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PLGLA Gene

pseudogene   GIFtS: 31
GCID: GC02P106998

Plasminogen-Like A (Pseudogene)

(Previous names: plasminogen pseudogene 2, plasminogen-like A1, plasminogen-like...)
(Previous symbols: PLGP2, PLGLA1)
  Search for PLGLA
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Plasminogen-Like A (Pseudogene)1 2     Plasminogen-Like A1
PLGLA11 2 3     Plasminogen-Like A11
PLGP21 2 3     Plasminogen-Like Protein A13
PRGA2 3 5     Plasminogen-Related Protein A3
Plasminogen Pseudogene 21     EC 3.4.21.78

External Ids:    HGNC: 90741   Entrez Gene: 2851892   Ensembl: ENSG000002409357   OMIM: 6122125   UniProtKB: Q151953   

Export aliases for PLGLA gene to outside databases

Previous GC identifers: GC02P106355 GC02U901555 GC02P100772


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PLGLA Gene:
PLGLA (plasminogen-like A (pseudogene)) is a pseudogene.

UniProtKB/Swiss-Prot: PLGA_HUMAN, Q15195
Function: May bind non-covalently to lysine binding sites present in the kringle structures of plasminogen. This
may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization
of activity at sites necessary for extracellular matrix destruction (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLGLA gene promoter:
         SRF   SRF (504 AA)   RelA   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   NF-kappaB   POU3F2   Sox9   NF-kappaB1   Pax-4a   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLGLA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12.2   Ensembl cytogenetic band:  2q12.2   HGNC cytogenetic band: 2q12.2

PLGLA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLGLA gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P106998:  view genomic region     (about GC identifiers)

Start:
106,998,562 bp from pter      End:
107,010,027 bp from pter
Size:
11,466 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PLGA_HUMAN, Q15195 (See protein sequence)
Recommended Name: Plasminogen-like protein A precursor  
Size: 96 amino acids; 10915 Da

Explore the universe of human proteins at neXtProt for PLGLA: NX_Q15195

Explore proteomics data for PLGLA at MOPED

3 DME Specific Peptides for PLGLA (Q15195)
 RDVVLFEK  CRAFQYHSK  FQYHSKEQQCV 


See PLGLA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR003609 Pan_app
 IPR003014 PAN-1_domain
 IPR016351 Plasminogen-rel

Graphical View of Domain Structure for InterPro Entry Q15195

ProtoNet protein and cluster: Q15195

UniProtKB/Swiss-Prot: PLGA_HUMAN, Q15195
Similarity: Contains 1 PAN domain


Find genes that share domains with PLGLA           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: PLGA_HUMAN, Q15195
Function: May bind non-covalently to lysine binding sites present in the kringle structures of plasminogen. This
may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization
of activity at sites necessary for extracellular matrix destruction (By similarity)

     Enzyme Number (IUBMB): EC 3.4.21.72

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
PLGA_HUMAN, Q15195: Secreted (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
cytosol1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

Find genes that share ontologies with PLGLA           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLGLA
Interactions:

    Search GeneGlobe Interaction Network for PLGLA

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for PLGLA (PLGA)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Unigene Cluster for PLGLA:

Plasminogen-like A
Hs.631263  [show with all ESTs]
Unigene Representative Sequence: NR_003506
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000465668 ENST00000484422(uc002tdp.3) ENST00000482249 ENST00000324709

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Additional mRNA sequence: 

NR_003506.3 U67178.1 

4 DOTS entries:

DT.115253  DT.95078359  DT.120968089  DT.120992132 

18 AceView cDNA sequences:

U67178 CB164799 H57692 AA865883 AA988082 BV203868 AI469198 AI206427 
AI760232 H83143 AI796082 AI656263 AI033945 R09489 AW897426 H57693 
BG190002 H79749 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PLGLA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
PLGLA Expression
About this image

PLGLA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

PLGLA Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.631263

UniProtKB/Swiss-Prot: PLGA_HUMAN, Q15195
Tissue specificity: Expressed in liver

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for PLGLA (if available)
TreeFam Gene Tree for PLGLA (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for PLGLA gene
4 SIMAP similar genes for PLGLA using alignment to 1 protein entry:     PLGA_HUMAN:
PLGL    PLGLB2    PLG    PLGLB1

Find genes that share paralogs with PLGLA           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for PLGLA (see all 212)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs46761281,2
C--106996587(+) CATAAA/GTCTCA 1 -- us2k10--------
rs1489955011,2
C--106996631(+) CTCTC-/TATATAT 1 -- us2k10--------
rs46761291,2
C,F--106996741(+) TTCCTG/ATGCAC 1 -- us2k13Minor allele frequency- A:0.33NA 6
rs46761301,2
C,F--106996794(+) AGGGCT/CGTGCC 1 -- us2k15Minor allele frequency- C:0.33NA WA CSA 9
rs1426588251,2
C--106996864(+) CTGCTC/TTCTTA 1 -- us2k10--------
rs1816423081,2
C--106996883(+) AGAGTA/GCGGTG 1 -- us2k10--------
rs46761311,2
C--106996976(+) CAGGAG/AGCCAT 1 -- us2k11Minor allele frequency- A:0.50NA 2
rs1862375591,2
C--106997181(+) ATAATA/TTTTTA 1 -- us2k10--------
rs45024051,2
C--106997203(+) ATACAG/TGCTGG 1 -- us2k10--------
rs800445771,2
C--106997234(+) GTTTG-/TTTTTT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for PLGLA (106998562 - 107010027 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for PLGLA:    About this table    
Variant IDTypeSubtypePubMed ID
esv2720482CNV Deletion23290073
nsv834322CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 612212    OMIM disorders: --


Find genes that share disorders with PLGLA           About GenesLikeMe


Export disorders for PLGLA gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for PLGLA gene integrated from 10 sources:
(articles sorted by number of sources associating them with PLGLA)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Homologous plasminogen N-terminal and plasminogen-related gene A and B peptides. Characterization of cDNAs and recombinant fusion proteins. (PubMed id 10092845)1, 2 Lewis V.O.... Schaller J. (Eur. J. Biochem. 1999)
  2. Multiple members of the plasminogen-apolipoprotein(a) gene family associated with thrombosis. (PubMed id 1554698)1, 2 Ichinose A. (Biochemistry 1992)
  3. Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis. (PubMed id 1986355)1, 3 Ichinose A.... Davie E.W. (Proc. Natl. Acad. Sci. U.S.A. 1991)
  4. Characterization of the 5'-flanking regions of plasminogen-related genes A and B. (PubMed id 9074645)1, 9 Kida M....Ichinose A. (FEBS Lett. 1997)
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 285189 HGNC: 9074 AceView: PRGA Ensembl:ENSG00000240935 euGenes: HUgn285189
ECgene: PLGLA H-InvDB: PLGLA

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for PLGLA Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for PLGLA gene:
Search GeneIP for patents involving PLGLA

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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