Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLGLA Gene

Aliases for PLGLA Gene

  • Plasminogen-Like A (Pseudogene) 2 3 5
  • Plasminogen-Related Protein A 3 4
  • Plasminogen Pseudogene 2 2 3
  • Plasminogen-Like A1 2 3
  • PLGLA1 3 4
  • PLGP2 3 4
  • PRGA 3 4
  • Plasminogen-Like Protein A1 4
  • Plasminogen-Like A 2
  • EC 3.4.21.7 61

External Ids for PLGLA Gene

Previous HGNC Symbols for PLGLA Gene

  • PLGP2
  • PLGLA1

Previous GeneCards Identifiers for PLGLA Gene

  • GC02P106355
  • GC02U901555
  • GC02P106998
  • GC02P100772

Summaries for PLGLA Gene

GeneCards Summary for PLGLA Gene

PLGLA (Plasminogen-Like A (Pseudogene)) is a Pseudogene.

UniProtKB/Swiss-Prot for PLGLA Gene

  • May bind non-covalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLGLA Gene

Genomics for PLGLA Gene

Regulatory Elements for PLGLA Gene

Enhancers for PLGLA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F105743 1.2 FANTOM5 ENCODE 4.4 -634.9 -634906 7.5 WRNIP1 SIN3A RAD21 SCRT2 ZNF548 CREM ZNF263 JUNB TGIF2 POLR2H ENSG00000272994 ENSG00000235522 TGFBRAP1 ENSG00000238273 NCK2 PLGLA C2orf49
GH02F106020 1 Ensembl ENCODE 4.8 -360.9 -360941 1.8 CTCF MAZ ZNF654 ZNF76 ZBTB8A FEZF1 ZIC2 ZNF843 RAD21 OSR2 C2orf40 PLGLA GC02M105995 PIR50296
GH02F106384 0.8 ENCODE 0.8 +2.6 2632 0.9 SOX13 MLX ZNF644 RARA TEAD3 HNF4G NR2F6 HOMEZ MIXL1 GATAD2A PLGLA PIR42667
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLGLA on UCSC Golden Path with GeneCards custom track

Genomic Location for PLGLA Gene

Chromosome:
2
Start:
106,382,114 bp from pter
End:
106,393,031 bp from pter
Size:
10,918 bases
Orientation:
Plus strand

Genomic View for PLGLA Gene

Genes around PLGLA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLGLA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLGLA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLGLA Gene

Proteins for PLGLA Gene

  • Protein details for PLGLA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15195-PLGA_HUMAN
    Recommended name:
    Plasminogen-like protein A
    Protein Accession:
    Q15195

    Protein attributes for PLGLA Gene

    Size:
    96 amino acids
    Molecular mass:
    10915 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLGLA Gene

Selected DME Specific Peptides for PLGLA Gene

Q15195:
  • RDVVLFEK
  • FQYHSKEQQCV
  • CRAFQYHSK

Post-translational modifications for PLGLA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PLGLA Gene

Protein Domains for PLGLA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLGLA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15195

UniProtKB/Swiss-Prot:

PLGA_HUMAN :
  • Contains 1 PAN domain.
Domain:
  • Contains 1 PAN domain.
genes like me logo Genes that share domains with PLGLA: view

No data available for Gene Families for PLGLA Gene

Function for PLGLA Gene

Molecular function for PLGLA Gene

UniProtKB/Swiss-Prot Function:
May bind non-covalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction (By similarity).

Enzyme Numbers (IUBMB) for PLGLA Gene

Phenotypes for PLGLA Gene

GenomeRNAi human phenotypes for PLGLA:
genes like me logo Genes that share phenotypes with PLGLA: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLGLA Gene

Localization for PLGLA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLGLA Gene

Secreted.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PLGLA Gene

Pathways & Interactions for PLGLA Gene

SuperPathways for PLGLA Gene

No Data Available

Interacting Proteins for PLGLA Gene

Selected Interacting proteins: Q15195-PLGA_HUMAN for PLGLA Gene via IID

Symbol External ID(s) Details
HGF

Gene Ontology (GO) - Biological Process for PLGLA Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PLGLA Gene

Transcripts for PLGLA Gene

mRNA/cDNA for PLGLA Gene

(2) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLGLA Gene

Plasminogen-like A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLGLA Gene

No ASD Table

Relevant External Links for PLGLA Gene

GeneLoc Exon Structure for
PLGLA
ECgene alternative splicing isoforms for
PLGLA

Expression for PLGLA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLGLA Gene

mRNA differential expression in normal tissues according to GTEx for PLGLA Gene

This gene is overexpressed in Liver (x46.2).

Protein differential expression in normal tissues from HIPED for PLGLA Gene

This gene is overexpressed in Cervix (40.4), Serum (18.9), and Plasma (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLGLA Gene



Protein tissue co-expression partners for PLGLA Gene

NURSA nuclear receptor signaling pathways regulating expression of PLGLA Gene:

PLGLA

SOURCE GeneReport for Unigene cluster for PLGLA Gene:

Hs.631263

mRNA Expression by UniProt/SwissProt for PLGLA Gene:

Q15195-PLGA_HUMAN
Tissue specificity: Expressed in liver.
genes like me logo Genes that share expression patterns with PLGLA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PLGLA Gene

Orthologs for PLGLA Gene

Evolution for PLGLA Gene

ENSEMBL:
Gene Tree for PLGLA (if available)
TreeFam:
Gene Tree for PLGLA (if available)

No data available for Orthologs for PLGLA Gene

Paralogs for PLGLA Gene

(4) SIMAP similar genes for PLGLA Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLGLA: view

No data available for Paralogs for PLGLA Gene

Variants for PLGLA Gene

Sequence variations from dbSNP and Humsavar for PLGLA Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10169094 -- 106,381,921(+) AGGCA(A/G)CGTGG upstream-variant-2KB
rs11124105 -- 106,383,374(+) TTGAA(C/T)ATTTC intron-variant
rs11124106 -- 106,387,942(+) GATTT(A/T)TAAAA intron-variant
rs111494773 -- 106,384,271(+) GTTTT(C/T)TTTTT intron-variant
rs111575954 -- 106,386,550(+) CATAG(C/T)ATGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLGLA Gene

Variant ID Type Subtype PubMed ID
nsv963679 CNV duplication 23825009
nsv834322 CNV gain 17160897
esv3591872 CNV gain 21293372
esv3591871 CNV loss 21293372
esv3591865 CNV loss 21293372
esv2720482 CNV deletion 23290073
dgv6988n54 CNV loss 21841781
dgv4034n100 CNV gain 25217958

Relevant External Links for PLGLA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLGLA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PLGLA Gene

Disorders for PLGLA Gene

Relevant External Links for PLGLA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLGLA

No disorders were found for PLGLA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLGLA Gene

Publications for PLGLA Gene

  1. Homologous plasminogen N-terminal and plasminogen-related gene A and B peptides. Characterization of cDNAs and recombinant fusion proteins. (PMID: 10092845) Lewis V.O. … Schaller J. (Eur. J. Biochem. 1999) 3 4 64
  2. Characterization of the 5'-flanking regions of plasminogen-related genes A and B. (PMID: 9074645) Kida M. … Ichinose A. (FEBS Lett. 1997) 3 22 64
  3. Multiple members of the plasminogen-apolipoprotein(a) gene family associated with thrombosis. (PMID: 1554698) Ichinose A. (Biochemistry 1992) 3 4 64
  4. Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis. (PMID: 1986355) Ichinose A. … Davie E.W. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for PLGLA Gene

Sources for PLGLA Gene

Content
Loading form....