Aliases for PLEKHH2 Gene
External Ids for PLEKHH2 Gene
Previous GeneCards Identifiers for PLEKHH2 Gene
GeneCards Summary for PLEKHH2 Gene
PLEKHH2 (Pleckstrin Homology, MyTH4 And FERM Domain Containing H2) is a Protein Coding gene. Diseases associated with PLEKHH2 include Focal Segmental Glomerulosclerosis and Glomerulosclerosis. GO annotations related to this gene include identical protein binding and actin binding. An important paralog of this gene is PLEKHH1.
UniProtKB/Swiss-Prot for PLEKHH2 Gene
In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.