PLEKHG1 Gene
protein-coding GIFtS : 48
GCID: GC06 P150920
pleckstrin homology domain containing, family G (with RhoGef...
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Aliasesfor PLEKHG1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member1 1 2 ARHGEF411 2 KIAA12091 3 Pleckstrin Homology Domain-Containing Family G Member 12
Export aliases for PLEKHG1 gene to outside databases Previous GC identifers: GC06P150997 GC06P151073 GC06P151013 GC06P148515
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Summariesfor PLEKHG1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor PLEKHG1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_025741.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the PLEKHG1 gene promoter: MEF-2A AML1a p53 MEF-2 aMEF-2 E47 C/EBPalpha Other transcription factors Search SABiosciences Chromatin IP Primers for PLEKHG1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat PLEKHG1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6q25.1 Ensembl cytogenetic band: 6q25.1 HGNC cytogenetic band: 6q25.1 PLEKHG1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P150920: view genomic region
(about GC identifiers )
Start:
150,920,999 bp from pter
End:
151,164,799 bp from pter
Size:
243,801 bases
Orientation:
plus strand
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Proteinsfor PLEKHG1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: PKHG1_HUMAN, Q9ULL1 (See
protein sequence )Recommended Name: Pleckstrin homology domain-containing family G member 1 Size : 1385 amino acids; 155439 Da
Secondary accessions : Q5T1F2Explore the universe of human proteins at neXtProt for PLEKHG1: NX_Q9ULL1 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9ULL1 PLEKHG1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_001025055.1 ENSEMBL proteins: ENSP00000356295 ENSP00000351318 ENSP00000433107 ENSP00000356297 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005622 intracellular
IEA --
PLEKHG1 for ontologies About GeneDecksing PLEKHG1 Antibody Products: Assay Products for PLEKHG1:
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Protein
Domains / Familiesfor PLEKHG1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
PLEKHG1 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9ULL1 ProtoNet protein and cluster: Q9ULL1
2 Blocks protein families : IPB000219 DH domain IPB001849 Pleckstrin-like UniProtKB/Swiss-Prot: PKHG1_HUMAN, Q9ULL1 Similarity : Contains 1 DH (DBL-homology) domainSimilarity : Contains 1 PH domain
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Functionfor PLEKHG1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for PLEKHG1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for PLEKHG1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: PLEKHG1 (NM_001029884 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PLEKHG1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PLEKHG1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHG1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005089 Rho guanyl-nucleotide exchange factor activity
IEA -- GO:0005543 phospholipid binding
IEA --
PLEKHG1 for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for PLEKHG1 :Animal Models: 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Plekhg1) :
PLEKHG1 for phenotypes About GeneDecksing
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Pathways & Interactionsfor PLEKHG1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLEKHG1 Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0035023 regulation of Rho protein signal transduction
IEA --
PLEKHG1 for ontologies About GeneDecksing
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Drugs & Compoundsfor PLEKHG1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for PLEKHG1 Search CenterWatch for drugs/clinical trials and news about PLEKHG1 / PKHG1
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Transcriptsfor PLEKHG1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for PLEKHG1 gene: NM_001029884.1 Unigene Cluster for PLEKHG1:
Pleckstrin homology domain containing, family G (with RhoGef domain) member 1 Hs.189781 [show with all ESTs ] Unigene Representative Sequence: NM_001029884 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000367326 ENST00000358517 (uc011eem.1 uc003qnz.2 ) ENST00000475490 ENST00000367328 (uc011eel.1 uc003qny.1 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for PLEKHG1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for PLEKHG1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: PLEKHG1 (NM_001029884 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PLEKHG1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PLEKHG1
Additional cDNA sequence: AB033035.1 AJ420468.1 AK056300.1 AK293288.1 AK294798.1 AK307631.1 BC089428.1 BC140864.1 BC151134.1
3 DOTS entries : DT.208151 DT.75163224
DT.97762352 24/88 AceView cDNA sequences (see all 88 ):
BQ004504 AA719089 AA719072 AA404653 AI148832 BU607617 AW628704 AA737629 CR606130 AI003646 BM747026 R02147 AB033035 AL545703 AA361039 N70181 AA829505 CA438343 AK056300 AI207794 AI564265 AL600191 AI138891 CB990736 GeneLoc Exon Structure
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Expression for PLEKHG1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section PLEKHG1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTTGTATTTT
About this image PLEKHG1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See PLEKHG1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for PLEKHG1 SOURCE GeneReport for Unigene cluster: Hs.189781 SABiosciences Custom PCR Arrays for PLEKHG1 Primer Products: Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat PLEKHG1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat PLEKHG1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat PLEKHG1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHG1
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Orthologsfor PLEKHG1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for PLEKHG1 gene from 6/19 species (see all 19 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
PLEKHG11
pleckstrin homology domain containing, family G (with more
68.27(n) 68.15(a)
 
421632 XM_419671.3 XP_419671.3
lizard (Anolis carolinensis)
Reptilia
PLEKHG16
--
64(a)
1 ↔ 1
GL343259.1(726240-780461)
tropical clawed frog (Xenopus tropicalis)
Amphibia
Str.40072
Transcribed sequence with weak similarity to protein more
77.67(n)
 
137718971
zebrafish (Danio rerio)
Actinopterygii
LOC5567271
pleckstrin homology domain-containing family G member more
47.43(n) 38.9(a)
 
556727 XM_679600.5 XP_684692.5
fruit fly (Drosophila melanogaster)
Insecta
GEFmeso6
Guanine nucleotide exchange factor in mesoderm
12(a)
possible ortholog
2R(14441624-14499260)
worm (Caenorhabditis elegans)
Secernentea
uig-16
UNC-112-Interacting Guanine nucleotide exchange fa...
18(a)
possible ortholog
V(13273553-13295900)
ENSEMBL Gene Tree for PLEKHG1 (if available)TreeFam Gene Tree for PLEKHG1 (if available)
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Paralogsfor PLEKHG1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for PLEKHG1 gene ARHGEF6 2 VAV1 2 PLEKHG2 2 PLEKHG3 2 PREX2 2 ARHGEF7 2 TIAM1 2 SPATA13 2 TIAM2 2 ARHGEF9 2 VAV3 2 VAV2 2 ARHGEF4 2 PREX1 2 2 SIMAP similar genes for PLEKHG1 using alignment to 5 protein entries: PKHG1_HUMAN (see all proteins ):PLEKHG3 PLEKHG2
PLEKHG1 for paralogs About GeneDecksing
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Genomic Variantsfor PLEKHG1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 6 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for PLEKHG1 (150920999 - 151164799 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for PLEKHG1 1 CNV : 44233 2 Indels : 10783 47020
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing PLEKHG1
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Disorders
/ Diseasesfor PLEKHG1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
PLEKHG1 for disorders About GeneDecksing 1 disease for PLEKHG1 : About MalaCards panic disorder 1 disease from the University of Copenhagen DISEASES database for PLEKHG1 :Panic disorder Human Genome Epidemiology (HuGE) Navigator: PLEKHG1 (4 documents) Export disorders for PLEKHG1 gene to outside databases
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Publicationsfor PLEKHG1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for PLEKHG1 gene integrated from 9 sources : (articles sorted by number of sources associating them with PLEKHG1) Utopia : connect your pdf to the dynamic world of online information
Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462) 1 , 2 , 3 Nagase T.... Ohara O. (1999) The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404) 1 , 2 Mungall A.J.... Beck S. (2003) Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. (PubMed id 22488850) 1 Zuo L....Luo X. (2012) Polymorphisms in predicted miRNA binding sites and os teoporosis. (PubMed id 20641033) 1 Lei S.F....Deng H.W. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Genome-wide association study of panic disorder in the Japanese population. (PubMed id 19165232) 1 Otowa T....Okazaki Y. (2009) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 Olsen J.V....Mann M. (2006) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for PLEKHG1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing PLEKHG1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing PLEKHG1 gene
(According to HUGE )
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Specialized Databases showing PLEKHG1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for PLEKHG1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for PLEKHG1 gene: Search GeneIP for patents involving PLEKHG1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor PLEKHG1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for PLEKHG1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for PLEKHG1 Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for PLEKHG1 OriGene 3'-UTR Clone for PLEKHG1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for PLEKHG1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for PLEKHG1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for PLEKHG1 OriGene Custom Protein Services for PLEKHG1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PLEKHG1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing PLEKHG1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat PLEKHG1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat PLEKHG1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat PLEKHG1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat PLEKHG1
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PLEKHG1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHG1
ThermoFisher Antibodies for PLEKHG1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PLEKHG1
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