PLEKHG1 Gene

Aliases
for PLEKHG1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC06P150997 GC06P151073 GC06P151013 GC06P148515

Summaries
for PLEKHG1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for PLEKHG1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000006.11  NT_025741.16  NC_018917.2  

SwitchGear Promoter luciferase reporter plasmids (see all 2): PLEKHG1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLEKHG1

PLEKHG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P150920:  view genomic region     (about GC identifiers)

Proteins
for PLEKHG1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for PLEKHG1: NX_Q9ULL1

Explore proteomics data for PLEKHG1 at MOPED

Post-translational modifications: 

PLEKHG1 Human Recombinant Protein Products:

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Domains /
Families
for PLEKHG1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9ULL1

Find genes that share domains with PLEKHG1           About GenesLikeMe

Function
for PLEKHG1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

(inferred from 1 allele) (MGI details for Plekhg1)

genOway: Develop your customized and physiologically relevant rodent model for PLEKHG1

miRNA Products:		miRTarBase miRNAs that target PLEKHG1: hsa-mir-335-5p (MIRT016820)
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		Selected qRT-PCR Assays for microRNAs that regulate PLEKHG1 (see all 27):
		hsa-miR-676 hsa-miR-4307 hsa-miR-520d-5p hsa-miR-1224-3p hsa-miR-106a hsa-miR-16-1* hsa-miR-218 hsa-miR-373*
		SwitchGear 3'UTR luciferase reporter plasmid: PLEKHG1 3' UTR sequence

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Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHG1

Localization
for PLEKHG1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Pathways & Interactions
for PLEKHG1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for PLEKHG1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for PLEKHG1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for PLEKHG1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PLEKHG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTTGTATTTT

About this image

Brain (Nervous System)    fully expand to see all 15 entries
Thalamus
Septum
Blood (Cardiovascular System)    fully expand to see all 4 entries
Mature B-Cells Peripheral Blood
Thymus (Hematopoietic System)
Double Positive Thymocytes Thymus
Inner Cell Mass (Early Embryonic Tissues)
Blimp1- mVenus and stella-ECFP genetically modified stem cells

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHG1

Orthologs
for PLEKHG1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for PLEKHG1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for PLEKHG1 gene

ARHGEF6²  PLEKHG2²  PLEKHG3²  PREX2²  ENSG00000273167²  ARHGEF7²  TIAM1²  SPATA13²  

TIAM2²  ARHGEF9²  ARHGEF4²  PREX1²  

2 SIMAP similar genes for PLEKHG1 using alignment to 5 protein entries:     PKHG1_HUMAN (see all proteins):

PLEKHG3    PLEKHG2

Find genes that share paralogs with PLEKHG1           About GenesLikeMe

Genomic Variants
for PLEKHG1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for PLEKHG1 (see all 5685)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1470829881,2		--	150919177(+)	AAGTTC/TGAGGC	1	--	us2k1		0	--	--	--	--
rs1837793381,2		--	150919205(+)	CGTGAA/CCCCGG	1	--	us2k1		0	--	--	--	--
rs1434496041,2	C	--	150919217(+)	TCTAC-/AAAAAA	1	--	us2k1		0	--	--	--	--
rs94787631,2		--	150919326(+)	ctacaA/Gtgagc	1	--	us2k1		0	--	--	--	--
rs1419823501,2		--	150919348(+)	CCACCA/GCACTC	1	--	us2k1		0	--	--	--	--
rs750269711,2	F	--	150919380(+)	ATCCCG/ATCTCA	1	--	us2k1		1		WA	118
rs3699464971,2	C	--	150919383(+)	CCCGT-/CAA      T/TCAACAATC	1	--	us2k1		0	--	--	--	--
rs799592611,2	F	--	150919454(+)	TTCCAA/GGTTGT	1	--	us2k1		1		WA	118
rs10137071,2	C	--	150919612(+)	CACTTC/TTAACA	1	--	us2k1		1		NA	2
rs1506985831,2		--	150919719(+)	AAAGGC/TGACTA	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for PLEKHG1 (150920999 - 151164799 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for PLEKHG1 (see all 12):    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2732887	CNV	Deletion	23290073
esv1000462	CNV	Deletion	20482838
esv2732888	CNV	Deletion	23290073
esv2086893	CNV	Deletion	18987734
esv2292678	CNV	Deletion	18987734
esv2664886	CNV	Deletion	23128226
nsv5539	CNV	Insertion	18451855
nsv886774	CNV	Loss	21882294
nsv464080	CNV	Loss	19166990
nsv522403	CNV	Loss	19592680

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing PLEKHG1

DNA2.0 Custom Variant and Variant Library Synthesis for PLEKHG1

Disorders / Diseases
for PLEKHG1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for PLEKHG1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{1, 2, 3} Nagase T.... Ohara O. (DNA Res. 1999)
2. Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. (PubMed id 22488850)^{1, 4} Zuo L....Luo X. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2012)
3. Polymorphisms in predicted miRNA binding sites and osteoporosis. (PubMed id 20641033)^{1, 4} Lei S.F....Deng H.W. (J. Bone Miner. Res. 2011)
4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
5. Genome-wide association study of panic disorder in the Japanese population. (PubMed id 19165232)^{1, 4} Otowa T....Okazaki Y. (J. Hum. Genet. 2009)
6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (Nature 2003)
7. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PubMed id 23535033)¹ Sherva R....Green R.C. (amp 2014)
8. Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. (PubMed id 23972371)¹ Franceschini N....Zhu X. (Am. J. Hum. Genet. 2013)
9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)¹ Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
10. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)¹ Couzens A.L....Gingras A.C. (Sci Signal 2013)

External Searches for PLEKHG1 gene

Genome Databases showing PLEKHG1 gene

Other Databases showing PLEKHG1 gene

Specialized Databases showing PLEKHG1 gene

Products
for PLEKHG1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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