Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLEKHG2 Gene

Aliases for PLEKHG2 Gene

  • Pleckstrin Homology And RhoGEF Domain Containing G2 2 3 5
  • Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 2 2 3
  • PH Domain-Containing Family G Member 2 3 4
  • Common-Site Lymphoma/Leukemia Guanine Nucleotide Exchange Factor 3
  • Pleckstrin Homology Domain-Containing Family G Member 2 3
  • CTB-60E11.4 3
  • ARHGEF42 3
  • LDAMD 3
  • CLG 3

External Ids for PLEKHG2 Gene

Previous GeneCards Identifiers for PLEKHG2 Gene

  • GC19P044596
  • GC19P039903
  • GC19P036350

Summaries for PLEKHG2 Gene

GeneCards Summary for PLEKHG2 Gene

PLEKHG2 (Pleckstrin Homology And RhoGEF Domain Containing G2) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and RET signaling. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is PLEKHG3.

UniProtKB/Swiss-Prot for PLEKHG2 Gene

  • May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHG2 Gene

Genomics for PLEKHG2 Gene

Regulatory Elements for PLEKHG2 Gene

Enhancers for PLEKHG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G039427 2.1 FANTOM5 Ensembl ENCODE dbSUPER 15.7 +19.6 19565 9.7 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 RPS16 ENSG00000205041 EID2B FBL ENSG00000269069 PLEKHG2 FBXO17 ZFP36 ACTN4 RN7SL566P
GH19G039552 1.2 FANTOM5 Ensembl ENCODE 22.9 +139.9 139909 0.6 SCRT2 IKZF1 SALL2 IKZF2 SPI1 PLEKHG2 MED29 EID2B ZFP36 DLL3 TIMM50 ENSG00000205041 EID2 RPS16 PAF1
GH19G039397 2 FANTOM5 ENCODE dbSUPER 8.8 -5.5 -5508 20.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ENSG00000205041 EID2B ZFP36 FBL RPS16 SUPT5H ENSG00000269069 RN7SL566P ENSG00000269688 MED29
GH19G039558 1.4 FANTOM5 Ensembl ENCODE 12.3 +146.0 145962 1.8 HDGF PKNOX1 FOXA2 ARID4B FEZF1 ZNF366 ZSCAN5C IKZF2 CREM ZNF362 PLEKHG2 EID2B CLC DLL3 LEUTX MED29 LGALS4 RPS16 PAF1 ZFP36
GH19G039351 1.2 ENCODE dbSUPER 11.1 -60.2 -60183 2.4 HDGF PKNOX1 FOXA2 ATF1 ARNT ZNF2 ZNF548 JUNB REST TSHZ1 RPS16 SUPT5H ZFP36 PLEKHG2 PAK4 IFNL1 EID2B SAMD4B GMFG GC19P039349
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLEKHG2 on UCSC Golden Path with GeneCards custom track

Promoters for PLEKHG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000288346 618 2801 MLX CREB3L1 AGO1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263

Genomic Location for PLEKHG2 Gene

Chromosome:
19
Start:
39,412,582 bp from pter
End:
39,428,415 bp from pter
Size:
15,834 bases
Orientation:
Plus strand

Genomic View for PLEKHG2 Gene

Genes around PLEKHG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLEKHG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLEKHG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHG2 Gene

Proteins for PLEKHG2 Gene

  • Protein details for PLEKHG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7P9-PKHG2_HUMAN
    Recommended name:
    Pleckstrin homology domain-containing family G member 2
    Protein Accession:
    Q9H7P9
    Secondary Accessions:
    • B8ZZK6
    • C9J0Y4
    • Q6DHV6
    • Q96BU2
    • Q96D18
    • Q9H699

    Protein attributes for PLEKHG2 Gene

    Size:
    1386 amino acids
    Molecular mass:
    147969 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15364.1; Type=Frameshift; Positions=84; Evidence={ECO:0000305}; Sequence=BAB15719.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PLEKHG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLEKHG2 Gene

Post-translational modifications for PLEKHG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLEKHG2 Gene

Domains & Families for PLEKHG2 Gene

Protein Domains for PLEKHG2 Gene

Suggested Antigen Peptide Sequences for PLEKHG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLEKHG2: view

No data available for UniProtKB/Swiss-Prot for PLEKHG2 Gene

Function for PLEKHG2 Gene

Molecular function for PLEKHG2 Gene

UniProtKB/Swiss-Prot Function:
May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein).

Gene Ontology (GO) - Molecular Function for PLEKHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA,TAS --
genes like me logo Genes that share ontologies with PLEKHG2: view
genes like me logo Genes that share phenotypes with PLEKHG2: view

Animal Model Products

CRISPR Products

miRNA for PLEKHG2 Gene

miRTarBase miRNAs that target PLEKHG2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLEKHG2 Gene

Localization for PLEKHG2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLEKHG2 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PLEKHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PLEKHG2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PLEKHG2 Gene

Pathways & Interactions for PLEKHG2 Gene

genes like me logo Genes that share pathways with PLEKHG2: view

Interacting Proteins for PLEKHG2 Gene

Gene Ontology (GO) - Biological Process for PLEKHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030833 regulation of actin filament polymerization IMP 26573021
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0043065 positive regulation of apoptotic process TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with PLEKHG2: view

No data available for SIGNOR curated interactions for PLEKHG2 Gene

Drugs & Compounds for PLEKHG2 Gene

No Compound Related Data Available

Transcripts for PLEKHG2 Gene

Unigene Clusters for PLEKHG2 Gene

Pleckstrin homology domain containing, family G (with RhoGef domain) member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHG2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2: -
SP3:
SP4: - - - -
SP5: - - - -
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for PLEKHG2 Gene

GeneLoc Exon Structure for
PLEKHG2
ECgene alternative splicing isoforms for
PLEKHG2

Expression for PLEKHG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLEKHG2 Gene

Protein differential expression in normal tissues from HIPED for PLEKHG2 Gene

This gene is overexpressed in Prostate (39.3) and Frontal cortex (17.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLEKHG2 Gene



NURSA nuclear receptor signaling pathways regulating expression of PLEKHG2 Gene:

PLEKHG2

SOURCE GeneReport for Unigene cluster for PLEKHG2 Gene:

Hs.631574

Evidence on tissue expression from TISSUES for PLEKHG2 Gene

  • Pancreas(4.6)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with PLEKHG2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLEKHG2 Gene

Orthologs for PLEKHG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLEKHG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLEKHG2 34 35
  • 99.04 (n)
cow
(Bos Taurus)
Mammalia PLEKHG2 34 35
  • 83.68 (n)
dog
(Canis familiaris)
Mammalia PLEKHG2 34 35
  • 83.07 (n)
rat
(Rattus norvegicus)
Mammalia Plekhg2 34
  • 77.74 (n)
mouse
(Mus musculus)
Mammalia Plekhg2 34 16 35
  • 77.44 (n)
oppossum
(Monodelphis domestica)
Mammalia PLEKHG2 35
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLEKHG2 35
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii plekhg2 35
  • 17 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta GEFmeso 35
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea uig-1 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
OneToMany
Species where no ortholog for PLEKHG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLEKHG2 Gene

ENSEMBL:
Gene Tree for PLEKHG2 (if available)
TreeFam:
Gene Tree for PLEKHG2 (if available)

Paralogs for PLEKHG2 Gene

genes like me logo Genes that share paralogs with PLEKHG2: view

Variants for PLEKHG2 Gene

Sequence variations from dbSNP and Humsavar for PLEKHG2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs373442104 Benign 39,425,206(+) CCGGT(C/T)GAACC reference, missense
rs863223387 Benign 39,418,970(+) CTCTT(A/C)TTTGA reference, missense
rs1000198214 -- 39,417,373(+) GTCTC(A/G)AACTC intron-variant
rs1000374028 -- 39,420,214(+) AATTA(C/T)CGGGT intron-variant
rs1000466550 -- 39,410,594(+) TACTC(-/CTT)CTCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLEKHG2 Gene

Variant ID Type Subtype PubMed ID
nsv523856 CNV loss 19592680

Variation tolerance for PLEKHG2 Gene

Residual Variation Intolerance Score: 98.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.80; 79.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLEKHG2 Gene

Human Gene Mutation Database (HGMD)
PLEKHG2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLEKHG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHG2 Gene

Disorders for PLEKHG2 Gene

Relevant External Links for PLEKHG2

Genetic Association Database (GAD)
PLEKHG2
Human Genome Epidemiology (HuGE) Navigator
PLEKHG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLEKHG2

No disorders were found for PLEKHG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLEKHG2 Gene

Publications for PLEKHG2 Gene

  1. Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42. (PMID: 18045877) Ueda H. … Asano T. (J. Biol. Chem. 2008) 2 3 4 64
  2. Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias. (PMID: 11839748) Himmel K.L. … Largaespada D.A. (J. Biol. Chem. 2002) 2 3 22 64
  3. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M. … Kaibuchi K. (J. Hum. Genet. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Autoantibodies binding to ubiquitin-fold modifier-conjugating enzyme 1 (Ufc1) and pleckstrin homology domain containing, family G (with RhoGef domain) member 2 (Plekhg2) are associated with mycobacterial infections. (PMID: 25213431) Tellermann A. … Baerlecken N.T. (HIV Med. 2015) 3 64

Products for PLEKHG2 Gene

Sources for PLEKHG2 Gene

Content
Loading form....