Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLGLB2 Gene

Aliases for PLGLB2 Gene

  • Plasminogen-Like B2 2 3
  • Plasminogen-Related Protein B 3 4
  • Plasminogen Pseudogene 1 2 3
  • PLGP1 3 4
  • Plasminogen-Like Protein B 3
  • Type B Plasminogen Related 3
  • PLGLB1 PLGLB2 4
  • EC 3.4.21.7 64
  • PLGL 4
  • PRGB 4

External Ids for PLGLB2 Gene

Previous Symbols for PLGLB2 Gene

  • PLGP1

Summaries for PLGLB2 Gene

GeneCards Summary for PLGLB2 Gene

PLGLB2 (Plasminogen-Like B2) is a Protein Coding gene. An important paralog of this gene is PLGLB1.

UniProtKB/Swiss-Prot for PLGLB2 Gene

  • May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction

Gene Wiki entry for PLGLB2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLGLB2 Gene

Genomics for PLGLB2 Gene

Genomic Location for PLGLB2 Gene

Start:
87,748,087 bp from pter
End:
87,759,476 bp from pter
Size:
11,390 bases
Orientation:
Plus strand

Genomic View for PLGLB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLGLB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLGLB2 Gene

Regulatory Elements for PLGLB2 Gene

Proteins for PLGLB2 Gene

  • Protein details for PLGLB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02325-PLGB_HUMAN
    Recommended name:
    Plasminogen-like protein B
    Protein Accession:
    Q02325
    Secondary Accessions:
    • Q580R1

    Protein attributes for PLGLB2 Gene

    Size:
    96 amino acids
    Molecular mass:
    10971 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLGLB2 Gene

Proteomics data for PLGLB2 Gene at MOPED

Selected DME Specific Peptides for PLGLB2 Gene

Post-translational modifications for PLGLB2 Gene

No Post-translational modifications

Other Protein References for PLGLB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PLGLB2 Gene

Protein Domains for PLGLB2 Gene

UniProtKB/Swiss-Prot:

PLGB_HUMAN
Domain:
  • Contains 1 PAN domain.:
    • Q02325
genes like me logo Genes that share domains with PLGLB2: view

No data available for Gene Families for PLGLB2 Gene

Function for PLGLB2 Gene

Molecular function for PLGLB2 Gene

UniProtKB/Swiss-Prot Function: May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction

Enzyme Numbers (IUBMB) for PLGLB2 Gene

No data available for Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PLGLB2 Gene

Localization for PLGLB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLGLB2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLGLB2 Gene COMPARTMENTS Subcellular localization image for PLGLB2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PLGLB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PLGLB2: view

Pathways for PLGLB2 Gene

SuperPathways for PLGLB2 Gene

No Data Available

Interacting Proteins for PLGLB2 Gene

Gene Ontology (GO) - Biological Process for PLGLB2 Gene

None

No data available for Pathways by source for PLGLB2 Gene

Transcripts for PLGLB2 Gene

mRNA/cDNA for PLGLB2 Gene

Unigene Clusters for PLGLB2 Gene

Plasminogen-like B2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLGLB2 Gene

No ASD Table

Relevant External Links for PLGLB2 Gene

GeneLoc Exon Structure for
PLGLB2
ECgene alternative splicing isoforms for
PLGLB2

Expression for PLGLB2 Gene

mRNA expression in normal human tissues for PLGLB2 Gene

mRNA differential expression in normal tissues according to GTEx for PLGLB2 Gene

This gene is overexpressed in Liver (34.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PLGLB2 Gene

SOURCE GeneReport for Unigene cluster for PLGLB2 Gene Hs.652169

genes like me logo Genes that share expressions with PLGLB2: view

Orthologs for PLGLB2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PLGLB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 97 (a)
OneToMany
Species with no ortholog for PLGLB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLGLB2 Gene

ENSEMBL:
Gene Tree for PLGLB2 (if available)
TreeFam:
Gene Tree for PLGLB2 (if available)

Paralogs for PLGLB2 Gene

Paralogs for PLGLB2 Gene

Selected SIMAP similar genes for PLGLB2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLGLB2: view

Variants for PLGLB2 Gene

Sequence variations from dbSNP and Humsavar for PLGLB2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3838218 -- 87,754,744(-) TTTTG(-/T)TTTTT intron-variant
rs4522601 -- 87,756,410(+) TCCCC(A/C)TTCTC intron-variant
rs56380319 -- 87,747,095(+) CAGGA(C/T)GTTCC upstream-variant-2KB
rs71234874 -- 87,746,774(-) TGGGG(-/A)AAAAA upstream-variant-2KB
rs71235509 -- 87,746,624(-) CTGTT(G/T)TTTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLGLB2 Gene

Variant ID Type Subtype PubMed ID
nsv7316 OTHER Inversion 18451855
nsv874473 CNV Gain 21882294
dgv1214e1 CNV Complex 17122850
nsv519198 CNV Loss 19592680
nsv874475 CNV Loss 21882294
esv33176 CNV Loss 17666407
dgv1215e1 CNV Complex 17122850
dgv1216e1 CNV Complex 17122850
dgv1217e1 CNV Complex 17122850
nsv428398 CNV Loss 18775914
nsv516958 CNV Gain+Loss 19592680
dgv61n16 CNV Deletion 17901297
nsv834287 CNV Gain 17160897
nsv834288 CNV Gain 17160897

Relevant External Links for PLGLB2 Gene

HapMap Linkage Disequilibrium report
PLGLB2

Disorders for PLGLB2 Gene

Relevant External Links for PLGLB2

Genetic Association Database (GAD)
PLGLB2
Human Genome Epidemiology (HuGE) Navigator
PLGLB2
genes like me logo Genes that share disorders with PLGLB2: view

No data available for UniProtKB/Swiss-Prot for PLGLB2 Gene

Publications for PLGLB2 Gene

  1. A plasminogen-related gene is expressed in cancer cells. (PMID: 1379800) Weissbach L. … Treadwell B.V. (Biochem. Biophys. Res. Commun. 1992) 3 4 23
  2. Expression of plasminogen-related gene B varies among normal tissues and increases in cancer tissues. (PMID: 10069369) Tateno T. … Ichinose A. (FEBS Lett. 1999) 3 23
  3. Multiple members of the plasminogen-apolipoprotein(a) gene family associated with thrombosis. (PMID: 1554698) Ichinose A. (Biochemistry 1992) 3 4
  4. Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis. (PMID: 1986355) Ichinose A. … Davie E.W. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PLGLB2 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate PLGLB2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PLGLB2
    • Block miRNA regulation of PLGLB2 using miScript Target Protectors

    Sources for PLGLB2 Gene

    Back to Top

    Content