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Aliases for PLEKHG4B Gene

Aliases for PLEKHG4B Gene

  • Pleckstrin Homology And RhoGEF Domain Containing G4B 2 3 5
  • Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 4B 2 3
  • PH Domain-Containing Family G Member 4B 3 4
  • CTD-2231H16.1 3
  • KIAA1909 4

External Ids for PLEKHG4B Gene

Previous GeneCards Identifiers for PLEKHG4B Gene

  • GC05P000194
  • GC05P000140

Summaries for PLEKHG4B Gene

GeneCards Summary for PLEKHG4B Gene

PLEKHG4B (Pleckstrin Homology And RhoGEF Domain Containing G4B) is a Protein Coding gene. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF40.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHG4B Gene

Genomics for PLEKHG4B Gene

Regulatory Elements for PLEKHG4B Gene

Transcription factor binding sites by QIAGEN in the PLEKHG4B gene promoter:

Genomic Location for PLEKHG4B Gene

Chromosome:
5
Start:
54,015 bp from pter
End:
189,972 bp from pter
Size:
135,958 bases
Orientation:
Plus strand

Genomic View for PLEKHG4B Gene

Genes around PLEKHG4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLEKHG4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLEKHG4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHG4B Gene

Proteins for PLEKHG4B Gene

  • Protein details for PLEKHG4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PX9-PKH4B_HUMAN
    Recommended name:
    Pleckstrin homology domain-containing family G member 4B
    Protein Accession:
    Q96PX9

    Protein attributes for PLEKHG4B Gene

    Size:
    1271 amino acids
    Molecular mass:
    139667 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLEKHG4B Gene

Proteomics data for PLEKHG4B Gene at MOPED

Post-translational modifications for PLEKHG4B Gene

  • Ubiquitination at Lys 942
  • Modification sites at PhosphoSitePlus

Other Protein References for PLEKHG4B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PLEKHG4B Gene

Domains & Families for PLEKHG4B Gene

Gene Families for PLEKHG4B Gene

Protein Domains for PLEKHG4B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PLEKHG4B Gene

Graphical View of Domain Structure for InterPro Entry

Q96PX9

UniProtKB/Swiss-Prot:

PKH4B_HUMAN :
  • Contains 1 DH (DBL-homology) domain.
Domain:
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with PLEKHG4B: view

Function for PLEKHG4B Gene

Phenotypes for PLEKHG4B Gene

GenomeRNAi human phenotypes for PLEKHG4B:
genes like me logo Genes that share phenotypes with PLEKHG4B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLEKHG4B Gene

Localization for PLEKHG4B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLEKHG4B Gene COMPARTMENTS Subcellular localization image for PLEKHG4B gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLEKHG4B Gene

Pathways & Interactions for PLEKHG4B Gene

SuperPathways for PLEKHG4B Gene

No Data Available

Interacting Proteins for PLEKHG4B Gene

Gene Ontology (GO) - Biological Process for PLEKHG4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with PLEKHG4B: view

No data available for Pathways by source and SIGNOR curated interactions for PLEKHG4B Gene

Drugs & Compounds for PLEKHG4B Gene

No Compound Related Data Available

Transcripts for PLEKHG4B Gene

Unigene Clusters for PLEKHG4B Gene

Pleckstrin homology domain containing, family G (with RhoGef domain) member 4B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHG4B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18
SP1: -
SP2:
SP3: -
SP4: -
SP5:

Relevant External Links for PLEKHG4B Gene

GeneLoc Exon Structure for
PLEKHG4B
ECgene alternative splicing isoforms for
PLEKHG4B

Expression for PLEKHG4B Gene

mRNA expression in normal human tissues for PLEKHG4B Gene

mRNA differential expression in normal tissues according to GTEx for PLEKHG4B Gene

This gene is overexpressed in Pituitary (x7.7) and Thyroid (x7.4).

Protein differential expression in normal tissues from HIPED for PLEKHG4B Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLEKHG4B Gene



SOURCE GeneReport for Unigene cluster for PLEKHG4B Gene Hs.535800

genes like me logo Genes that share expression patterns with PLEKHG4B: view

Protein tissue co-expression partners for PLEKHG4B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PLEKHG4B Gene

Orthologs for PLEKHG4B Gene

This gene was present in the common ancestor of animals.

Orthologs for PLEKHG4B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PLEKHG4B 35
  • 75.66 (n)
  • 66.49 (a)
PLEKHG4B 36
  • 43 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLEKHG4B 35
  • 99.06 (n)
  • 98.5 (a)
PLEKHG4B 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLEKHG4B 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLEKHG4B 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLEKHG4B 36
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PLEKHG4B (1 of 2) 36
  • 18 (a)
OneToMany
PLEKHG4B (2 of 2) 36
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30456 36
  • 19 (a)
ManyToMany
CG33275 36
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for PLEKHG4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLEKHG4B Gene

ENSEMBL:
Gene Tree for PLEKHG4B (if available)
TreeFam:
Gene Tree for PLEKHG4B (if available)

Paralogs for PLEKHG4B Gene

Paralogs for PLEKHG4B Gene

(2) SIMAP similar genes for PLEKHG4B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLEKHG4B: view

Variants for PLEKHG4B Gene

Sequence variations from dbSNP and Humsavar for PLEKHG4B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs12523402 - 140,521(+) CAGGA(A/G)CTGCA reference, missense
rs11949577 - 143,082(+) CAGAC(A/G)GCGGC reference, missense
rs13436090 - 143,419(+) GGTCC(A/G)CACCA reference, missense
rs3810869 - 163,119(-) GAAGC(A/G)CTCGT reference, missense
rs12516846 - 140,417(+) GGCAG(C/T)AGCCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PLEKHG4B Gene

Variant ID Type Subtype PubMed ID
essv22552 CNV CNV 17122850
dgv1733e1 CNV Complex 17122850
esv2752083 CNV Gain 17911159
nsv822925 CNV Gain 20364138
nsv881533 CNV Gain 21882294
dgv1734e1 CNV Complex 17122850
nsv428458 CNV Loss 18775914
nsv881278 CNV Loss 21882294
dgv5878n71 CNV Loss 21882294
nsv880815 CNV Loss 21882294
nsv512844 CNV Insertion 21212237
nsv470983 CNV Loss 18288195
nsv515806 CNV Loss 19592680
nsv518607 CNV Gain 19592680
nsv523382 CNV Loss 19592680
nsv881464 CNV Gain 21882294
dgv5879n71 CNV Loss 21882294
esv21566 CNV Loss 19812545
nsv821536 CNV Deletion 20802225
esv2548346 CNV Deletion 19546169
esv1220599 CNV Insertion 17803354
esv1181815 CNV Deletion 17803354
esv1691643 CNV Insertion 17803354
esv272238 CNV Insertion 20981092
esv268019 CNV Insertion 20981092
nsv461886 CNV Loss 19166990
nsv327306 CNV Loss 16902084
dgv140e180 CNV Deletion 20482838
esv1561581 CNV Deletion 17803354
nsv329414 CNV Loss 16902084
nsv509954 CNV Loss 20534489
nsv880380 CNV Loss 21882294
nsv881455 CNV Loss 21882294

Variation tolerance for PLEKHG4B Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.33; 98.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLEKHG4B Gene

HapMap Linkage Disequilibrium report
PLEKHG4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHG4B Gene

Disorders for PLEKHG4B Gene

Relevant External Links for PLEKHG4B

Human Genome Epidemiology (HuGE) Navigator
PLEKHG4B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLEKHG4B

No disorders were found for PLEKHG4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLEKHG4B Gene

Publications for PLEKHG4B Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PLEKHG4B Gene

Sources for PLEKHG4B Gene

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