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Aliases for PLEKHG3 Gene

Aliases for PLEKHG3 Gene

  • Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 3 2 3
  • KIAA0599 2 3 4
  • PH Domain-Containing Family G Member 3 3 4
  • Pleckstrin Homology Domain Containing, Family G, Member 3 3
  • ARHGEF43 3

External Ids for PLEKHG3 Gene

Previous HGNC Symbols for PLEKHG3 Gene

  • KIAA0599

Previous GeneCards Identifiers for PLEKHG3 Gene

  • GC14P064240
  • GC14P065172
  • GC14P045343

Summaries for PLEKHG3 Gene

GeneCards Summary for PLEKHG3 Gene

PLEKHG3 (Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 3) is a Protein Coding gene. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHG3 Gene

Genomics for PLEKHG3 Gene

Regulatory Elements for PLEKHG3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PLEKHG3 Gene

Chromosome:
14
Start:
64,704,102 bp from pter
End:
64,750,247 bp from pter
Size:
46,146 bases
Orientation:
Plus strand

Genomic View for PLEKHG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for PLEKHG3 Gene

Proteins for PLEKHG3 Gene

  • Protein details for PLEKHG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L390-PKHG3_HUMAN
    Recommended name:
    Pleckstrin homology domain-containing family G member 3
    Protein Accession:
    A1L390
    Secondary Accessions:
    • A1L389
    • B5MEC9
    • O60339
    • Q6GMS3
    • Q6P4B1
    • Q7L3S3
    • Q86SW7
    • Q8TEF5
    • Q96EW6
    • Q9BT82

    Protein attributes for PLEKHG3 Gene

    Size:
    1219 amino acids
    Molecular mass:
    134412 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84995.1; Type=Miscellaneous discrepancy; Note=Intron retention. There are two regions of intron retention within the sequence which cause it to shift frame.; Evidence={ECO:0000305}; Sequence=CAD66586.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PLEKHG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLEKHG3 Gene

Proteomics data for PLEKHG3 Gene at MOPED

Post-translational modifications for PLEKHG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLEKHG3 Gene

No data available for DME Specific Peptides for PLEKHG3 Gene

Domains & Families for PLEKHG3 Gene

Protein Domains for PLEKHG3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLEKHG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1L390

UniProtKB/Swiss-Prot:

PKHG3_HUMAN :
  • Contains 1 DH (DBL-homology) domain.
Domain:
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with PLEKHG3: view

Function for PLEKHG3 Gene

Gene Ontology (GO) - Molecular Function for PLEKHG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with PLEKHG3: view
genes like me logo Genes that share phenotypes with PLEKHG3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLEKHG3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PLEKHG3 Gene

Localization for PLEKHG3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PLEKHG3 Gene

Pathways & Interactions for PLEKHG3 Gene

SuperPathways for PLEKHG3 Gene

No Data Available

Interacting Proteins for PLEKHG3 Gene

Gene Ontology (GO) - Biological Process for PLEKHG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with PLEKHG3: view

No data available for Pathways by source and SIGNOR curated interactions for PLEKHG3 Gene

Drugs & Compounds for PLEKHG3 Gene

No Compound Related Data Available

Transcripts for PLEKHG3 Gene

Unigene Clusters for PLEKHG3 Gene

Pleckstrin homology domain containing, family G (with RhoGef domain) member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLEKHG3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHG3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^
SP1: -
SP2: - - - - - -
SP3: -
SP4:
SP5:
SP6:
SP7: - - - - -
SP8:
SP9:
SP10: -

ExUns: 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PLEKHG3 Gene

GeneLoc Exon Structure for
PLEKHG3
ECgene alternative splicing isoforms for
PLEKHG3

Expression for PLEKHG3 Gene

mRNA expression in normal human tissues for PLEKHG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLEKHG3 Gene

This gene is overexpressed in Placenta (22.9), Pancreas (15.5), Islet of Langerhans (13.5), and CD8 Tcells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLEKHG3 Gene



SOURCE GeneReport for Unigene cluster for PLEKHG3 Gene Hs.509637

genes like me logo Genes that share expression patterns with PLEKHG3: view

Protein tissue co-expression partners for PLEKHG3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PLEKHG3 Gene

Orthologs for PLEKHG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLEKHG3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLEKHG3 35
  • 81.84 (n)
  • 76.02 (a)
PLEKHG3 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLEKHG3 35
  • 84.59 (n)
  • 83.55 (a)
PLEKHG3 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plekhg3 35
  • 81.65 (n)
  • 79.63 (a)
Plekhg3 16
Plekhg3 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLEKHG3 35
  • 92.97 (n)
  • 90.63 (a)
PLEKHG3 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plekhg3 35
  • 81.73 (n)
  • 79.3 (a)
oppossum
(Monodelphis domestica)
Mammalia PLEKHG3 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves PLEKHG3 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLEKHG3 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497371 35
  • 58.32 (n)
  • 53.07 (a)
Str.10469 35
zebrafish
(Danio rerio)
Actinopterygii LOC101886323 35
  • 53.98 (n)
  • 49.29 (a)
PLEKHG3 (1 of 2) 36
  • 38 (a)
OneToMany
PLEKHG3 (2 of 2) 36
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta GEFmeso 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea uig-1 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for PLEKHG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLEKHG3 Gene

ENSEMBL:
Gene Tree for PLEKHG3 (if available)
TreeFam:
Gene Tree for PLEKHG3 (if available)

Paralogs for PLEKHG3 Gene

(3) SIMAP similar genes for PLEKHG3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PLEKHG3 Gene

genes like me logo Genes that share paralogs with PLEKHG3: view

Variants for PLEKHG3 Gene

Sequence variations from dbSNP and Humsavar for PLEKHG3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs106111 -- 64,723,721(+) GTCTC(A/G)AACTC intron-variant
rs170683 -- 64,735,512(-) ccacc(C/T)cagcc intron-variant
rs170685 -- 64,737,649(+) GTAGA(C/G)AAGTA intron-variant
rs229620 -- 64,734,760(-) CTGGG(C/T)GACAG intron-variant
rs229621 -- 64,734,103(-) CTTCT(A/C)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLEKHG3 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV Deletion 23290073
nsv1309 CNV Insertion 18451855
dgv1944n71 CNV Loss 21882294

Variation tolerance for PLEKHG3 Gene

Residual Variation Intolerance Score: 98.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLEKHG3 Gene

HapMap Linkage Disequilibrium report
PLEKHG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHG3 Gene

Disorders for PLEKHG3 Gene

Relevant External Links for PLEKHG3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLEKHG3
genes like me logo Genes that share disorders with PLEKHG3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLEKHG3 Gene

Publications for PLEKHG3 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  2. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 67
  3. A de novo 1.5a88Mb microdeletion on chromosome 14q23.2-23.3 in a patient with autism and spherocytosis. (PMID: 21360829) Griswold A.J. … Pericak-Vance M.A. (Autism Res 2011) 67
  4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 67
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 67

Products for PLEKHG3 Gene

Sources for PLEKHG3 Gene

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