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Aliases for PLGLB2 Gene

Aliases for PLGLB2 Gene

  • Plasminogen-Like B2 2 3 5
  • Plasminogen-Related Protein B 3 4
  • Plasminogen Pseudogene 1 2 3
  • PLGP1 3 4
  • Plasminogen-Related Protein A 3
  • Plasminogen-Like Protein A1 3
  • Plasminogen-Like Protein B 3
  • Type B Plasminogen Related 3
  • Plasminogen-Like Protein A 3
  • PLGLB1 PLGLB2 4
  • EC 3.4.21.7 58
  • PLGLA1 3
  • PLGP2 3
  • PLGLA 3
  • PRGA 3
  • PLGL 4
  • PRGB 4

External Ids for PLGLB2 Gene

Previous HGNC Symbols for PLGLB2 Gene

  • PLGP1

Previous GeneCards Identifiers for PLGLB2 Gene

  • GC00U921622
  • GC02P087887
  • GC02P088045
  • GC02P088050

Summaries for PLGLB2 Gene

GeneCards Summary for PLGLB2 Gene

PLGLB2 (Plasminogen-Like B2) is a Protein Coding gene. An important paralog of this gene is PLGLB1.

UniProtKB/Swiss-Prot for PLGLB2 Gene

  • May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction.

Gene Wiki entry for PLGLB2 Gene

Additional gene information for PLGLB2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLGLB2 Gene

Genomics for PLGLB2 Gene

Regulatory Elements for PLGLB2 Gene


Genomic Location for PLGLB2 Gene

Chromosome:
2
Start:
87,748,087 bp from pter
End:
87,759,476 bp from pter
Size:
11,390 bases
Orientation:
Plus strand

Genomic View for PLGLB2 Gene

Genes around PLGLB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLGLB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLGLB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLGLB2 Gene

Proteins for PLGLB2 Gene

  • Protein details for PLGLB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02325-PLGB_HUMAN
    Recommended name:
    Plasminogen-like protein B
    Protein Accession:
    Q02325
    Secondary Accessions:
    • Q580R1

    Protein attributes for PLGLB2 Gene

    Size:
    96 amino acids
    Molecular mass:
    10971 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLGLB2 Gene

Selected DME Specific Peptides for PLGLB2 Gene

Q02325:
  • FQYHSKEQQCV
  • CRAFQYHSK

Post-translational modifications for PLGLB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLGLB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PLGLB2 Gene

Gene Families for PLGLB2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PLGLB2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLGLB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLGLB2: view

No data available for UniProtKB/Swiss-Prot for PLGLB2 Gene

Function for PLGLB2 Gene

Molecular function for PLGLB2 Gene

UniProtKB/Swiss-Prot Function:
May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction.

Enzyme Numbers (IUBMB) for PLGLB2 Gene

genes like me logo Genes that share phenotypes with PLGLB2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PLGLB2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLGLB2 Gene

Localization for PLGLB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLGLB2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLGLB2 gene
Compartment Confidence
extracellular 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLGLB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PLGLB2: view

Pathways & Interactions for PLGLB2 Gene

SuperPathways for PLGLB2 Gene

No Data Available

Interacting Proteins for PLGLB2 Gene

Gene Ontology (GO) - Biological Process for PLGLB2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PLGLB2 Gene

Drugs & Compounds for PLGLB2 Gene

No Compound Related Data Available

Transcripts for PLGLB2 Gene

mRNA/cDNA for PLGLB2 Gene

Unigene Clusters for PLGLB2 Gene

Plasminogen-like B2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PLGLB2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PLGLB2 Gene

No ASD Table

Relevant External Links for PLGLB2 Gene

GeneLoc Exon Structure for
PLGLB2
ECgene alternative splicing isoforms for
PLGLB2

Expression for PLGLB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLGLB2 Gene

mRNA differential expression in normal tissues according to GTEx for PLGLB2 Gene

This gene is overexpressed in Liver (x34.4).

Protein differential expression in normal tissues from HIPED for PLGLB2 Gene

This gene is overexpressed in Serum (59.0) and Skin (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLGLB2 Gene



Protein tissue co-expression partners for PLGLB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PLGLB2 Gene:

PLGLB2

SOURCE GeneReport for Unigene cluster for PLGLB2 Gene:

Hs.652169

Evidence on tissue expression from TISSUES for PLGLB2 Gene

  • Liver(4.6)
  • Muscle(4)
genes like me logo Genes that share expression patterns with PLGLB2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLGLB2 Gene

Orthologs for PLGLB2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PLGLB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 97 (a)
OneToMany
Species where no ortholog for PLGLB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLGLB2 Gene

ENSEMBL:
Gene Tree for PLGLB2 (if available)
TreeFam:
Gene Tree for PLGLB2 (if available)

Paralogs for PLGLB2 Gene

Paralogs for PLGLB2 Gene

(4) SIMAP similar genes for PLGLB2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLGLB2: view

Variants for PLGLB2 Gene

Sequence variations from dbSNP and Humsavar for PLGLB2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1001594829 -- 87,747,918(+) CTGAG(A/G)GGGGA upstream-variant-2KB
rs1001930945 -- 87,749,082(+) TTTGA(A/G)ATAAT intron-variant
rs1002541870 -- 87,753,672(+) TCCTC(C/T)CCATC intron-variant
rs1004935061 -- 87,758,153(+) AATCA(C/G)ACAGA intron-variant, utr-variant-3-prime
rs1005433062 -- 87,746,964(+) AGTGA(A/G)GCTAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLGLB2 Gene

Variant ID Type Subtype PubMed ID
dgv1141e212 CNV loss 25503493
dgv3887n100 CNV gain 25217958
dgv3888n100 CNV gain 25217958
dgv3889n100 CNV loss 25217958
dgv3893n100 CNV gain 25217958
dgv3900n100 CNV gain 25217958
dgv3901n100 CNV gain+loss 25217958
dgv3908n100 CNV gain 25217958
dgv3909n100 CNV loss 25217958
dgv61n16 CNV deletion 17901297
esv2759073 CNV gain+loss 17122850
esv2760646 CNV gain+loss 21179565
esv2763649 CNV gain+loss 21179565
esv33176 CNV loss 17666407
nsv1072005 CNV deletion 25765185
nsv1130752 CNV deletion 24896259
nsv1148611 CNV deletion 26484159
nsv428398 CNV loss 18775914
nsv516958 CNV gain+loss 19592680
nsv519198 CNV loss 19592680
nsv7316 OTHER inversion 18451855
nsv834287 CNV gain 17160897
nsv834288 CNV gain 17160897
nsv979034 CNV duplication 23825009
nsv979040 CNV duplication 23825009

Variation tolerance for PLGLB2 Gene

Gene Damage Index Score: 0.80; 16.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLGLB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLGLB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLGLB2 Gene

Disorders for PLGLB2 Gene

Relevant External Links for PLGLB2

Genetic Association Database (GAD)
PLGLB2
Human Genome Epidemiology (HuGE) Navigator
PLGLB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLGLB2

No disorders were found for PLGLB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLGLB2 Gene

Publications for PLGLB2 Gene

  1. A plasminogen-related gene is expressed in cancer cells. (PMID: 1379800) Weissbach L … Treadwell BV (Biochemical and biophysical research communications 1992) 3 4 22 60
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Expression of plasminogen-related gene B varies among normal tissues and increases in cancer tissues. (PMID: 10069369) Tateno T … Ichinose A (FEBS letters 1999) 3 22 60

Products for PLGLB2 Gene

Sources for PLGLB2 Gene

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