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Aliases for PLEKHG4B Gene

Aliases for PLEKHG4B Gene

  • Pleckstrin Homology And RhoGEF Domain Containing G4B 2 3 5
  • Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 4B 2 3
  • PH Domain-Containing Family G Member 4B 3 4
  • Pleckstrin Homology Domain-Containing Family G Member 4B 3
  • CTD-2231H16.1 3
  • KIAA1909 4

External Ids for PLEKHG4B Gene

Previous GeneCards Identifiers for PLEKHG4B Gene

  • GC05P000194
  • GC05P000140

Summaries for PLEKHG4B Gene

GeneCards Summary for PLEKHG4B Gene

PLEKHG4B (Pleckstrin Homology And RhoGEF Domain Containing G4B) is a Protein Coding gene. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is PLEKHG4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHG4B Gene

Genomics for PLEKHG4B Gene

Regulatory Elements for PLEKHG4B Gene

Enhancers for PLEKHG4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F000187 1.6 FANTOM5 Ensembl ENCODE 10.6 +136.3 136298 5.6 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZNF48 YY1 GLIS2 ZNF143 KLF7 LRRC14B LOC100288152 HRAT5 SDHA CCDC127 PLEKHG4B EXOC3 PDCD6 PIR34013
GH05F000052 1.5 FANTOM5 Ensembl ENCODE 7.6 -0.4 -364 1.9 CTCF KLF1 KLF17 ZIC2 ZNF2 ZNF335 ZNF121 ZFHX2 GLIS2 POLR2A PLEKHG4B EXOC3-AS1 LOC105374602
GH05F000166 0.9 Ensembl ENCODE 7.6 +114.4 114396 3.5 ZBTB10 L3MBTL2 FOXP2 FOS MNT MAFK EGR2 NR2F2 CCDC127 SDHA PLEKHG4B HRAT5 PIR34013 LRRC14B
GH05F000153 0.4 ENCODE 7.2 +100.0 99998 0.4 ZBTB33 PLEKHG4B CCDC127 ENSG00000199540 GC05M000144 PIR34013
GH05F000104 0.5 ENCODE 5 +51.5 51478 1.5 SMARCA4 RNF2 ZNF341 ZNF600 CCDC127 AHRR PLEKHG4B LOC102725009 LOC102723561
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLEKHG4B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PLEKHG4B gene promoter:

Genomic Location for PLEKHG4B Gene

Chromosome:
5
Start:
54,015 bp from pter
End:
189,972 bp from pter
Size:
135,958 bases
Orientation:
Plus strand

Genomic View for PLEKHG4B Gene

Genes around PLEKHG4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLEKHG4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLEKHG4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHG4B Gene

Proteins for PLEKHG4B Gene

  • Protein details for PLEKHG4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PX9-PKH4B_HUMAN
    Recommended name:
    Pleckstrin homology domain-containing family G member 4B
    Protein Accession:
    Q96PX9

    Protein attributes for PLEKHG4B Gene

    Size:
    1271 amino acids
    Molecular mass:
    139667 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLEKHG4B Gene

Post-translational modifications for PLEKHG4B Gene

  • Ubiquitination at Lys 942
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PLEKHG4B Gene

Domains & Families for PLEKHG4B Gene

Gene Families for PLEKHG4B Gene

Protein Domains for PLEKHG4B Gene

Suggested Antigen Peptide Sequences for PLEKHG4B Gene

Graphical View of Domain Structure for InterPro Entry

Q96PX9

UniProtKB/Swiss-Prot:

PKH4B_HUMAN :
  • Contains 1 DH (DBL-homology) domain.
Domain:
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with PLEKHG4B: view

Function for PLEKHG4B Gene

Gene Ontology (GO) - Molecular Function for PLEKHG4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 27107012
genes like me logo Genes that share ontologies with PLEKHG4B: view

Phenotypes for PLEKHG4B Gene

GenomeRNAi human phenotypes for PLEKHG4B:
genes like me logo Genes that share phenotypes with PLEKHG4B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLEKHG4B Gene

Localization for PLEKHG4B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLEKHG4B gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLEKHG4B Gene

Pathways & Interactions for PLEKHG4B Gene

SuperPathways for PLEKHG4B Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLEKHG4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with PLEKHG4B: view

No data available for Pathways by source and SIGNOR curated interactions for PLEKHG4B Gene

Transcripts for PLEKHG4B Gene

Unigene Clusters for PLEKHG4B Gene

Pleckstrin homology domain containing, family G (with RhoGef domain) member 4B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHG4B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18
SP1: -
SP2:
SP3: -
SP4: -
SP5:

Relevant External Links for PLEKHG4B Gene

GeneLoc Exon Structure for
PLEKHG4B
ECgene alternative splicing isoforms for
PLEKHG4B

Expression for PLEKHG4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLEKHG4B Gene

mRNA differential expression in normal tissues according to GTEx for PLEKHG4B Gene

This gene is overexpressed in Pituitary (x7.7) and Thyroid (x7.4).

Protein differential expression in normal tissues from HIPED for PLEKHG4B Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLEKHG4B Gene



Protein tissue co-expression partners for PLEKHG4B Gene

NURSA nuclear receptor signaling pathways regulating expression of PLEKHG4B Gene:

PLEKHG4B

SOURCE GeneReport for Unigene cluster for PLEKHG4B Gene:

Hs.535800
genes like me logo Genes that share expression patterns with PLEKHG4B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PLEKHG4B Gene

Orthologs for PLEKHG4B Gene

This gene was present in the common ancestor of animals.

Orthologs for PLEKHG4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLEKHG4B 34 35
  • 99.06 (n)
dog
(Canis familiaris)
Mammalia PLEKHG4B 34 35
  • 75.66 (n)
oppossum
(Monodelphis domestica)
Mammalia PLEKHG4B 35
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLEKHG4B 35
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLEKHG4B 35
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PLEKHG4B (2 of 2) 35
  • 59 (a)
OneToMany
PLEKHG4B (1 of 2) 35
  • 18 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30456 35
  • 19 (a)
ManyToMany
CG33275 35
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToMany
Species where no ortholog for PLEKHG4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLEKHG4B Gene

ENSEMBL:
Gene Tree for PLEKHG4B (if available)
TreeFam:
Gene Tree for PLEKHG4B (if available)

Paralogs for PLEKHG4B Gene

Paralogs for PLEKHG4B Gene

(2) SIMAP similar genes for PLEKHG4B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLEKHG4B: view

Variants for PLEKHG4B Gene

Sequence variations from dbSNP and Humsavar for PLEKHG4B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs193920840 Uncertain significance 156,173(+) TGGCG(C/T)GGCTG nc-transcript-variant, reference, missense
rs116480186 Benign 171,224(+) GCAGC(A/G)GGAGC nc-transcript-variant, reference, missense
rs568109142 Benign 161,930(+) CGTCC(A/G)AGTTG nc-transcript-variant, reference, missense
rs10037069 -- 94,530(+) TTGGT(C/T)CTGGG intron-variant
rs10037256 -- 135,461(+) cagat(C/T)gagac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLEKHG4B Gene

Variant ID Type Subtype PubMed ID
nsv822925 CNV gain 20364138
nsv821536 CNV deletion 20802225
nsv596611 CNV loss 21841781
nsv596610 CNV loss 21841781
nsv596609 CNV loss 21841781
nsv596608 CNV gain+loss 21841781
nsv523382 CNV loss 19592680
nsv518607 CNV gain 19592680
nsv515806 CNV loss 19592680
nsv512844 CNV insertion 21212237
nsv509954 OTHER sequence alteration 20534489
nsv470983 CNV loss 18288195
nsv461886 CNV loss 19166990
nsv428458 CNV loss 18775914
nsv329414 CNV deletion 16902084
nsv327306 CNV deletion 16902084
nsv1152640 CNV deletion 26484159
nsv1148702 CNV deletion 26484159
nsv1139359 CNV deletion 24896259
nsv1137518 CNV deletion 24896259
nsv1074789 CNV deletion 25765185
nsv1073408 CNV deletion 25765185
nsv1032615 CNV gain 25217958
nsv1030767 CNV gain 25217958
nsv1028927 CNV loss 25217958
nsv1028658 CNV gain 25217958
nsv1018481 CNV gain 25217958
esv3894107 CNV gain 25118596
esv3603733 CNV loss 21293372
esv3603731 CNV gain 21293372
esv3603721 CNV gain 21293372
esv3603720 CNV loss 21293372
esv3575802 CNV gain 25503493
esv3569899 CNV loss 25503493
esv3569895 CNV loss 25503493
esv3569893 CNV loss 25503493
esv3418267 CNV duplication 20981092
esv3397427 CNV insertion 20981092
esv3307964 CNV mobile element insertion 20981092
esv3303740 CNV mobile element insertion 20981092
esv2763907 CNV gain+loss 21179565
esv2759315 CNV loss 17122850
esv2752083 CNV gain 17911159
esv2548346 CNV deletion 19546169
esv21566 CNV loss 19812545
esv1691643 CNV insertion 17803354
esv1561581 CNV deletion 17803354
esv1220599 CNV insertion 17803354
esv1181815 CNV deletion 17803354
dgv9475n54 CNV gain 21841781
dgv9471n54 CNV loss 21841781
dgv5517n100 CNV loss 25217958
dgv5515n100 CNV gain 25217958
dgv3008n106 CNV deletion 24896259
dgv140e180 CNV deletion 20482838

Variation tolerance for PLEKHG4B Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.33; 98.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLEKHG4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLEKHG4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHG4B Gene

Disorders for PLEKHG4B Gene

Relevant External Links for PLEKHG4B

Human Genome Epidemiology (HuGE) Navigator
PLEKHG4B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLEKHG4B

No disorders were found for PLEKHG4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLEKHG4B Gene

Publications for PLEKHG4B Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N. … Roth F.P. (Mol. Syst. Biol. 2016) 3 64
  3. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for PLEKHG4B Gene

Sources for PLEKHG4B Gene

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