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Aliases for PLGRKT Gene

Aliases for PLGRKT Gene

  • Plasminogen Receptor With A C-Terminal Lysine 2 2 3 5
  • Plasminogen Receptor, C-Terminal Lysine Transmembrane Protein 2 3
  • Plg-R(KT) 3 4
  • C9orf46 3 4
  • Uncharacterized Hematopoietic Stem/Progenitor Cells Protein MDS030 2
  • Chromosome 9 Open Reading Frame 46 2
  • Transmembrane Protein C9orf46 3
  • Plasminogen Receptor (KT) 3
  • 5033414D02Rik 3
  • PLG-RKT 3
  • MDS030 3
  • AD025 3

External Ids for PLGRKT Gene

Previous HGNC Symbols for PLGRKT Gene

  • C9orf46

Summaries for PLGRKT Gene

GeneCards Summary for PLGRKT Gene

PLGRKT (Plasminogen Receptor With A C-Terminal Lysine) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PLGRKT Gene

  • Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLGRKT Gene

Genomics for PLGRKT Gene

Regulatory Elements for PLGRKT Gene

Enhancers for PLGRKT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F005585 1.3 FANTOM5 Ensembl ENCODE 15.9 -148.3 -148342 2.3 TBP PKNOX1 EBF1 RELA POLR2A EED FOS CREM BHLHE40 ZBED1 CD274 PLGRKT PDCD1LG2 RLN2 HMGN2P31 RIC1 ENSG00000231509 GC09M005608
GH09F005459 1.5 FANTOM5 Ensembl ENCODE 13.6 -21.2 -21201 1.1 TBP MXI1 TBL1XR1 BMI1 EBF1 RELA POLR2A CBX5 EED ETV6 CD274 PLGRKT PDCD1LG2 JAK2 RIC1
GH09F005582 1.4 FANTOM5 Ensembl ENCODE 11.7 -145.0 -144962 2.1 HDGF TBP PKNOX1 MAX SIN3A EBF1 RELA RFX5 CTBP1 POLR2A PLGRKT CD274 PDCD1LG2 ENSG00000231509 GC09P005578
GH09F005623 1.5 FANTOM5 ENCODE 10.9 -188.8 -188784 7.1 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF766 ZNF143 ZNF207 RIC1 PLGRKT KIAA2026 CD274 RANBP6 GC09P005625 LOC105375967
GH09F005568 1.3 FANTOM5 Ensembl ENCODE 11.4 -131.1 -131145 1.6 MAFG TBX21 RAD51 ZNF316 ATF3 NFE2 EMSY MAFK CD274 PDCD1LG2 PLGRKT RIC1 GC09M005559 GC09P005527
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLGRKT on UCSC Golden Path with GeneCards custom track

Promoters for PLGRKT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001907187 -244 201 MXI1 PKNOX1 TBL1XR1 SIN3A BMI1 ZBTB40 RELA ZNF335 CBX5 POLR2A
ENSR00001299519 856 1601 PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 DEK

Genomic Location for PLGRKT Gene

Chromosome:
9
Start:
5,357,966 bp from pter
End:
5,438,456 bp from pter
Size:
80,491 bases
Orientation:
Minus strand

Genomic View for PLGRKT Gene

Genes around PLGRKT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLGRKT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLGRKT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLGRKT Gene

Proteins for PLGRKT Gene

  • Protein details for PLGRKT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBL7-PLRKT_HUMAN
    Recommended name:
    Plasminogen receptor (KT)
    Protein Accession:
    Q9HBL7
    Secondary Accessions:
    • B2R6W0
    • Q9NZ44

    Protein attributes for PLGRKT Gene

    Size:
    147 amino acids
    Molecular mass:
    17201 Da
    Quaternary structure:
    • Interacts with PLAT and PLAUR.

neXtProt entry for PLGRKT Gene

Post-translational modifications for PLGRKT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLGRKT Gene

No data available for DME Specific Peptides for PLGRKT Gene

Domains & Families for PLGRKT Gene

Protein Domains for PLGRKT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLGRKT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLGRKT: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PLGRKT Gene

Function for PLGRKT Gene

Molecular function for PLGRKT Gene

UniProtKB/Swiss-Prot Function:
Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9.

Gene Ontology (GO) - Molecular Function for PLGRKT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PLGRKT: view

Phenotypes for PLGRKT Gene

genes like me logo Genes that share phenotypes with PLGRKT: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLGRKT Gene

Localization for PLGRKT Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLGRKT Gene

Cell membrane; Multi-pass membrane protein. Note=Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/PLAUR. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLGRKT gene
Compartment Confidence
mitochondrion 4
plasma membrane 2
nucleus 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLGRKT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLGRKT: view

Pathways & Interactions for PLGRKT Gene

SuperPathways for PLGRKT Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLGRKT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IEA --
GO:0010756 positive regulation of plasminogen activation IEA --
genes like me logo Genes that share ontologies with PLGRKT: view

No data available for Pathways by source and SIGNOR curated interactions for PLGRKT Gene

Transcripts for PLGRKT Gene

Unigene Clusters for PLGRKT Gene

Plasminogen receptor, C-terminal lysine transmembrane protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLGRKT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -
SP3:

Relevant External Links for PLGRKT Gene

GeneLoc Exon Structure for
PLGRKT
ECgene alternative splicing isoforms for
PLGRKT

Expression for PLGRKT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLGRKT Gene

Protein differential expression in normal tissues from HIPED for PLGRKT Gene

This gene is overexpressed in Nasal epithelium (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLGRKT Gene



Protein tissue co-expression partners for PLGRKT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PLGRKT Gene:

PLGRKT

SOURCE GeneReport for Unigene cluster for PLGRKT Gene:

Hs.584242

mRNA Expression by UniProt/SwissProt for PLGRKT Gene:

Q9HBL7-PLRKT_HUMAN
Tissue specificity: Expressed in peripheral blood cells and monocytes. Expressed in adrenal medulla.
genes like me logo Genes that share expression patterns with PLGRKT: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PLGRKT Gene

Orthologs for PLGRKT Gene

This gene was present in the common ancestor of animals.

Orthologs for PLGRKT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLGRKT 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia PLGRKT 34 35
  • 91.84 (n)
cow
(Bos Taurus)
Mammalia PLGRKT 34
  • 88.44 (n)
C8H9ORF46 35
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plgrkt 34
  • 86.17 (n)
mouse
(Mus musculus)
Mammalia Plgrkt 34 16 35
  • 85.03 (n)
oppossum
(Monodelphis domestica)
Mammalia PLGRKT 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLGRKT 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLGRKT 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plgrkt 34
  • 69.43 (n)
zebrafish
(Danio rerio)
Actinopterygii plgrkt 34 35
  • 59.21 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8238 34
fruit fly
(Drosophila melanogaster)
Insecta CG13404 35
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10710 35
  • 45 (a)
OneToOne
Species where no ortholog for PLGRKT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLGRKT Gene

ENSEMBL:
Gene Tree for PLGRKT (if available)
TreeFam:
Gene Tree for PLGRKT (if available)

Paralogs for PLGRKT Gene

No data available for Paralogs for PLGRKT Gene

Variants for PLGRKT Gene

Sequence variations from dbSNP and Humsavar for PLGRKT Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10121219 -- 5,420,254(+) GAGGA(A/G)TTGGA intron-variant
rs10125332 -- 5,393,324(+) GAAAT(A/G)TATTT intron-variant
rs10125658 -- 5,358,505(+) GGAGA(A/G)GTAAT intron-variant
rs10283595 -- 5,407,628(+) GCATT(A/C)TAATG intron-variant
rs10283755 -- 5,407,803(+) AATAG(C/T)AACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLGRKT Gene

Variant ID Type Subtype PubMed ID
dgv12486n54 CNV loss 21841781
dgv12487n54 CNV loss 21841781
dgv7385n100 CNV loss 25217958
esv2075617 CNV deletion 18987734
esv2421735 CNV deletion 20811451
esv25929 CNV loss 19812545
esv2675911 CNV deletion 23128226
esv2676957 CNV deletion 23128226
esv2738159 CNV deletion 23290073
esv2759660 CNV loss 17122850
esv2761250 CNV loss 21179565
esv2764129 CNV loss 21179565
esv34378 CNV loss 17911159
esv3573094 CNV loss 25503493
esv3619378 CNV loss 21293372
esv3619379 CNV loss 21293372
esv3619380 CNV loss 21293372
esv3891536 CNV loss 25118596
nsv1017268 CNV loss 25217958
nsv1029795 CNV loss 25217958
nsv1116575 OTHER inversion 24896259
nsv442131 CNV loss 18776908
nsv466108 CNV gain 19166990
nsv466109 CNV loss 19166990
nsv466110 CNV loss 19166990
nsv515508 CNV loss 19592680
nsv527495 CNV gain 19592680
nsv613192 CNV loss 21841781
nsv613196 CNV gain 21841781
nsv613198 CNV loss 21841781
nsv818676 CNV loss 17921354
nsv8408 CNV gain 18304495

Variation tolerance for PLGRKT Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLGRKT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLGRKT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLGRKT Gene

Disorders for PLGRKT Gene

Relevant External Links for PLGRKT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLGRKT

No disorders were found for PLGRKT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLGRKT Gene

Publications for PLGRKT Gene

  1. Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT. (PMID: 21940822) Lighvani S. … Miles L.A. (Blood 2011) 2 3 4 64
  2. The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release. (PMID: 21795689) Bai H. … Parmer R.J. (J. Biol. Chem. 2011) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PLGRKT Gene

Sources for PLGRKT Gene

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