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Aliases for PLEKHS1 Gene

Aliases for PLEKHS1 Gene

  • Pleckstrin Homology Domain Containing, Family S Member 1 2 3
  • PH Domain-Containing Family S Member 1 3 4
  • Epididymis Luminal Protein 185 3 4
  • C10orf81 3 4
  • HEL185 3 4
  • Pleckstrin Homology Domain-Containing Family S Member 1 3
  • PH Domain-Containing Protein C10orf81 3
  • Chromosome 10 Open Reading Frame 81 2
  • BA211N11.2 3

External Ids for PLEKHS1 Gene

Previous HGNC Symbols for PLEKHS1 Gene

  • C10orf81

Previous GeneCards Identifiers for PLEKHS1 Gene

  • GC10P115511

Summaries for PLEKHS1 Gene

GeneCards Summary for PLEKHS1 Gene

PLEKHS1 (Pleckstrin Homology Domain Containing, Family S Member 1) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHS1 Gene

Genomics for PLEKHS1 Gene

Genomic Location for PLEKHS1 Gene

113,751,315 bp from pter
113,783,429 bp from pter
32,115 bases
Plus strand

Genomic View for PLEKHS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLEKHS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHS1 Gene

No data available for Regulatory Elements for PLEKHS1 Gene

Proteins for PLEKHS1 Gene

  • Protein details for PLEKHS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pleckstrin homology domain-containing family S member 1
    Protein Accession:
    Secondary Accessions:
    • A8KA02
    • B3KX00
    • B6EDE1
    • Q5SXH8
    • Q5SXI0
    • Q6ZQR5
    • Q8NE42
    • Q9H5D9

    Protein attributes for PLEKHS1 Gene

    462 amino acids
    Molecular mass:
    51839 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH36365.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB15687.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12642.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12643.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12644.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PLEKHS1 Gene


neXtProt entry for PLEKHS1 Gene

Proteomics data for PLEKHS1 Gene at MOPED

Post-translational modifications for PLEKHS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLEKHS1 Gene

Domains for PLEKHS1 Gene

Gene Families for PLEKHS1 Gene

Protein Domains for PLEKHS1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PH domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with PLEKHS1: view

No data available for Suggested Antigen Peptide Sequences for PLEKHS1 Gene

Function for PLEKHS1 Gene

Phenotypes for PLEKHS1 Gene

GenomeRNAi human phenotypes for PLEKHS1:
genes like me logo Genes that share phenotypes with PLEKHS1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLEKHS1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLEKHS1 Gene

Localization for PLEKHS1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PLEKHS1 Gene

Pathways for PLEKHS1 Gene

SuperPathways for PLEKHS1 Gene

No Data Available

Interacting Proteins for PLEKHS1 Gene

Gene Ontology (GO) - Biological Process for PLEKHS1 Gene


No data available for Pathways by source for PLEKHS1 Gene

Transcripts for PLEKHS1 Gene

Unigene Clusters for PLEKHS1 Gene

Pleckstrin homology domain containing, family S member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLEKHS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHS1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5: -

Relevant External Links for PLEKHS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLEKHS1 Gene

mRNA expression in normal human tissues for PLEKHS1 Gene

mRNA differential expression in normal tissues according to GTEx for PLEKHS1 Gene

This gene is overexpressed in Cervix - Endocervix (13.4), Minor Salivary Gland (11.6), Pancreas (8.6), Small Intestine - Terminal Ileum (5.7), and Breast - Mammary Tissue (5.2).

Protein differential expression in normal tissues for PLEKHS1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (54.7) and Nasal epithelium (10.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PLEKHS1 Gene

SOURCE GeneReport for Unigene cluster for PLEKHS1 Gene Hs.228320

genes like me logo Genes that share expressions with PLEKHS1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Expression partners for PLEKHS1 Gene

Orthologs for PLEKHS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLEKHS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PLEKHS1 35
  • 81.86 (n)
  • 69.53 (a)
  • 58 (a)
(Canis familiaris)
Mammalia PLEKHS1 35
  • 81.56 (n)
  • 71.95 (a)
  • 61 (a)
(Mus musculus)
Mammalia Plekhs1 35
  • 74.78 (n)
  • 65.97 (a)
Plekhs1 16
Plekhs1 36
  • 54 (a)
(Rattus norvegicus)
Mammalia Plekhs1 35
  • 73.86 (n)
  • 64.74 (a)
(Monodelphis domestica)
Mammalia PLEKHS1 36
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia PLEKHS1 36
  • 43 (a)
(Pan troglodytes)
Mammalia PLEKHS1 36
  • 92 (a)
(Gallus gallus)
Aves PLEKHS1 35
  • 52.81 (n)
  • 40.76 (a)
  • 30 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
-- 36
  • 47 (a)
(Danio rerio)
Actinopterygii zgc:158404 35
  • 43.71 (n)
  • 30.54 (a)
plekhs1 36
  • 21 (a)
PLEKHS1 (1 of 4) 36
  • 24 (a)
PLEKHS1 (3 of 4) 36
  • 21 (a)
PLEKHS1 (4 of 4) 36
  • 23 (a)
Species with no ortholog for PLEKHS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLEKHS1 Gene

Gene Tree for PLEKHS1 (if available)
Gene Tree for PLEKHS1 (if available)

Paralogs for PLEKHS1 Gene

No data available for Paralogs for PLEKHS1 Gene

Variants for PLEKHS1 Gene

Sequence variations from dbSNP and Humsavar for PLEKHS1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs114651130 -- 113,773,751(+) TAAGG(A/G)GGCTA intron-variant
rs114706335 -- 113,760,908(+) TTACA(C/T)CTATG intron-variant
rs114723686 -- 113,770,300(+) TCTTG(C/T)TAATC intron-variant
rs114847505 -- 113,763,691(+) ATAAT(A/G)AAAGA intron-variant, upstream-variant-2KB
rs148229443 -- 113,768,288(+) AAAGC(G/T)GGTGT intron-variant

Relevant External Links for PLEKHS1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PLEKHS1 Gene

Disorders for PLEKHS1 Gene

No disorders were found for PLEKHS1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PLEKHS1 Gene

Publications for PLEKHS1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for PLEKHS1 Gene

Sources for PLEKHS1 Gene

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