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Aliases for PLEKHG3 Gene

Aliases for PLEKHG3 Gene

  • Pleckstrin Homology And RhoGEF Domain Containing G3 2 3 5
  • KIAA0599 2 3 4
  • Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 3 2 3
  • PH Domain-Containing Family G Member 3 3 4
  • Pleckstrin Homology Domain Containing, Family G, Member 3 3
  • Pleckstrin Homology Domain-Containing Family G Member 3 3
  • ARHGEF43 3

External Ids for PLEKHG3 Gene

Previous HGNC Symbols for PLEKHG3 Gene

  • KIAA0599

Previous GeneCards Identifiers for PLEKHG3 Gene

  • GC14P064240
  • GC14P065172
  • GC14P045343

Summaries for PLEKHG3 Gene

GeneCards Summary for PLEKHG3 Gene

PLEKHG3 (Pleckstrin Homology And RhoGEF Domain Containing G3) is a Protein Coding gene. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is PLEKHG1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHG3 Gene

Genomics for PLEKHG3 Gene

Regulatory Elements for PLEKHG3 Gene

Enhancers for PLEKHG3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F064700 1.7 FANTOM5 Ensembl ENCODE 30.4 +1.9 1929 10.4 HDGF PKNOX1 ARID4B SIN3A YY1 CBX5 ZNF143 ZNF207 FOS ZNF263 PLEKHG3 MAX ENSG00000272158 PPP1R36 GPX2 CHURC1 SYNE2 MTHFD1 ZBTB1 LOC102723809
GH14F064714 1.4 FANTOM5 ENCODE 18.7 +17.1 17059 14.0 PKNOX1 ZFP64 ETS1 YY1 GLIS2 FOS ZNF263 ZHX2 TSHZ1 KAT8 PLEKHG3 ZBTB1 PPP1R36 MAX ZBTB25 CHURC1 PIR60020 GC14P064746
GH14F064671 1.4 FANTOM5 Ensembl ENCODE 17.7 -30.0 -30002 5.0 CTCF KLF1 PKNOX1 MAX BMI1 EBF1 RAD21 RELA GTF3C2 ZNF335 PLEKHG3 ZBTB1 MAX LOC102723809 LOC100506321 CHURC1 SYNE2 PPP1R36 LOC105370533
GH14F064754 1.4 FANTOM5 ENCODE 13.1 +53.6 53598 5.5 PKNOX1 ATF1 CREB3L1 SIN3A ZNF48 GLIS2 ZNF143 FOS ZNF263 SP5 LOC100506321 LOC102723809 CHURC1 PLEKHG3 PPP1R36 CHURC1-FNTB RPPH1-2P GPX2 SPTB ZBTB1
GH14F064745 0.8 Ensembl ENCODE 20.8 +42.1 42128 2.2 FOSL1 CTCF ATF3 BHLHE40 ZNF175 ZNF600 RAD21 PLEKHG3 PPP1R36 GPX2 HSPA2 GC14P064746 PIR60020 PIR49393
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLEKHG3 on UCSC Golden Path with GeneCards custom track

Promoters for PLEKHG3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000419350 498 2801 PKNOX1 ARID4B SIN3A ZNF48 ETS1 GLIS2 CBX5 ZNF263 SP3 SP5

Genomic Location for PLEKHG3 Gene

Chromosome:
14
Start:
64,704,102 bp from pter
End:
64,750,247 bp from pter
Size:
46,146 bases
Orientation:
Plus strand

Genomic View for PLEKHG3 Gene

Genes around PLEKHG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLEKHG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLEKHG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHG3 Gene

Proteins for PLEKHG3 Gene

  • Protein details for PLEKHG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L390-PKHG3_HUMAN
    Recommended name:
    Pleckstrin homology domain-containing family G member 3
    Protein Accession:
    A1L390
    Secondary Accessions:
    • A1L389
    • B5MEC9
    • O60339
    • Q6GMS3
    • Q6P4B1
    • Q7L3S3
    • Q86SW7
    • Q8TEF5
    • Q96EW6
    • Q9BT82

    Protein attributes for PLEKHG3 Gene

    Size:
    1219 amino acids
    Molecular mass:
    134412 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84995.1; Type=Miscellaneous discrepancy; Note=Intron retention. There are two regions of intron retention within the sequence which cause it to shift frame.; Evidence={ECO:0000305}; Sequence=CAD66586.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PLEKHG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLEKHG3 Gene

Post-translational modifications for PLEKHG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLEKHG3 Gene

Domains & Families for PLEKHG3 Gene

Protein Domains for PLEKHG3 Gene

Suggested Antigen Peptide Sequences for PLEKHG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1L390

UniProtKB/Swiss-Prot:

PKHG3_HUMAN :
  • Contains 1 DH (DBL-homology) domain.
Domain:
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with PLEKHG3: view

Function for PLEKHG3 Gene

Gene Ontology (GO) - Molecular Function for PLEKHG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with PLEKHG3: view
genes like me logo Genes that share phenotypes with PLEKHG3: view

Animal Models for PLEKHG3 Gene

MGI Knock Outs for PLEKHG3:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLEKHG3 Gene

Localization for PLEKHG3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLEKHG3 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLEKHG3 Gene

Pathways & Interactions for PLEKHG3 Gene

SuperPathways for PLEKHG3 Gene

No Data Available

Interacting Proteins for PLEKHG3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000247226%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000318089%0d%0a9606.ENSP00000200457%0d%0a9606.ENSP00000200457%0d%0a9606.ENSP00000431284%0d%0a
Selected Interacting proteins: ENSP00000247226 A1L390-PKHG3_HUMAN for PLEKHG3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for PLEKHG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with PLEKHG3: view

No data available for Pathways by source and SIGNOR curated interactions for PLEKHG3 Gene

Transcripts for PLEKHG3 Gene

Unigene Clusters for PLEKHG3 Gene

Pleckstrin homology domain containing, family G (with RhoGef domain) member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHG3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^
SP1: -
SP2: - - - - - -
SP3: -
SP4:
SP5:
SP6:
SP7: - - - - -
SP8:
SP9:
SP10: -

ExUns: 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PLEKHG3 Gene

GeneLoc Exon Structure for
PLEKHG3
ECgene alternative splicing isoforms for
PLEKHG3

Expression for PLEKHG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLEKHG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLEKHG3 Gene

This gene is overexpressed in Placenta (22.9), Pancreas (15.5), Islet of Langerhans (13.5), and CD8 Tcells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLEKHG3 Gene



Protein tissue co-expression partners for PLEKHG3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLEKHG3 Gene:

PLEKHG3

SOURCE GeneReport for Unigene cluster for PLEKHG3 Gene:

Hs.509637
genes like me logo Genes that share expression patterns with PLEKHG3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PLEKHG3 Gene

Orthologs for PLEKHG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLEKHG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLEKHG3 34 35
  • 92.97 (n)
dog
(Canis familiaris)
Mammalia PLEKHG3 34 35
  • 84.59 (n)
cow
(Bos Taurus)
Mammalia PLEKHG3 34 35
  • 81.84 (n)
rat
(Rattus norvegicus)
Mammalia Plekhg3 34
  • 81.73 (n)
mouse
(Mus musculus)
Mammalia Plekhg3 34 16 35
  • 81.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 78 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia PLEKHG3 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLEKHG3 35
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLEKHG3 35
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497371 34
  • 58.32 (n)
Str.10469 34
zebrafish
(Danio rerio)
Actinopterygii PLEKHG3 (2 of 2) 35
  • 64 (a)
OneToMany
LOC101886323 34
  • 53.98 (n)
PLEKHG3 (1 of 2) 35
  • 38 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta GEFmeso 35
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea uig-1 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for PLEKHG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLEKHG3 Gene

ENSEMBL:
Gene Tree for PLEKHG3 (if available)
TreeFam:
Gene Tree for PLEKHG3 (if available)

Paralogs for PLEKHG3 Gene

(3) SIMAP similar genes for PLEKHG3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PLEKHG3 Gene

genes like me logo Genes that share paralogs with PLEKHG3: view

Variants for PLEKHG3 Gene

Sequence variations from dbSNP and Humsavar for PLEKHG3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10135368 -- 64,728,495(+) gtggc(C/T)taaaa intron-variant
rs10135575 -- 64,737,910(+) CCCGT(A/C)CTCGG intron-variant, reference, missense
rs10138034 -- 64,710,484(+) GGCCA(A/G)CATGG intron-variant
rs10138311 -- 64,710,499(+) acccc(A/G)tctct intron-variant
rs10147271 -- 64,716,466(+) cacac(A/C)acaca intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLEKHG3 Gene

Variant ID Type Subtype PubMed ID
nsv952853 CNV deletion 24416366
nsv1309 CNV insertion 18451855
nsv1049097 CNV gain 25217958
nsv1035833 CNV gain 25217958
esv2748779 CNV deletion 23290073

Variation tolerance for PLEKHG3 Gene

Residual Variation Intolerance Score: 98.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLEKHG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLEKHG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHG3 Gene

Disorders for PLEKHG3 Gene

Relevant External Links for PLEKHG3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLEKHG3

No disorders were found for PLEKHG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLEKHG3 Gene

Publications for PLEKHG3 Gene

  1. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  2. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3 64
  3. Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. (PMID: 24129315) Guo A. … Comb M.J. (Mol. Cell. Proteomics 2014) 4 64
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for PLEKHG3 Gene

Sources for PLEKHG3 Gene

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