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PLEKHG2 Gene

protein-coding   GIFtS: 55
GCID: GC19P039903

Pleckstrin Homology Domain Containing, Family G (With RhoGef...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain)
Member 21 2
     CTB-60E11.42
PH Domain-Containing Family G Member 22 3     Common-Site Lymphoma/Leukemia Guanine Nucleotide Exchange Factor2
CLG2 5     Pleckstrin Homology Domain-Containing Family G Member 22
ARHGEF422     

External Ids:    HGNC: 295151   Entrez Gene: 648572   Ensembl: ENSG000000909247   OMIM: 6118935   UniProtKB: Q9H7P93   

Export aliases for PLEKHG2 gene to outside databases

Previous GC identifers: GC19P044596 GC19P036350


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PLEKHG2 Gene:
PLEKHG2 (pleckstrin homology domain containing, family G (with RhoGef domain) member 2) is a protein-coding gene. Diseases associated with PLEKHG2 include spasticity, and leukemia. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF6.

UniProtKB/Swiss-Prot: PKHG2_HUMAN, Q9H7P9
Function: May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a
guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma
of the heterotrimeric guanine nucleotide-binding protein (G protein)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLEKHG2 gene promoter:
         c-Fos   Sox5   AP-1   p300   c-Ets-1   HEN1   c-Jun   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLEKHG2 promoter sequence
   Search Chromatin IP Primers for PLEKHG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLEKHG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

PLEKHG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLEKHG2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P039903:  view genomic region     (about GC identifiers)

Start:
39,903,225 bp from pter      End:
39,919,055 bp from pter
Size:
15,831 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PKHG2_HUMAN, Q9H7P9 (See protein sequence)
Recommended Name: Pleckstrin homology domain-containing family G member 2  
Size: 1386 amino acids; 147969 Da
Sequence caution: Sequence=BAB15364.1; Type=Frameshift; Positions=84; Sequence=BAB15719.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: B8ZZK6 C9J0Y4 Q6DHV6 Q96BU2 Q96D18 Q9H699
Alternative splicing: 3 isoforms:  Q9H7P9-1   Q9H7P9-2   Q9H7P9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PLEKHG2: NX_Q9H7P9

Explore proteomics data for PLEKHG2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PLEKHG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_073746.2  
    ENSEMBL proteins: 
     ENSP00000386733   ENSP00000473068   ENSP00000408857   ENSP00000397615   ENSP00000386492  
     ENSP00000412818   ENSP00000205135   ENSP00000468829   ENSP00000473251   ENSP00000473213  
     ENSP00000471460   ENSP00000470763   ENSP00000472989   ENSP00000392906   ENSP00000367812  
    Reactome Protein details: Q9H7P9

    PLEKHG2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for PLEKHG2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    3 InterPro protein domains:
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9H7P9

    ProtoNet protein and cluster: Q9H7P9

    2 Blocks protein domains:
    IPB000219 DH domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: PKHG2_HUMAN, Q9H7P9
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain


    PLEKHG2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PKHG2_HUMAN, Q9H7P9
    Function: May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a
    guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma
    of the heterotrimeric guanine nucleotide-binding protein (G protein)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
         
    PLEKHG2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PLEKHG2:
     G0/1 arrest  Increased G1 DNA content  Synthetic lethal with Ras  Upregulation of NF-kappaB path 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target PLEKHG2:
    hsa-mir-1 (MIRT002749), hsa-mir-197-3p (MIRT048117), hsa-mir-324-3p (MIRT042993), hsa-mir-744-5p (MIRT037583), hsa-mir-192-5p (MIRT026245)

    Block miRNA regulation of human, mouse, rat PLEKHG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLEKHG2 (see all 11):
    hsa-miR-495 hsa-miR-7-2* hsa-miR-378b hsa-miR-146a* hsa-miR-422a hsa-miR-10b* hsa-miR-2355-5p hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidPLEKHG2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PLEKHG2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHG2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    PLEKHG2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLEKHG2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    NRAGE signals death through JNK0.71
    Cell death signalling via NRAGE, NRIF and NADE0.74
    G alpha (12/13) signalling events0.44
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    4Signaling by FGFR
    Signalling by NGF0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for PLEKHG2
        G alpha (12/13) signalling events
    NRAGE signals death through JNK
    Rho GTPase cycle



    PLEKHG2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLEKHG2
    Interactions:

        Search GeneGlobe Interaction Network for PLEKHG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLEKHG2 (Q9H7P93 ENSP000003867334) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOAP615863, ENSP000004001754I2D: score=2 STRING: ENSP00000400175
    CDC42P609533, ENSP000003144584I2D: score=2 STRING: ENSP00000314458
    RAC1P630003, ENSP000003484614I2D: score=2 STRING: ENSP00000348461
    ARHGAP39ENSP000003665224STRING: ENSP00000366522
    ARHGEF1ENSP000003372614STRING: ENSP00000337261
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0035023regulation of Rho protein signal transduction ----
    GO:0043065positive regulation of apoptotic process TAS--
    GO:0048011neurotrophin TRK receptor signaling pathway TAS--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    PLEKHG2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PLEKHG2 (PKHG2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PLEKHG2 gene: 
    NM_022835.2  

    Unigene Cluster for PLEKHG2:

    Pleckstrin homology domain containing, family G (with RhoGef domain) member 2
    Hs.631574  [show with all ESTs]
    Unigene Representative Sequence: NM_022835
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409794(uc010xuy.2) ENST00000595920 ENST00000458508 ENST00000438123
    ENST00000409797(uc002olj.3) ENST00000451354 ENST00000205135 ENST00000478523
    ENST00000596443 ENST00000594307 ENST00000474449 ENST00000600210 ENST00000598238
    ENST00000594161 ENST00000596339 ENST00000594124 ENST00000425673(uc010xuz.2 uc010xva.2)
    ENST00000378550
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PLEKHG2 (see all 11):
    hsa-miR-495 hsa-miR-7-2* hsa-miR-378b hsa-miR-146a* hsa-miR-422a hsa-miR-10b* hsa-miR-2355-5p hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidPLEKHG2 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat PLEKHG2
      QuantiFast Probe-based Assays in human, mouse, rat PLEKHG2

    Additional mRNA sequence: 

    AK024429.1 AK026111.1 AK095957.1 AK302476.1 AL832850.1 BC013426.1 BC015174.1 BC075858.1 

    9 DOTS entries:

    DT.75102878  DT.92015630  DT.100812222  DT.100812221  DT.100036087  DT.100036088  DT.121445411  DT.97815546 
    DT.95331991 

    Selected AceView cDNA sequences (see all 172):

    BG830165 BQ006024 BX646380 BM701791 AI827787 BU634129 BQ689255 AA257988 
    BM917933 CA308778 BQ890594 BM473901 AA806884 CA422169 BQ642467 AW968326 
    BQ894005 BQ687283 AA470031 AL832850 BM836764 BU681308 CN482842 BM747887 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHG2 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                            -                                                               
    SP3:                                                                                                                                                            
    SP4:              -     -     -     -                                                                                                                           
    SP5:              -     -     -     -                                                                                                                           

    ExUns: 20 ^ 21 ^ 22
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for PLEKHG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLEKHG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATGATGTG
    PLEKHG2 Expression
    About this image

    PLEKHG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLEKHG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631574
        Custom PCR Arrays for PLEKHG2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PLEKHG2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plekhg21 , 5 pleckstrin homology domain containing, family G (with more1, 5 77.44(n)1
    74.66(a)1
      7 (16.71 cM)5
    1014971  NM_138752.21  NP_620091.21 
     283596045 
    lizard
    (Anolis carolinensis)
    Reptilia PLEKHG26
    pleckstrin homology domain containing, family G (w...
    63(a)
    1 ↔ 1
    GL344052.1(12456-67440)
    zebrafish
    (Danio rerio)
    Actinopterygii plekhg26
    pleckstrin homology domain containing, family G (w...
    17(a)
    1 ↔ 1
    15(19242947-19312278) ENSDARG00000058459
    fruit fly
    (Drosophila melanogaster)
    Insecta GEFmeso6
    Guanine nucleotide exchange factor in mesoderm
    15(a)
    1 → many
    2R(14441624-14499260)
    worm
    (Caenorhabditis elegans)
    Secernentea uig-16
    Protein UIG-1, isoform c
    22(a)
    1 → many
    V(13273177-13295913) WBGene00009337


    ENSEMBL Gene Tree for PLEKHG2 (if available)
    TreeFam Gene Tree for PLEKHG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLEKHG2 gene
    ARHGEF62  PLEKHG32  PREX22  ENSG000002731672  ARHGEF72  TIAM12  SPATA132  TIAM22  
    ARHGEF92  ARHGEF42  PLEKHG12  PREX12  
    2 SIMAP similar genes for PLEKHG2 using alignment to 12 protein entries:     PKHG2_HUMAN (see all proteins):
    PLEKHG3    PLEKHG1

    PLEKHG2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLEKHG2 (see all 557)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs356868581,2
    C,F,H--39902339(+) TGTTCA/GCTGCT 1 -- us2k120Minor allele frequency- G:0.39NS EA NA CSA WA 2344
    rs1846958191,2
    --39902468(+) TAGCTA/GTGTTC 1 -- us2k10--------
    rs1164315311,2
    F--39902522(+) GCAGAG/CTCATA 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1385034531,2
    --39902609(+) AGAGAC/TGATAC 1 -- us2k10--------
    rs1429475621,2
    --39902700(+) TCTTTC/TGAGCC 1 -- us2k10--------
    rs1433605271,2
    --39902721(+) AAAGAC/TAGAAA 1 -- us2k10--------
    rs1483198721,2
    C--39902763(+) GGTTGG/TTTTAT 1 -- us2k10--------
    rs114793661,2
    C,F--39902796(+) CTGATG/-GGGAA 1 -- us2k1 trp33Minor allele frequency- -:0.50NA CSA 6
    rs2021352861,2
    C--39902799(+) ATGGGA/GAAAAA 1 -- us2k10--------
    rs1414816901,2
    --39902825(+) GGATCA/GAACTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PLEKHG2 (39903225 - 39919055 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PLEKHG2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523856CNV Loss19592680
    nsv911685CNV Loss21882294
    nsv911680CNV Loss21882294
    dgv3862n71CNV Loss21882294
    nsv911679CNV Loss21882294
    dgv3863n71CNV Loss21882294
    dgv3860n71CNV Loss21882294
    dgv3861n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611893    OMIM disorders: --

    3 diseases for PLEKHG2:    About MalaCards
    spasticity    leukemia    myeloid leukemia


    PLEKHG2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PLEKHG2
    Human Genome Epidemiology (HuGE) Navigator: PLEKHG2 (1 document)

    Export disorders for PLEKHG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLEKHG2 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with PLEKHG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42. (PubMed id 18045877)1, 2, 3 Ueda H.... Asano T. (J. Biol. Chem. 2008)
    2. Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias. (PubMed id 11839748)1, 3, 9 Himmel K.L....Largaespada D.A. (J. Biol. Chem. 2002)
    3. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (J. Hum. Genet. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Identification of a Rho family specific guanine nucleotide exchange factor, FLJ00018, as a novel actin-binding protein. (PubMed id 23000341)1 Sato K....Ueda H. (Cell. Signal. 2013)
    6. PLEKHG2 promotes heterotrimeric G protein I^I^-stimulated lymphocyte migration via Rac and Cdc42 activation and actin polymerization. (PubMed id 24001768)1 Runne C. and Chen S. (Mol. Cell. Biol. 2013)
    7. The importance of interaction with membrane lipids through the pleckstrin homology domain of the guanine nucleotide exchange factor for rho family small guanosine triphosphatase, FLJ00018. (PubMed id 23811570)1 Kimura S....Ueda H. (amp 2013)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64857 HGNC: 29515 AceView: CLG Ensembl:ENSG00000090924 euGenes: HUgn64857
    ECgene: PLEKHG2 H-InvDB: PLEKHG2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PLEKHG2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PLEKHG2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLEKHG2 gene:
    Search GeneIP for patents involving PLEKHG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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