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Aliases for PLEKHG4B Gene

Aliases for PLEKHG4B Gene

  • Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 4B 2 3
  • PH Domain-Containing Family G Member 4B 3 4
  • Pleckstrin Homology Domain-Containing Family G Member 4B 3
  • CTD-2231H16.1 3
  • KIAA1909 4

External Ids for PLEKHG4B Gene

Previous GeneCards Identifiers for PLEKHG4B Gene

  • GC05P000194

Summaries for PLEKHG4B Gene

GeneCards Summary for PLEKHG4B Gene

PLEKHG4B (Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 4B) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF40.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHG4B Gene

Genomics for PLEKHG4B Gene

Regulatory Elements for PLEKHG4B Gene

Transcription factor binding sites by QIAGEN in the PLEKHG4B gene promoter:

Genomic Location for PLEKHG4B Gene

92,190 bp from pter
189,972 bp from pter
97,783 bases
Plus strand

Genomic View for PLEKHG4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLEKHG4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHG4B Gene

Proteins for PLEKHG4B Gene

  • Protein details for PLEKHG4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pleckstrin homology domain-containing family G member 4B
    Protein Accession:
    Secondary Accessions:

    Protein attributes for PLEKHG4B Gene

    1271 amino acids
    Molecular mass:
    139667 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLEKHG4B Gene

Proteomics data for PLEKHG4B Gene at MOPED

Post-translational modifications for PLEKHG4B Gene

  • Ubiquitination at Lys942
  • Modification sites at PhosphoSitePlus

Other Protein References for PLEKHG4B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PLEKHG4B Gene

Domains for PLEKHG4B Gene

Gene Families for PLEKHG4B Gene

  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for PLEKHG4B Gene


Suggested Antigen Peptide Sequences for PLEKHG4B Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96PX9
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with PLEKHG4B: view

Function for PLEKHG4B Gene

Gene Ontology (GO) - Molecular Function for PLEKHG4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with PLEKHG4B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLEKHG4B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PLEKHG4B Gene

Localization for PLEKHG4B Gene

Subcellular locations from

Jensen Localization Image for PLEKHG4B Gene COMPARTMENTS Subcellular localization image for PLEKHG4B gene
Compartment Confidence
cytosol 3
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLEKHG4B Gene

Pathways for PLEKHG4B Gene

SuperPathways for PLEKHG4B Gene

No Data Available

Interacting Proteins for PLEKHG4B Gene

Gene Ontology (GO) - Biological Process for PLEKHG4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035023 regulation of Rho protein signal transduction --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with PLEKHG4B: view

No data available for Pathways by source for PLEKHG4B Gene

Transcripts for PLEKHG4B Gene

Unigene Clusters for PLEKHG4B Gene

Pleckstrin homology domain containing, family G (with RhoGef domain) member 4B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLEKHG4B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHG4B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18
SP1: -
SP3: -
SP4: -

Relevant External Links for PLEKHG4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLEKHG4B Gene

mRNA expression in normal human tissues for PLEKHG4B Gene

mRNA differential expression in normal tissues according to GTEx for PLEKHG4B Gene

This gene is overexpressed in Pituitary (7.7) and Thyroid (7.4).

Protein differential expression in normal tissues for PLEKHG4B Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PLEKHG4B Gene

SOURCE GeneReport for Unigene cluster for PLEKHG4B Gene Hs.535800

genes like me logo Genes that share expressions with PLEKHG4B: view

Expression partners for PLEKHG4B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PLEKHG4B Gene

Orthologs for PLEKHG4B Gene

This gene was present in the common ancestor of animals.

Orthologs for PLEKHG4B Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia PLEKHG4B 35
  • 75.66 (n)
  • 66.49 (a)
  • 43 (a)
(Pan troglodytes)
Mammalia PLEKHG4B 35
  • 99.06 (n)
  • 98.5 (a)
  • 99 (a)
(Monodelphis domestica)
Mammalia PLEKHG4B 36
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia PLEKHG4B 36
  • 37 (a)
(Anolis carolinensis)
Reptilia PLEKHG4B 36
  • 51 (a)
(Danio rerio)
Actinopterygii PLEKHG4B (1 of 2) 36
  • 18 (a)
PLEKHG4B (2 of 2) 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30456 36
  • 19 (a)
CG33275 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
Species with no ortholog for PLEKHG4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLEKHG4B Gene

Gene Tree for PLEKHG4B (if available)
Gene Tree for PLEKHG4B (if available)

Paralogs for PLEKHG4B Gene

Paralogs for PLEKHG4B Gene

Selected SIMAP similar genes for PLEKHG4B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLEKHG4B: view

Variants for PLEKHG4B Gene

Sequence variations from dbSNP and Humsavar for PLEKHG4B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs29673 -- 162,262(+) GCCTG(C/T)GAGCT intron-variant
rs29674 - 163,145(+) GGGAG(A/C)CCCTG reference, missense
rs29675 -- 163,654(+) AATCC(A/G)CAGAC intron-variant
rs29676 -- 164,730(+) CTAAT(A/G)CTCTG intron-variant
rs29677 -- 165,950(+) CTGAC(A/G)GGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLEKHG4B Gene

Variant ID Type Subtype PubMed ID
essv22552 CNV CNV 17122850
dgv1733e1 CNV Complex 17122850
esv2752083 CNV Gain 17911159
nsv822925 CNV Gain 20364138
nsv881533 CNV Gain 21882294
dgv1734e1 CNV Complex 17122850
nsv428458 CNV Loss 18775914
nsv881278 CNV Loss 21882294
dgv5878n71 CNV Loss 21882294
nsv880815 CNV Loss 21882294
nsv512844 CNV Insertion 21212237
nsv470983 CNV Loss 18288195
nsv515806 CNV Loss 19592680
nsv518607 CNV Gain 19592680
nsv523382 CNV Loss 19592680
nsv881464 CNV Gain 21882294
dgv5879n71 CNV Loss 21882294
esv21566 CNV Loss 19812545
nsv821536 CNV Deletion 20802225
esv2548346 CNV Deletion 19546169
esv1220599 CNV Insertion 17803354
esv1181815 CNV Deletion 17803354
esv1691643 CNV Insertion 17803354
esv272238 CNV Insertion 20981092
esv268019 CNV Insertion 20981092
nsv461886 CNV Loss 19166990
nsv327306 CNV Loss 16902084
dgv140e180 CNV Deletion 20482838
esv1561581 CNV Deletion 17803354
nsv329414 CNV Loss 16902084
nsv509954 CNV Loss 20534489
nsv880380 CNV Loss 21882294
nsv881455 CNV Loss 21882294

Relevant External Links for PLEKHG4B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHG4B Gene

Disorders for PLEKHG4B Gene

Relevant External Links for PLEKHG4B

Human Genome Epidemiology (HuGE) Navigator

No disorders were found for PLEKHG4B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PLEKHG4B Gene

Publications for PLEKHG4B Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Quantitative Lys-I/-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson J.W. … Luchansky S.J. (J. Biol. Chem. 2014) 3

Products for PLEKHG4B Gene

Sources for PLEKHG4B Gene

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