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Aliases for PLEKHG2 Gene

Aliases for PLEKHG2 Gene

  • Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 2 2 3
  • PH Domain-Containing Family G Member 2 3 4
  • CLG 3 6
  • Common-Site Lymphoma/Leukemia Guanine Nucleotide Exchange Factor 3
  • Pleckstrin Homology Domain-Containing Family G Member 2 3
  • CTB-60E11.4 3
  • ARHGEF42 3

External Ids for PLEKHG2 Gene

Summaries for PLEKHG2 Gene

GeneCards Summary for PLEKHG2 Gene

PLEKHG2 (Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 2) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF7.

UniProtKB/Swiss-Prot for PLEKHG2 Gene

  • May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHG2 Gene

Genomics for PLEKHG2 Gene

Genomic Location for PLEKHG2 Gene

Start:
39,412,582 bp from pter
End:
39,428,415 bp from pter
Size:
15,834 bases
Orientation:
Plus strand

Genomic View for PLEKHG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLEKHG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHG2 Gene

Regulatory Elements for PLEKHG2 Gene

Proteins for PLEKHG2 Gene

  • Protein details for PLEKHG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7P9-PKHG2_HUMAN
    Recommended name:
    Pleckstrin homology domain-containing family G member 2
    Protein Accession:
    Q9H7P9
    Secondary Accessions:
    • B8ZZK6
    • C9J0Y4
    • Q6DHV6
    • Q96BU2
    • Q96D18
    • Q9H699

    Protein attributes for PLEKHG2 Gene

    Size:
    1386 amino acids
    Molecular mass:
    147969 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15364.1; Type=Frameshift; Positions=84; Evidence={ECO:0000305}; Sequence=BAB15719.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PLEKHG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLEKHG2 Gene

Proteomics data for PLEKHG2 Gene at MOPED

Post-translational modifications for PLEKHG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLEKHG2 Gene

Domains for PLEKHG2 Gene

Gene Families for PLEKHG2 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • ARHGEF :Rho guanine nucleotide exchange factors

Protein Domains for PLEKHG2 Gene

UniProtKB/Swiss-Prot:

PKHG2_HUMAN
Domain:
  • Contains 1 DH (DBL-homology) domain.:
    • Q9H7P9
  • Contains 1 PH domain.:
    • Q9H7P9
genes like me logo Genes that share domains with PLEKHG2: view

Function for PLEKHG2 Gene

Molecular function for PLEKHG2 Gene

UniProtKB/Swiss-Prot Function: May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein).

Gene Ontology (GO) - Molecular Function for PLEKHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PLEKHG2: view
genes like me logo Genes that share phenotypes with PLEKHG2: view

miRNA for PLEKHG2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PLEKHG2 Gene

Localization for PLEKHG2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLEKHG2 Gene COMPARTMENTS Subcellular localization image for PLEKHG2 gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PLEKHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PLEKHG2: view

Pathways for PLEKHG2 Gene

genes like me logo Genes that share pathways with PLEKHG2: view

Interacting Proteins for PLEKHG2 Gene

Selected Interacting proteins: Q9H7P9-PKHG2_HUMAN for PLEKHG2 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for PLEKHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0035023 regulation of Rho protein signal transduction --
GO:0043065 positive regulation of apoptotic process TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0048011 neurotrophin TRK receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PLEKHG2: view

Transcripts for PLEKHG2 Gene

Unigene Clusters for PLEKHG2 Gene

Pleckstrin homology domain containing, family G (with RhoGef domain) member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHG2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2: -
SP3:
SP4: - - - -
SP5: - - - -
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for PLEKHG2 Gene

GeneLoc Exon Structure for
PLEKHG2
ECgene alternative splicing isoforms for
PLEKHG2

Expression for PLEKHG2 Gene

mRNA expression in normal human tissues for PLEKHG2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PLEKHG2 Gene

SOURCE GeneReport for Unigene cluster for PLEKHG2 Gene Hs.631574

genes like me logo Genes that share expressions with PLEKHG2: view

Orthologs for PLEKHG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLEKHG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLEKHG2 36
  • 99.04 (n)
  • 98.67 (a)
PLEKHG2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLEKHG2 36
  • 83.68 (n)
  • 80.22 (a)
PLEKHG2 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLEKHG2 36
  • 83.07 (n)
  • 80.77 (a)
PLEKHG2 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plekhg2 36
  • 77.44 (n)
  • 74.66 (a)
Plekhg2 16
Plekhg2 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLEKHG2 37
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plekhg2 36
  • 77.74 (n)
  • 75.84 (a)
lizard
(Anolis carolinensis)
Reptilia PLEKHG2 37
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii plekhg2 37
  • 17 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta GEFmeso 37
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea uig-1 37
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 27 (a)
OneToMany
Species with no ortholog for PLEKHG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLEKHG2 Gene

ENSEMBL:
Gene Tree for PLEKHG2 (if available)
TreeFam:
Gene Tree for PLEKHG2 (if available)

Paralogs for PLEKHG2 Gene

genes like me logo Genes that share paralogs with PLEKHG2: view

Variants for PLEKHG2 Gene

Sequence variations from dbSNP and Humsavar for PLEKHG2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs16746 -- 39,425,471(-) ATTCC(-/TCC)CTTCC cds-indel
rs31724 -- 39,419,387(+) agccc(A/G)ggagt intron-variant
rs31725 -- 39,423,668(+) GGGTA(C/T)GTGGT intron-variant
rs31726 - 39,424,108(-) GACTT(A/C/G/T)TATGC missense, reference
rs31727 -- 39,424,997(-) AGGCT(C/T)TGGCT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for PLEKHG2 Gene

Variant ID Type Subtype PubMed ID
nsv911679 CNV Loss 21882294
nsv911680 CNV Loss 21882294
dgv3860n71 CNV Loss 21882294
dgv3861n71 CNV Loss 21882294
nsv911685 CNV Loss 21882294
dgv3862n71 CNV Loss 21882294
dgv3863n71 CNV Loss 21882294
nsv523856 CNV Loss 19592680

Relevant External Links for PLEKHG2 Gene

HapMap Linkage Disequilibrium report
PLEKHG2

Disorders for PLEKHG2 Gene

Relevant External Links for PLEKHG2

Genetic Association Database (GAD)
PLEKHG2
Human Genome Epidemiology (HuGE) Navigator
PLEKHG2
genes like me logo Genes that share disorders with PLEKHG2: view

No data available for UniProtKB/Swiss-Prot for PLEKHG2 Gene

Publications for PLEKHG2 Gene

  1. Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42. (PMID: 18045877) Ueda H. … Asano T. (J. Biol. Chem. 2008) 2 3 4
  2. Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias. (PMID: 11839748) Himmel K.L. … Largaespada D.A. (J. Biol. Chem. 2002) 2 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M. … Kaibuchi K. (J. Hum. Genet. 2010) 3 49
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for PLEKHG2 Gene

Sources for PLEKHG2 Gene

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