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Aliases for PLGLA Gene

Aliases for PLGLA Gene

  • Plasminogen-Like A (Pseudogene) 2 3 5
  • Plasminogen-Related Protein A 3 4
  • Plasminogen Pseudogene 2 2 3
  • Plasminogen-Like A1 2 3
  • PLGLA1 3 4
  • PLGP2 3 4
  • PRGA 3 4
  • Plasminogen-Like Protein A1 4
  • Plasminogen-Like A 2
  • EC 3.4.21.7 63

External Ids for PLGLA Gene

Previous HGNC Symbols for PLGLA Gene

  • PLGP2
  • PLGLA1

Previous GeneCards Identifiers for PLGLA Gene

  • GC02P106355
  • GC02U901555
  • GC02P106998
  • GC02P100772

Summaries for PLGLA Gene

GeneCards Summary for PLGLA Gene

PLGLA (Plasminogen-Like A (Pseudogene)) is a Pseudogene.

UniProtKB/Swiss-Prot for PLGLA Gene

  • May bind non-covalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLGLA Gene

Genomics for PLGLA Gene

Regulatory Elements for PLGLA Gene

Enhancers for PLGLA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLGLA on UCSC Golden Path with GeneCards custom track

Genomic Location for PLGLA Gene

Chromosome:
2
Start:
106,382,114 bp from pter
End:
106,393,031 bp from pter
Size:
10,918 bases
Orientation:
Plus strand

Genomic View for PLGLA Gene

Genes around PLGLA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLGLA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLGLA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLGLA Gene

Proteins for PLGLA Gene

  • Protein details for PLGLA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15195-PLGA_HUMAN
    Recommended name:
    Plasminogen-like protein A
    Protein Accession:
    Q15195

    Protein attributes for PLGLA Gene

    Size:
    96 amino acids
    Molecular mass:
    10915 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLGLA Gene

Proteomics data for PLGLA Gene at MOPED

Selected DME Specific Peptides for PLGLA Gene

Post-translational modifications for PLGLA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PLGLA Gene

Protein Domains for PLGLA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLGLA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15195

UniProtKB/Swiss-Prot:

PLGA_HUMAN :
  • Contains 1 PAN domain.
Domain:
  • Contains 1 PAN domain.
genes like me logo Genes that share domains with PLGLA: view

No data available for Gene Families for PLGLA Gene

Function for PLGLA Gene

Molecular function for PLGLA Gene

UniProtKB/Swiss-Prot Function:
May bind non-covalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction (By similarity).

Enzyme Numbers (IUBMB) for PLGLA Gene

Phenotypes for PLGLA Gene

GenomeRNAi human phenotypes for PLGLA:
genes like me logo Genes that share phenotypes with PLGLA: view

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLGLA Gene

Localization for PLGLA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLGLA Gene

Secreted.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PLGLA Gene

Pathways & Interactions for PLGLA Gene

SuperPathways for PLGLA Gene

No Data Available

Interacting Proteins for PLGLA Gene

Gene Ontology (GO) - Biological Process for PLGLA Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PLGLA Gene

Drugs & Compounds for PLGLA Gene

No Compound Related Data Available

Transcripts for PLGLA Gene

mRNA/cDNA for PLGLA Gene

(2) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLGLA Gene

Plasminogen-like A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLGLA Gene

No ASD Table

Relevant External Links for PLGLA Gene

GeneLoc Exon Structure for
PLGLA
ECgene alternative splicing isoforms for
PLGLA

Expression for PLGLA Gene

mRNA expression in normal human tissues for PLGLA Gene

mRNA differential expression in normal tissues according to GTEx for PLGLA Gene

This gene is overexpressed in Liver (x46.2).

Protein differential expression in normal tissues from HIPED for PLGLA Gene

This gene is overexpressed in Cervix (40.4), Serum (18.9), and Plasma (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLGLA Gene



SOURCE GeneReport for Unigene cluster for PLGLA Gene Hs.631263

mRNA Expression by UniProt/SwissProt for PLGLA Gene

Q15195-PLGA_HUMAN
Tissue specificity: Expressed in liver.
genes like me logo Genes that share expression patterns with PLGLA: view

Protein tissue co-expression partners for PLGLA Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PLGLA Gene

Orthologs for PLGLA Gene

Evolution for PLGLA Gene

ENSEMBL:
Gene Tree for PLGLA (if available)
TreeFam:
Gene Tree for PLGLA (if available)

No data available for Orthologs for PLGLA Gene

Paralogs for PLGLA Gene

(4) SIMAP similar genes for PLGLA Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLGLA: view

No data available for Paralogs for PLGLA Gene

Variants for PLGLA Gene

Sequence variations from dbSNP and Humsavar for PLGLA Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6757378 -- 106,381,773(+) GGTCT(C/T)GTCAT upstream-variant-2KB
rs6761636 -- 106,382,935(+) CATAT(C/T)CATCC intron-variant
rs10169094 -- 106,381,921(+) AGGCA(A/G)CGTGG upstream-variant-2KB
rs4261719 -- 106,389,739(+) TAAAC(A/G)TTTTA intron-variant
rs4299336 -- 106,385,286(+) ACCAA(A/G)ACCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLGLA Gene

Variant ID Type Subtype PubMed ID
nsv834322 CNV Gain 17160897
esv2720482 CNV Deletion 23290073

Relevant External Links for PLGLA Gene

HapMap Linkage Disequilibrium report
PLGLA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PLGLA Gene

Disorders for PLGLA Gene

Relevant External Links for PLGLA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLGLA

No disorders were found for PLGLA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLGLA Gene

Publications for PLGLA Gene

  1. Homologous plasminogen N-terminal and plasminogen-related gene A and B peptides. Characterization of cDNAs and recombinant fusion proteins. (PMID: 10092845) Lewis V.O. … Schaller J. (Eur. J. Biochem. 1999) 3 4 67
  2. Characterization of the 5'-flanking regions of plasminogen-related genes A and B. (PMID: 9074645) Kida M. … Ichinose A. (FEBS Lett. 1997) 3 23
  3. Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis. (PMID: 1986355) Ichinose A. … Davie E.W. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Multiple members of the plasminogen-apolipoprotein(a) gene family associated with thrombosis. (PMID: 1554698) Ichinose A. (Biochemistry 1992) 3

Products for PLGLA Gene

Sources for PLGLA Gene

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