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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLEKHJ1 Gene

protein-coding   GIFtS: 47
GCID: GC19M002233

Pleckstrin Homology Domain Containing, Family J Member 1

  Search for PLEKHJ1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pleckstrin Homology Domain Containing, Family J Member 11 2     PH Domain-Containing Family J Member 12 3
Guanine Nucleotide Releasing Protein X1 2     9530063M10Rik2
Guanine Nucleotide-Releasing Protein X2 3     Pleckstrin Homology Domain-Containing Family J Member 12
GNRPX2 3     

External Ids:    HGNC: 182111   Entrez Gene: 551112   Ensembl: ENSG000001048867   UniProtKB: Q9NW613   

Export aliases for PLEKHJ1 gene to outside databases

Previous GC identifers: GC19M002185 GC19M002186 GC19M002004


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PLEKHJ1 Gene: 
PLEKHJ1 (pleckstrin homology domain containing, family J member 1) is a protein-coding gene. GO annotations related to this gene include phospholipid binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLEKHJ1 gene promoter:
         Spz1   p53   AP-1   ATF-2   MyoD   GATA-1   SREBP-1a   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLEKHJ1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PLEKHJ1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLEKHJ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

PLEKHJ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLEKHJ1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M002233:  view genomic region     (about GC identifiers)

Start:
2,230,093 bp from pter      End:
2,237,703 bp from pter
Size:
7,611 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PKHJ1_HUMAN, Q9NW61 (See protein sequence)
Recommended Name: Pleckstrin homology domain-containing family J member 1  
Size: 149 amino acids; 17551 Da
Secondary accessions: B3KUQ9 D6W604

Explore the universe of human proteins at neXtProt for PLEKHJ1: NX_Q9NW61

Explore proteomics data for PLEKHJ1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NW61

  • PLEKHJ1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLEKHJ1 Protein Expression
    REFSEQ proteins: NP_060519.1  
    ENSEMBL proteins: 
     ENSP00000464955   ENSP00000465664   ENSP00000465391   ENSP00000466739   ENSP00000468441  
     ENSP00000464924   ENSP00000468257   ENSP00000318075  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    2 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NW61

    ProtoNet protein and cluster: Q9NW61

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: PKHJ1_HUMAN, Q9NW61
    Similarity: Contains 1 PH domain


    PLEKHJ1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
         
    PLEKHJ1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PLEKHJ1:
     Decreased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PLEKHJ1 
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    SwitchGear 3'UTR luciferase reporter plasmidPLEKHJ1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLEKHJ1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for PLEKHJ1 (Q9NW612, 3 ENSP000003180754) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FAM109AQ8N4B12, 3, ENSP000003544614MINT-8266755 I2D: score=2 STRING: ENSP00000354461
    PPBPP027752, 3MINT-8266766 I2D: score=2 
    DNMT3BQ9UBC32, 3, ENSP000003285474MINT-8266744 I2D: score=2 STRING: ENSP00000328547
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    KRT33BQ145253, ENSP000002516464I2D: score=2 STRING: ENSP00000251646
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PLEKHJ1 (PKHJ1)

    Search CenterWatch for drugs/clinical trials and news about PLEKHJ1 / PKHJ1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLEKHJ1 gene: 
    NM_018049.1  

    Unigene Cluster for PLEKHJ1:

    Pleckstrin homology domain containing, family J member 1
    Hs.501353  [show with all ESTs]
    Unigene Representative Sequence: AK092742
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587394 ENST00000592552 ENST00000588450 ENST00000589097 ENST00000589791
    ENST00000588633 ENST00000588545 ENST00000587962 ENST00000586608 ENST00000591099
    ENST00000585423 ENST00000586497 ENST00000588356 ENST00000326631(uc002lvf.1)

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidPLEKHJ1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK001159.1 AK092742.1 AK097723.1 AK098725.1 BC003084.2 BC008966.2 CR457253.1 

    20 DOTS entries:

    DT.448054  DT.101964236  DT.100807784  DT.403963  DT.121414422  DT.121414213  DT.92433550  DT.97780970 
    DT.100749671  DT.100807776  DT.100028718  DT.121414513  DT.100028713  DT.100807775  DT.100807777  DT.121414705 
    DT.121414842  DT.121414847  DT.91844266  DT.75138156 

    24/241 AceView cDNA sequences (see all 241):

    BM792054 BM821176 AX747701 CK904935 BM127773 BF195928 BM714525 BC003084 
    BM853368 BQ070977 CB113220 CA442067 CA503043 CB145404 CB241268 AI804203 
    BQ892843 AK092742 BU839709 CA394421 BM128038 BM712316 AI025506 BM998159 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHJ1 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
    SP1:        -     -     -                 -     -     -                                 
    SP2:                                      -     -     -                                 
    SP3:                                      -     -     -                 -     -         
    SP4:                                      -     -     -                                 
    SP5:                                      -     -     -     -                           


    ECgene alternative splicing isoforms for PLEKHJ1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLEKHJ1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCCCCTGC
    PLEKHJ1 Expression
    About this image


    See PLEKHJ1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLEKHJ1

    SOURCE GeneReport for Unigene cluster: Hs.501353

    UniProtKB/Swiss-Prot: PKHJ1_HUMAN, Q9NW61
    Tissue specificity: Expressed in testis and liver

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PLEKHJ1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plekhj11 , 5 pleckstrin homology domain containing, family J member more1, 5 86.17(n)1
    87.76(a)1
      10 (39.72 cM)5
    786701  NM_023900.21  NP_076389.21 
     807961005 
    chicken
    (Gallus gallus)
    Aves PLEKHJ11 pleckstrin homology domain containing, family J member more 79.08(n)
    83.45(a)
      428324  NM_001031503.1  NP_001026674.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLEKHJ16
    Uncharacterized protein
    80(a)
    1 ↔ 1
    AAWZ02038099(807-1183)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005379511 pleckstrin homology domain-containing family J member more 68.51(n)
    69.66(a)
      100537951  XM_003197976.1  XP_003198024.1 


    ENSEMBL Gene Tree for PLEKHJ1 (if available)
    TreeFam Gene Tree for PLEKHJ1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLEKHJ1 gene
    1 SIMAP similar gene for PLEKHJ1 using alignment to 7 protein entries:     PKHJ1_HUMAN (see all proteins):
    FAM109A

    PLEKHJ1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/22 SNPs in PLEKHJ1 are shown (see all 22)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38332831,2
    C--2233193(-) GGGCCA/-GGGTG 1 -- ut313Minor allele frequency- -:0.17NA CSA 6
    rs721014601,2
    C--2233329(+) CGGGG-/CAGGGGGGCCATGCC
    ACCAGCCTGGGGGCTCAC
    CAGGC
    1 -- cds10--------
    rs1819206241,2
    --2233386(+) AACTCA/CGGCAG 1 -- ut310--------
    rs802241421,2
    C,F--2233410(+) AGGCGC/TATATC 1 -- ut311Minor allele frequency- T:0.13EA 120
    rs1148003351,2
    C,F--2233432(+) AGCACG/ATGGCA 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs775855721,2
    C,F--2233482(+) GGAGCG/ACAGCT 1 -- ut313Minor allele frequency- A:0.04WA NA EA 358
    rs748073051,2
    C--2234086(+) GGGTCA/TAATGC 1 -- int10--------
    rs1907888381,2
    C--2234093(+) ATGCCC/TGCTCT 1 -- int10--------
    rs2019976891,2
    C--2234134(+) CCACCA/GCCGCC 1 -- int10--------
    rs1124406281,2
    ----2234146(+) GGCCCG/CACCTG 1 -- int11Minor allele frequency- C:0.50NA 2

    HapMap Linkage Disequilibrium report for PLEKHJ1 (2230093 - 2237703 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for PLEKHJ1 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2389CNV Insertion18451855
    dgv3631n71CNV Loss21882294
    dgv3630n71CNV Loss21882294
    dgv3614n71CNV Loss21882294
    dgv3629n71CNV Loss21882294
    nsv910499CNV Loss21882294
    dgv3632n71CNV Loss21882294
    dgv3626n71CNV Loss21882294
    dgv3622n71CNV Loss21882294
    dgv3633n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLEKHJ1 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with PLEKHJ1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An expressed GNRP-like gene shares a bi-directional promoter with SF3A2 (SAP62) immediately upstream of AMH. (PubMed id 11602354)1, 2, 3 Dresser D.W.... Guerrier D. (2001)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    6. Expanding the substantial interactome of NEMO using p rotein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (2010)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
    9. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55111 HGNC: 18211 AceView: PLEKHJ1 Ensembl:ENSG00000104886 euGenes: HUgn55111
    ECgene: PLEKHJ1 H-InvDB: PLEKHJ1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLEKHJ1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLEKHJ1 gene:
    Search GeneIP for patents involving PLEKHJ1

    GeneCards and IP:
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