PLEKHG5 Gene
protein-coding GIFtS: 52
GCID: GC01M006526
|
|
pleckstrin homology domain containing, family G (with RhoGef...
| |
Aliases
for PLEKHG5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member51 2 | | DSMA42 5 | | GEF7201 2 3 | | NFkB Activating Protein2 | | KIAA07201 3 5 | | Novel PH Domain-Containing Protein2 | | Syx1 2 | | Pleckstrin Homology Domain Containing Family G Member 52 | | Tech1 2 | | Pleckstrin Homology Domain-Containing Family G Member 52 | | Guanine Nucleotide Exchange Factor 7202 3 | | Synectin-Binding Guanine Exchange Factor2 | | PH Domain-Containing Family G Member 52 3 | | |
Export aliases for PLEKHG5 gene to outside databasesPrevious GC identifers: GC01M006462 GC01M005673 |
Summaries
for PLEKHG5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PLEKHG5:
This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this geneare associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encodingdifferent isoforms have been found for this gene. (provided by RefSeq, May 2012)
UniProtKB/Swiss-Prot: PKHG5_HUMAN, O94827Function: Activates the NF-kappa-B signaling pathway and RHOA. Appears to be involved in the control of neuronal celldifferentiation
|
Genomic Views
for PLEKHG5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PLEKHG5 gene promoter:
AP-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PLEKHG5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLEKHG5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.31 Ensembl cytogenetic band: 1p36.31 HGNC cytogenetic band: 1p36.31PLEKHG5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M006526: view genomic region
(about GC identifiers)
Start:
|
6,526,152 bp from pter |
End:
|
6,580,121 bp from pter |
Size:
|
53,970 bases |
Orientation:
|
minus strand |
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Proteins
for PLEKHG5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PKHG5_HUMAN, O94827 (See
protein sequence)Recommended Name: Pleckstrin homology domain-containing family G member 5 Size: 1062 amino acids; 117451 Da
Subunit: Interacts with GIPC1/synectin and RHOA (By similarity)
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Note=Predominantly cytoplasmic, however when cells arestimulated found in perinuclear regions (By similarity)
Sequence caution: Sequence=BAA34440.2; Type=Erroneous initiation; Sequence=BAC77354.1; Type=Miscellaneous discrepancy;Note=Aberrant splicing; Sequence=BAC85124.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: B3KU07 B7Z2M3 B7Z5X2 F5GZ21 F5H1I0 Q5SY17 Q5T8W5 Q5T8W9 Q6ZNM0 Q7Z436 Q86YD8Q96BS1Alternative splicing: 7 isoforms: O94827-1 O94827-2 O94827-3 O94827-4 O94827-5 O94827-6 O94827-7 (No experimental confirmation available. Ref.2 (BAH13058) sequence is in conflict in position: 38:D->E)Explore the universe of human proteins at neXtProt for PLEKHG5: NX_O94827
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O94827
PLEKHG5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (8 alternative transcripts):
NP_001036128.1 NP_001036129.1 NP_001036130.1 NP_001252521.1 NP_001252522.1 NP_001252523.1 NP_065682.2 NP_941374.2
ENSEMBL proteins: ENSP00000366977 ENSP00000468085 ENSP00000366954 ENSP00000366957 ENSP00000366961 ENSP00000383706 ENSP00000366969 ENSP00000439625 ENSP00000441445 ENSP00000344570 ENSP00000383704 ENSP00000366966 ENSP00000437710 Reactome Protein details: O94827
Human Recombinant Protein Products for PLEKHG5:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
PLEKHG5 for ontologies About GeneDecksing
PLEKHG5 Antibody Products:
Assay Products for PLEKHG5: |
Protein
Domains /
Families
for PLEKHG5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PLEKHG5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O94827ProtoNet protein and cluster: O94827 2 Blocks protein families: IPB000219 DH domain IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: PKHG5_HUMAN, O94827Similarity: Contains 1 DH (DBL-homology) domainSimilarity: Contains 1 PH domain |
Function
for PLEKHG5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PKHG5_HUMAN, O94827Function: Activates the NF-kappa-B signaling pathway and RHOA. Appears to be involved in the control of neuronal celldifferentiation Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
PLEKHG5 for ontologies About GeneDecksing
Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Plekhg5):
PLEKHG5 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Plekhg5tm1.1Jbar for PLEKHG5
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLEKHG5 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLEKHG5 (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 5): PLEKHG5 (NM_198681) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PLEKHG5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLEKHG5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHG5 |
|
Pathways & Interactions
for PLEKHG5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell death signalling via NRAGE, NRIF and NADE | | | 2 | Signaling by GPCR | | | 3 | Signaling by FGFR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/10 
Reactome Pathways for PLEKHG5 (see all 10)
PLEKHG5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLEKHG5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/52 Interacting proteins for PLEKHG5 (ENSP000003669774) via UniProtKB, MINT, STRING, and/or I2D (see all 52)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006915 | apoptotic process |
TAS | -- | | GO:0007165 | signal transduction |
-- | -- | | GO:0007264 | small GTPase mediated signal transduction |
TAS | -- | | GO:0035023 | regulation of Rho protein signal transduction |
IEA | -- | | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade |
IMP | 12761501 |
PLEKHG5 for ontologies About GeneDecksing
|
Drugs & Compounds
for PLEKHG5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PLEKHG5
Search CenterWatch for drugs/clinical trials and news about PLEKHG5 / PKHG5
|
Transcripts
for PLEKHG5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PLEKHG5 gene (8 alternative transcripts): NM_001042663.1 NM_001042664.1 NM_001042665.1 NM_001265592.1 NM_001265593.1 NM_001265594.1 NM_020631.4 NM_198681.3 Unigene Cluster for PLEKHG5: Pleckstrin homology domain containing, family G (with RhoGef domain) member 5 Hs.284232 [show with all ESTs]Unigene Representative Sequence: NM_19868115 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000489097(uc009vma.1) ENST00000377748(uc001ann.1 uc001ano.1 uc001anq.1 uc001anp.1)
ENST00000487949 ENST00000491384 ENST00000377725 ENST00000377728 ENST00000377732
ENST00000400915 ENST00000377740 ENST00000537245 ENST00000535355 ENST00000340850(uc009vmb.1 uc001anl.1)
ENST00000400913(uc001anj.1 uc010nzr.1 uc001ank.1 uc001anm.1)
ENST00000377737 ENST00000544978
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLEKHG5 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLEKHG5 (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): PLEKHG5 (NM_198681) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PLEKHG5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLEKHG5 |
Additional cDNA sequence: AB018263.2 AB097001.1 AK024676.1 AK096347.1 AK125550.1 AK294875.1 AK299523.1 AK301239.1 BC015231.1 BC036671.2 16 DOTS entries: DT.97763290 DT.92431005 DT.86847340 DT.100790315 DT.101984073 DT.95177003 DT.100779737 DT.95268062 DT.100779738 DT.100779736 DT.121426112 DT.121426128 DT.121426129 DT.91981409 DT.40258074 DT.95268043 24/180 AceView cDNA sequences (see all 180): BF063042 U94509 NM_148969 U94501 BF002663 AK091201 BF063258 U72763 AK131074 Z39975 NM_148973 U94510 AI805704 NM_148966 AK094463 AK096347 U94507 AI275938 AI963243 U74611 NM_148970 BQ024649 AA326431 AB018263
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHG5 (see all 17) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | - | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | - | | | | | | | | | | - | | - | | - | | | | - | | - | | - | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | - | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for PLEKHG5
|
Expression
for PLEKHG5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PLEKHG5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCGGATGC
About this image
See PLEKHG5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLEKHG5
SOURCE GeneReport for Unigene cluster: Hs.284232
UniProtKB/Swiss-Prot: PKHG5_HUMAN, O94827Tissue specificity: Predominantly expressed in the peripheral nervous system and brain. Highest expression is observedin heart, lung, kidney, testis and moderate expression is present in spleen, pancreas, skeletal muscle, ovary andliver. Weakly expressed in glioblastoma (GBM) cell lines
SABiosciences Custom PCR Arrays for PLEKHG5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLEKHG5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PLEKHG5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLEKHG5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLEKHG5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHG5 |
Orthologs
for PLEKHG5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PLEKHG5 gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PLEKHG51 |
pleckstrin homology domain containing, family G (with more |
74.23(n)
72.75(a) |
|
426013 XM_423692.3 XP_423692.3 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC7964041 |
pleckstrin homology domain-containing family G member more |
61.04(n)
55.89(a) |
|
796404 XM_002666521.2 XP_002666567.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG426746 |
-- |
13(a) |
1 → many |
3L(20142714-20191417) |
worm
(Caenorhabditis elegans) |
Secernentea |
rhgf-26 |
RHo Guanine nucleotide exchange Factor family memb... |
20(a) |
1 → many |
II(4120340-4127852) |
ENSEMBL Gene Tree for PLEKHG5 (if available)
TreeFam Gene Tree for PLEKHG5 (if available) |
Paralogs
for PLEKHG5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PLEKHG5 gene
- PLEKHG72 PLEKHG62
2 SIMAP similar genes for PLEKHG5 using alignment to 2 protein entries: PKHG5_HUMAN (see all proteins):PLEKHG6 ARHGEF16
PLEKHG5 for paralogs About GeneDecksing
|
Genomic Variants
for PLEKHG5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PLEKHG5 (6526152 - 6580121 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PLEKHG5
3 CNVs: 53700 30364 4201
Human Gene Mutation Database (HGMD): PLEKHG5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLEKHG5 |
|
Disorders
/ Diseases
for PLEKHG5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PLEKHG5 for disorders About GeneDecksing
OMIM gene information: 611101
OMIM disorders: 611067
UniProtKB/Swiss-Prot: PKHG5_HUMAN, O94827
Defects in PLEKHG5 are the cause of distal spinal muscular atrophy autosomal recessive type 4 (DSMA4)[MIM:611067]. Distal spinal muscular atrophy, also known as distal hereditary motor neuronopathy, represents aheterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior hornof the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of aclassical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weaknessand wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness andatrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. DSMA4 is characterizedby childhood onset, generalized muscle weakness and atrophy with denervation and normal sensation. Bulbar symptoms andpyramidal signs are absent
8  diseases for PLEKHG5: About MalaCardsspinal muscular atrophy spinal muscular atrophy, distal, autosomal recessive, 4 muscular atrophy lower motor neuron disease
motor neuronopathy motor neuron disease glioblastoma neuronitis
Human Genome Epidemiology (HuGE) Navigator: PLEKHG5 (2 documents)
Export disorders for PLEKHG5 gene to outside databases
|
Publications
for PLEKHG5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PLEKHG5 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with PLEKHG5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The nuclear factor kappaB-activator gene PLEKHG5 is mutated in a form of autosomal recessive lower motor neuron disease with childhood onset. (PubMed id 17564964)1, 2, 3 Maystadt I....Verellen-Dumoulin C. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2 Matsuda A....Sugano S. (2003)
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (1998)
- The GTPase-deficient Rnd proteins are stabilized by th eir effectors. (PubMed id 22807448)1 Goh L.L. and Manser E. (2012)
- Biochemical and computational analysis of LNX1 interac ting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (2011)
- Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (2009)
- Common variants at ten loci influence QT interval duration in the QTGEN Study. (PubMed id 19305408)1 Newton-Cheh C....Stricker B.H. (2009)
- A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype. (PubMed id 16467373)2 Liu M. and Horowitz A. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for PLEKHG5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PLEKHG5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PLEKHG5 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing PLEKHG5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PLEKHG5 | Pharmacogenomics, SNPs, Pathways |
|
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About This Section
| Patent Information for PLEKHG5 gene:
Search GeneIP for patents involving PLEKHG5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PLEKHG5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PLEKHG5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLEKHG5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLEKHG5 | | | OriGene Protein Over-expression Lysate for PLEKHG5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PLEKHG5 | | OriGene 3'-UTR Clone for PLEKHG5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLEKHG5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLEKHG5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PLEKHG5 | | OriGene Custom Protein Services for PLEKHG5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PLEKHG5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLEKHG5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLEKHG5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLEKHG5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLEKHG5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLEKHG5 |
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| | | | Search Tocris compounds for PLEKHG5 |
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 | | | PLEKHG5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHG5 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for PLEKHG5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLEKHG5 |
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