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PLGLB2 Gene

protein-coding   GIFtS: 43
GCID: GC02P088050

Plasminogen-Like B2

(Previous name: plasminogen pseudogene 1)
(Previous symbol: PLGP1)
  Search for PLGLB2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Plasminogen-Like B21 2     Type B Plasminogen Related2
PLGP11 2 3     PLGL3
Plasminogen Pseudogene 11 2     PRGB3
Plasminogen-Related Protein B2 3     EC 3.4.21.78
Plasminogen-Like Protein B2     

External Ids:    HGNC: 90731   Entrez Gene: 53422   Ensembl: ENSG000001255517   UniProtKB: Q023253   

Export aliases for PLGLB2 gene to outside databases

Previous GC identifers: GC00U921622 GC02P087887 GC02P088045


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PLGLB2 Gene:
PLGLB2 (plasminogen-like B2) is a protein-coding gene. An important paralog of this gene is PLGLB1.

UniProtKB/Swiss-Prot: PLGB_HUMAN, Q02325
Function: May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This
may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization
of activity at sites necessary for extracellular matrix destruction

Gene Wiki entry for PLGLB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLGLB2 gene promoter:
         TBP   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Meis-1b   FOXO1a   Meis-1a   MRF-2   FOXO1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLGLB2 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLGLB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

PLGLB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLGLB2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P088050:  view genomic region     (about GC identifiers)

Start:
88,047,606 bp from pter      End:
88,058,995 bp from pter
Size:
11,390 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PLGB_HUMAN, Q02325 (See protein sequence)
Recommended Name: Plasminogen-like protein B precursor  
Size: 96 amino acids; 10971 Da
Secondary accessions: Q580R1

Explore the universe of human proteins at neXtProt for PLGLB2: NX_Q02325

Explore proteomics data for PLGLB2 at MOPED

2 DME Specific Peptides for PLGLB2 (Q02325)
 CRAFQYHSK  FQYHSKEQQCV 


See PLGLB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002656.1  
ENSEMBL proteins: 
 ENSP00000352458   ENSP00000386317  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR003609 Pan_app
 IPR003014 PAN-1_domain
 IPR016351 Plasminogen-rel

Graphical View of Domain Structure for InterPro Entry Q02325

ProtoNet protein and cluster: Q02325

UniProtKB/Swiss-Prot: PLGB_HUMAN, Q02325
Similarity: Contains 1 PAN domain


PLGLB2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: PLGB_HUMAN, Q02325
Function: May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This
may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization
of activity at sites necessary for extracellular matrix destruction

     Enzyme Number (IUBMB): EC 3.4.21.72

Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
PLGB_HUMAN, Q02325: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----

PLGLB2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLGLB2
Interactions:

    Search GeneGlobe Interaction Network for PLGLB2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for PLGLB2 (PLGB)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for PLGLB2 gene: 
NM_002665.4  

Unigene Cluster for PLGLB2:

Plasminogen-like B2
Hs.652169  [show with all ESTs]
Unigene Representative Sequence: NM_002665
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000359481(uc002ssl.3) ENST00000410086 ENST00000465361
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Additional mRNA sequence: 

AF075095.1 BC005379.1 BC022294.1 BC070296.1 BC107767.1 BC109248.2 M93143.2 

19 DOTS entries:

DT.86855200  DT.91938200  DT.121025805  DT.92414250  DT.121025724  DT.91671965  DT.40280299  DT.100777514 
DT.121024424  DT.121025836  DT.309339  DT.91748454  DT.95078359  DT.121324519  DT.92044277  DT.95274717 
DT.95361932  DT.97771437  DT.97776307 

Selected AceView cDNA sequences (see all 122):

AI887874 Z41205 AA343648 H93627 BC070296 BE504475 BG568844 AV646001 
H59201 BG566981 AA916867 AF075095 H73621 AV699135 BG616458 BG617272 
BG563291 BG568422 AW082345 AV656003 BG566350 T28643 AI215672 BG565673 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PLGLB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTGACTCAA
PLGLB2 Expression
About this image

PLGLB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

PLGLB2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.652169
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLGLB2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for PLGLB2 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia --
Uncharacterized protein
97(a)
1 → many
2A(88181988-88191600)


ENSEMBL Gene Tree for PLGLB2 (if available)
TreeFam Gene Tree for PLGLB2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for PLGLB2 gene
PLGLB11 2  
4 SIMAP similar genes for PLGLB2 using alignment to 1 protein entry:     PLGB_HUMAN:
PLGL    PLGLA    PLG    PLGLB1

PLGLB2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for PLGLB2 (see all 37)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2007915951,2
F--88047701(+) TCTACT/CTCTTT 2 /P /L mis11Minor allele frequency- C:0.00EU 875
rs2014772921,2
C--88049891(+) CACTGC/TGAGCT 1 -- int10--------
rs1392157781,2
--88050297(+) CAGTGC/TGCTCT 1 -- int10--------
rs2014917531,2
C--88050547(+) TGAAAA/GTCACT 1 -- int10--------
rs2016540231,2
F--88053035(+) CCTGCT/CTCGTT 1 -- int11Minor allele frequency- C:0.03EU 263
rs1999575031,2
F--88053077(+) CAACAA/GTGTGT 2 Q syn11Minor allele frequency- G:0.07EU 747
rs2017676231,2
C--88053903(+) AAGACC/TGTTAA 1 -- int10--------
rs2009157791,2
C--88054197(+) GTAAAG/TTTATT 1 -- int10--------
rs38382181,2
C--88054263(-) TTTTG-/TTTTTT 1 -- int1 trp30--------
rs2018494341,2
C--88055705(+) GGCACC/GGGACT 1 -- int10--------

HapMap Linkage Disequilibrium report for PLGLB2 (88047606 - 88058995 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for PLGLB2 (see all 14):    About this table    
Variant IDTypeSubtypePubMed ID
dgv61n16CNV Deletion17901297
nsv519198CNV Loss19592680
esv33176CNV Loss17666407
nsv874475CNV Loss21882294
nsv428398CNV Loss18775914
nsv834287CNV Gain17160897
nsv834288CNV Gain17160897
nsv874473CNV Gain21882294
nsv516958CNV Gain+Loss19592680
dgv1215e1CNV Complex17122850

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PLGLB2 for disorders           About GeneDecksing

Genetic Association Database (GAD): PLGLB2
Human Genome Epidemiology (HuGE) Navigator: PLGLB2 (3 documents)

Export disorders for PLGLB2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for PLGLB2 gene, integrated from 10 sources (see all 14):
(articles sorted by number of sources associating them with PLGLB2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A plasminogen-related gene is expressed in cancer cells. (PubMed id 1379800)1, 2, 9 Weissbach L. and Treadwell B.V. (Biochem. Biophys. Res. Commun. 1992)
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Multiple members of the plasminogen-apolipoprotein(a) gene family associated with thrombosis. (PubMed id 1554698)1, 2 Ichinose A. (Biochemistry 1992)
  6. Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis. (PubMed id 1986355)1, 3 Ichinose A.... Davie E.W. (Proc. Natl. Acad. Sci. U.S.A. 1991)
  7. Expression of plasminogen-related gene B varies among normal tissues and increases in cancer tissues. (PubMed id 10069369)1, 9 Tateno T. and Ichinose A. (FEBS Lett. 1999)
  8. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
  9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5342 HGNC: 9073 AceView: PLGL.1 Ensembl:ENSG00000125551 euGenes: HUgn5342
ECgene: PLGLB2 H-InvDB: PLGLB2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for PLGLB2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for PLGLB2 gene:
Search GeneIP for patents involving PLGLB2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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