Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLEKHG1 Gene

Aliases for PLEKHG1 Gene

  • Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 1 2 3
  • Pleckstrin Homology Domain-Containing Family G Member 1 3
  • ARHGEF41 3
  • KIAA1209 4

External Ids for PLEKHG1 Gene

Previous GeneCards Identifiers for PLEKHG1 Gene

  • GC06P150997
  • GC06P151073
  • GC06P151013
  • GC06P150920
  • GC06P148515

Summaries for PLEKHG1 Gene

GeneCards Summary for PLEKHG1 Gene

PLEKHG1 (Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 1) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHG1 Gene

Genomics for PLEKHG1 Gene

Regulatory Elements for PLEKHG1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PLEKHG1 Gene

150,599,863 bp from pter
150,843,665 bp from pter
243,803 bases
Plus strand

Genomic View for PLEKHG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLEKHG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHG1 Gene

Proteins for PLEKHG1 Gene

  • Protein details for PLEKHG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pleckstrin homology domain-containing family G member 1
    Protein Accession:
    Secondary Accessions:
    • Q5T1F2

    Protein attributes for PLEKHG1 Gene

    1385 amino acids
    Molecular mass:
    155439 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLEKHG1 Gene

Proteomics data for PLEKHG1 Gene at MOPED

Post-translational modifications for PLEKHG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLEKHG1 Gene

No data available for DME Specific Peptides for PLEKHG1 Gene

Domains for PLEKHG1 Gene

Gene Families for PLEKHG1 Gene

  • ARHGEF :Rho guanine nucleotide exchange factors
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for PLEKHG1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9ULL1
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with PLEKHG1: view

Function for PLEKHG1 Gene

Gene Ontology (GO) - Molecular Function for PLEKHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with PLEKHG1: view

Phenotypes for PLEKHG1 Gene

genes like me logo Genes that share phenotypes with PLEKHG1: view

Animal Model Products

CRISPR Products

miRNA for PLEKHG1 Gene

miRTarBase miRNAs that target PLEKHG1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLEKHG1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PLEKHG1 Gene

Localization for PLEKHG1 Gene

Subcellular locations from

Jensen Localization Image for PLEKHG1 Gene COMPARTMENTS Subcellular localization image for PLEKHG1 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLEKHG1 Gene

Pathways for PLEKHG1 Gene

SuperPathways for PLEKHG1 Gene

No Data Available

Interacting Proteins for PLEKHG1 Gene

Gene Ontology (GO) - Biological Process for PLEKHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035023 regulation of Rho protein signal transduction --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with PLEKHG1: view

No data available for Pathways by source for PLEKHG1 Gene

Transcripts for PLEKHG1 Gene

Unigene Clusters for PLEKHG1 Gene

Pleckstrin homology domain containing, family G (with RhoGef domain) member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLEKHG1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHG1 Gene

No ASD Table

Relevant External Links for PLEKHG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLEKHG1 Gene

mRNA expression in normal human tissues for PLEKHG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PLEKHG1 Gene

This gene is overexpressed in Plasma (45.8) and Prostate (10.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PLEKHG1 Gene

SOURCE GeneReport for Unigene cluster for PLEKHG1 Gene Hs.189781

genes like me logo Genes that share expressions with PLEKHG1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for PLEKHG1 Gene

Orthologs for PLEKHG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLEKHG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PLEKHG1 35
  • 83.7 (n)
  • 82.94 (a)
  • 82 (a)
(Canis familiaris)
Mammalia PLEKHG1 35
  • 86.01 (n)
  • 85.4 (a)
  • 85 (a)
(Mus musculus)
Mammalia Plekhg1 35
  • 80.77 (n)
  • 79.58 (a)
Plekhg1 16
Plekhg1 36
  • 78 (a)
(Pan troglodytes)
Mammalia PLEKHG1 35
  • 99.45 (n)
  • 99.2 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Plekhg1 35
  • 81.96 (n)
  • 80.82 (a)
(Monodelphis domestica)
Mammalia PLEKHG1 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia PLEKHG1 36
  • 70 (a)
(Gallus gallus)
Aves PLEKHG1 35
  • 68.39 (n)
  • 68.15 (a)
  • 58 (a)
(Anolis carolinensis)
Reptilia PLEKHG1 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia plekhg1 35
  • 60.93 (n)
  • 59.47 (a)
Str.4007 35
(Danio rerio)
Actinopterygii LOC101886810 35
  • 70.65 (n)
  • 77.72 (a)
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta GEFmeso 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea uig-1 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for PLEKHG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLEKHG1 Gene

Gene Tree for PLEKHG1 (if available)
Gene Tree for PLEKHG1 (if available)

Paralogs for PLEKHG1 Gene

Selected SIMAP similar genes for PLEKHG1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PLEKHG1: view

Variants for PLEKHG1 Gene

Sequence variations from dbSNP and Humsavar for PLEKHG1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2167 -- 150,803,778(-) AATAT(A/G)GCGAA intron-variant
rs3050 -- 150,601,979(-) TTAAC(C/T)TCTTT intron-variant
rs166697 -- 150,641,926(-) ATATT(C/T)TATTT intron-variant
rs182140 -- 150,674,778(+) CCTGG(A/G)TTCAA intron-variant, upstream-variant-2KB
rs183909 -- 150,642,116(-) GGTTT(C/T)TTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLEKHG1 Gene

Variant ID Type Subtype PubMed ID
nsv886772 CNV Gain 21882294
nsv437526 CNV Loss 16327808
nsv464080 CNV Loss 19166990
nsv886774 CNV Loss 21882294
nsv522403 CNV Loss 19592680
nsv5539 CNV Insertion 18451855
esv2086893 CNV Deletion 18987734
esv2292678 CNV Deletion 18987734
esv2664886 CNV Deletion 23128226
esv2732887 CNV Deletion 23290073
esv1000462 CNV Deletion 20482838
esv2732888 CNV Deletion 23290073

Relevant External Links for PLEKHG1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHG1 Gene

Disorders for PLEKHG1 Gene

(1) University of Copenhagen DISEASES for PLEKHG1 Gene

Relevant External Links for PLEKHG1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PLEKHG1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for PLEKHG1 Gene

Publications for PLEKHG1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Genome-wide association study of panic disorder in the Japanese population. (PMID: 19165232) Otowa T. … Okazaki Y. (J. Hum. Genet. 2009) 3 48
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Polymorphisms in predicted miRNA binding sites and osteoporosis. (PMID: 20641033) Lei S.F. … Deng H.W. (J. Bone Miner. Res. 2011) 3 48

Products for PLEKHG1 Gene

Sources for PLEKHG1 Gene

Back to Top