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Aliases for PLGRKT Gene

Aliases for PLGRKT Gene

  • Plasminogen Receptor With A C-Terminal Lysine 2 3 2
  • Plasminogen Receptor, C-Terminal Lysine Transmembrane Protein 2 3 5
  • Plg-R(KT) 3 4
  • C9orf46 3 4
  • Uncharacterized Hematopoietic Stem/Progenitor Cells Protein MDS030 2
  • Chromosome 9 Open Reading Frame 46 2
  • Transmembrane Protein C9orf46 3
  • 5033414D02Rik 3
  • PLG-RKT 3
  • MDS030 3
  • AD025 3

External Ids for PLGRKT Gene

Previous HGNC Symbols for PLGRKT Gene

  • C9orf46

Summaries for PLGRKT Gene

GeneCards Summary for PLGRKT Gene

PLGRKT (Plasminogen Receptor With A C-Terminal Lysine) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PLGRKT Gene

  • Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLGRKT Gene

Genomics for PLGRKT Gene

Regulatory Elements for PLGRKT Gene

Promoters for PLGRKT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLGRKT on UCSC Golden Path with GeneCards custom track

Genomic Location for PLGRKT Gene

Chromosome:
9
Start:
5,357,966 bp from pter
End:
5,438,456 bp from pter
Size:
80,491 bases
Orientation:
Minus strand

Genomic View for PLGRKT Gene

Genes around PLGRKT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLGRKT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLGRKT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLGRKT Gene

Proteins for PLGRKT Gene

  • Protein details for PLGRKT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBL7-PLRKT_HUMAN
    Recommended name:
    Plasminogen receptor (KT)
    Protein Accession:
    Q9HBL7
    Secondary Accessions:
    • B2R6W0
    • Q9NZ44

    Protein attributes for PLGRKT Gene

    Size:
    147 amino acids
    Molecular mass:
    17201 Da
    Quaternary structure:
    • Interacts with PLAT and PLAUR.

neXtProt entry for PLGRKT Gene

Proteomics data for PLGRKT Gene at MOPED

Post-translational modifications for PLGRKT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLGRKT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLGRKT Gene

Domains & Families for PLGRKT Gene

Protein Domains for PLGRKT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLGRKT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLGRKT: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PLGRKT Gene

Function for PLGRKT Gene

Molecular function for PLGRKT Gene

UniProtKB/Swiss-Prot Function:
Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9.

Phenotypes for PLGRKT Gene

genes like me logo Genes that share phenotypes with PLGRKT: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLGRKT Gene

Localization for PLGRKT Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLGRKT Gene

Cell membrane; Multi-pass membrane protein. Note=Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/PLAUR. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLGRKT Gene COMPARTMENTS Subcellular localization image for PLGRKT gene
Compartment Confidence
mitochondrion 4
cytosol 2
nucleus 2
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLGRKT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with PLGRKT: view

Pathways & Interactions for PLGRKT Gene

SuperPathways for PLGRKT Gene

No Data Available

Interacting Proteins for PLGRKT Gene

Gene Ontology (GO) - Biological Process for PLGRKT Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PLGRKT Gene

Drugs & Compounds for PLGRKT Gene

No Compound Related Data Available

Transcripts for PLGRKT Gene

Unigene Clusters for PLGRKT Gene

Plasminogen receptor, C-terminal lysine transmembrane protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLGRKT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -
SP3:

Relevant External Links for PLGRKT Gene

GeneLoc Exon Structure for
PLGRKT
ECgene alternative splicing isoforms for
PLGRKT

Expression for PLGRKT Gene

mRNA expression in normal human tissues for PLGRKT Gene

Protein differential expression in normal tissues from HIPED for PLGRKT Gene

This gene is overexpressed in Nasal epithelium (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLGRKT Gene



SOURCE GeneReport for Unigene cluster for PLGRKT Gene Hs.584242

mRNA Expression by UniProt/SwissProt for PLGRKT Gene

Q9HBL7-PLRKT_HUMAN
Tissue specificity: Expressed in peripheral blood cells and monocytes. Expressed in adrenal medulla.
genes like me logo Genes that share expression patterns with PLGRKT: view

Protein tissue co-expression partners for PLGRKT Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PLGRKT Gene

Orthologs for PLGRKT Gene

This gene was present in the common ancestor of animals.

Orthologs for PLGRKT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLGRKT 35
  • 88.44 (n)
  • 83.67 (a)
C8H9ORF46 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLGRKT 35
  • 91.84 (n)
  • 89.8 (a)
PLGRKT 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plgrkt 35
  • 85.03 (n)
  • 82.31 (a)
Plgrkt 16
Plgrkt 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLGRKT 35
  • 99.55 (n)
  • 100 (a)
PLGRKT 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plgrkt 35
  • 86.17 (n)
  • 85.71 (a)
oppossum
(Monodelphis domestica)
Mammalia PLGRKT 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLGRKT 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLGRKT 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plgrkt 35
  • 69.43 (n)
  • 60.69 (a)
zebrafish
(Danio rerio)
Actinopterygii plgrkt 35
  • 59.21 (n)
  • 63.64 (a)
plgrkt 36
  • 62 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8238 35
fruit fly
(Drosophila melanogaster)
Insecta CG13404 36
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10710 36
  • 45 (a)
OneToOne
Species with no ortholog for PLGRKT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLGRKT Gene

ENSEMBL:
Gene Tree for PLGRKT (if available)
TreeFam:
Gene Tree for PLGRKT (if available)

Paralogs for PLGRKT Gene

No data available for Paralogs for PLGRKT Gene

Variants for PLGRKT Gene

Sequence variations from dbSNP and Humsavar for PLGRKT Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs582816 -- 5,398,351(+) AAGTA(C/T)TTAAT intron-variant
rs584156 -- 5,398,625(+) CTGCA(C/T)CCCAA intron-variant
rs702276 -- 5,439,876(+) TACAT(C/G)TATAT upstream-variant-2KB
rs702277 -- 5,438,852(+) gcatt(G/T)agcac upstream-variant-2KB
rs529119 -- 5,398,224(+) GGGTG(A/G)GTTAC intron-variant

Variation tolerance for PLGRKT Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLGRKT Gene

HapMap Linkage Disequilibrium report
PLGRKT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PLGRKT Gene

Disorders for PLGRKT Gene

Relevant External Links for PLGRKT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLGRKT

No disorders were found for PLGRKT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLGRKT Gene

Publications for PLGRKT Gene

  1. Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT. (PMID: 21940822) Lighvani S. … Miles L.A. (Blood 2011) 2 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release. (PMID: 21795689) Bai H. … Parmer R.J. (J. Biol. Chem. 2011) 3

Products for PLGRKT Gene

Sources for PLGRKT Gene

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