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Aliases for PLEKHS1 Gene

Aliases for PLEKHS1 Gene

  • Pleckstrin Homology Domain Containing S1 2 3 5
  • PH Domain-Containing Family S Member 1 3 4
  • Epididymis Luminal Protein 185 3 4
  • C10orf81 3 4
  • HEL185 3 4
  • Pleckstrin Homology Domain Containing, Family S Member 1 2
  • Pleckstrin Homology Domain-Containing Family S Member 1 3
  • PH Domain-Containing Protein C10orf81 3
  • Chromosome 10 Open Reading Frame 81 2
  • BA211N11.2 3

External Ids for PLEKHS1 Gene

Previous HGNC Symbols for PLEKHS1 Gene

  • C10orf81

Previous GeneCards Identifiers for PLEKHS1 Gene

  • GC10P115511

Summaries for PLEKHS1 Gene

GeneCards Summary for PLEKHS1 Gene

PLEKHS1 (Pleckstrin Homology Domain Containing S1) is a Protein Coding gene.

Additional gene information for PLEKHS1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHS1 Gene

Genomics for PLEKHS1 Gene

Regulatory Elements for PLEKHS1 Gene

Enhancers for PLEKHS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H113788 1.1 Ensembl ENCODE 11 +37.7 37713 1 BMI1 BATF ATF7 ETV6 FOS RUNX3 CREM IKZF2 CBFB JUNB CASP7 ENSG00000234393 RNU6-709P PLEKHS1 ADRB1 NRAP MIR4483 ENSG00000212589
GH10H113946 1.1 Ensembl ENCODE dbSUPER 9.2 +196.4 196353 1 PKNOX1 TAL1 NR2F1 PBX2 IKZF1 MNT TCF7L2 RNU6-709P ADRB1 TDRD1 PLEKHS1 GC10P113911 LOC105378492
GH10H113799 0.7 ENCODE 10 +48.5 48505 0 CTCF ZNF654 TRIM22 MAX REST RAD21 KLF16 ZNF143 SMC3 ZNF600 CASP7 ENSG00000234393 ADRB1 PLEKHS1 TDRD1 ENSG00000212589 MIR4483
GH10H114228 0.5 ENCODE 8.7 +477.1 477115 0 OSR2 GATA3 TRIM28 TDRD1 PLEKHS1 VWA2 CCDC186
GH10H114130 0.4 ENCODE 10.2 +380.0 379959 0 SPI1 TDRD1 VWA2 PLEKHS1 UBE2V1P5 ENSG00000273904
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLEKHS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLEKHS1 Gene

Chromosome:
10
Start:
113,751,262 bp from pter
End:
113,783,429 bp from pter
Size:
32,168 bases
Orientation:
Plus strand

Genomic View for PLEKHS1 Gene

Genes around PLEKHS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLEKHS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLEKHS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHS1 Gene

Proteins for PLEKHS1 Gene

  • Protein details for PLEKHS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SXH7-PKHS1_HUMAN
    Recommended name:
    Pleckstrin homology domain-containing family S member 1
    Protein Accession:
    Q5SXH7
    Secondary Accessions:
    • A8KA02
    • B3KX00
    • B6EDE1
    • Q5SXH8
    • Q5SXI0
    • Q6ZQR5
    • Q8NE42
    • Q9H5D9

    Protein attributes for PLEKHS1 Gene

    Size:
    462 amino acids
    Molecular mass:
    51839 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36365.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB15687.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12642.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12643.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12644.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PLEKHS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLEKHS1 Gene

Post-translational modifications for PLEKHS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLEKHS1 Gene

Domains & Families for PLEKHS1 Gene

Gene Families for PLEKHS1 Gene

Protein Domains for PLEKHS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLEKHS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLEKHS1: view

No data available for UniProtKB/Swiss-Prot for PLEKHS1 Gene

Function for PLEKHS1 Gene

Phenotypes From GWAS Catalog for PLEKHS1 Gene

Gene Ontology (GO) - Molecular Function for PLEKHS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25814554
genes like me logo Genes that share ontologies with PLEKHS1: view
genes like me logo Genes that share phenotypes with PLEKHS1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLEKHS1 Gene

Localization for PLEKHS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLEKHS1 gene
Compartment Confidence
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLEKHS1 Gene

Pathways & Interactions for PLEKHS1 Gene

SuperPathways for PLEKHS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLEKHS1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PLEKHS1 Gene

Drugs & Compounds for PLEKHS1 Gene

No Compound Related Data Available

Transcripts for PLEKHS1 Gene

Unigene Clusters for PLEKHS1 Gene

Pleckstrin homology domain containing, family S member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHS1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5: -

Relevant External Links for PLEKHS1 Gene

GeneLoc Exon Structure for
PLEKHS1
ECgene alternative splicing isoforms for
PLEKHS1

Expression for PLEKHS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLEKHS1 Gene

mRNA differential expression in normal tissues according to GTEx for PLEKHS1 Gene

This gene is overexpressed in Cervix - Endocervix (x13.4), Minor Salivary Gland (x11.6), Pancreas (x8.6), Small Intestine - Terminal Ileum (x5.7), and Breast - Mammary Tissue (x5.2).

Protein differential expression in normal tissues from HIPED for PLEKHS1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (54.7) and Nasal epithelium (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLEKHS1 Gene



NURSA nuclear receptor signaling pathways regulating expression of PLEKHS1 Gene:

PLEKHS1

SOURCE GeneReport for Unigene cluster for PLEKHS1 Gene:

Hs.228320
genes like me logo Genes that share expression patterns with PLEKHS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLEKHS1 Gene

Orthologs for PLEKHS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLEKHS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLEKHS1 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLEKHS1 33 34
  • 81.86 (n)
dog
(Canis familiaris)
Mammalia PLEKHS1 33 34
  • 81.56 (n)
mouse
(Mus musculus)
Mammalia Plekhs1 33 16 34
  • 74.78 (n)
rat
(Rattus norvegicus)
Mammalia Plekhs1 33
  • 73.86 (n)
oppossum
(Monodelphis domestica)
Mammalia PLEKHS1 34
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLEKHS1 34
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLEKHS1 33 34
  • 52.81 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
OneToMany
-- 34
  • 23 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:158404 33
  • 43.71 (n)
PLEKHS1 (1 of 4) 34
  • 24 (a)
OneToMany
PLEKHS1 (4 of 4) 34
  • 23 (a)
OneToMany
plekhs1 34
  • 21 (a)
OneToMany
PLEKHS1 (3 of 4) 34
  • 21 (a)
OneToMany
Species where no ortholog for PLEKHS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLEKHS1 Gene

ENSEMBL:
Gene Tree for PLEKHS1 (if available)
TreeFam:
Gene Tree for PLEKHS1 (if available)

Paralogs for PLEKHS1 Gene

No data available for Paralogs for PLEKHS1 Gene

Variants for PLEKHS1 Gene

Sequence variations from dbSNP and Humsavar for PLEKHS1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000075483 -- 113,778,457(+) TTGTG(C/T)AGCAT intron-variant, upstream-variant-2KB
rs1000145928 -- 113,777,735(+) ACCAT(A/G)GAATG intron-variant, downstream-variant-500B
rs1000323506 -- 113,772,158(+) GCACT(C/G/T)TTCGT intron-variant
rs1000448111 -- 113,777,984(+) GACCC(C/T)GTCTC intron-variant, downstream-variant-500B
rs1000507821 -- 113,765,615(+) TCTCT(A/G)TAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLEKHS1 Gene

Variant ID Type Subtype PubMed ID
dgv105e201 CNV deletion 23290073
esv2741106 CNV deletion 23290073
esv28320 CNV gain 19812545
nsv1048819 CNV gain 25217958
nsv1122559 CNV deletion 24896259
nsv7211 OTHER inversion 18451855
nsv7556 CNV deletion 18451855
nsv825571 CNV gain 20364138

Variation tolerance for PLEKHS1 Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.13; 75.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLEKHS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLEKHS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHS1 Gene

Disorders for PLEKHS1 Gene

Relevant External Links for PLEKHS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLEKHS1

No disorders were found for PLEKHS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLEKHS1 Gene

Publications for PLEKHS1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. Plekhs1 and Prdx3 are candidate genes responsible for mild hyperglycemia associated with obesity in a new animal model of F344-fa-nidd6 rat. (PMID: 27523322) Kotoh J … Maeda A (The Journal of veterinary medical science 2016) 3 60
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 60
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 60

Products for PLEKHS1 Gene

Sources for PLEKHS1 Gene

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