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Aliases for PLIN3 Gene

Aliases for PLIN3 Gene

  • Perilipin 3 2 3 5
  • Placental Protein 17 2 3 4
  • Mannose-6-Phosphate Receptor-Binding Protein 1 3 4
  • Cargo Selection Protein TIP47 3 4
  • 47 KDa MPR-Binding Protein 3 4
  • M6PRBP1 3 4
  • TIP47 3 4
  • Pp17 3 4
  • Cargo Selection Protein (Mannose 6 Phosphate Receptor Binding Protein) 2
  • 47 KDa Mannose 6-Phosphate Receptor-Binding Protein 4
  • Mannose-6-Phosphate Receptor Binding Protein 1 2
  • Testicular Tissue Protein Li 114 3
  • Tail-Interacting Protein, 47 KD 3
  • MPR-BINDING PROTEIN, 47-KD 2
  • Perilipin-3 3

External Ids for PLIN3 Gene

Previous HGNC Symbols for PLIN3 Gene

  • M6PRBP1

Previous GeneCards Identifiers for PLIN3 Gene

  • GC19M004790
  • GC19M004600

Summaries for PLIN3 Gene

Entrez Gene Summary for PLIN3 Gene

  • Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009]

GeneCards Summary for PLIN3 Gene

PLIN3 (Perilipin 3) is a Protein Coding gene. Diseases associated with PLIN3 include Cervical Cancer, Somatic. Among its related pathways are Vesicle-mediated transport and Golgi-to-ER retrograde transport. An important paralog of this gene is PLIN2.

UniProtKB/Swiss-Prot for PLIN3 Gene

  • Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.

Gene Wiki entry for PLIN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLIN3 Gene

Genomics for PLIN3 Gene

Regulatory Elements for PLIN3 Gene

Enhancers for PLIN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PLIN3 on UCSC Golden Path with GeneCards custom track

Promoters for PLIN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLIN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLIN3 Gene

Chromosome:
19
Start:
4,838,334 bp from pter
End:
4,867,768 bp from pter
Size:
29,435 bases
Orientation:
Minus strand

Genomic View for PLIN3 Gene

Genes around PLIN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLIN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLIN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLIN3 Gene

Proteins for PLIN3 Gene

  • Protein details for PLIN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60664-PLIN3_HUMAN
    Recommended name:
    Perilipin-3
    Protein Accession:
    O60664
    Secondary Accessions:
    • A8K4Y9
    • K7EQF4
    • Q53G77
    • Q9BS03
    • Q9UBD7
    • Q9UP92

    Protein attributes for PLIN3 Gene

    Size:
    434 amino acids
    Molecular mass:
    47075 Da
    Quaternary structure:
    • Homooligomer. Interacts with M6PR (via the cytoplasmic domain). Interacts with IGF2R (via the cytoplasmic domain). Isoform 2 may exist as a homodimer (known as PP17C).

    Alternative splice isoforms for PLIN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLIN3 Gene

Post-translational modifications for PLIN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLIN3 Gene

Domains & Families for PLIN3 Gene

Gene Families for PLIN3 Gene

Protein Domains for PLIN3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PLIN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60664

UniProtKB/Swiss-Prot:

PLIN3_HUMAN :
  • Belongs to the perilipin family.
Family:
  • Belongs to the perilipin family.
genes like me logo Genes that share domains with PLIN3: view

Function for PLIN3 Gene

Molecular function for PLIN3 Gene

UniProtKB/Swiss-Prot Function:
Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.

Gene Ontology (GO) - Molecular Function for PLIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19490898
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with PLIN3: view
genes like me logo Genes that share phenotypes with PLIN3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLIN3 Gene

Localization for PLIN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLIN3 Gene

Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet. Note=Membrane associated on endosomes. Detected in the envelope and the core of lipid bodies and in lipid sails.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLIN3 Gene COMPARTMENTS Subcellular localization image for PLIN3 gene
Compartment Confidence
endosome 5
golgi apparatus 5
cytosol 4
nucleus 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PLIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005768 endosome TAS 9590177
GO:0005794 Golgi apparatus TAS 9590177
GO:0005811 lipid particle IDA 14741744
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PLIN3: view

Pathways & Interactions for PLIN3 Gene

genes like me logo Genes that share pathways with PLIN3: view

Gene Ontology (GO) - Biological Process for PLIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport TAS 9590177
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with PLIN3: view

No data available for SIGNOR curated interactions for PLIN3 Gene

Drugs & Compounds for PLIN3 Gene

(3) Drugs for PLIN3 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Galsulfase Approved, Investigational Pharma binder, Target 0
Idursulfase Approved Pharma Target 0

(3) Additional Compounds for PLIN3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Mannose 6-phosphate
  • alpha-D-Mannose-6-P
  • alpha-D-Mannose-6-phosphate
  • alpha-delta-Mannose-6-P
  • alpha-delta-Mannose-6-phosphate
  • D-Mannose 6-phosphate
3672-15-9
genes like me logo Genes that share compounds with PLIN3: view

Transcripts for PLIN3 Gene

mRNA/cDNA for PLIN3 Gene

Unigene Clusters for PLIN3 Gene

Perilipin 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLIN3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5: - -
SP6: - - -
SP7: -
SP8:

Relevant External Links for PLIN3 Gene

GeneLoc Exon Structure for
PLIN3
ECgene alternative splicing isoforms for
PLIN3

Expression for PLIN3 Gene

mRNA expression in normal human tissues for PLIN3 Gene

mRNA differential expression in normal tissues according to GTEx for PLIN3 Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for PLIN3 Gene

This gene is overexpressed in Bone (27.0) and Bone marrow stromal cell (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLIN3 Gene



Protein tissue co-expression partners for PLIN3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLIN3 Gene:

PLIN3

SOURCE GeneReport for Unigene cluster for PLIN3 Gene:

Hs.140452
genes like me logo Genes that share expression patterns with PLIN3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PLIN3 Gene

Orthologs for PLIN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLIN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLIN3 34
  • 83.1 (n)
  • 82.7 (a)
M6PRBP1 35
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLIN3 34
  • 84.48 (n)
  • 84.52 (a)
PLIN3 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plin3 34
  • 77.12 (n)
  • 75.3 (a)
Plin3 16
Plin3 35
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLIN3 34
  • 98.56 (n)
  • 98.67 (a)
PLIN3 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plin3 34
  • 76.48 (n)
  • 74.35 (a)
oppossum
(Monodelphis domestica)
Mammalia PLIN3 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLIN3 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857433 34
  • 67.74 (n)
  • 55.97 (a)
PLIN3 35
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLIN3 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487248 34
  • 58.48 (n)
  • 54.09 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53750 34
zebrafish
(Danio rerio)
Actinopterygii si:rp71-61h23.4 34
  • 55.04 (n)
  • 45.64 (a)
worm
(Caenorhabditis elegans)
Secernentea lea-1 35
  • 7 (a)
OneToMany
Species where no ortholog for PLIN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLIN3 Gene

ENSEMBL:
Gene Tree for PLIN3 (if available)
TreeFam:
Gene Tree for PLIN3 (if available)

Paralogs for PLIN3 Gene

Paralogs for PLIN3 Gene

(3) SIMAP similar genes for PLIN3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PLIN3: view

Variants for PLIN3 Gene

Sequence variations from dbSNP and Humsavar for PLIN3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs8289 - 4,859,925(-) CGCAC(A/G)TCAAG reference, missense
rs9973235 - 4,847,701(+) TTAGG(A/G)CCTGC reference, missense
rs10425773 -- 4,846,337(+) aaaaT(C/G)GTCAT intron-variant
rs3760946 -- 4,869,338(-) GCTGG(A/G)TGTGG upstream-variant-2KB
rs3760947 -- 4,869,210(-) AGAGC(A/G)AGACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLIN3 Gene

Variant ID Type Subtype PubMed ID
esv2664700 CNV deletion 23128226
esv2762022 CNV loss 21179565
esv3584953 CNV gain 24956385
esv3643514 CNV loss 21293372
esv3643515 CNV loss 21293372
esv3893158 CNV loss 25118596
nsv1062709 CNV loss 25217958
nsv1065556 CNV loss 25217958
nsv1131389 CNV deletion 24896259
nsv470117 CNV loss 18288195
nsv516323 CNV loss 19592680
nsv522005 CNV loss 19592680
nsv528462 CNV loss 19592680
nsv578455 CNV loss 21841781

Variation tolerance for PLIN3 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLIN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLIN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLIN3 Gene

Disorders for PLIN3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLIN3 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
cervical cancer, somatic
  • cervical cancer
- elite association - COSMIC cancer census association via MalaCards
Search PLIN3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PLIN3

Genetic Association Database (GAD)
PLIN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLIN3
genes like me logo Genes that share disorders with PLIN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLIN3 Gene

Publications for PLIN3 Gene

  1. TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking. (PMID: 9590177) Diaz E. … Pfeffer S.R. (Cell 1998) 2 3 4 22 65
  2. Spatial integration of TIP47 and adipophilin in macrophage lipid bodies. (PMID: 15545278) Robenek H. … Troyer D. (J. Biol. Chem. 2005) 3 4 22 65
  3. Cloning and sequencing of human oncodevelopmental soluble placental tissue protein 17 (PP17): homology with adipophilin and the mouse adipose differentiation-related protein. (PMID: 10393528) Than N.G. … Bohn H. (Tumor Biol. 1999) 3 4 22 65
  4. Cloning and sequence analysis of cDNAs encoding human placental tissue protein 17 (PP17) variants. (PMID: 9874244) Than N.G. … Bohn H. (Eur. J. Biochem. 1998) 3 4 22 65
  5. Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17). (PMID: 6856484) Bohn H. … Winckler W. (Oncodev. Biol. Med. 1983) 2 3 4 65

Products for PLIN3 Gene

Sources for PLIN3 Gene

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