Aliases for PLEKHG1 Gene
Aliases for PLEKHG1 Gene
External Ids for PLEKHG1 Gene
- HGNC: 20884
- Entrez Gene: 57480
- Ensembl: ENSG00000120278
- UniProtKB: Q9ULL1
Previous GeneCards Identifiers for PLEKHG1 Gene
- GC06P150997
- GC06P151073
- GC06P151013
- GC06P150920
- GC06P148515
Summaries for PLEKHG1 Gene
GeneCards Summary for PLEKHG1 Gene
PLEKHG1 (Pleckstrin Homology And RhoGEF Domain Containing G1) is a Protein Coding gene. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is PLEKHG3.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHG1 Gene
Genomics for PLEKHG1 Gene
Regulatory Elements for PLEKHG1 Gene
Enhancers for PLEKHG1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around PLEKHG1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PLEKHG1 gene promoter:
Regulatory Element Products
Genomic Location for PLEKHG1 Gene
- Chromosome:
- 6
- Start:
- 150,599,863 bp from pter
- End:
- 150,843,665 bp from pter
- Size:
- 243,803 bases
- Orientation:
- Plus strand
Genomic View for PLEKHG1 Gene
Genes around PLEKHG1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q25.1 by Ensembl
- 6q25.1 by Entrez Gene
- 6q25.1 by HGNC
PLEKHG1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLEKHG1 Gene
Proteins for PLEKHG1 Gene
-
Protein details for PLEKHG1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9ULL1-PKHG1_HUMAN
- Recommended name:
- Pleckstrin homology domain-containing family G member 1
- Protein Accession:
- Q9ULL1
- Q5T1F2
Protein attributes for PLEKHG1 Gene
- Size:
- 1385 amino acids
- Molecular mass:
- 155439 Da
- Quaternary structure:
- No Data Available
Protein Expression for PLEKHG1 Gene
Post-translational modifications for PLEKHG1 Gene
Other Protein References for PLEKHG1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PLEKHG1
- Novus Biologicals Antibodies for PLEKHG1
- Invitrogen Antibodies for PLEKHG1
- Search GeneTex for Antibodies for PLEKHG1
Protein Products
-
OriGene Purified Proteins for PLEKHG1
- Search Origene for MassSpec and Protein Over-expression Lysates for PLEKHG1
- Origene Custom Protein Services for PLEKHG1
- Novus Biologicals proteins for PLEKHG1
- Search GeneTex for Proteins for PLEKHG1
No data available for DME Specific Peptides for PLEKHG1 Gene
Domains & Families for PLEKHG1 Gene
Gene Families for PLEKHG1 Gene
Protein Domains for PLEKHG1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PLEKHG1 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for PLEKHG1 Gene
Function for PLEKHG1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | -- |
Phenotypes for PLEKHG1 Gene
- MGI mutant phenotypes for PLEKHG1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PLEKHG1:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability
- shRNA abundance <= 50%
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased transferrin (TF) endocytosis
- Decreased viability with paclitaxel
- Increased shRNA abundance (Z-score > 2)
Animal Models for PLEKHG1 Gene
- MGI Knock Outs for PLEKHG1:
-
- Plekhg1 tm1a(EUCOMM)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PLEKHG1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PLEKHG1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PLEKHG1 gene
- Search ViGene Biosciences for PLEKHG1
CRISPR Products
-
OriGene CRISPR knockouts for PLEKHG1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLEKHG1
- GenScript: Design CRISPR guide RNA sequences for PLEKHG1
miRNA for PLEKHG1 Gene
- miRTarBase miRNAs that target PLEKHG1
miRNA Products
- Search ViGene Biosciences for PLEKHG1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PLEKHG1
- Browse OriGene Inhibitory RNA Products For PLEKHG1
-
ViGene Biosciences ready-to-package AAV shRNAs for PLEKHG1 gene
Clone Products
-
OriGene ORF clones in human for PLEKHG1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PLEKHG1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PLEKHG1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for PLEKHG1
-
ViGene Biosciences adenoviral particle packaged cDNA for PLEKHG1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PLEKHG1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PLEKHG1 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLEKHG1 Gene
Localization for PLEKHG1 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PLEKHG1 Gene
Pathways & Interactions for PLEKHG1 Gene
No Data Available
Interacting Proteins for PLEKHG1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035023 | regulation of Rho protein signal transduction | IEA | -- |
| GO:0043547 | positive regulation of GTPase activity | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for PLEKHG1 Gene
Transcripts for PLEKHG1 Gene
mRNA/cDNA for PLEKHG1 Gene
- (19) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (88) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PLEKHG1 Gene
- Pleckstrin homology domain containing, family G (with RhoGef domain) member 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PLEKHG1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLEKHG1
- GenScript: Design CRISPR guide RNA sequences for PLEKHG1
miRNA Products
- Search ViGene Biosciences for PLEKHG1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PLEKHG1
- Browse OriGene Inhibitory RNA Products For PLEKHG1
-
ViGene Biosciences ready-to-package AAV shRNAs for PLEKHG1 gene
Clone Products
-
OriGene ORF clones in human for PLEKHG1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PLEKHG1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PLEKHG1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for PLEKHG1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
- Granulocytes Peripheral Blood
- Double Positive Thymocytes Thymus
- Mature B-Cells Peripheral Blood
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
- Inner Cell Mass (Early Embryonic Tissues)
This gene is overexpressed in Plasma (45.8) and Prostate (10.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLEKHG1 Gene
NURSA nuclear receptor signaling pathways regulating expression of PLEKHG1 Gene:
PLEKHG1SOURCE GeneReport for Unigene cluster for PLEKHG1 Gene:
Hs.189781Evidence on tissue expression from TISSUES for PLEKHG1 Gene
- Nervous system(4.2)
Primer Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLEKHG1 Gene
Orthologs for PLEKHG1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PLEKHG1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | PLEKHG1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | PLEKHG1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Plekhg1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Plekhg1 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PLEKHG1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PLEKHG1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PLEKHG1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PLEKHG1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | plekhg1 34 |
|
||
| Str.4007 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | LOC101886810 34 |
|
||
| PLEKHG1 35 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | GEFmeso 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | uig-1 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for PLEKHG1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PLEKHG1 Gene
Paralogs for PLEKHG1 Gene
(2) SIMAP similar genes for PLEKHG1 Gene using alignment to 5 proteins:
Variants for PLEKHG1 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs193920959 | Uncertain significance | 150,831,404(+) | CAAAG(C/T)GGAGC | intron-variant, reference, missense | |
| rs1000002071 | -- | 150,729,140(+) | AGGCT(A/G)CAGTG | intron-variant | |
| rs1000030876 | -- | 150,708,392(+) | GCCCC(A/G)CCTTC | intron-variant | |
| rs1000066190 | -- | 150,610,018(+) | GAACT(A/C)CCCTC | intron-variant | |
| rs1000098932 | -- | 150,651,795(+) | CAGAC(A/G)TTGCA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10964n54 | CNV | gain | 21841781 |
| esv1000462 | CNV | deletion | 20482838 |
| esv2086893 | CNV | deletion | 18987734 |
| esv2292678 | CNV | deletion | 18987734 |
| esv2664886 | CNV | deletion | 23128226 |
| esv2732887 | CNV | deletion | 23290073 |
| esv2732888 | CNV | deletion | 23290073 |
| esv3436812 | CNV | duplication | 20981092 |
| esv3540635 | CNV | deletion | 23714750 |
| esv3571466 | CNV | loss | 25503493 |
| esv3611236 | CNV | loss | 21293372 |
| esv3611237 | CNV | loss | 21293372 |
| nsv1021285 | CNV | gain | 25217958 |
| nsv1077479 | CNV | duplication | 25765185 |
| nsv1109825 | CNV | deletion | 24896259 |
| nsv1115727 | CNV | duplication | 24896259 |
| nsv437526 | CNV | loss | 16327808 |
| nsv464080 | CNV | loss | 19166990 |
| nsv522403 | CNV | loss | 19592680 |
| nsv5539 | CNV | insertion | 18451855 |
| nsv604851 | CNV | loss | 21841781 |
| nsv969457 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.33;
70.70% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PLEKHG1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PLEKHG1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHG1 Gene
Disorders for PLEKHG1 Gene
Relevant External Links for PLEKHG1
No disorders were found for PLEKHG1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLEKHG1 Gene
Publications for PLEKHG1 Gene
- Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
- Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. (PMID: 22488850) Zuo L. … Luo X. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2012) 3 46 64
- Polymorphisms in predicted miRNA binding sites and osteoporosis. (PMID: 20641033) Lei S.F. … Deng H.W. (J. Bone Miner. Res. 2011) 3 46 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Genome-wide association study of panic disorder in the Japanese population. (PMID: 19165232) Otowa T. … Okazaki Y. (J. Hum. Genet. 2009) 3 46 64
Products for PLEKHG1 Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for PLEKHG1
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- OriGene Purified Proteins for PLEKHG1
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- Browse OriGene qPCR primer pairs and template standards
- OriGene CRISPR knockouts for PLEKHG1
- OriGene ORF clones in human for PLEKHG1
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- Browse OriGene miRNA Products For PLEKHG1
- GenScript: Next-day shipping cDNA ORF clone for PLEKHG1 in any vector
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- GenScript Custom Assay Services for PLEKHG1
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- GenScript: Design CRISPR guide RNA sequences for PLEKHG1
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- Novus Biologicals Antibodies for PLEKHG1
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- Invitrogen Antibodies for PLEKHG1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Search GeneTex for Antibodies for PLEKHG1
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- ViGene Biosciences adenoviral particle packaged cDNA for PLEKHG1 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for PLEKHG1 gene
- Search ViGene Biosciences for PLEKHG1
- Horizon Cell Lines for PLEKHG1
- Cyagen custom Knockout/knockin (KOKI) mouse models for PLEKHG1
- VectorBuilder custom plasmid, inducible vectors for PLEKHG1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PLEKHG1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for PLEKHG1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (122) diseasecard
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- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer