PLEKHG4B Gene
protein-coding GIFtS: 44
GCID: GC05P000140
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pleckstrin homology domain containing, family G (with RhoGef...
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Aliases
for PLEKHG4B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member4B1 2 | | KIAA19091 3 | | PH Domain-Containing Family G Member 4B2 3 | | Pleckstrin Homology Domain-Containing Family G Member 4B2 |
Export aliases for PLEKHG4B gene to outside databasesPrevious GC identifer: GC05P000194 |
Summaries
for PLEKHG4B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for PLEKHG4B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006576.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PLEKHG4B gene promoter:
Pax-6
Other transcription factors
Search SABiosciences Chromatin IP Primers for PLEKHG4B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLEKHG4B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5p15.33 Ensembl cytogenetic band: 5p15.33 HGNC cytogenetic band: 5p15.33PLEKHG4B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P000140: view genomic region
(about GC identifiers)
Start:
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140,373 bp from pter |
End:
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190,087 bp from pter |
Size:
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49,715 bases |
Orientation:
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plus strand |
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Proteins
for PLEKHG4B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PKH4B_HUMAN, Q96PX9 (See
protein sequence)Recommended Name: Pleckstrin homology domain-containing family G member 4B Size: 1271 amino acids; 139667 DaExplore the universe of human proteins at neXtProt for PLEKHG4B: NX_Q96PX9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96PX9
PLEKHG4B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_443141.3
ENSEMBL proteins: ENSP00000283426 ENSP00000422493
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
PLEKHG4B for ontologies About GeneDecksing
PLEKHG4B Antibody Products:
Assay Products for PLEKHG4B: |
Protein
Domains /
Families
for PLEKHG4B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PLEKHG4B for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96PX9ProtoNet protein and cluster: Q96PX9 1 Blocks protein family: IPB000219 DH domain
UniProtKB/Swiss-Prot: PKH4B_HUMAN, Q96PX9Similarity: Contains 1 DH (DBL-homology) domainSimilarity: Contains 1 PH domain |
Function
for PLEKHG4B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLEKHG4B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLEKHG4B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHG4B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
IEA | -- | | GO:0005543 | phospholipid binding |
IEA | -- |
PLEKHG4B for ontologies About GeneDecksing
|
Pathways & Interactions
for PLEKHG4B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLEKHG4B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for PLEKHG4B (ENSP000002834264) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035023 | regulation of Rho protein signal transduction |
IEA | -- |
PLEKHG4B for ontologies About GeneDecksing
|
Drugs & Compounds
for PLEKHG4B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PLEKHG4B
Search CenterWatch for drugs/clinical trials and news about PLEKHG4B / PKH4B
|
Transcripts
for PLEKHG4B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PLEKHG4B gene: NM_052909.3 Unigene Cluster for PLEKHG4B: Pleckstrin homology domain containing, family G (with RhoGef domain) member 4B Hs.535800 [show with all ESTs]Unigene Representative Sequence: NM_0529093 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000283426(uc003jak.2) ENST00000502646 ENST00000504041
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLEKHG4B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLEKHG4B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PLEKHG4B (NM_052909) | | | DNA2.0 Custom Codon Optimized Gene
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Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLEKHG4B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PLEKHG4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLEKHG4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLEKHG4B |
Additional cDNA sequence: AB067496.2 AK075513.1 AK125163.1 AK309784.1 BC008352.1 7 DOTS entries: DT.442899 DT.407696 DT.95074141 DT.101958999 DT.99936068 DT.91750772 DT.100643750 24/53 AceView cDNA sequences (see all 53): AW262547 AK125163 CB147632 AI890356 BU737324 BE222242 BU169148 NM_052909 BC008352 BQ686524 AW245359 BX442102 BF445407 AA453285 BX431226 AA960934 AA987521 BG112423 BE549685 BM006782 AK075513 AW245715 BE710812 BQ690738
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHG4B About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PLEKHG4B
|
Expression
for PLEKHG4B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PLEKHG4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See PLEKHG4B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLEKHG4B
SOURCE GeneReport for Unigene cluster: Hs.535800
SABiosciences Custom PCR Arrays for PLEKHG4B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLEKHG4B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PLEKHG4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLEKHG4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLEKHG4B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHG4B |
Orthologs
for PLEKHG4B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PLEKHG4B gene from 3/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
PLEKHG4B6 |
-- |
53(a) |
1 ↔ 1 |
6(56505059-56551716) |
zebrafish
(Danio rerio) |
Actinopterygii |
CR848746.16 |
-- |
70(a) |
1 ↔ 1 |
16(56731985-56755227) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG332756 |
-- |
16(a) |
1 → many |
3L(7586191-7632673) |
ENSEMBL Gene Tree for PLEKHG4B (if available)
TreeFam Gene Tree for PLEKHG4B (if available) |
Paralogs
for PLEKHG4B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PLEKHG4B gene
- KALRN2 ARHGEF252 MCF2L22 TRIO2 MCF2L2 KIAA17552 PLEKHG42 ARHGEF402
- MCF22
2 SIMAP similar genes for PLEKHG4B using alignment to 2 protein entries: PKH4B_HUMAN (see all proteins):KIAA1755 PLEKHG4
PLEKHG4B for paralogs About GeneDecksing
|
Genomic Variants
for PLEKHG4B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PLEKHG4B (140373 - 190087 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 12 variations for PLEKHG4B
10 CNVs: 92764 51670 68920 51662 99027 51661 3536 92765 8470 80739
2 Indels: 12631 27907 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLEKHG4B |
|
Disorders
/ Diseases
for PLEKHG4B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 PLEKHG4B for disorders About MalaCards
PLEKHG4B for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: PLEKHG4B (1 document)
Export disorders for PLEKHG4B gene to outside databases
|
Publications
for PLEKHG4B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PLEKHG4B gene integrated from 9 sources:
(articles sorted by number of sources associating them with PLEKHG4B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2, 3 Nagase T....Ohara O. (2001)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for PLEKHG4B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PLEKHG4B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PLEKHG4B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing PLEKHG4B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PLEKHG4B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PLEKHG4B gene:
Search GeneIP for patents involving PLEKHG4B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PLEKHG4B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PLEKHG4B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLEKHG4B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLEKHG4B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PLEKHG4B | | OriGene 3'-UTR Clone for PLEKHG4B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLEKHG4B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLEKHG4B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | PLEKHG4B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHG4B |
|  |  |  | | | | Search ThermoFisher Antibodies for PLEKHG4B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLEKHG4B |
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