PLEKHJ1 Gene
protein-coding GIFtS: 47
GCID: GC19M002233
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pleckstrin homology domain containing, family J member 1
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Aliases
for PLEKHJ1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Pleckstrin Homology Domain Containing, Family J Member 11 2 | | FLJ102971 | | Guanine Nucleotide-Releasing Protein X2 3 | | 9530063M10Rik2 | | GNRPX2 3 | | Guanine Nucleotide Releasing Protein X2 | | PH Domain-Containing Family J Member 12 3 | | Pleckstrin Homology Domain-Containing Family J Member 12 |
Export aliases for PLEKHJ1 gene to outside databasesPrevious GC identifers: GC19M002185 GC19M002186 GC19M002004 |
Summaries
for PLEKHJ1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for PLEKHJ1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PLEKHJ1 gene promoter:
Spz1 p53 AP-1 ATF-2 MyoD GATA-1 SREBP-1a c-Jun NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PLEKHJ1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLEKHJ1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3PLEKHJ1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M002233: view genomic region
(about GC identifiers)
Start:
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2,230,093 bp from pter |
End:
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2,237,703 bp from pter |
Size:
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7,611 bases |
Orientation:
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minus strand |
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Proteins
for PLEKHJ1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PKHJ1_HUMAN, Q9NW61 (See
protein sequence)Recommended Name: Pleckstrin homology domain-containing family J member 1 Size: 149 amino acids; 17551 Da
Secondary accessions: B3KUQ9 D6W604Explore the universe of human proteins at neXtProt for PLEKHJ1: NX_Q9NW61
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NW61
PLEKHJ1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060519.1
ENSEMBL proteins: ENSP00000464955 ENSP00000465664 ENSP00000465391 ENSP00000466739 ENSP00000468441 ENSP00000464924 ENSP00000468257 ENSP00000318075
Human Recombinant Protein Products:
PLEKHJ1 Antibody Products:
Assay Products for PLEKHJ1: |
Protein
Domains /
Families
for PLEKHJ1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PLEKHJ1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NW61ProtoNet protein and cluster: Q9NW61 1 Blocks protein family: IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: PKHJ1_HUMAN, Q9NW61Similarity: Contains 1 PH domain |
Function
for PLEKHJ1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLEKHJ1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLEKHJ1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PLEKHJ1 (NM_018049) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PLEKHJ1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLEKHJ1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHJ1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005543 | phospholipid binding |
IEA | -- |
PLEKHJ1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PLEKHJ1:
|
Pathways & Interactions
for PLEKHJ1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLEKHJ1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/9 Interacting proteins for PLEKHJ1 (Q9NW612, 3 ENSP000003180754) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
|
Drugs & Compounds
for PLEKHJ1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PLEKHJ1
Search CenterWatch for drugs/clinical trials and news about PLEKHJ1 / PKHJ1
|
Transcripts
for PLEKHJ1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PLEKHJ1 gene: NM_018049.1 Unigene Cluster for PLEKHJ1: Pleckstrin homology domain containing, family J member 1 Hs.501353 [show with all ESTs]Unigene Representative Sequence: AK09274214 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000587394 ENST00000592552 ENST00000588450 ENST00000589097 ENST00000589791
ENST00000588633 ENST00000588545 ENST00000587962 ENST00000586608 ENST00000591099
ENST00000585423 ENST00000586497 ENST00000588356 ENST00000326631(uc002lvf.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLEKHJ1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLEKHJ1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PLEKHJ1 (NM_018049) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PLEKHJ1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLEKHJ1 |
Additional cDNA sequence: AK001159.1 AK092742.1 AK097723.1 AK098725.1 BC003084.2 BC008966.2 CR457253.1 20 DOTS entries: DT.448054 DT.101964236 DT.100807784 DT.403963 DT.121414422 DT.121414213 DT.92433550 DT.97780970 DT.100807776 DT.100028718 DT.121414513 DT.100028713 DT.100749671 DT.100807775 DT.100807777 DT.121414705 DT.121414842 DT.121414847 DT.91844266 DT.75138156 24/241 AceView cDNA sequences (see all 241): CB241268 BM714525 BC008966 AI697086 CB145404 CA503043 BU839709 BM821176 CB242308 AK092742 CA394421 AA025744 AW027647 BE796955 CA420383 CR602576 AK098725 BM563769 BF149231 BC003084 CR605294 BQ892843 AI804203 NM_018049
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHJ1 (see all 9) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 |
|---|
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| SP1: | | | - | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | - | | | | | | - | | - | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for PLEKHJ1
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Expression
for PLEKHJ1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PLEKHJ1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCCCCTGC
About this image
See PLEKHJ1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLEKHJ1
SOURCE GeneReport for Unigene cluster: Hs.501353
UniProtKB/Swiss-Prot: PKHJ1_HUMAN, Q9NW61Tissue specificity: Expressed in testis and liver
SABiosciences Custom PCR Arrays for PLEKHJ1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLEKHJ1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PLEKHJ1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLEKHJ1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLEKHJ1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHJ1 |
Orthologs
for PLEKHJ1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PLEKHJ1 gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for PLEKHJ1 (if available)
TreeFam Gene Tree for PLEKHJ1 (if available) |
Paralogs
for PLEKHJ1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for PLEKHJ1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PLEKHJ1 (2230093 - 2237703 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PLEKHJ1
2 CNVs: 5068 5067 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLEKHJ1 |
|
Disorders
/ Diseases
for PLEKHJ1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for PLEKHJ1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PLEKHJ1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with PLEKHJ1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- An expressed GNRP-like gene shares a bi-directional promoter with SF3A2 (SAP62) immediately upstream of AMH. (PubMed id 11602354)1, 2, 3 Dresser D.W.... Guerrier D. (2001)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Expanding the substantial interactome of NEMO using p rotein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for PLEKHJ1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PLEKHJ1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PLEKHJ1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PLEKHJ1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PLEKHJ1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for PLEKHJ1 gene:
Search GeneIP for patents involving PLEKHJ1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PLEKHJ1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for PLEKHJ1 | | OriGene Custom Protein Services for PLEKHJ1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | | Search Tocris compounds for PLEKHJ1 |
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 | | | PLEKHJ1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHJ1 |
|  |  |  | | | | ThermoFisher Antibodies for PLEKHJ1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLEKHJ1 |
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