Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLIN2 Gene

Aliases for PLIN2 Gene

  • Perilipin 2 2 3 5
  • Adipose Differentiation-Related Protein 2 3 4
  • Adipophilin 2 3 4
  • ADFP 3 4
  • ADRP 3 4

External Ids for PLIN2 Gene

Previous HGNC Symbols for PLIN2 Gene

  • ADFP

Previous GeneCards Identifiers for PLIN2 Gene

  • GC09M019106

Summaries for PLIN2 Gene

Entrez Gene Summary for PLIN2 Gene

  • The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for PLIN2 Gene

PLIN2 (Perilipin 2) is a Protein Coding gene. Diseases associated with PLIN2 include lipid-rich carcinoma and acrodermatitis enteropathica. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). An important paralog of this gene is PLIN3.

UniProtKB/Swiss-Prot for PLIN2 Gene

  • May be involved in development and maintenance of adipose tissue.

Gene Wiki entry for PLIN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLIN2 Gene

Genomics for PLIN2 Gene

Genomic Location for PLIN2 Gene

Chromosome:
9
Start:
19,108,375 bp from pter
End:
19,149,290 bp from pter
Size:
40,916 bases
Orientation:
Minus strand

Genomic View for PLIN2 Gene

Genes around PLIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLIN2 Gene

No data available for Regulatory Elements for PLIN2 Gene

Proteins for PLIN2 Gene

  • Protein details for PLIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99541-PLIN2_HUMAN
    Recommended name:
    Perilipin-2
    Protein Accession:
    Q99541
    Secondary Accessions:
    • Q9BSC3

    Protein attributes for PLIN2 Gene

    Size:
    437 amino acids
    Molecular mass:
    48075 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLIN2 Gene

Proteomics data for PLIN2 Gene at MOPED

Post-translational modifications for PLIN2 Gene

Other Protein References for PLIN2 Gene

Antibody Products

No data available for DME Specific Peptides for PLIN2 Gene

Domains & Families for PLIN2 Gene

Gene Families for PLIN2 Gene

Protein Domains for PLIN2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q99541

UniProtKB/Swiss-Prot:

PLIN2_HUMAN :
  • Belongs to the perilipin family.
Family:
  • Belongs to the perilipin family.
genes like me logo Genes that share domains with PLIN2: view

Function for PLIN2 Gene

Molecular function for PLIN2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in development and maintenance of adipose tissue.
genes like me logo Genes that share phenotypes with PLIN2: view

Animal Models for PLIN2 Gene

MGI Knock Outs for PLIN2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PLIN2 Gene

Localization for PLIN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLIN2 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLIN2 Gene COMPARTMENTS Subcellular localization image for PLIN2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
plasma membrane 5
cytosol 4
nucleus 3
cytoskeleton 2
peroxisome 2
golgi apparatus 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PLIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 9003395
GO:0005783 endoplasmic reticulum TAS 9003395
GO:0005811 lipid particle IEA,IDA 14741744
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with PLIN2: view

Pathways & Interactions for PLIN2 Gene

genes like me logo Genes that share pathways with PLIN2: view

Gene Ontology (GO) - Biological Process for PLIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014070 response to organic cyclic compound IEA --
GO:0015909 long-chain fatty acid transport IEA --
GO:0044255 cellular lipid metabolic process TAS --
genes like me logo Genes that share ontologies with PLIN2: view

No data available for SIGNOR curated interactions for PLIN2 Gene

Drugs & Compounds for PLIN2 Gene

(13) Drugs for PLIN2 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
arachidonic acid Experimental Nutra Activator 27
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 20
Stearic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0

(15) Additional Compounds for PLIN2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
Pentadecanoic acid
  • N-Pentadecanoate
  • N-Pentadecanoic acid
  • N-Pentadecylate
  • N-Pentadecylic acid
  • Pentadecanoate
1002-84-2
genes like me logo Genes that share compounds with PLIN2: view

Transcripts for PLIN2 Gene

Unigene Clusters for PLIN2 Gene

Perilipin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLIN2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8 ^ 9
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - - -
SP10: - - - - -
SP11: - - -
SP12: - - -
SP13: - -

Relevant External Links for PLIN2 Gene

GeneLoc Exon Structure for
PLIN2
ECgene alternative splicing isoforms for
PLIN2

Expression for PLIN2 Gene

mRNA expression in normal human tissues for PLIN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLIN2 Gene

This gene is overexpressed in Whole Blood (x7.7), Adipose - Subcutaneous (x6.0), Muscle - Skeletal (x4.7), and Liver (x4.3).

Protein differential expression in normal tissues from HIPED for PLIN2 Gene

This gene is overexpressed in Milk (62.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLIN2 Gene



SOURCE GeneReport for Unigene cluster for PLIN2 Gene Hs.3416

mRNA Expression by UniProt/SwissProt for PLIN2 Gene

Q99541-PLIN2_HUMAN
Tissue specificity: Milk lipid globules.
genes like me logo Genes that share expression patterns with PLIN2: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for PLIN2 Gene

Orthologs for PLIN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLIN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLIN2 35
  • 98.93 (n)
  • 98.63 (a)
PLIN2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLIN2 36
  • 82 (a)
OneToOne
PLIN2 35
  • 88.78 (n)
  • 88.07 (a)
dog
(Canis familiaris)
Mammalia PLIN2 35
  • 90.16 (n)
  • 89.7 (a)
PLIN2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plin2 36
  • 83 (a)
OneToOne
Plin2 16
Plin2 35
  • 84.4 (n)
  • 84.16 (a)
oppossum
(Monodelphis domestica)
Mammalia PLIN2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Plin2 35
  • 83.45 (n)
  • 81.71 (a)
chicken
(Gallus gallus)
Aves PLIN2 36
  • 71 (a)
OneToOne
PLIN2 35
  • 74.45 (n)
  • 72.2 (a)
lizard
(Anolis carolinensis)
Reptilia PLIN2 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia fatvg 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76047 35
plin2 35
  • 67.57 (n)
  • 62.5 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5121 35
zebrafish
(Danio rerio)
Actinopterygii plin2 36
  • 52 (a)
OneToOne
plin2 35
  • 62.32 (n)
  • 58.31 (a)
worm
(Caenorhabditis elegans)
Secernentea lea-1 36
  • 6 (a)
OneToMany
Species with no ortholog for PLIN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLIN2 Gene

ENSEMBL:
Gene Tree for PLIN2 (if available)
TreeFam:
Gene Tree for PLIN2 (if available)

Paralogs for PLIN2 Gene

Paralogs for PLIN2 Gene

(4) SIMAP similar genes for PLIN2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PLIN2 Gene

genes like me logo Genes that share paralogs with PLIN2: view

Variants for PLIN2 Gene

Sequence variations from dbSNP and Humsavar for PLIN2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs35568725 - 19,119,676(-) CCATT(C/T)CTCAG nc-transcript-variant, reference, missense
rs2228416 -- 19,126,283(-) AACCT(A/G)CCCTT nc-transcript-variant, reference, synonymous-codon
rs2229536 -- 19,116,545(-) AACAT(C/T)CAAGA nc-transcript-variant, reference, synonymous-codon
rs3802335 -- 19,126,478(-) ATCCC(A/G/T)GTGTT intron-variant
rs3808657 -- 19,127,879(-) GCCGG(A/C)CTGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLIN2 Gene

Variant ID Type Subtype PubMed ID
nsv892700 CNV Gain 21882294
esv2657658 CNV Deletion 23128226
esv2738257 CNV Deletion 23290073
esv2738258 CNV Deletion 23290073
esv1298160 CNV Deletion 17803354
nsv8423 CNV Gain 18304495
dgv2295e1 CNV Complex 17122850
nsv892702 CNV Gain 21882294

Variation tolerance for PLIN2 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 57.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLIN2 Gene

HapMap Linkage Disequilibrium report
PLIN2
Human Gene Mutation Database (HGMD)
PLIN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLIN2 Gene

Disorders for PLIN2 Gene

MalaCards: The human disease database

(13) MalaCards diseases for PLIN2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lipid-rich carcinoma
acrodermatitis enteropathica
  • acrodermatitis enteropathica zinc deficiency type
placental choriocarcinoma
  • choriocarcinoma of the placenta
sebaceous adenocarcinoma
  • adenocarcinoma of the sebaceous gland
very long-chain acyl-coenzyme a dehydrogenase deficiency
  • very long-chain acyl-coa dehydrogenase deficiency
- elite association - COSMIC cancer census association via MalaCards
Search PLIN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PLIN2

Human Genome Epidemiology (HuGE) Navigator
PLIN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLIN2
genes like me logo Genes that share disorders with PLIN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLIN2 Gene

Publications for PLIN2 Gene

  1. Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane. (PMID: 9003395) Heid H.W. … Keenan T.W. (Biochem. J. 1996) 2 3 4 23 67
  2. Adipophilin affects the expression of TNF-alpha, MCP-1, and IL-6 in THP-1 macrophages. (PMID: 19851831) Chen F.L. … Hu R.M. (Mol. Cell. Biochem. 2010) 3 23
  3. Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins. (PMID: 19638644) Kimmel A.R. … Londos C. (J. Lipid Res. 2010) 2 3
  4. Adipophilin expression in sebaceous tumors and other cutaneous lesions with clear cell histology: an immunohistochemical study of 117 cases. (PMID: 20118912) Ostler D.A. … Ivan D. (Mod. Pathol. 2010) 3 23
  5. Downregulation of hepatic stellate cell activation by retinol and palmitate mediated by adipose differentiation-related protein (ADRP). (PMID: 20143336) Lee T.F. … Friedman S.L. (J. Cell. Physiol. 2010) 3 23

Products for PLIN2 Gene

Sources for PLIN2 Gene

Back to Top

Content