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Aliases for PLET1 Gene

Aliases for PLET1 Gene

  • Placenta Expressed Transcript 1 2 3 5
  • C11orf34 3 4
  • Chromosome 11 Open Reading Frame 34 2
  • Placenta-Expressed Transcript 1 2

External Ids for PLET1 Gene

Previous HGNC Symbols for PLET1 Gene

  • C11orf34

Previous GeneCards Identifiers for PLET1 Gene

  • GC11M112140
  • GC11U900122
  • GC11M112119

Summaries for PLET1 Gene

GeneCards Summary for PLET1 Gene

PLET1 (Placenta Expressed Transcript 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PLET1 Gene

  • Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLET1 Gene

Genomics for PLET1 Gene

Regulatory Elements for PLET1 Gene

Enhancers for PLET1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLET1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLET1 Gene

Chromosome:
11
Start:
112,248,153 bp from pter
End:
112,260,860 bp from pter
Size:
12,708 bases
Orientation:
Minus strand

Genomic View for PLET1 Gene

Genes around PLET1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLET1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLET1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLET1 Gene

Proteins for PLET1 Gene

  • Protein details for PLET1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UQ28-PLET1_HUMAN
    Recommended name:
    Placenta-expressed transcript 1 protein
    Protein Accession:
    Q6UQ28
    Secondary Accessions:
    • Q6UQ24
    • Q6UQ25
    • Q6UQ27

    Protein attributes for PLET1 Gene

    Size:
    207 amino acids
    Molecular mass:
    23385 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLET1 Gene

Proteomics data for PLET1 Gene at MOPED

Post-translational modifications for PLET1 Gene

Other Protein References for PLET1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLET1 Gene

Domains & Families for PLET1 Gene

Protein Domains for PLET1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLET1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLET1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PLET1 Gene

Function for PLET1 Gene

Molecular function for PLET1 Gene

UniProtKB/Swiss-Prot Function:
Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity).

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLET1 Gene

Localization for PLET1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLET1 Gene

Apical cell membrane; Lipid-anchor, GPI-anchor. Note=Localized at the apical membrane of the most differentiated keratinocytes of the outer root sheath (ORS), clustered mainly in planar regions of the plasma membrane at the base of microvilli. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for PLET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IEA,IBA --
genes like me logo Genes that share ontologies with PLET1: view

No data available for Subcellular locations from COMPARTMENTS for PLET1 Gene

Pathways & Interactions for PLET1 Gene

SuperPathways for PLET1 Gene

No Data Available

Interacting Proteins for PLET1 Gene

Gene Ontology (GO) - Biological Process for PLET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001953 negative regulation of cell-matrix adhesion ISS --
genes like me logo Genes that share ontologies with PLET1: view

No data available for Pathways by source and SIGNOR curated interactions for PLET1 Gene

Drugs & Compounds for PLET1 Gene

No Compound Related Data Available

Transcripts for PLET1 Gene

mRNA/cDNA for PLET1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for PLET1 Gene

No ASD Table

Relevant External Links for PLET1 Gene

GeneLoc Exon Structure for
PLET1
ECgene alternative splicing isoforms for
PLET1

Expression for PLET1 Gene

mRNA expression in normal human tissues for PLET1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLET1 Gene

This gene is overexpressed in Pituitary (x6.7).

Protein differential expression in normal tissues from HIPED for PLET1 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLET1 Gene



genes like me logo Genes that share expression patterns with PLET1: view

Protein tissue co-expression partners for PLET1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PLET1 Gene

Orthologs for PLET1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PLET1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C15H11orf34 35
  • 56.52 (n)
  • 34.16 (a)
PLET1 36
  • 26 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5H11orf34 35
  • 61.3 (n)
  • 39.51 (a)
PLET1 36
  • 29 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plet1 35
  • 55.39 (n)
  • 33.84 (a)
Plet1 16
1600029D21Rik 36
  • 26 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf34 35
  • 99.36 (n)
  • 98.55 (a)
PLET1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plet1 35
  • 55.48 (n)
  • 33.57 (a)
oppossum
(Monodelphis domestica)
Mammalia PLET1 36
  • 30 (a)
OneToOne
Species with no ortholog for PLET1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLET1 Gene

ENSEMBL:
Gene Tree for PLET1 (if available)
TreeFam:
Gene Tree for PLET1 (if available)

Paralogs for PLET1 Gene

No data available for Paralogs for PLET1 Gene

Variants for PLET1 Gene

Sequence variations from dbSNP and Humsavar for PLET1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2564872 - 112,252,372(-) TACTT(C/T)CTACT reference, missense
rs1367037 -- 112,257,396(-) AAGAA(C/T)GCAAC intron-variant
rs1469504 -- 112,258,876(+) GTGAG(C/T)GCGTG intron-variant
rs7128270 -- 112,248,929(+) GCTTG(A/G)AGGCT reference, missense
rs61070452 -- 112,254,326(+) GTGTG(C/T)GGGGG intron-variant

Variation tolerance for PLET1 Gene

Gene Damage Index Score: 2.52; 44.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for PLET1 Gene

Disorders for PLET1 Gene

Relevant External Links for PLET1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLET1

No disorders were found for PLET1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLET1 Gene

Publications for PLET1 Gene

  1. PLET1 (C11orf34), a highly expressed and processed novel gene in pig and mouse placenta, is transcribed but poorly spliced in human. (PMID: 15203209) Zhao S.-H. … Tuggle C.K. (Genomics 2004) 3 4 67
  2. Identification of Plet-1 as a specific marker of early thymic epithelial progenitor cells. (PMID: 18195351) Depreter M.G. … Blackburn C.C. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3

Products for PLET1 Gene

Sources for PLET1 Gene

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