Aliases for PLEKHG2 Gene
External Ids for PLEKHG2 Gene
Previous GeneCards Identifiers for PLEKHG2 Gene
GeneCards Summary for PLEKHG2 Gene
PLEKHG2 (Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF7.
UniProtKB/Swiss-Prot for PLEKHG2 Gene
May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein).