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Aliases for PLEKHS1 Gene

Aliases for PLEKHS1 Gene

  • Pleckstrin Homology Domain Containing, Family S Member 1 2 3
  • PH Domain-Containing Family S Member 1 3 4
  • Epididymis Luminal Protein 185 3 4
  • C10orf81 3 4
  • HEL185 3 4
  • Pleckstrin Homology Domain-Containing Family S Member 1 3
  • PH Domain-Containing Protein C10orf81 3
  • Chromosome 10 Open Reading Frame 81 2
  • BA211N11.2 3

External Ids for PLEKHS1 Gene

Previous Symbols for PLEKHS1 Gene

  • C10orf81

Summaries for PLEKHS1 Gene

GeneCards Summary for PLEKHS1 Gene

PLEKHS1 (Pleckstrin Homology Domain Containing, Family S Member 1) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHS1 Gene

Genomics for PLEKHS1 Gene

Genomic Location for PLEKHS1 Gene

Start:
113,751,315 bp from pter
End:
113,783,429 bp from pter
Size:
32,115 bases
Orientation:
Plus strand

Genomic View for PLEKHS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLEKHS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHS1 Gene

No data available for Regulatory Elements for PLEKHS1 Gene

Proteins for PLEKHS1 Gene

  • Protein details for PLEKHS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SXH7-PKHS1_HUMAN
    Recommended name:
    Pleckstrin homology domain-containing family S member 1
    Protein Accession:
    Q5SXH7
    Secondary Accessions:
    • A8KA02
    • B3KX00
    • B6EDE1
    • Q5SXH8
    • Q5SXI0
    • Q6ZQR5
    • Q8NE42
    • Q9H5D9

    Protein attributes for PLEKHS1 Gene

    Size:
    462 amino acids
    Molecular mass:
    51839 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36365.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB15687.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12642.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12643.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12644.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PLEKHS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLEKHS1 Gene

Proteomics data for PLEKHS1 Gene at MOPED

Post-translational modifications for PLEKHS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLEKHS1 Gene

Domains for PLEKHS1 Gene

Gene Families for PLEKHS1 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for PLEKHS1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

PKHS1_HUMAN
Domain:
  • Contains 1 PH domain.:
    • Q5SXH7
genes like me logo Genes that share domains with PLEKHS1: view

Function for PLEKHS1 Gene

Phenotypes for PLEKHS1 Gene

GenomeRNAi human phenotypes for PLEKHS1:
genes like me logo Genes that share phenotypes with PLEKHS1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PLEKHS1 Gene

Localization for PLEKHS1 Gene

No data available for Gene Ontology (GO) - Cellular Components for PLEKHS1 Gene

Pathways for PLEKHS1 Gene

SuperPathways for PLEKHS1 Gene

No Data Available

Interacting Proteins for PLEKHS1 Gene

Gene Ontology (GO) - Biological Process for PLEKHS1 Gene

None

No data available for Pathways by source for PLEKHS1 Gene

Transcripts for PLEKHS1 Gene

Unigene Clusters for PLEKHS1 Gene

Pleckstrin homology domain containing, family S member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHS1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5: -

Relevant External Links for PLEKHS1 Gene

GeneLoc Exon Structure for
PLEKHS1
ECgene alternative splicing isoforms for
PLEKHS1

Expression for PLEKHS1 Gene

mRNA expression in normal human tissues for PLEKHS1 Gene

mRNA differential expression in normal tissues according to GTEx for PLEKHS1 Gene

This gene is overexpressed in Cervix - Endocervix (13.4), Minor Salivary Gland (11.6), Pancreas (8.6), Small Intestine - Terminal Ileum (5.7), and Breast - Mammary Tissue (5.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PLEKHS1 Gene

SOURCE GeneReport for Unigene cluster for PLEKHS1 Gene Hs.228320

genes like me logo Genes that share expressions with PLEKHS1: view

Orthologs for PLEKHS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLEKHS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLEKHS1 37
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLEKHS1 36
  • 81.86 (n)
  • 69.53 (a)
PLEKHS1 37
  • 58 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLEKHS1 36
  • 81.56 (n)
  • 71.95 (a)
PLEKHS1 37
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plekhs1 36
  • 74.78 (n)
  • 65.97 (a)
Plekhs1 16
Plekhs1 37
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLEKHS1 37
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLEKHS1 37
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plekhs1 36
  • 73.86 (n)
  • 64.74 (a)
chicken
(Gallus gallus)
Aves PLEKHS1 36
  • 52.81 (n)
  • 40.76 (a)
PLEKHS1 37
  • 30 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 23 (a)
OneToMany
-- 37
  • 47 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii plekhs1 37
  • 21 (a)
OneToMany
PLEKHS1 (1 of 4) 37
  • 24 (a)
OneToMany
PLEKHS1 (3 of 4) 37
  • 21 (a)
OneToMany
PLEKHS1 (4 of 4) 37
  • 23 (a)
OneToMany
zgc:158404 36
  • 43.71 (n)
  • 30.54 (a)
Species with no ortholog for PLEKHS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLEKHS1 Gene

ENSEMBL:
Gene Tree for PLEKHS1 (if available)
TreeFam:
Gene Tree for PLEKHS1 (if available)

Paralogs for PLEKHS1 Gene

No data available for Paralogs for PLEKHS1 Gene

Variants for PLEKHS1 Gene

Sequence variations from dbSNP and Humsavar for PLEKHS1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs867300 -- 113,753,339(+) TGATA(A/C)GAAAT intron-variant
rs867301 -- 113,753,374(+) ATCCA(C/T)GCATT intron-variant
rs2009428 -- 113,754,090(-) TGGCT(C/T)ATGCC intron-variant
rs2009429 -- 113,754,061(-) GGAGG(C/T)TGAGG intron-variant
rs2009431 -- 113,754,050(-) TGGGC(A/G)GATTG intron-variant

Relevant External Links for PLEKHS1 Gene

HapMap Linkage Disequilibrium report
PLEKHS1

No data available for Structural Variations from Database of Genomic Variants (DGV) for PLEKHS1 Gene

Disorders for PLEKHS1 Gene

No disorders were found for PLEKHS1 Gene.

No data available for UniProtKB/Swiss-Prot for PLEKHS1 Gene

Publications for PLEKHS1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for PLEKHS1 Gene

Sources for PLEKHS1 Gene

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