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Aliases for PLEKHM3 Gene

Aliases for PLEKHM3 Gene

  • Pleckstrin Homology Domain Containing M3 2 3 5
  • PH Domain-Containing Family M Member 3 3 4
  • Differentiation Associated Protein 2 3
  • PLEKHM1L 3 4
  • Pleckstrin Homology Domain Containing, Family M, Member 1-Like 2
  • Pleckstrin Homology Domain Containing, Family M, Member 3 2
  • Pleckstrin Homology Domain-Containing Family M Member 3 3
  • DAPR 3

External Ids for PLEKHM3 Gene

Previous HGNC Symbols for PLEKHM3 Gene


Previous GeneCards Identifiers for PLEKHM3 Gene

  • GC02M208402
  • GC02M208687
  • GC02M200528

Summaries for PLEKHM3 Gene

GeneCards Summary for PLEKHM3 Gene

PLEKHM3 (Pleckstrin Homology Domain Containing M3) is a Protein Coding gene. An important paralog of this gene is PLEKHM1.

Additional gene information for PLEKHM3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHM3 Gene

Genomics for PLEKHM3 Gene

Regulatory Elements for PLEKHM3 Gene

Enhancers for PLEKHM3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H207968 2.1 Ensembl ENCODE dbSUPER 10.9 +70.6 70595 3 SOX5 ZNF664 SOX13 PRDM6 BCL6 EBF1 EZH2 FZD5 PLEKHM3 RNU6-360P METTL21A GC02M208020 ENSG00000225111
GH02H207791 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10 +248.1 248072 1 ELF3 TBP PKNOX1 ATF1 NFRKB ARID4B RAD21 RARA FOS ATF7 FZD5 RNU6-360P PLEKHM3 ENSG00000225111
GH02H207925 1.5 Ensembl ENCODE dbSUPER 10.7 +113.8 113831 1 PKNOX1 FOXA2 ATF1 ZFP64 ARID4B FEZF1 YY1 ZHX2 REST MIER2 PLEKHM3 FZD5 ENSG00000200764 PPP1R14BP2 RNU6-664P ENSG00000225111 RNU6-360P GC02M208020
GH02H207845 1.5 Ensembl ENCODE dbSUPER 10.5 +192.5 192543 3 FOXA2 ATF1 MLX ARID4B FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ATF7 FZD5 PLEKHM3 ENSG00000225111
GH02H207796 1.5 Ensembl ENCODE dbSUPER 10.2 +243.1 243136 1 MLX ZNF133 ARID4B DMAP1 SP5 KAT8 NFIL3 MIER3 ZSCAN16 RCOR2 FZD5 PLEKHM3 ENSG00000225111
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLEKHM3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLEKHM3 Gene

207,821,288 bp from pter
208,040,372 bp from pter
219,085 bases
Minus strand

Genomic View for PLEKHM3 Gene

Genes around PLEKHM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLEKHM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLEKHM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHM3 Gene

Proteins for PLEKHM3 Gene

  • Protein details for PLEKHM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pleckstrin homology domain-containing family M member 3
    Protein Accession:
    Secondary Accessions:
    • B9EKV2
    • Q8WW68

    Protein attributes for PLEKHM3 Gene

    761 amino acids
    Molecular mass:
    87166 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC85557.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PLEKHM3 Gene


neXtProt entry for PLEKHM3 Gene

Post-translational modifications for PLEKHM3 Gene

  • Ubiquitination at posLast=9292
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PLEKHM3 Gene

Domains & Families for PLEKHM3 Gene

Gene Families for PLEKHM3 Gene

Protein Domains for PLEKHM3 Gene

Suggested Antigen Peptide Sequences for PLEKHM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLEKHM3: view

No data available for UniProtKB/Swiss-Prot for PLEKHM3 Gene

Function for PLEKHM3 Gene

Gene Ontology (GO) - Molecular Function for PLEKHM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PLEKHM3: view
genes like me logo Genes that share phenotypes with PLEKHM3: view

Animal Model Products

CRISPR Products

miRNA for PLEKHM3 Gene

miRTarBase miRNAs that target PLEKHM3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PLEKHM3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLEKHM3 Gene

Localization for PLEKHM3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLEKHM3 gene
Compartment Confidence
cytosol 4
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLEKHM3 Gene

Pathways & Interactions for PLEKHM3 Gene

SuperPathways for PLEKHM3 Gene

No Data Available

Interacting Proteins for PLEKHM3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
Selected Interacting proteins: Q6ZWE6-PKHM3_HUMAN ENSP00000417003 for PLEKHM3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for PLEKHM3 Gene


No data available for Pathways by source and SIGNOR curated interactions for PLEKHM3 Gene

Drugs & Compounds for PLEKHM3 Gene

(4) Additional Compounds for PLEKHM3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-behenoyl-sn-glycerol
  • 1-Tetradecanoyl-3-docosanoyl-sn-glycerol
  • DAG(14:0/0:0/22:0)
  • DAG(36:0)
  • DG(36:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with PLEKHM3: view

Transcripts for PLEKHM3 Gene

mRNA/cDNA for PLEKHM3 Gene

(8) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PLEKHM3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHM3 Gene

No ASD Table

Relevant External Links for PLEKHM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLEKHM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLEKHM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PLEKHM3 Gene:


SOURCE GeneReport for Unigene cluster for PLEKHM3 Gene:


Evidence on tissue expression from TISSUES for PLEKHM3 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with PLEKHM3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLEKHM3 Gene

Orthologs for PLEKHM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLEKHM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLEKHM3 33 34
  • 99.3 (n)
(Canis familiaris)
Mammalia PLEKHM3 33 34
  • 90.93 (n)
(Bos Taurus)
Mammalia PLEKHM3 33 34
  • 88.67 (n)
(Rattus norvegicus)
Mammalia Plekhm3 33
  • 88.33 (n)
(Mus musculus)
Mammalia Plekhm3 16 34 33
  • 87.89 (n)
(Monodelphis domestica)
Mammalia PLEKHM3 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 17 (a)
(Gallus gallus)
Aves PLEKHM3 33 34
  • 73.47 (n)
(Anolis carolinensis)
Reptilia PLEKHM3 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia plekhm3 33
  • 66.17 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7874 33
(Danio rerio)
Actinopterygii plekhm3 33 34
  • 58.27 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6613 34
  • 21 (a)
(Caenorhabditis elegans)
Secernentea Y51H1A.2 34
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.897 34
  • 37 (a)
Species where no ortholog for PLEKHM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLEKHM3 Gene

Gene Tree for PLEKHM3 (if available)
Gene Tree for PLEKHM3 (if available)

Paralogs for PLEKHM3 Gene

Paralogs for PLEKHM3 Gene

(2) SIMAP similar genes for PLEKHM3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLEKHM3: view

Variants for PLEKHM3 Gene

Sequence variations from dbSNP and Humsavar for PLEKHM3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000006933 -- 207,864,621(+) TTATC(C/T)AGGCT intron-variant
rs1000017108 -- 207,965,918(+) ACCAC(A/G)TTAAT intron-variant
rs1000028238 -- 207,966,426(+) CTTTT(-/CTC)CTCTA intron-variant
rs1000051977 -- 207,997,643(+) CCTTG(C/T)TAACT intron-variant
rs1000069809 -- 207,874,166(+) CATGG(G/T)AATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLEKHM3 Gene

Variant ID Type Subtype PubMed ID
esv2664003 CNV deletion 23128226
esv3584289 CNV loss 25503493
esv3584290 CNV loss 25503493
esv3594100 CNV loss 21293372
esv3594101 CNV loss 21293372
nsv520066 CNV loss 19592680
nsv527843 CNV loss 19592680

Variation tolerance for PLEKHM3 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.26; 52.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLEKHM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHM3 Gene

Disorders for PLEKHM3 Gene

Relevant External Links for PLEKHM3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PLEKHM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLEKHM3 Gene

Publications for PLEKHM3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling. (PMID: 19028694) Virtanen C … Takahashi M (The Journal of biological chemistry 2009) 2 3 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for PLEKHM3 Gene

Sources for PLEKHM3 Gene

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