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PLEKHH1 Gene

protein-coding   GIFtS: 50
GCID: GC14P068000

Pleckstrin Homology Domain Containing, Family H (With MyTH4...

  Search for PLEKHH1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pleckstrin Homology Domain Containing, Family H (With MyTH4 Domain)
Member 11 2
PH Domain-Containing Family H Member 12 3
Pleckstrin Homology Domain-Containing Family H Member 12
KIAA12003

External Ids:    HGNC: 177331   Entrez Gene: 574752   Ensembl: ENSG000000546907   UniProtKB: Q9ULM03   

Export aliases for PLEKHH1 gene to outside databases

Previous GC identifers: GC14P065990 GC14U900232 GC14P065989 GC14P067069 GC14P048169


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PLEKHH1 Gene:
PLEKHH1 (pleckstrin homology domain containing, family H (with MyTH4 domain) member 1) is a protein-coding gene. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is PLEKHH2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLEKHH1 gene promoter:
         AML1a   GATA-3   Sp1   MyoD   Lmo2   STAT5A   GATA-2   GATA-1   AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLEKHH1 promoter sequence
   Search Chromatin IP Primers for PLEKHH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLEKHH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1   Ensembl cytogenetic band:  14q24.1   HGNC cytogenetic band: 14q24.1

PLEKHH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLEKHH1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P068000:  view genomic region     (about GC identifiers)

Start:
68,000,008 bp from pter      End:
68,056,329 bp from pter
Size:
56,322 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PKHH1_HUMAN, Q9ULM0 (See protein sequence)
Recommended Name: Pleckstrin homology domain-containing family H member 1  
Size: 1364 amino acids; 151232 Da
Sequence caution: Sequence=BAA86514.1; Type=Erroneous initiation;
Secondary accessions: A6H8X6 Q6PJL4 Q6ZWC7
Alternative splicing: 2 isoforms:  Q9ULM0-1   Q9ULM0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PLEKHH1: NX_Q9ULM0

Explore proteomics data for PLEKHH1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PLEKHH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065766.1  
    ENSEMBL proteins: 
     ENSP00000330278   ENSP00000452988   ENSP00000453343   ENSP00000453699   ENSP00000397712  

    PLEKHH1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PLEKHH1

     
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    PLEKHH1 Antibody Products:

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    Novus Biologicals PLEKHH1 Antibody
    Abcam antibodies for PLEKHH1
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    Search ThermoFisher Antibodies for PLEKHH1
    LSBio Antibodies in human, mouse, rat for PLEKHH1

    PLEKHH1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for PLEKHH1
    Cloud-Clone Corp. CLIAs for PLEKHH1
    Search eBioscience for ELISAs for PLEKHH1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    Selected InterPro protein domains (see all 7):
     IPR019748 FERM_central
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR014352 FERM/acyl-CoA-bd_prot_3-hlx
     IPR000857 MyTH4_dom

    Graphical View of Domain Structure for InterPro Entry Q9ULM0

    ProtoNet protein and cluster: Q9ULM0

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: PKHH1_HUMAN, Q9ULM0
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 MyTH4 domain
    Similarity: Contains 2 PH domains


    Find genes that share domains with PLEKHH1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for PLEKHH1:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLEKHH1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLEKHH1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLEKHH1

    miRNA
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    miRTarBase miRNAs that target PLEKHH1:
    hsa-mir-7-5p (MIRT025661)

    Block miRNA regulation of human, mouse, rat PLEKHH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLEKHH1 (see all 57):
    hsa-miR-3164 hsa-let-7d hsa-miR-15a hsa-miR-199a-3p hsa-miR-128 hsa-let-7g hsa-miR-223 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidPLEKHH1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PLEKHH1
    Predesigned siRNA for gene silencing in human, mouse, rat PLEKHH1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: PLEKHH1 (NM_020715)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLEKHH1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for PLEKHH1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHH1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    cytosol2
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005856cytoskeleton IEA--

    Find genes that share ontologies with PLEKHH1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLEKHH1
    Interactions:

        Search GeneGlobe Interaction Network for PLEKHH1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for PLEKHH1 (Q9ULM03 ENSP000003302784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PLEKHH1 (PKHH1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLEKHH1 gene: 
    NM_020715.2  

    Unigene Cluster for PLEKHH1:

    Pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
    Hs.594236  [show with all ESTs]
    Unigene Representative Sequence: NM_020715
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329153(uc001xjl.1 uc010tsw.1 uc010tsx.1) ENST00000558386
    ENST00000561456 ENST00000558981(uc001xjm.1) ENST00000557971(uc001xjn.1)
    ENST00000561135 ENST00000561370 ENST00000558296 ENST00000560100 ENST00000558366
    ENST00000559981(uc001xjo.1 uc001xjp.1) ENST00000561057 ENST00000559766
    ENST00000559832 ENST00000559168 ENST00000558214 ENST00000417684
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PLEKHH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLEKHH1 (see all 57):
    hsa-miR-3164 hsa-let-7d hsa-miR-15a hsa-miR-199a-3p hsa-miR-128 hsa-let-7g hsa-miR-223 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidPLEKHH1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PLEKHH1
    Predesigned siRNA for gene silencing in human, mouse, rat PLEKHH1
    Clone
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    OriGene clones in human, mouse for PLEKHH1 (see all 7)
    OriGene ORF clones in mouse, rat for PLEKHH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PLEKHH1 (NM_020715)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLEKHH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLEKHH1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PLEKHH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLEKHH1
      QuantiTect SYBR Green Assays in human, mouse, rat PLEKHH1
      QuantiFast Probe-based Assays in human, mouse, rat PLEKHH1

    Additional mRNA sequence: 

    AB033026.1 AK123262.1 AK123305.1 AK124787.1 AK293950.1 AK295896.1 AK307428.1 BC014159.2 
    BC037820.1 BC146787.1 BX648137.1 BX648464.1 

    19 DOTS entries:

    DT.95161816  DT.91917011  DT.101983119  DT.97836072  DT.447626  DT.95296765  DT.101954282  DT.91749162 
    DT.120751174  DT.107434  DT.120751148  DT.95161817  DT.95346562  DT.120751196  DT.91744656  DT.95161819 
    DT.97786763  DT.100785746  DT.120751208 

    Selected AceView cDNA sequences (see all 106):

    BU184088 BU161850 AA887831 AA443376 AK123305 BX098618 BM462794 AA233540 
    BM981592 BE465481 AB033026 AW272894 AA461293 AA446951 BF224217 AW131558 
    CD643147 AI741079 BX481523 BI915984 BU678533 CK430843 BF933692 BM718259 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHH1 (see all 20)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a · 15b ^ 16a ·
    SP1:                                                                                                                                -                       -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                        -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c ^ 25a · 25b · 25c · 25d ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29a ·
    SP1:                                                                                                                                                            
    SP2:                                                                    -                             -                                                         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 29b ^ 30a · 30b ^ 31 ^ 32a · 32b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for PLEKHH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLEKHH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGAAATAC
    PLEKHH1 Expression
    About this image


    PLEKHH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Thyroid (Endocrine System)
    PLEKHH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLEKHH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.594236
        Custom PCR Arrays for PLEKHH1
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    QuantiFast Probe-based Assays in human, mouse, rat PLEKHH1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PLEKHH1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plekhh11 , 5 pleckstrin homology domain containing, family H (with more1, 5 85.41(n)1
    84.13(a)1
      12 (35.51 cM)5
    2119451  NM_181073.31  NP_851418.21 
     790291635 
    chicken
    (Gallus gallus)
    Aves PLEKHH11 pleckstrin homology domain containing, family H (with more 70.04(n)
    70.42(a)
      423270  XM_004941711.1  XP_004941768.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLEKHH16
    pleckstrin homology domain containing, family H (w...
    57(a)
    1 ↔ 1
    GL343272.1(928485-972722)
    zebrafish
    (Danio rerio)
    Actinopterygii plekhh11 pleckstrin homology domain containing, family H (with more 62.1(n)
    59.88(a)
      565914  NM_001077519.2  NP_001070987.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG438671 CG43867 54.65(n)
    48.61(a)
      31031  NM_001272180.1  NP_001259109.1 
    worm
    (Caenorhabditis elegans)
    Secernentea max-11 max-1 42.62(n)
    33.45(a)
      179794  NM_001047627.3  NP_001041092.2 


    ENSEMBL Gene Tree for PLEKHH1 (if available)
    TreeFam Gene Tree for PLEKHH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLEKHH1 gene
    PLEKHH22  
    2 SIMAP similar genes for PLEKHH1 using alignment to 5 protein entries:     PKHH1_HUMAN (see all proteins):
    PLEKHH2    FAM109A

    Find genes that share paralogs with PLEKHH1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLEKHH1 (see all 1247)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1126318721,2
    F--67998034(+) AACTTG/TCCCAA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs49024781,2
    C,F,A,H--67998049(+) CATAGA/CTAAAA 1 -- us2k111Minor allele frequency- C:0.45NA WA CSA EA 374
    rs1894028361,2
    --67998068(+) AGACAA/TAACTG 1 -- us2k10--------
    rs96715431,2
    C,F,A--67998106(+) TAGGGT/GTCAGT 1 -- us2k17Minor allele frequency- G:0.46NA WA EA 366
    rs1443720511,2
    --67998125(+) ACCACA/CCTCCC 1 -- us2k10--------
    rs671383631,2
    C,F--67998156(+) GCTCAG/TAGTTG 1 -- us2k17Minor allele frequency- T:0.26WA NA EA 366
    rs49024791,2
    C,F,H--67998204(+) TGAAAC/GTAACA 1 -- us2k128Minor allele frequency- G:0.44NS EA NA WA CSA 2778
    rs1823121631,2
    --67998216(+) CTGAGC/GTGAAA 1 -- us2k10--------
    rs96719801,2
    C,F,A--67998352(+) TGGGCC/TGAGGT 1 -- us2k17Minor allele frequency- T:0.46NA WA EA 366
    rs1478029481,2
    --67998369(+) GCTCAA/TCCCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PLEKHH1 (68000008 - 68056329 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PLEKHH1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666682CNV Deletion23128226
    dgv138n21CNV Loss19592680
    nsv470651CNV Gain18288195
    nsv902066CNV Gain21882294
    nsv456331CNV Gain19166990

    Human Gene Mutation Database (HGMD): PLEKHH1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLEKHH1
    DNA2.0 Custom Variant and Variant Library Synthesis for PLEKHH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with PLEKHH1           About GenesLikeMe


    Export disorders for PLEKHH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLEKHH1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PLEKHH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)1 Demirkan A....Schmitz G. (PLoS Genet. 2012)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57475 HGNC: 17733 AceView: PLEKHH1 Ensembl:ENSG00000054690 euGenes: HUgn57475
    ECgene: PLEKHH1 H-InvDB: PLEKHH1

    (According to HUGE)
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    HUGE: KIAA1200

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PLEKHH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLEKHH1 gene:
    Search GeneIP for patents involving PLEKHH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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