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Aliases for PLEKHG2 Gene

Aliases for PLEKHG2 Gene

  • Pleckstrin Homology And RhoGEF Domain Containing G2 2 3 5
  • Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 2 2 3
  • PH Domain-Containing Family G Member 2 3 4
  • Common-Site Lymphoma/Leukemia Guanine Nucleotide Exchange Factor 3
  • CTB-60E11.4 3
  • ARHGEF42 3
  • LDAMD 3
  • CLG 3

External Ids for PLEKHG2 Gene

Previous GeneCards Identifiers for PLEKHG2 Gene

  • GC19P044596
  • GC19P039903
  • GC19P036350

Summaries for PLEKHG2 Gene

GeneCards Summary for PLEKHG2 Gene

PLEKHG2 (Pleckstrin Homology And RhoGEF Domain Containing G2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF7.

UniProtKB/Swiss-Prot for PLEKHG2 Gene

  • May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHG2 Gene

Genomics for PLEKHG2 Gene

Regulatory Elements for PLEKHG2 Gene

Genomic Location for PLEKHG2 Gene

Chromosome:
19
Start:
39,412,582 bp from pter
End:
39,428,415 bp from pter
Size:
15,834 bases
Orientation:
Plus strand

Genomic View for PLEKHG2 Gene

Genes around PLEKHG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLEKHG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLEKHG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHG2 Gene

Proteins for PLEKHG2 Gene

  • Protein details for PLEKHG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7P9-PKHG2_HUMAN
    Recommended name:
    Pleckstrin homology domain-containing family G member 2
    Protein Accession:
    Q9H7P9
    Secondary Accessions:
    • B8ZZK6
    • C9J0Y4
    • Q6DHV6
    • Q96BU2
    • Q96D18
    • Q9H699

    Protein attributes for PLEKHG2 Gene

    Size:
    1386 amino acids
    Molecular mass:
    147969 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15364.1; Type=Frameshift; Positions=84; Evidence={ECO:0000305}; Sequence=BAB15719.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PLEKHG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLEKHG2 Gene

Proteomics data for PLEKHG2 Gene at MOPED

Post-translational modifications for PLEKHG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for PLEKHG2 Gene

Domains & Families for PLEKHG2 Gene

Protein Domains for PLEKHG2 Gene

Suggested Antigen Peptide Sequences for PLEKHG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7P9

UniProtKB/Swiss-Prot:

PKHG2_HUMAN :
  • Contains 1 DH (DBL-homology) domain.
Domain:
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with PLEKHG2: view

Function for PLEKHG2 Gene

Molecular function for PLEKHG2 Gene

UniProtKB/Swiss-Prot Function:
May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein).
genes like me logo Genes that share phenotypes with PLEKHG2: view

Animal Model Products

CRISPR Products

miRNA for PLEKHG2 Gene

miRTarBase miRNAs that target PLEKHG2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLEKHG2 Gene

Localization for PLEKHG2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLEKHG2 Gene COMPARTMENTS Subcellular localization image for PLEKHG2 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLEKHG2 Gene

Pathways & Interactions for PLEKHG2 Gene

genes like me logo Genes that share pathways with PLEKHG2: view

Interacting Proteins for PLEKHG2 Gene

Selected Interacting proteins: Q9H7P9-PKHG2_HUMAN for PLEKHG2 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for PLEKHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
GO:0097190 apoptotic signaling pathway TAS --
genes like me logo Genes that share ontologies with PLEKHG2: view

No data available for SIGNOR curated interactions for PLEKHG2 Gene

Drugs & Compounds for PLEKHG2 Gene

No Compound Related Data Available

Transcripts for PLEKHG2 Gene

Unigene Clusters for PLEKHG2 Gene

Pleckstrin homology domain containing, family G (with RhoGef domain) member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHG2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2: -
SP3:
SP4: - - - -
SP5: - - - -
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for PLEKHG2 Gene

GeneLoc Exon Structure for
PLEKHG2
ECgene alternative splicing isoforms for
PLEKHG2

Expression for PLEKHG2 Gene

mRNA expression in normal human tissues for PLEKHG2 Gene

Protein differential expression in normal tissues from HIPED for PLEKHG2 Gene

This gene is overexpressed in Prostate (39.3) and Frontal cortex (17.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PLEKHG2 Gene



SOURCE GeneReport for Unigene cluster for PLEKHG2 Gene Hs.631574

genes like me logo Genes that share expression patterns with PLEKHG2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PLEKHG2 Gene

Orthologs for PLEKHG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLEKHG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLEKHG2 35
  • 99.04 (n)
  • 98.67 (a)
PLEKHG2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLEKHG2 36
  • 80 (a)
OneToOne
PLEKHG2 35
  • 83.68 (n)
  • 80.22 (a)
dog
(Canis familiaris)
Mammalia PLEKHG2 35
  • 83.07 (n)
  • 80.77 (a)
PLEKHG2 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plekhg2 16
Plekhg2 36
  • 74 (a)
OneToOne
Plekhg2 35
  • 77.44 (n)
  • 74.66 (a)
oppossum
(Monodelphis domestica)
Mammalia PLEKHG2 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plekhg2 35
  • 77.74 (n)
  • 75.84 (a)
lizard
(Anolis carolinensis)
Reptilia PLEKHG2 36
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii plekhg2 36
  • 17 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta GEFmeso 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea uig-1 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for PLEKHG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLEKHG2 Gene

ENSEMBL:
Gene Tree for PLEKHG2 (if available)
TreeFam:
Gene Tree for PLEKHG2 (if available)

Paralogs for PLEKHG2 Gene

genes like me logo Genes that share paralogs with PLEKHG2: view

Variants for PLEKHG2 Gene

Sequence variations from dbSNP and Humsavar for PLEKHG2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs35904695 - 39,422,230(+) TGGGA(C/T)CTCAA reference, missense
rs16973407 - 39,422,918(+) GTTCC(A/G)TTGCA reference, missense
rs10407035 - 39,422,994(+) CAGCC(A/C/G/T)CTGTG reference, missense
rs31726 - 39,424,108(-) GACTT(A/C/G/T)TATGC reference, missense
rs34603507 - 39,425,037(+) CCCCC(A/G)CAGCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PLEKHG2 Gene

Variant ID Type Subtype PubMed ID
nsv911679 CNV Loss 21882294
nsv911680 CNV Loss 21882294
dgv3860n71 CNV Loss 21882294
dgv3861n71 CNV Loss 21882294
nsv911685 CNV Loss 21882294
dgv3862n71 CNV Loss 21882294
dgv3863n71 CNV Loss 21882294
nsv523856 CNV Loss 19592680

Variation tolerance for PLEKHG2 Gene

Residual Variation Intolerance Score: 98.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.80; 79.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLEKHG2 Gene

HapMap Linkage Disequilibrium report
PLEKHG2
Human Gene Mutation Database (HGMD)
PLEKHG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHG2 Gene

Disorders for PLEKHG2 Gene

Relevant External Links for PLEKHG2

Genetic Association Database (GAD)
PLEKHG2
Human Genome Epidemiology (HuGE) Navigator
PLEKHG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLEKHG2

No disorders were found for PLEKHG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLEKHG2 Gene

Publications for PLEKHG2 Gene

  1. Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42. (PMID: 18045877) Ueda H. … Asano T. (J. Biol. Chem. 2008) 2 3 4 67
  2. Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias. (PMID: 11839748) Himmel K.L. … Largaespada D.A. (J. Biol. Chem. 2002) 2 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Autoantibodies binding to ubiquitin-fold modifier-conjugating enzyme 1 (Ufc1) and pleckstrin homology domain containing, family G (with RhoGef domain) member 2 (Plekhg2) are associated with mycobacterial infections. (PMID: 25213431) Tellermann A. … Baerlecken N.T. (HIV Med. 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for PLEKHG2 Gene

Sources for PLEKHG2 Gene

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