pathways are Gene Expression and DNA Damage. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PLK3.
UniProtKB/Swiss-Prot for PLK2 Gene
-
Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLK2 Gene
Genomics for PLK2 Gene
GeneHancer (GH) Regulatory Elements for PLK2 Gene
Promoters and enhancers for PLK2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH05I058451 | Promoter/Enhancer | 2.5 | EPDnew FANTOM5 Ensembl ENCODE | 550.8 | +3.1 | 3080 | 11.5 | PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF213 | PLK2 GAPT GC05P058452 | |
| GH05I057777 | Enhancer | 1.2 | FANTOM5 Ensembl ENCODE | 11.5 | +680.9 | 680907 | 2.9 | CTCF FEZF1 CEBPG RAD21 GATA3 ZNF316 GLI2 SMC3 ATF7 MAFK | PLK2 MAP3K1 GC05P057752 LINC02225 | |
| GH05I057822 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 10 | +635.6 | 635553 | 4 | PKNOX1 JUN CEBPB FEZF1 EP300 ZNF843 RFX5 MAFF GATA3 JUND | PLK2 LINC02225 GC05P057752 | |
| GH05I057886 | Enhancer | 0.9 | Ensembl ENCODE | 12.6 | +571.6 | 571614 | 3.9 | NCOA3 CTCF MXI1 MAX SIN3A RAD21 RFX5 ZNF335 GATA3 POLR2A | PLK2 LINC02225 GC05P057752 | |
| GH05I057498 | Enhancer | 1 | Ensembl ENCODE | 11.2 | +960.7 | 960725 | 1.3 | CTCF FOXA2 TEAD4 MAX ZNF384 BMI1 KLF5 RAD21 ZKSCAN1 GATA3 | MIER3 ENSG00000271828 PLK2 ACTBL2 LINCR-0003 LOC102724122 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PLK2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PLK2 Gene
Genomic Locations for PLK2 Gene
- chr5:58,453,982-58,460,260
- (GRCh38/hg38)
- Size:
- 6,279 bases
- Orientation:
- Minus strand
- chr5:57,749,809-57,756,087
- (GRCh37/hg19)
Genomic View for PLK2 Gene
Genes around PLK2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q11.2 by Ensembl
- 5q11.2 by Entrez Gene
- 5q11.2 by HGNC
PLK2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLK2 Gene
Proteins for PLK2 Gene
-
Protein details for PLK2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NYY3-PLK2_HUMAN
- Recommended name:
- Serine/threonine-protein kinase PLK2
- Protein Accession:
- Q9NYY3
- O60679
- Q96CV7
- Q9UE61
Protein attributes for PLK2 Gene
- Size:
- 685 amino acids
- Molecular mass:
- 78237 Da
- Quaternary structure:
-
- Interacts with NSF; causing NSF dissociation from GRIA2. Interacts with CIB1 (By similarity).
- Miscellaneous:
-
- There are indications that PLK2 might act as a tumor suppressor: PLK2 is significantly down-regulated in a wide range of acute myeloid leukemias (AMLs) and B-cell lymphomas due to aberrant cytosine methylation in the CpG island located at the 5 of the PLK2 gene (PubMed:16160013, PubMed:21340720). Moreover, miR-126, a microRNA that negatively regulates PLK2 is up-regulated in AMLs, suggesting that PLK2 down-regulation by miR-126 could also contribute to leukemogenesis (PubMed:18832181).
Protein Expression for PLK2 Gene
Selected DME Specific Peptides for PLK2 Gene
- Q9NYY3:
-
- ILHRDLK
- LGKGGFA
- HHKHVVQ
- SITQQPSKHR
- LKETYRCI
- VLRGCLE
- HRDLKLGN
- KPHQREK
- TICGTPNY
- MELKVGDFGLAARLEP
- GVLFNNG
- ILHRDLKLGNFFI
Post-translational modifications for PLK2 Gene
- Catalytic activity is enhanced by phosphorylation of Thr-239.
Other Protein References for PLK2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for PLK2 (PLK2)
- Novus Biologicals Antibodies for PLK2
-
Abcam antibodies for PLK2
- Invitrogen Antibodies for PLK2
- GeneTex PLK2 antibody for PLK2
-
Santa Cruz Biotechnology (SCBT) Antibodies for PLK2
Protein Products
-
OriGene Purified Proteins for PLK2
- Search Origene for MassSpec and Protein Over-expression Lysates for PLK2
- Origene Custom Protein Services for PLK2
- Search GeneTex for Proteins for PLK2
-
Abcam proteins for PLK2
Assay Products
- antibodies-online: Search results for 4 available PLK2 Elisa Kits ranked by validation data
- Compare Top PLK2 Elisa Kits
-
Quality Products:
Domains & Families for PLK2 Gene
Gene Families for PLK2 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PLK2 Gene
Suggested Antigen Peptide Sequences for PLK2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NYY3UniProtKB/Swiss-Prot:
PLK2_HUMAN :- The POLO box domains act as phosphopeptide-binding module that recognize and bind serine-[phosphothreonine/phosphoserine]-(proline/X) motifs. PLK2 recognizes and binds docking proteins that are already phosphorylated on these motifs, and then phosphorylates them (By similarity).
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
- Domain:
-
- The POLO box domains act as phosphopeptide-binding module that recognize and bind serine-[phosphothreonine/phosphoserine]-(proline/X) motifs. PLK2 recognizes and binds docking proteins that are already phosphorylated on these motifs, and then phosphorylates them (By similarity).
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
Function for PLK2 Gene
Molecular function for PLK2 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by phosphorylation of Thr-239. Once activated, activity is stimulated by binding target proteins (By similarity).
- UniProtKB/Swiss-Prot Function:
- Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.
- UniProtKB/Swiss-Prot Induction:
- Directly regulated by p53/TP53. Negatively regulated by miR-126.
Enzyme Numbers (IUBMB) for PLK2 Gene
Phenotypes From GWAS Catalog for PLK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA,TAS | -- |
| GO:0004871 | signal transducer activity | IMP,HMP | 12761501 |
| GO:0005515 | protein binding | IPI | 20352051 |
Phenotypes for PLK2 Gene
- MGI mutant phenotypes for PLK2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PLK2:
-
- Increased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased ionizing radiation sensitivity
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- G0/1 arrest
- Transferrin accumulation in the perinuclear area
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell viability after pRB stimulation
- Apoptosis resistance
- Decreased 12E8 tau but not total tau protein expression and decreased ratio of 12E8/total tau protein expression
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PLK2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PLK2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PLK2 gene
- Search ViGene Biosciences for PLK2
CRISPR Products
-
OriGene CRISPR knockouts for PLK2
- genomics-online: gRNA clones - Search results for available PLK2 gene related products
- Applied Biological Materials CRISPR for PLK2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLK2
- GenScript: Design CRISPR guide RNA sequences for PLK2
miRNA for PLK2 Gene
- miRTarBase miRNAs that target PLK2
-
- hsa-mir-126-3p (MIRT000344)
- hsa-mir-1-3p (MIRT023782)
- hsa-mir-98-5p (MIRT027672)
- hsa-mir-3187-3p (MIRT535126)
- hsa-mir-190a-3p (MIRT535127)
- hsa-mir-4529-5p (MIRT535128)
- hsa-mir-676-5p (MIRT535129)
- hsa-mir-3613-3p (MIRT535130)
- hsa-mir-8076 (MIRT535131)
- hsa-mir-5011-5p (MIRT535132)
- hsa-mir-27b-3p (MIRT731598)
miRNA Products
- Search ViGene Biosciences for PLK2
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for PLK2
- Browse OriGene Inhibitory RNA Products For PLK2
- genomics-online: shRNA clones - Search results for available PLK2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PLK2 gene
Clone Products
- Sino Biological Human cDNA Clone for PLK2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PLK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PLK2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PLK2
- genomics-online: cdna clones - Search results for available PLK2 gene related products
- orf clones - Search results for available PLK2 gene related products
- Applied Biological Materials Clones for PLK2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PLK2
-
ViGene Biosciences adenoviral particle packaged cDNA for PLK2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PLK2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PLK2 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLK2 Gene
Localization for PLK2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PLK2 Gene
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, dendrite. Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| cytosol | 5 |
| nucleus | 3 |
| extracellular | 1 |
- Cytosol (2)
- Mitochondria (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IEA | -- |
| GO:0005622 | intracellular | ISS,IEA | -- |
| GO:0005737 | cytoplasm | IDA | 23983262 |
| GO:0005813 | centrosome | IDA | 15242618 |
| GO:0005814 | centriole | IEA,IDA | 19001868 |
Pathways & Interactions for PLK2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | FoxO signaling pathway | ||
| 2 | Gene Expression |
.48
|
|
| 3 | TP53 Regulates Transcription of Cell Cycle Genes | ||
| 4 | DNA Damage | ||
| 5 | Regulation of TP53 Activity | ||
Pathways by source for PLK2 Gene
1 Cell Signaling Technology pathway for PLK2 Gene
2 BioSystems pathways for PLK2 Gene
5 Reactome pathways for PLK2 Gene
1 KEGG pathway for PLK2 Gene
Interacting Proteins for PLK2 Gene
Selected Interacting proteins:
ENSP00000274289
Q9NYY3-PLK2_HUMAN
for PLK2 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IMP | 15242618 |
| GO:0000278 | mitotic cell cycle | IEA | -- |
| GO:0006468 | protein phosphorylation | IEA,IDA | 20352051 |
| GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | TAS | -- |
| GO:0007052 | mitotic spindle organization | IDA | 19001868 |
Drugs & Compounds for PLK2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| ATP | Investigational | Nutra | Agonist | 0 | ||
| BI6727 (Volasertib) | Pharma | Plk inhibitor,highly potent | 0 | |||
| GSK461364 | Pharma | Plk1 inhibitor, Kinase Inhibitors, Polo-like kinase inhibitor | 0 | |||
| HMN-214 | Pharma | Plk inhibitor,broad-spectrum anti-tumor agent | 0 | |||
| MLN0905 | Pharma | Potent PLK1 inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(7) ApexBio Compounds for PLK2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BI6727 (Volasertib) | Plk inhibitor,highly potent | 755038-65-4 |
| GSK461364 | Plk1 inhibitor | 929095-18-1 |
| HMN-214 | Plk inhibitor,broad-spectrum anti-tumor agent | 173529-46-9 |
| MLN0905 | Potent PLK1 inhibitor | 1228960-69-7 |
| NMS-1286937 | 1034616-18-6 | |
| Rigosertib (ON-01910,Estybon) | Plk1 inhibitor | 1225497-78-8 |
| Rigosertib sodium | 592542-60-4 |
Transcripts for PLK2 Gene
mRNA/cDNA for PLK2 Gene
- (2) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (392) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PLK2
- genomics-online: gRNA clones - Search results for available PLK2 gene related products
- Applied Biological Materials CRISPR for PLK2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLK2
- GenScript: Design CRISPR guide RNA sequences for PLK2
miRNA Products
- Search ViGene Biosciences for PLK2
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for PLK2
- Browse OriGene Inhibitory RNA Products For PLK2
- genomics-online: shRNA clones - Search results for available PLK2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PLK2 gene
Clone Products
- Sino Biological Human cDNA Clone for PLK2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PLK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PLK2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PLK2
- genomics-online: cdna clones - Search results for available PLK2 gene related products
- orf clones - Search results for available PLK2 gene related products
- Applied Biological Materials Clones for PLK2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 14b | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | |||||||||||
| SP8: | |||||||||||
| SP9: | |||||||||||
| SP10: | |||||||||||
| SP11: | |||||||||||
| SP12: |
Expression for PLK2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
- Optic Nerve
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Autopod
- Neural Tube (Nervous System)
- Inner Cell Mass (Early Embryonic Tissues)
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
-
Bone (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Smooth Muscle (Muscoskeletal System)
This gene is overexpressed in Plasma (63.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLK2 Gene
NURSA nuclear receptor signaling pathways regulating expression of PLK2 Gene:
PLK2SOURCE GeneReport for Unigene cluster for PLK2 Gene:
Hs.398157mRNA Expression by UniProt/SwissProt for PLK2 Gene:
Q9NYY3-PLK2_HUMAN
Tissue specificity:
Expressed at higher level in the fetal lung, kidney, spleen and heart.
Evidence on tissue expression from TISSUES for PLK2 Gene
- Nervous system(4.9)
- Skin(4.4)
- Intestine(4.3)
- Liver(3.4)
- Kidney(3)
- Spleen(2.8)
- Lung(2.7)
- Heart(2)
- Pancreas(2)
Primer Products
-
OriGene qPCR primer pairs for PLK2
-
OriGene qPCR primer pairs and template standards for PLK2
- genomics-online: primer clones - Search results for available PLK2 gene related products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLK2 Gene
Orthologs for PLK2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PLK2 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PLK2 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PLK2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PLK2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Plk2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Plk2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PLK2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PLK2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PLK2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | plk2 33 |
|
||
| Str.15804 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | plk2a 33 34 |
|
||
| cnk 33 |
|
||||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC5 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8152 34 |
|
OneToMany |
- Species where no ortholog for PLK2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PLK2 Gene
Variants for PLK2 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_041023 | An ovarian Endometrioid carcinoma sample | p.Ser14Thr | |||
| VAR_041024 | A lung adenocarcinoma sample | p.Gly92Ser | |||
| rs1000096381 | -- | 58,460,471(-) | C/G | upstream_transcript_variant | |
| rs1001482201 | -- | 58,456,342(-) | T/C | intron_variant | |
| rs1001510011 | -- | 58,456,010(-) | A/T | intron_variant |
Residual Variation Intolerance Score:
14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.44;
28.25% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PLK2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PLK2 Gene
Disorders for PLK2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| kummell's disease |
|
|
Search PLK2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PLK2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PLK2 Gene
Publications for PLK2 Gene
- Plk2 regulated centriole duplication is dependent on its localization to the centrioles and a functional polo-box domain. (PMID: 19001868) Cizmecioglu O … Hoffmann I (Cell cycle (Georgetown, Tex.) 2008) 3 4 22 58
- Polo-like kinase-2 is required for centriole duplication in mammalian cells. (PMID: 15242618) Warnke S … Hoffmann I (Current biology : CB 2004) 3 4 22 58
- Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase. (PMID: 11696980) Liby K … Dai W (DNA sequence : the journal of DNA sequencing and mapping 2001) 3 4 22 58
- Radiation-inducible hSNK gene is transcriptionally regulated by p53 binding homology element in human thyroid cells. (PMID: 11716500) Shimizu-Yoshida Y … Yamashita S (Biochemical and biophysical research communications 2001) 3 4 22 58
- Polo-like kinase 2 (SNK/PLK2) is a novel epigenetically regulated gene in acute myeloid leukemia and myelodysplastic syndromes: genetic and epigenetic interactions. (PMID: 21340720) Benetatos L … Crook T (Annals of hematology 2011) 3 4 58
Products for PLK2 Gene
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- Invitrogen Antibodies for PLK2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PLK2
- antibodies-online: Search results for 59 available PLK2 Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for PLK2
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- genomics-online: cdna clones - Search results for available PLK2 gene related products
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Sources for PLK2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew