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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PLEKHG4 Gene

protein-coding GIFtS: 54
GCID: GC16P067311

pleckstrin homology domain containing, family G (with RhoGef...

(Previous name: spinocerebellar ataxia 4 )
(Previous symbol: SCA4)

Explore 12 diseases affiliated with
PLEKHG4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 4¹ ²		Purkinje Cell Atrophy-Associated Protein 1² ³
ARHGEF44¹ ²		DKFZP434I216¹
SCA4¹ ²		Spinocerebellar Ataxia 4¹
Pleckstrin Homology Domain-Containing Family G Member 4² ³		Puratrophin-1¹
PRTPHN1² ³		Purkinje Cell Atrophy Associated Protein 1²
PH Domain-Containing Family G Member 4² ³

External Ids:	HGNC: 24501¹	Entrez Gene: 25894²	Ensembl: ENSG00000196155⁷	OMIM: 609526⁵	UniProtKB: Q58EX7³

Export aliases for PLEKHG4 gene to outside databases

Previous GC identifers: GC16P065870 GC16P053184

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLEKHG4:

The protein encoded by this gene contains multiple domains suggestive of a role in intracellular signaling and

cytoskeleton dynamics at the Golgi apparatus. Mutations in this gene are associated with spinocerebellar ataxia

16q22-linked. Several alternatively spliced transcript variants, differing only in the 5' UTR, or encoding a different

isoform, have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PKHG4_HUMAN, Q58EX7

Function: Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi

Gene Wiki entry for PLEKHG4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PLEKHG4 gene promoter:
E2F-4 E2F-3a E2F
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PLEKHG4 promoter sequence

Search SABiosciences Chromatin IP Primers for PLEKHG4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLEKHG4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1

PLEKHG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLEKHG4 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P067311: view genomic region (about GC identifiers)

Start:	67,311,413 bp from pter	End:	67,323,403 bp from pter
Size:	11,991 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PKHG4_HUMAN, Q58EX7 (See protein sequence)

Recommended Name: Puratrophin-1

Size: 1191 amino acids; 130803 Da

Caution: Defects in PLEKHG4 were initially thought (PubMed:16001362) to be the cause of spinocerebellar ataxia

16q22-linked. However, it was later shown (PubMed:17611710) that it is not the case. Spinocerebellar ataxia

16q22-linked, also known as spinocerebellar ataxia type 31 (SCA31), is caused by defects in BEAN gene

Sequence caution: Sequence=AAH82974.1; Type=Frameshift; Positions=3; Sequence=BAB15765.1; Type=Erroneous initiation;

Secondary accessions: Q4G0J8 Q4H485 Q56A69 Q9H7K4 Q9UFW0

Alternative splicing: 3 isoforms: Q58EX7-1 Q58EX7-2 Q58EX7-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PLEKHG4: NX_Q58EX7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q58EX7

PLEKHG4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001123199.1 NP_001123200.1 NP_001123201.1 NP_001123203.1 NP_056247.1

ENSEMBL proteins:

ENSP00000457086 ENSP00000353646 ENSP00000454348 ENSP00000455423 ENSP00000455876

ENSP00000455622 ENSP00000401118 ENSP00000368649 ENSP00000456873 ENSP00000398030

ENSP00000455740 ENSP00000462601 ENSP00000464631 ENSP00000455228

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	Uscn Proteins for PLEKHG4

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--

PLEKHG4 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PLEKHG4 for domains About GeneDecksing

3 InterPro domains/families:

IPR000219 DH-domain

IPR001849 Pleckstrin_homology

IPR011993 PH_like_dom

Graphical View of Domain Structure for InterPro Entry Q58EX7

ProtoNet protein and cluster: Q58EX7

1 Blocks protein family: IPB000219 DH domain

UniProtKB/Swiss-Prot: PKHG4_HUMAN, Q58EX7

Similarity: Contains 1 DH (DBL-homology) domain

Similarity: Contains 1 PH domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PKHG4_HUMAN, Q58EX7

Function: Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi

miRNA Products:		OriGene 3'-UTR Clone (see all 5): PLEKHG4 Browse MicroRNA Expression Plasmids
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		hsa-miR-1287 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-590-3p hsa-miR-340 hsa-miR-3921 hsa-miR-432
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In Situ Assay
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA	--
GO:0005543	phospholipid binding	IEA	--

PLEKHG4 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for PLEKHG4:

Increased G2M DNA content

Increased number of mitotic ce

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PLEKHG4

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for PLEKHG4 (Q58EX7^{2, 3} ENSP00000353646⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COIL	P38432²^,³, ENSP00000240316⁴	MINT-2871676 I2D: score=3 STRING: ENSP00000240316
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
--	Q9WMX2²	MINT-7048230

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0035023	regulation of Rho protein signal transduction	IEA	--

PLEKHG4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about PLEKHG4 / PKHG4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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About This Section

REFSEQ mRNAs for PLEKHG4 gene (5 alternative transcripts):

NM_001129727.1 NM_001129728.1 NM_001129729.1 NM_001129731.1 NM_015432.3

Unigene Cluster for PLEKHG4:

Pleckstrin homology domain containing, family G (with RhoGef domain) member 4

Hs.188781 [show with all ESTs]

Unigene Representative Sequence: AB197663

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000563969(uc002esp.4) ENST00000360461(uc002esr.1 uc002eso.4 uc002esq.4 uc010cef.3 uc002ess.4)

ENST00000562144 ENST00000565899 ENST00000565773 ENST00000562744 ENST00000427155

ENST00000379344 ENST00000568621 ENST00000450733(uc010ceg.3) ENST00000567938

ENST00000393966 ENST00000562289 ENST00000569875 ENST00000567136

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		hsa-miR-1287 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-590-3p hsa-miR-340 hsa-miR-3921 hsa-miR-432
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Additional cDNA sequence:

AB197663.1 AK024475.1 AK304723.1 AK308298.1 AL117435.1 BC001520.2 BC054486.1 BC063501.1

BC082974.1 BC115389.1 BC115390.1

9 DOTS entries:

DT.411290 DT.403101 DT.101982869 DT.91747807 DT.120699172 DT.97783644 DT.120699176 DT.120699173

DT.92423713

24/94 AceView cDNA sequences (see all 94):

AW628468 AL043975 BC063501 BG165005 AK024475 AL044874 BE304515 BQ683502

AL043976 BQ054299 BG758747 BU727050 CD358076 BE302700 AL117435 BC001520

AI298335 BX391908 BF980115 AA723269 BU501259 BF515557 BG037152 BG437241

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHG4 (see all 9) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^
SP1:					-		-		-		-
SP2:
SP3:
SP4:
SP5:																	-		-

ExUns:	22	^	23	^	24a	·	24b	^	25a	·	25b	^	26a	·	26b	^	27a	·	27b	·	27c
SP1:													-
SP2:													-
SP3:													-
SP4:													-
SP5:													-

ECgene alternative splicing isoforms for PLEKHG4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PLEKHG4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTGCCTTTC

About this image

PLEKHG4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

See PLEKHG4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLEKHG4

SOURCE GeneReport for Unigene cluster: Hs.188781

UniProtKB/Swiss-Prot: PKHG4_HUMAN, Q58EX7

Tissue specificity: Expressed in kidney, Leydig cells in the testis, epithelial cells in the prostate gland and

Langerhans islet in the pancreas. Isoform 1 and isoform 3 are strongly expressed in Purkinje cells and to a lower

extent in other neurons (at protein level). Widely expressed at low levels. More strongly expressed in testis and

pancreas

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PLEKHG4 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC100859373¹	pleckstrin homology domain-containing family G member more	62.25(n) 55.88(a)		100859373 XM_003641900.1 XP_003641948.1
lizard (Anolis carolinensis)	Reptilia	PLEKHG4⁶	--	30(a)	1 ↔ 1	GL344217.1(37684-57470)
African clawed frog (Xenopus laevis)	Amphibia	BX843829.1²	--	76.28(n)		BX843829.1
zebrafish (Danio rerio)	Actinopterygii	57059697²	--	73.08(n)		57059697
fruit fly (Drosophila melanogaster)	Insecta	CG33275⁶	--	16(a)	1 → many	3L(7586191-7632673)

ENSEMBL Gene Tree for PLEKHG4 (if available)
TreeFam Gene Tree for PLEKHG4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PLEKHG4 gene

KALRN² ARHGEF25² PLEKHG4B² MCF2L2² TRIO² MCF2L² KIAA1755² ARHGEF40²

MCF2²

2 SIMAP similar genes for PLEKHG4 using alignment to 10 protein entries: PKHG4_HUMAN (see all proteins):

tgat PLEKHG4B

PLEKHG4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78985162^1,2		--	53182581(+)	`TGGAAG/AGTTAT`	1	--	us2k¹		4		CSA WA NA	240
rs111770084^1,2	C,	--	53183022(+)	`GGCATG/CAGCCA`	1	--	us2k¹		1		WA	2
rs12930163^1,2	C,H	--	53183257(+)	`ATTTGT/GCGGGC`	2	--	us2k¹		4		NS EA	418
rs73592820^1,2	C,F,	--	53184306(+)	`TGATTG/AAGTCA`	3	--	us2k¹		4		WA CSA	123
rs111959251^1,2	C,	--	53184535(+)	`CCCCAA/GTATTC`	3	--	ut5¹ us2k¹		2		NA WA	120
rs78132437^1,2	C,	--	53184700(+)	`GGAGCC/GTCAGG`	5	--	us2k¹ ut5¹		2		NA	122
rs115328599^1,2	C,F,	--	53184803(+)	`ACATAC/TAGTCT`	5	--	us2k¹ ut5¹		2		WA NA	238
rs8050745^1,2	C,F,H,	--	53184849(+)	`GGAGTG/AGAGAA`	5	--	us2k¹ ut5¹		21		NS EA NA WA CSA	2142
rs60548246^1,2	F,	--	53186141(+)	`TCGCTC/TACCCA`	5	--	int¹ ut5¹ us2k¹		1		WA	118
rs60932762^1,2		--	53186287(+)	`GGCCCA/GGGGGT`	5	--	us2k¹ int¹ ut5¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PLEKHG4 (67311413 - 67323403 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PLEKHG4: --
Human Gene Mutation Database (HGMD): PLEKHG4

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLEKHG4

DNA2.0 Custom Variant and Variant Library Synthesis for PLEKHG4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PLEKHG4 for disorders           About GeneDecksing

OMIM gene information: 609526    OMIM disorders: --

12 diseases for PLEKHG4:    About MalaCards

spinocerebellar ataxia spinocerebellar ataxia 4 ataxia sensory peripheral neuropathy

spotted fever peripheral neuropathy axonal neuropathy cerebellar ataxia

typhus neuropathy prostatitis neuronitis

4 diseases from the University of Copenhagen DISEASES database for PLEKHG4:

dentatorubral-pallidoluysian atrophy Cerebellar ataxia Spinocerebellar ataxia Axonal neuropathy

Human Genome Epidemiology (HuGE) Navigator: PLEKHG4 (4 documents)

Export disorders for PLEKHG4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PLEKHG4 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with PLEKHG4)

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An autosomal dominant cerebellar ataxia linked to chromosome 16q22.1 is associated with a single-nucleotide substitution in the 5' untranslated region of the gene encoding a protein with spectrin repeat and Rho guanine-nucleotide exchange-factor domains. (PubMed id 16001362)^{1, 2, 3, 9} Ishikawa K....Mizusawa H. (2005)
Mutations of the puratrophin-1 (PLEKHG4) gene on chromosome 16q22.1 are not a common genetic cause of cerebellar ataxia in a European population. (PubMed id 16491300)^{1, 3, 9} Wieczorek S....Epplen J.T. (2006)
Redefining the disease locus of 16q22.1-linked autosomal dominant cerebellar ataxia. (PubMed id 17611710)^{1, 2} Amino T....Mizusawa H. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
New gene of spinocerebellar ataxia. (PubMed id 21357611)¹ Teive H.A....Ashizawa T. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Analysis of an insertion mutation in a cohort of 94 p atients with spinocerebellar ataxia type 31 from Nagano, Japan. (PubMed id 20424877)¹ Sakai H....Matsumoto N. (2010)
[Study on the single-nucleotide substitution (c.-16C to T) of the PURATROPHIN-1 gene in Chinese patients with spinocerebellar ataxia] (PubMed id 19065522)¹ Zhou Y....Tang B. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 25894	HGNC: 24501	AceView: DKFZP434I216	Ensembl:ENSG00000196155	euGenes: HUgn25894
ECgene: PLEKHG4	H-InvDB: PLEKHG4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PLEKHG4	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PLEKHG4

Intellectual Property for PLEKHG4 gene
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Patent Information for PLEKHG4 gene:
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PLEKHG4 Gene

pleckstrin homology domain containing, family G (with RhoGef...

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PLEKHG4 Gene

pleckstrin homology domain containing, family G (with RhoGef...

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