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Aliases for PLGLA Gene

Aliases for PLGLA Gene

  • Plasminogen-Like A (Pseudogene) 2 3
  • PRGA 3 4 6
  • Plasminogen-Related Protein A 3 4
  • Plasminogen Pseudogene 2 2 3
  • Plasminogen-Like A1 2 3
  • PLGLA1 3 4
  • PLGP2 3 4
  • Plasminogen-Like Protein A1 4
  • Plasminogen-Like A 2
  • EC 3.4.21.7 63

External Ids for PLGLA Gene

Previous HGNC Symbols for PLGLA Gene

  • PLGP2
  • PLGLA1

Previous GeneCards Identifiers for PLGLA Gene

  • GC02U901555
  • GC02P106998
  • GC02P100772

Summaries for PLGLA Gene

GeneCards Summary for PLGLA Gene

PLGLA (Plasminogen-Like A (Pseudogene)) is a Pseudogene.

UniProtKB/Swiss-Prot for PLGLA Gene

  • May bind non-covalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLGLA Gene

Genomics for PLGLA Gene

Genomic Location for PLGLA Gene

Start:
106,382,114 bp from pter
End:
106,393,031 bp from pter
Size:
10,918 bases
Orientation:
Plus strand

Genomic View for PLGLA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLGLA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLGLA Gene

Proteins for PLGLA Gene

  • Protein details for PLGLA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15195-PLGA_HUMAN
    Recommended name:
    Plasminogen-like protein A
    Protein Accession:
    Q15195
    Secondary Accessions:

    Protein attributes for PLGLA Gene

    Size:
    96 amino acids
    Molecular mass:
    10915 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLGLA Gene

Proteomics data for PLGLA Gene at MOPED

Selected DME Specific Peptides for PLGLA Gene

Post-translational modifications for PLGLA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for PLGLA Gene

Protein Domains for PLGLA Gene

Suggested Antigen Peptide Sequences for PLGLA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15195

UniProtKB/Swiss-Prot:

PLGA_HUMAN :
  • Q15195
Domain:
  • Contains 1 PAN domain.
genes like me logo Genes that share domains with PLGLA: view

No data available for Gene Families for PLGLA Gene

Function for PLGLA Gene

Molecular function for PLGLA Gene

UniProtKB/Swiss-Prot Function: May bind non-covalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction (By similarity).

Enzyme Numbers (IUBMB) for PLGLA Gene

No data available for Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PLGLA Gene

Localization for PLGLA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLGLA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLGLA Gene COMPARTMENTS Subcellular localization image for PLGLA gene
Compartment Confidence
extracellular 3
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for PLGLA Gene

Pathways for PLGLA Gene

SuperPathways for PLGLA Gene

No Data Available

Interacting Proteins for PLGLA Gene

Gene Ontology (GO) - Biological Process for PLGLA Gene

None

No data available for Pathways by source for PLGLA Gene

Transcripts for PLGLA Gene

mRNA/cDNA for PLGLA Gene

(18) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLGLA Gene

Plasminogen-like A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLGLA

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLGLA Gene

No ASD Table

Relevant External Links for PLGLA Gene

GeneLoc Exon Structure for
PLGLA
ECgene alternative splicing isoforms for
PLGLA

Expression for PLGLA Gene

mRNA expression in normal human tissues for PLGLA Gene

mRNA differential expression in normal tissues according to GTEx for PLGLA Gene

This gene is overexpressed in Liver (46.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PLGLA Gene

SOURCE GeneReport for Unigene cluster for PLGLA Gene Hs.631263

mRNA Expression by UniProt/SwissProt for PLGLA Gene

Q15195-PLGA_HUMAN
Tissue specificity: Expressed in liver.
genes like me logo Genes that share expressions with PLGLA: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PLGLA Gene

Orthologs for PLGLA Gene

Evolution for PLGLA Gene

ENSEMBL:
Gene Tree for PLGLA (if available)
TreeFam:
Gene Tree for PLGLA (if available)

No data available for Orthologs for PLGLA Gene

Paralogs for PLGLA Gene

Selected SIMAP similar genes for PLGLA Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLGLA: view

No data available for Paralogs for PLGLA Gene

Variants for PLGLA Gene

Sequence variations from dbSNP and Humsavar for PLGLA Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs4261719 -- 106,389,739(+) TAAAC(A/G)TTTTA intron-variant
rs4384784 -- 106,386,190(+) TAATG(C/G)AAACC intron-variant
rs4402758 -- 106,385,396(+) TGACT(G/T)TCATC intron-variant
rs4502405 -- 106,380,747(+) ATACA(G/T)GCTGG upstream-variant-2KB
rs4539791 -- 106,381,466(+) CATAA(G/T)TTATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLGLA Gene

Variant ID Type Subtype PubMed ID
nsv834322 CNV Gain 17160897
esv2720482 CNV Deletion 23290073

Relevant External Links for PLGLA Gene

HapMap Linkage Disequilibrium report
PLGLA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLGLA Gene

Disorders for PLGLA Gene

No disorders were found for PLGLA Gene.

No data available for UniProtKB/Swiss-Prot for PLGLA Gene

Publications for PLGLA Gene

  1. Characterization of the 5'-flanking regions of plasminogen-related genes A and B. (PMID: 9074645) Kida M. … Ichinose A. (FEBS Lett. 1997) 3 23
  2. Multiple members of the plasminogen-apolipoprotein(a) gene family associated with thrombosis. (PMID: 1554698) Ichinose A. (Biochemistry 1992) 3 4
  3. Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis. (PMID: 1986355) Ichinose A. … Davie E.W. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3
  4. Homologous plasminogen N-terminal and plasminogen-related gene A and B peptides. Characterization of cDNAs and recombinant fusion proteins. (PMID: 10092845) Lewis V.O. … Schaller J. (Eur. J. Biochem. 1999) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for PLGLA Gene

Sources for PLGLA Gene

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