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Aliases for PLK1 Gene

Aliases for PLK1 Gene

  • Polo-Like Kinase 1 2 3 4
  • Serine/Threonine-Protein Kinase 13 3 4
  • EC 2.7.11.21 4 64
  • STPK13 3 4
  • PLK-1 3 4
  • PLK 3 4
  • Serine/Threonine-Protein Kinase PLK1 3
  • Cell Cycle Regulated Protein Kinase 3
  • Polo-Like Kinase (Drosophila) 2
  • Polo (Drosophia)-Like Kinase 3
  • Polo Like Kinase 3
  • EC 2.7.11 64

External Ids for PLK1 Gene

Previous Symbols for PLK1 Gene

  • PLK

Summaries for PLK1 Gene

GeneCards Summary for PLK1 Gene

PLK1 (Polo-Like Kinase 1) is a Protein Coding gene. Diseases associated with PLK1 include tetraploidy. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is PLK4.

UniProtKB/Swiss-Prot for PLK1 Gene

  • Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2. Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1. Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase. Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2. PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation. Required for kinetochore localization of BUB1B. Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2. Phosphorylates SGOL1: required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome. Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53. Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Also required for recovery after DNA damage checkpoint and entry into mitosis. Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:8991084, PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity).

Tocris Summary for PLK1 Gene

  • Polo-like kinases (PLKs) are a family of four serine/threonine protein kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. PLK1, -2 and -3 are ubiquitously expressed, whereas PLK4 is restricted to a few tissues including the testes and the thymus. The mRNA and protein expression of PLK1, -2 and -4 are coordinately regulated during cell cycle progression, but PLK3 levels are independent of the other three family members. Furthermore, PLK3 is a much more stable protein than PLK1, -2 or -4. PLK1 is the most well characterized member of this family and strongly promotes the progression of cells through mitosis. During the various stages of mitosis PLK1 localizes to the centrosomes, kinetochores and central spindle. PLKs are dysregulated in a variety of human cancers. PLK1 overexpression correlates with cellular proliferation and poor prognosis. PLK2 and PLK3 are involved in checkpoint-mediated cell cycle arrest to ensure genetic stability. Loss-of-function mutations in these enzymes can lead to oncogenic transformation.

Gene Wiki entry for PLK1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLK1 Gene

Genomics for PLK1 Gene

Genomic Location for PLK1 Gene

Start:
23,677,656 bp from pter
End:
23,690,367 bp from pter
Size:
12,712 bases
Orientation:
Plus strand

Genomic View for PLK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLK1 Gene

Regulatory Elements for PLK1 Gene

Proteins for PLK1 Gene

  • Protein details for PLK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53350-PLK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PLK1
    Protein Accession:
    P53350
    Secondary Accessions:
    • Q15153
    • Q99746

    Protein attributes for PLK1 Gene

    Size:
    603 amino acids
    Molecular mass:
    68255 Da
    Quaternary structure:
    • Interacts with CEP170 and EVI5. Interacts and phosphorylates ERCC6L. Interacts with FAM29A. Interacts with SLX4/BTBD12 and TTDN1. Interacts with BUB1B. Interacts (via POLO-box domain) with the phosphorylated form of BUB1, CENPU and CDC25C. Interacts with isoform 3 of SGOL1. Interacts with BORA, KIF2A and AURKA. Interacts with TOPORS and CYLD. Interacts with ECT2; the interaction is stimulated upon phosphorylation of ECT2 on Thr-444. Interacts with PRC1. Interacts with KIF20A/MKLP2 (when phosphorylated), leading to the recruitment at the central spindle. Interacts (via POLO box domains) with PPP1R12A/MYPT1 (when previously phosphorylated by CDK1). Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGOL2. Interacts with BIRC6/bruce. Interacts with CDK1-phosphorylated FRY; this interaction occurs in mitotic cells, but not in interphase cells. FRY interaction facilitates AURKA-mediated PLK1 phosphorylation. Interacts with CDK1-phosphorylated DCTN6 during mitotic prometaphase; the interaction facilitates recruitment to kinetochores.

    Three dimensional structures from OCA and Proteopedia for PLK1 Gene

neXtProt entry for PLK1 Gene

Proteomics data for PLK1 Gene at MOPED

Post-translational modifications for PLK1 Gene

  • Catalytic activity is enhanced by phosphorylation of Thr-210. Phosphorylation at Thr-210 is first detected on centrosomes in the G2 phase of the cell cycle, peaks in prometaphase and gradually disappears from centrosomes during anaphase. Dephosphorylation at Thr-210 at centrosomes is probably mediated by protein phosphatase 1C (PP1C), via interaction with PPP1R12A/MYPT1. Autophosphorylation and phosphorylation of Ser-137 may not be significant for the activation of PLK1 during mitosis, but may enhance catalytic activity during recovery after DNA damage checkpoint. Phosphorylated in vitro by STK10.
  • Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) in anaphase and following DNA damage, leading to its degradation by the proteasome. Ubiquitination is mediated via its interaction with FZR1/CDH1. Ubiquitination and subsequent degradation prevents entry into mitosis and is essential to maintain an efficient G2 DNA damage checkpoint. Monoubiquitination at Lys-492 by the BCR(KLHL22) ubiquitin ligase complex does not lead to degradation: it promotes PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys9, Lys19, Lys272, Lys480, and Lys492

Other Protein References for PLK1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PLK1 Gene

Gene Families for PLK1 Gene

UniProtKB/Swiss-Prot:

PLK1_HUMAN
Domain:
  • The POLO box domains act as phosphopeptide-binding module that recognize and bind serine-[phosphothreonine/phosphoserine]-(proline/X) motifs. PLK1 recognizes and binds docking proteins that are already phosphorylated on these motifs, and then phosphorylates them. PLK1 can also create its own docking sites by mediating phosphorylation of serine-[phosphothreonine/phosphoserine]-(proline/X) motifs subsequently recognized by the POLO box domains.:
    • P53350
  • Contains 2 POLO box domains.:
    • P53350
  • Contains 1 protein kinase domain.:
    • P53350
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.:
    • P53350
genes like me logo Genes that share domains with PLK1: view

Function for PLK1 Gene

Molecular function for PLK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation of Thr-210 by AURKA; phosphorylation by AURKA is enhanced by BORA. Once activated, activity is stimulated by binding target proteins. Binding of target proteins has no effect on the non-activated kinase. Several inhibitors targeting PLKs are currently in development and are under investigation in a growing number of clinical trials, such as BI 2536, an ATP-competitive PLK1 inhibitor or BI 6727, a dihydropteridinone that specifically inhibits the catalytic activity of PLK1.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2. Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1. Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase. Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2. PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation. Required for kinetochore localization of BUB1B. Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2. Phosphorylates SGOL1: required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome. Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53. Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Also required for recovery after DNA damage checkpoint and entry into mitosis. Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:8991084, PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity).
UniProtKB/Swiss-Prot Induction: By growth-stimulating agents

Enzyme Numbers (IUBMB) for PLK1 Gene

Gene Ontology (GO) - Molecular Function for PLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 17146433
GO:0004674 protein serine/threonine kinase activity IMP 19473992
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 12493754
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PLK1: view
genes like me logo Genes that share phenotypes with PLK1: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PLK1 Gene

Localization for PLK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLK1 Gene

Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=During early stages of mitosis, the phosphorylated form is detected on centrosomes and kinetochores. Localizes to the outer kinetochore. Presence of SGOL1 and interaction with the phosphorylated form of BUB1 is required for the kinetochore localization. Localizes onto the central spindle by phosphorylating and docking at midzone proteins KIF20A/MKLP2 and PRC1. Colocalizes with FRY to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLK1 Gene COMPARTMENTS Subcellular localization image for PLK1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 17617734
GO:0000922 spindle pole IDA 18331714
GO:0000942 condensed nuclear chromosome outer kinetochore IDA 18195732
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PLK1: view

Pathways for PLK1 Gene

genes like me logo Genes that share pathways with PLK1: view

Gene Ontology (GO) - Biological Process for PLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IMP 23455478
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 18174154
GO:0000278 mitotic cell cycle TAS --
GO:0000281 mitotic cytokinesis IDA 19468302
genes like me logo Genes that share ontologies with PLK1: view

Compounds for PLK1 Gene

(8) ApexBio Compounds for PLK1 Gene

Compound Action Cas Number
BI 2536 PLK1 inhibitor [755038-02-9]
BI6727 (Volasertib) highly potent Polo-like kinase inhibitor. [755038-65-4]
GSK461364 inhibits purified Plk1. [929095-18-1]
GW843682X selective inhibitor of PLK1 and PLK3 [660868-91-7]
HMN-214 potent inhibitor of Polo-like kinase (Plk) [173529-46-9]
MLN0905 small-molecule PLK1 inhibitor. [1228960-69-7]
Poloxin non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor [321688-88-4]
Rigosertib (ON-01910) PLK1 Inhibitor [1225497-78-8]

(2) Tocris Compounds for PLK1 Gene

Compound Action Cas Number
Cyclapolin 9 Selective, ATP-competitive PLK1 inhibitor [40533-25-3]
SBE 13 hydrochloride Potent and selective PLK1 inhibitor [1052532-15-6]

(2) HMDB Compounds for PLK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(30) Novoseek inferred chemical compound relationships for PLK1 Gene

Compound -log(P) Hits PubMed IDs
threonine 71.9 39
serine 64.3 44
scytonemin 60.9 2
pyridoxine 5-phosphate 53.3 2
pyridoxal 50.5 11
genes like me logo Genes that share compounds with PLK1: view

Transcripts for PLK1 Gene

Unigene Clusters for PLK1 Gene

Polo-like kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLK1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - - - -
SP2: - - -
SP3:
SP4:
SP5: -
SP6: - -
SP7: -
SP8: -

Relevant External Links for PLK1 Gene

GeneLoc Exon Structure for
PLK1
ECgene alternative splicing isoforms for
PLK1

Expression for PLK1 Gene

mRNA expression in normal human tissues for PLK1 Gene

mRNA differential expression in normal tissues according to GTEx for PLK1 Gene

This gene is overexpressed in Testis (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLK1 Gene

SOURCE GeneReport for Unigene cluster for PLK1 Gene Hs.592049

mRNA Expression by UniProt/SwissProt for PLK1 Gene

P53350-PLK1_HUMAN
Tissue specificity: Placenta and colon
genes like me logo Genes that share expressions with PLK1: view

Orthologs for PLK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PLK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLK1 36
  • 99.45 (n)
  • 99.83 (a)
PLK1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLK1 36
  • 90.9 (n)
  • 95.84 (a)
PLK1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLK1 36
  • 90.27 (n)
  • 96.02 (a)
PLK1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plk1 36
  • 88.5 (n)
  • 95.02 (a)
Plk1 16
Plk1 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLK1 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLK1 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plk1 36
  • 87.4 (n)
  • 94.2 (a)
chicken
(Gallus gallus)
Aves PLK1 36
  • 76.44 (n)
  • 82.69 (a)
PLK1 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLK1 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia plk-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia plk1 36
  • 74.26 (n)
  • 81.63 (a)
zebrafish
(Danio rerio)
Actinopterygii plk1 36
  • 69.7 (n)
  • 77.36 (a)
plk1 37
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004239 36
  • 57.24 (n)
  • 53.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta polo 36
  • 58.74 (n)
  • 54.84 (a)
polo 37
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea plk-1 36
  • 56.93 (n)
  • 55.9 (a)
plk-1 37
  • 48 (a)
OneToMany
plk-2 37
  • 48 (a)
OneToMany
plk-3 37
  • 37 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL006W 36
  • 50.87 (n)
  • 42.89 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC5 36
  • 48.2 (n)
  • 43.19 (a)
CDC5 37
  • 28 (a)
OneToMany
CDC5 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C06138g 36
  • 46.79 (n)
  • 41.21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2496 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5715 37
  • 63 (a)
OneToOne
Species with no ortholog for PLK1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLK1 Gene

ENSEMBL:
Gene Tree for PLK1 (if available)
TreeFam:
Gene Tree for PLK1 (if available)

Paralogs for PLK1 Gene

Paralogs for PLK1 Gene

Selected SIMAP similar genes for PLK1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PLK1 Gene

genes like me logo Genes that share paralogs with PLK1: view

Variants for PLK1 Gene

Sequence variations from dbSNP and Humsavar for PLK1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs26765 -- 23,688,945(+) TCTGT(A/C)GCCCA intron-variant
rs26766 -- 23,688,097(+) CTTCT(C/G)ACCCA intron-variant
rs26767 -- 23,687,136(-) GCAGA(G/T)GGAAG intron-variant
rs35634 -- 23,686,358(-) CCTTC(A/G)GGTAA intron-variant
rs35635 -- 23,682,449(+) CTTAA(G/T)CTTTA intron-variant

Relevant External Links for PLK1 Gene

HapMap Linkage Disequilibrium report
PLK1
Human Gene Mutation Database (HGMD)
PLK1

No data available for Structural Variations from Database of Genomic Variants (DGV) for PLK1 Gene

Disorders for PLK1 Gene

UniProtKB/Swiss-Prot

PLK1_HUMAN
  • Note=Defects in PLK1 are associated with some cancers, such as gastric, thyroid or B-cell lymphomas. Expression is cancer increased in tumor tissues with a poor prognosis, suggesting a role in malignant transformations and carcinogenesis.

(1) MalaCards Diseases for PLK1 Gene

Search for PLK1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for PLK1 Gene

(42) Novoseek inferred disease relationships for PLK1 Gene

Disease -log(P) Hits PubMed IDs
cancer 53.3 98
tumors 44.3 97
retinoblastoma 26.7 3
multiple tumors 22.1 3
ataxia telangiectasia 15.9 3

Relevant External Links for PLK1

Genetic Association Database (GAD)
PLK1
Human Genome Epidemiology (HuGE) Navigator
PLK1
genes like me logo Genes that share disorders with PLK1: view

Publications for PLK1 Gene

  1. Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors. (PMID: 8127874) Holtrich U. … Strebhardt K. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23
  2. Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes. (PMID: 8991084) Lane H.A. … Nigg E.A. (J. Cell Biol. 1996) 3 4 23
  3. Cell cycle regulation of the human polo-like kinase (PLK) promoter. (PMID: 9083047) Uchiumi T. … Ferris D.K. (J. Biol. Chem. 1997) 3 4 23
  4. Identification and functional characterization of the human and murine polo-like kinase (Plk) promoter. (PMID: 7478607) Brauninger A. … Rubsamen-Waigmann H. (Oncogene 1995) 3 4 23
  5. Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5. (PMID: 7962193) Golsteyn R.M. … Nigg E.A. (J. Cell Sci. 1994) 3 4 23

Products for PLK1 Gene

  • Addgene plasmids for PLK1

Sources for PLK1 Gene

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