Aliases for PLEKHG1 Gene
Aliases for PLEKHG1 Gene
External Ids for PLEKHG1 Gene
- HGNC: 20884
- Entrez Gene: 57480
- Ensembl: ENSG00000120278
- UniProtKB: Q9ULL1
Previous GeneCards Identifiers for PLEKHG1 Gene
- GC06P150997
- GC06P151073
- GC06P151013
- GC06P150920
- GC06P148515
Summaries for PLEKHG1 Gene
GeneCards Summary for PLEKHG1 Gene
PLEKHG1 (Pleckstrin Homology And RhoGEF Domain Containing G1) is a Protein Coding gene. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF7.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHG1 Gene
Genomics for PLEKHG1 Gene
Regulatory Elements for PLEKHG1 Gene
Enhancers for PLEKHG1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around PLEKHG1 on UCSC Golden Path with GeneCards custom track
Promoters for PLEKHG1 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around PLEKHG1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PLEKHG1 gene promoter:
Regulatory Element Products
Genomic Location for PLEKHG1 Gene
- Chromosome:
- 6
- Start:
- 150,599,863 bp from pter
- End:
- 150,843,665 bp from pter
- Size:
- 243,803 bases
- Orientation:
- Plus strand
Genomic View for PLEKHG1 Gene
Genes around PLEKHG1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q25.1 by Ensembl
- 6q25.1 by Entrez Gene
- 6q25.1 by HGNC
PLEKHG1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLEKHG1 Gene
Proteins for PLEKHG1 Gene
-
Protein details for PLEKHG1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9ULL1-PKHG1_HUMAN
- Recommended name:
- Pleckstrin homology domain-containing family G member 1
- Protein Accession:
- Q9ULL1
- Q5T1F2
Protein attributes for PLEKHG1 Gene
- Size:
- 1385 amino acids
- Molecular mass:
- 155439 Da
- Quaternary structure:
- No Data Available
Protein Expression for PLEKHG1 Gene
Post-translational modifications for PLEKHG1 Gene
Other Protein References for PLEKHG1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PLEKHG1
- Invitrogen Antibodies for PLEKHG1
- Search GeneTex for Antibodies for PLEKHG1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PLEKHG1
Protein Products
-
OriGene Purified Proteins for PLEKHG1
- Search Origene for MassSpec and Protein Over-expression Lysates for PLEKHG1
- Origene Custom Protein Services for PLEKHG1
- Novus Biologicals proteins for PLEKHG1
- Search GeneTex for Proteins for PLEKHG1
Assay Products
No data available for DME Specific Peptides for PLEKHG1 Gene
Domains & Families for PLEKHG1 Gene
Gene Families for PLEKHG1 Gene
Protein Domains for PLEKHG1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PLEKHG1 Gene
Graphical View of Domain Structure for InterPro Entry
Q9ULL1- Domain:
-
- Contains 1 DH (DBL-homology) domain.
- Contains 1 PH domain.
Function for PLEKHG1 Gene
Phenotypes for PLEKHG1 Gene
- MGI mutant phenotypes for PLEKHG1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PLEKHG1:
Animal Models for PLEKHG1 Gene
- MGI Knock Outs for PLEKHG1:
-
- Plekhg1 tm1a(EUCOMM)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for PLEKHG1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PLEKHG1 gene
- Search ViGene Biosciences for PLEKHG1
CRISPR Products
-
OriGene CRISPR knockouts for PLEKHG1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLEKHG1
- GenScript: Design CRISPR guide RNA sequences for PLEKHG1
miRNA for PLEKHG1 Gene
- miRTarBase miRNAs that target PLEKHG1
miRNA Products
- Search ViGene Biosciences for PLEKHG1
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for PLEKHG1
- Browse OriGene Inhibitory RNA Products For PLEKHG1
-
ViGene Biosciences ready-to-package AAV shRNAs for PLEKHG1 gene
Clone Products
- OriGene clones in human for PLEKHG1
- OriGene ORF clones in human,mouse,rat for PLEKHG1
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PLEKHG1 gene
-
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-
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Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLEKHG1 Gene
Localization for PLEKHG1 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLEKHG1 Gene
Pathways & Interactions for PLEKHG1 Gene
More details on SuperPathways for PLEKHG1
No Data Available
Interacting Proteins for PLEKHG1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0043547 | positive regulation of GTPase activity | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for PLEKHG1 Gene
Transcripts for PLEKHG1 Gene
mRNA/cDNA for PLEKHG1 Gene
- (9) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (88) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PLEKHG1 Gene
- Pleckstrin homology domain containing, family G (with RhoGef domain) member 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PLEKHG1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLEKHG1
- GenScript: Design CRISPR guide RNA sequences for PLEKHG1
miRNA Products
- Search ViGene Biosciences for PLEKHG1
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for PLEKHG1
- Browse OriGene Inhibitory RNA Products For PLEKHG1
-
ViGene Biosciences ready-to-package AAV shRNAs for PLEKHG1 gene
Clone Products
- OriGene clones in human for PLEKHG1
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for PLEKHG1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
- Granulocytes Peripheral Blood
- Double Positive Thymocytes Thymus
- Mature B-Cells Peripheral Blood
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
- Inner Cell Mass (Early Embryonic Tissues)
This gene is overexpressed in Plasma (45.8) and Prostate (10.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLEKHG1 Gene
SOURCE GeneReport for Unigene cluster for PLEKHG1 Gene Hs.189781
Primer Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PLEKHG1 Gene
Orthologs for PLEKHG1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | PLEKHG1 35 |
|
||
| PLEKHG1 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | PLEKHG1 35 |
|
||
| PLEKHG1 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Plekhg1 35 |
|
||
| Plekhg1 16 |
|
||||
| Plekhg1 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | PLEKHG1 35 |
|
||
| PLEKHG1 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Plekhg1 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PLEKHG1 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PLEKHG1 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PLEKHG1 35 |
|
||
| PLEKHG1 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | PLEKHG1 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | plekhg1 35 |
|
||
| Str.4007 35 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | LOC101886810 35 |
|
||
| PLEKHG1 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | GEFmeso 36 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | uig-1 36 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToMany |
- Species with no ortholog for PLEKHG1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PLEKHG1 Gene
Paralogs for PLEKHG1 Gene
(2) SIMAP similar genes for PLEKHG1 Gene using alignment to 5 proteins:
Variants for PLEKHG1 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs17080381 | - | 150,831,471(+) | TTCCC(A/G)AGACA | reference, missense | |
| rs17080410 | - | 150,839,950(+) | GTCTG(C/T)GTCAC | reference, missense | |
| rs17054318 | - | 150,840,700(+) | CACAT(C/T)GCATT | reference, missense | |
| rs58786678 | - | 150,840,868(+) | ATTTC(A/C)GTGTC | reference, missense | |
| rs1040557 | -- | 150,773,258(-) | CTGCA(C/T)CCAGC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv886772 | CNV | Gain | 21882294 |
| nsv437526 | CNV | Loss | 16327808 |
| nsv464080 | CNV | Loss | 19166990 |
| nsv886774 | CNV | Loss | 21882294 |
| nsv522403 | CNV | Loss | 19592680 |
| nsv5539 | CNV | Insertion | 18451855 |
| esv2086893 | CNV | Deletion | 18987734 |
| esv2292678 | CNV | Deletion | 18987734 |
| esv2664886 | CNV | Deletion | 23128226 |
| esv2732887 | CNV | Deletion | 23290073 |
| esv1000462 | CNV | Deletion | 20482838 |
| esv2732888 | CNV | Deletion | 23290073 |
Residual Variation Intolerance Score:
33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.33;
70.70% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PLEKHG1 Gene
Disorders for PLEKHG1 Gene
Relevant External Links for PLEKHG1
No disorders were found for PLEKHG1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLEKHG1 Gene
Publications for PLEKHG1 Gene
- Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
- A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
- Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PMID: 23535033) Sherva R. … Green R.C. (Alzheimers Dement 2014) 3
- Gene expression analysis of a panel of cell lines that differentially restrict HIV-1 CA mutants infection in a cyclophilin a-dependent manner. (PMID: 24663101) Shah V.B. … Aiken C. (PLoS ONE 2014) 3
Products for PLEKHG1 Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Custom Assay Services
- OriGene Purified Proteins for PLEKHG1
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- OriGene CRISPR knockouts for PLEKHG1
- OriGene clones in human for PLEKHG1
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- ViGene Biosciences adenoviral particle packaged cDNA for PLEKHG1 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for PLEKHG1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PLEKHG1 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for PLEKHG1
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Sources for PLEKHG1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
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- (129) SIGNOR
- (130) diseasecard
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- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
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- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon