Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PLEKHG1 Gene

protein-coding GIFtS: 49
GCID: GC06P150920

Pleckstrin Homology Domain Containing, Family G (With RhoGef...

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 1¹ ²
ARHGEF41²
Pleckstrin Homology Domain-Containing Family G Member 1²
KIAA1209³

External Ids:	HGNC: 20884¹	Entrez Gene: 57480²	Ensembl: ENSG00000120278⁷	UniProtKB: Q9ULL1³

Export aliases for PLEKHG1 gene to outside databases

Previous GC identifers: GC06P150997 GC06P151073 GC06P151013 GC06P148515

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PLEKHG1 Gene:

PLEKHG1 (pleckstrin homology domain containing, family G (with RhoGef domain) member 1) is a protein-coding gene. Diseases associated with PLEKHG1 include panic disorder, and alcoholism. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF6.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NT_025741.15 NC_018917.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PLEKHG1 gene promoter:
MEF-2A AML1a p53 MEF-2 aMEF-2 E47 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PLEKHG1 promoter sequence

Search SABiosciences Chromatin IP Primers for PLEKHG1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLEKHG1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.1 Ensembl cytogenetic band: 6q25.1 HGNC cytogenetic band: 6q25.1

PLEKHG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLEKHG1 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P150920: view genomic region (about GC identifiers)

Start:	150,920,999 bp from pter	End:	151,164,799 bp from pter
Size:	243,801 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PKHG1_HUMAN, Q9ULL1 (See protein sequence)

Recommended Name: Pleckstrin homology domain-containing family G member 1

Size: 1385 amino acids; 155439 Da

Secondary accessions: Q5T1F2

Explore the universe of human proteins at neXtProt for PLEKHG1: NX_Q9ULL1

Explore proteomics data for PLEKHG1 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9ULL1

PLEKHG1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_001025055.1

ENSEMBL proteins:

ENSP00000356295 ENSP00000351318 ENSP00000433107 ENSP00000356297

Human Recombinant Protein Products for PLEKHG1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom MassSpec OriGene Custom Protein Services for PLEKHG1
	GenScript Custom Purified and Recombinant Proteins Services for PLEKHG1
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for PLEKHG1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--

PLEKHG1 for ontologies About GeneDecksing

PLEKHG1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for PLEKHG1
	GenScript Custom Superior Antibodies Services for PLEKHG1
	Novus Biologicals PLEKHG1 Antibodies
	Abcam antibodies for PLEKHG1
	Cloud-Clone Corp. Antibodies for PLEKHG1
	ThermoFisher Antibodies for PLEKHG1
	LSBio Antibodies in human, mouse, rat for PLEKHG1

Assay Products for PLEKHG1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for PLEKHG1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PLEKHG1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for PLEKHG1 Cloud-Clone Corp. CLIAs for PLEKHG1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

PLEKH: Pleckstrin homology (PH) domain containing

ARHGEF: Rho guanine nucleotide exchange factors

3 InterPro protein domains:

IPR000219 DH-domain

IPR001849 Pleckstrin_homology

IPR011993 PH_like_dom

Graphical View of Domain Structure for InterPro Entry Q9ULL1

ProtoNet protein and cluster: Q9ULL1

2 Blocks protein domains:

IPB000219 DH domain

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: PKHG1_HUMAN, Q9ULL1

Similarity: Contains 1 DH (DBL-homology) domain

Similarity: Contains 1 PH domain

PLEKHG1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA	--
GO:0005515	protein binding	--	--
GO:0005543	phospholipid binding	IEA	--

PLEKHG1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for PLEKHG1:

Decreased viability with pacli

Increased gamma-H2AX phosphory

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Plekhg1):

hematopoietic system

immune system

PLEKHG1 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for PLEKHG1

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PLEKHG1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLEKHG1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLEKHG1

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLEKHG1
		8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate PLEKHG1 (see all 27):
		hsa-miR-676 hsa-miR-4307 hsa-miR-520d-5p hsa-miR-1224-3p hsa-miR-106a hsa-miR-16-1* hsa-miR-218 hsa-miR-373*

		SwitchGear 3'UTR luciferase reporter plasmid: PLEKHG1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for PLEKHG1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLEKHG1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PLEKHG1
			Sirion Biotech Customized adenovirus for overexpression of PLEKHG1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for PLEKHG1 (see all 6) OriGene ORF clones in mouse, rat for PLEKHG1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PLEKHG1 (NM_001029884)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLEKHG1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLEKHG1
		Sirion Biotech Customized lentivirus for stable overexpression of PLEKHG1 Customized lentivirus expression plasmids for stable overexpression of PLEKHG1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PLEKHG1
		Search LifeMap BioReagents cell lines for PLEKHG1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHG1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PLEKHG1

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0035023	regulation of Rho protein signal transduction	IEA	--

PLEKHG1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PLEKHG1 (PKHG1)

Search CenterWatch for drugs/clinical trials and news about PLEKHG1 / PKHG1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PLEKHG1 gene:

NM_001029884.1

Unigene Cluster for PLEKHG1:

Pleckstrin homology domain containing, family G (with RhoGef domain) member 1

Hs.189781 [show with all ESTs]

Unigene Representative Sequence: NM_001029884

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367326 ENST00000358517(uc011eem.1 uc003qnz.2) ENST00000475490

ENST00000367328(uc011eel.1 uc003qny.1)

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLEKHG1
		8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate PLEKHG1 (see all 27):
		hsa-miR-676 hsa-miR-4307 hsa-miR-520d-5p hsa-miR-1224-3p hsa-miR-106a hsa-miR-16-1* hsa-miR-218 hsa-miR-373*

		SwitchGear 3'UTR luciferase reporter plasmid: PLEKHG1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for PLEKHG1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLEKHG1

Clone Products:		OriGene clones in human, mouse for PLEKHG1 (see all 6) OriGene ORF clones in mouse, rat for PLEKHG1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PLEKHG1 (NM_001029884)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLEKHG1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLEKHG1
		Sirion Biotech Customized lentivirus for stable overexpression of PLEKHG1 Customized lentivirus expression plasmids for stable overexpression of PLEKHG1

Primer Products:		Browse OriGene qPCR
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PLEKHG1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLEKHG1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLEKHG1

Additional mRNA sequence:

AB033035.1 AJ420468.1 AK056300.1 AK293288.1 AK294798.1 AK307631.1 BC089428.1 BC140864.1

BC151134.1

3 DOTS entries:

DT.208151 DT.75163224 DT.97762352

24/88 AceView cDNA sequences (see all 88):

AA361039 AB033035 AA719089 AI148832 AA737629 R02147 AI003646 CA438343

AA719072 BQ004504 CR606130 AA404653 N70181 AL545703 BU607617 AW628704

AA829505 BM747026 AI268119 AA317045 AA436308 BX114805 AI400610 AJ420468

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PLEKHG1 expression in normal human tissues (normalized intensities) PLEKHG1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTTGTATTTT

About this image

PLEKHG1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/6 selected tissues (see all 6) fully expand


Brain (Nervous System) fully expand to see all 15 entries
Thalamus
Septum

Blood (Hematopoietic System) fully expand to see all 3 entries
Small Pre B-Cells Hematopoietic Bone Marrow

Spinal Cord (Nervous System) fully expand to see all 2 entries
Dorsal Horn

Thymus (Hematopoietic System)
Double Positive Thymocytes Thymus

Pancreas (Endocrine System)
Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

See PLEKHG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLEKHG1

SOURCE GeneReport for Unigene cluster: Hs.189781

SABiosciences Custom PCR Arrays for PLEKHG1

Primer Products:		Browse OriGene qPCR
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PLEKHG1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLEKHG1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLEKHG1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHG1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PLEKHG1 gene from 7/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Plekhg1^{1 , 5}	pleckstrin homology domain containing, family G (with more^{1, 5}	80.77(n)¹ 79.58(a)¹		10 (2.06 cM)⁵ 213783¹ NM_001033253.3¹ NP_001028425.1¹ 3740364⁵
chicken (Gallus gallus)	Aves	PLEKHG1¹	pleckstrin homology domain containing, family G (with more	68.27(n) 68.15(a)		421632 XM_419671.3 XP_419671.3
lizard (Anolis carolinensis)	Reptilia	PLEKHG1⁶	Uncharacterized protein	63(a)	1 ↔ 1	GL343259.1(638809-780461)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.4007²	Transcribed sequence with weak similarity to protein more	77.67(n)		137718971
zebrafish (Danio rerio)	Actinopterygii	LOC556727¹	pleckstrin homology domain-containing family G member more	47.43(n) 38.9(a)		556727 XM_679600.5 XP_684692.5
fruit fly (Drosophila melanogaster)	Insecta	GEFmeso⁶	Guanine nucleotide exchange factor in mesoderm	14(a)	1 → many	2R(14441624-14499260)
worm (Caenorhabditis elegans)	Secernentea	uig-1⁶	Protein UIG-1, isoform d	18(a)	1 → many	V(13273567-13295913)

ENSEMBL Gene Tree for PLEKHG1 (if available)
TreeFam Gene Tree for PLEKHG1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PLEKHG1 gene

ARHGEF6² VAV1² PLEKHG2² PLEKHG3² PREX2² ARHGEF7² TIAM1² SPATA13²

TIAM2² ARHGEF9² VAV3² VAV2² ARHGEF4² PREX1²

2 SIMAP similar genes for PLEKHG1 using alignment to 5 protein entries: PKHG1_HUMAN (see all proteins):

PLEKHG3 PLEKHG2

PLEKHG1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147082988^1,2		--	150919177(+)	`AAGTTC/TGAGGC`	1	--	us2k¹		0	--	--	--	--
rs183779338^1,2		--	150919205(+)	`CGTGAA/CCCCGG`	1	--	us2k¹		0	--	--	--	--
rs143449604^1,2	C	--	150919217(+)	`TCTAC-/AAAAAA`	1	--	us2k¹		0	--	--	--	--
rs9478763^1,2		--	150919326(+)	`ctacaA/Gtgagc`	1	--	us2k¹		0	--	--	--	--
rs141982350^1,2		--	150919348(+)	`CCACCA/GCACTC`	1	--	us2k¹		0	--	--	--	--
rs75026971^1,2	F	--	150919380(+)	`ATCCCG/ATCTCA`	1	--	us2k¹		1		WA	118
rs369946497^1,2	C	--	150919383(+)	`CCCGT-/CAA T/TCAACAATC`	1	--	us2k¹		0	--	--	--	--
rs79959261^1,2	F	--	150919454(+)	`TTCCAA/GGTTGT`	1	--	us2k¹		1		WA	118
rs1013707^1,2	C	--	150919612(+)	`CACTTC/TTAACA`	1	--	us2k¹		1		NA	2
rs150698583^1,2		--	150919719(+)	`AAAGGC/TGACTA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PLEKHG1 (150920999 - 151164799 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/12 variations for PLEKHG1 (see all 12): About this table

Variant ID	Type	Subtype	PubMed ID
esv2732887	CNV	Deletion	23290073
esv1000462	CNV	Deletion	20482838
esv2732888	CNV	Deletion	23290073
esv2086893	CNV	Deletion	18987734
esv2292678	CNV	Deletion	18987734
esv2664886	CNV	Deletion	23128226
nsv5539	CNV	Insertion	18451855
nsv886774	CNV	Loss	21882294
nsv464080	CNV	Loss	19166990
nsv522403	CNV	Loss	19592680

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing PLEKHG1

DNA2.0 Custom Variant and Variant Library Synthesis for PLEKHG1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

2 diseases for PLEKHG1: About MalaCards

panic disorder alcoholism

1 disease from the University of Copenhagen DISEASES database for PLEKHG1:

Panic disorder

PLEKHG1 for disorders About GeneDecksing

Genetic Association Database (GAD): PLEKHG1
Human Genome Epidemiology (HuGE) Navigator: PLEKHG1 (4 documents)

Export disorders for PLEKHG1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PLEKHG1 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with PLEKHG1)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{1, 2, 3} Nagase T.... Ohara O. (1999)
Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. (PubMed id 22488850)^{1, 4} Zuo L....Luo X. (2012)
Polymorphisms in predicted miRNA binding sites and os teoporosis. (PubMed id 20641033)^{1, 4} Lei S.F....Deng H.W. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
Genome-wide association study of panic disorder in the Japanese population. (PubMed id 19165232)^{1, 4} Otowa T....Okazaki Y. (2009)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)¹ Varjosalo M....Superti-Furga G. (2013)
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PubMed id 23535033)¹ Sherva R....Green R.C. (2013)
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)¹ Comuzzie A.G....Butte N.F. (2012)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57480	HGNC: 20884	AceView: PLEKHG1	Ensembl:ENSG00000120278	euGenes: HUgn57480
ECgene: PLEKHG1	H-InvDB: PLEKHG1

(According to HUGE)
About This Section

HUGE: KIAA1209

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PLEKHG1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PLEKHG1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PLEKHG1 gene:
Search GeneIP for patents involving PLEKHG1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for PLEKHG1
	Browse OriGene qPCR primer pairs and template standards		Browse OriGene Protein Over-expression Lysates
	OriGene Custom Mass Spec		OriGene clones in human, mouse for PLEKHG1
	Browse OriGene qSTAR qPCR primer pairs		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for PLEKHG1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for PLEKHG1		OriGene Custom Protein Services for PLEKHG1

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PLEKHG1
	QIAGEN SeqTarget long-range PCR primers for resequencing PLEKHG1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLEKHG1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLEKHG1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLEKHG1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLEKHG1

	GenScript Custom Purified and Recombinant Proteins Services for PLEKHG1		GenScript cDNA clones with any tag delivered in your preferred vector for PLEKHG1
	GenScript Custom Assay Services for PLEKHG1		GenScript Custom Superior Antibodies Services for PLEKHG1
	GenScript Custom overexpressing Cell Line Services for PLEKHG1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in PLEKHG1 promoter
	Search Chromatin IP Primers for PLEKHG1
	RT² qPCR Primer Assay in human, mouse, rat PLEKHG1
	Search GNC Networks for PLEKHG1
	SABiosciences Custom PCR Arrays for PLEKHG1

Search Tocris compounds for PLEKHG1 (PKHG1)

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	PLEKHG1 antibodies

	Antibodies for PLEKHG1
	See all of Abcam's Antibodies, Kits and Proteins for PLEKHG1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for PLEKHG1
	Antibodies for PLEKHG1
	ELISAs for PLEKHG1
	CLIAs for PLEKHG1

Search LifeMap BioReagents cell lines for PLEKHG1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHG1

	SwitchGear 3'UTR luciferase reporter plasmids for PLEKHG1
	SwitchGear Promoter luciferase reporter plasmids for PLEKHG1

ThermoFisher Antibodies for PLEKHG1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLEKHG1

	inGenious Targeting Laboratory - Custom generated mouse model solutions for PLEKHG1
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PLEKHG1

Customized:

	lentivirus for stable overexpression of PLEKHG1
	lentivirus expression plasmids for stable overexpression of PLEKHG1
	adenovirus for overexpression of PLEKHG1

LSBio Antibodies in human, mouse, rat for PLEKHG1

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PLEKHG1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

PLEKHG1 Gene

Pleckstrin Homology Domain Containing, Family G (With RhoGef...

Aliases
for PLEKHG1 gene

Summaries
for PLEKHG1 gene

Genomic Views
for PLEKHG1 gene

Proteins
for PLEKHG1 gene

Protein Domains /
Families
for PLEKHG1 gene

Function
for PLEKHG1 gene

Pathways & Interactions
for PLEKHG1 gene

Drugs & Compounds
for PLEKHG1 gene

Transcripts
for PLEKHG1 gene

Expression
for PLEKHG1 gene

Orthologs
for PLEKHG1 gene

Paralogs
for PLEKHG1 gene

Genomic Variants
for PLEKHG1 gene

Disorders / Diseases
for PLEKHG1 gene

Publications
for PLEKHG1 gene

External Searches for PLEKHG1 gene

Genome Databases showing PLEKHG1 gene

Other Databases showing PLEKHG1 gene

Specialized Databases showing PLEKHG1 gene

Intellectual Property
for PLEKHG1 gene

Products
for PLEKHG1 gene

View Random Gene

Advanced Search

Export list of displayed genes

PLEKHG1 Gene

Pleckstrin Homology Domain Containing, Family G (With RhoGef...

Aliasesfor PLEKHG1 gene

Summariesfor PLEKHG1 gene

Genomic Viewsfor PLEKHG1 gene

Proteinsfor PLEKHG1 gene

Protein Domains /Familiesfor PLEKHG1 gene

Functionfor PLEKHG1 gene

Pathways & Interactionsfor PLEKHG1 gene

Drugs & Compoundsfor PLEKHG1 gene

Transcriptsfor PLEKHG1 gene

Expression for PLEKHG1 gene

Orthologsfor PLEKHG1 gene

Paralogsfor PLEKHG1 gene

Genomic Variantsfor PLEKHG1 gene

Disorders / Diseasesfor PLEKHG1 gene

Publicationsfor PLEKHG1 gene

External Searches for PLEKHG1 gene

Genome Databases showing PLEKHG1 gene

Other Databases showing PLEKHG1 gene

Specialized Databases showing PLEKHG1 gene

Intellectual Propertyfor PLEKHG1 gene

Productsfor PLEKHG1 gene

View Random Gene

Aliases
for PLEKHG1 gene

Summaries
for PLEKHG1 gene

Genomic Views
for PLEKHG1 gene

Proteins
for PLEKHG1 gene

Protein Domains /
Families
for PLEKHG1 gene

Function
for PLEKHG1 gene

Pathways & Interactions
for PLEKHG1 gene

Drugs & Compounds
for PLEKHG1 gene

Transcripts
for PLEKHG1 gene

Expression
for PLEKHG1 gene

Orthologs
for PLEKHG1 gene

Paralogs
for PLEKHG1 gene

Genomic Variants
for PLEKHG1 gene

Disorders / Diseases
for PLEKHG1 gene

Publications
for PLEKHG1 gene

Intellectual Property
for PLEKHG1 gene

Products
for PLEKHG1 gene