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Aliases for PLEKHG1 Gene

Aliases for PLEKHG1 Gene

  • Pleckstrin Homology And RhoGEF Domain Containing G1 2 3 5
  • Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 1 2 3
  • Pleckstrin Homology Domain-Containing Family G Member 1 3
  • ARHGEF41 3
  • KIAA1209 4

External Ids for PLEKHG1 Gene

Previous GeneCards Identifiers for PLEKHG1 Gene

  • GC06P150997
  • GC06P151073
  • GC06P151013
  • GC06P150920
  • GC06P148515

Summaries for PLEKHG1 Gene

GeneCards Summary for PLEKHG1 Gene

PLEKHG1 (Pleckstrin Homology And RhoGEF Domain Containing G1) is a Protein Coding gene. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is PLEKHG3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHG1 Gene

Genomics for PLEKHG1 Gene

Regulatory Elements for PLEKHG1 Gene

Enhancers for PLEKHG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F150616 1.6 FANTOM5 Ensembl ENCODE 36 +22.8 22822 13.2 PKNOX1 ATF1 BMI1 FEZF1 RAD21 YY1 ZNF121 ZNF366 SCRT2 ETV6 PLEKHG1 ENSG00000232891 PPP1R14C ENSG00000224029
GH06F150630 1.4 FANTOM5 Ensembl ENCODE 8.3 +34.6 34620 7.1 TBP TBL1XR1 YBX1 BMI1 RAD21 CREM ZNF362 JUNB ZEB2 TBX21 PLEKHG1 ENSG00000224029 ENSG00000226599
GH06F150681 1.6 FANTOM5 Ensembl ENCODE 6.3 +85.2 85209 7.3 ARNT CREB3L1 SIN3A ZNF2 KLF7 FOS SP3 JUNB REST ZNF518A LATS1 HSPA8P15 PLEKHG1 ENSG00000232891 PPP1R14C ENSG00000226599 PDCL3P5
GH06F150698 0.6 Ensembl 12.1 +97.6 97639 0.2 ZNF692 CEBPA ZNF600 ZIC2 RAD21 ENSG00000232891 PLEKHG1 ENSG00000226599 PDCL3P5
GH06F150719 1.4 Ensembl ENCODE 5 +120.8 120755 2.5 HDGF PKNOX1 ARNT MLX CREB3L1 SIN3A FEZF1 ZNF2 ZNF766 FOS PLEKHG1 ENSG00000226599 PDCL3P5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLEKHG1 on UCSC Golden Path with GeneCards custom track

Promoters for PLEKHG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001230709 437 2201 PKNOX1 FEZF1 RAD21 ZNF2 ZBTB40 GLIS2 ZNF366 SCRT2 ZNF391 CREM

Genomic Location for PLEKHG1 Gene

150,599,863 bp from pter
150,843,665 bp from pter
243,803 bases
Plus strand

Genomic View for PLEKHG1 Gene

Genes around PLEKHG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLEKHG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLEKHG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHG1 Gene

Proteins for PLEKHG1 Gene

  • Protein details for PLEKHG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pleckstrin homology domain-containing family G member 1
    Protein Accession:
    Secondary Accessions:
    • Q5T1F2

    Protein attributes for PLEKHG1 Gene

    1385 amino acids
    Molecular mass:
    155439 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLEKHG1 Gene

Post-translational modifications for PLEKHG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLEKHG1 Gene

Domains & Families for PLEKHG1 Gene

Protein Domains for PLEKHG1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with PLEKHG1: view

Function for PLEKHG1 Gene

Gene Ontology (GO) - Molecular Function for PLEKHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with PLEKHG1: view
genes like me logo Genes that share phenotypes with PLEKHG1: view

Animal Models for PLEKHG1 Gene

MGI Knock Outs for PLEKHG1:

Animal Model Products

miRNA for PLEKHG1 Gene

miRTarBase miRNAs that target PLEKHG1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLEKHG1 Gene

Localization for PLEKHG1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLEKHG1 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLEKHG1 Gene

Pathways & Interactions for PLEKHG1 Gene

SuperPathways for PLEKHG1 Gene

No Data Available

Interacting Proteins for PLEKHG1 Gene

Gene Ontology (GO) - Biological Process for PLEKHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with PLEKHG1: view

No data available for Pathways by source and SIGNOR curated interactions for PLEKHG1 Gene

Transcripts for PLEKHG1 Gene

Unigene Clusters for PLEKHG1 Gene

Pleckstrin homology domain containing, family G (with RhoGef domain) member 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHG1 Gene

No ASD Table

Relevant External Links for PLEKHG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLEKHG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLEKHG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLEKHG1 Gene

This gene is overexpressed in Plasma (45.8) and Prostate (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLEKHG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLEKHG1 Gene:


SOURCE GeneReport for Unigene cluster for PLEKHG1 Gene:

genes like me logo Genes that share expression patterns with PLEKHG1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PLEKHG1 Gene

Orthologs for PLEKHG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLEKHG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLEKHG1 34 35
  • 99.45 (n)
(Canis familiaris)
Mammalia PLEKHG1 34 35
  • 86.01 (n)
(Bos Taurus)
Mammalia PLEKHG1 34 35
  • 83.7 (n)
(Rattus norvegicus)
Mammalia Plekhg1 34
  • 81.96 (n)
(Mus musculus)
Mammalia Plekhg1 34 16 35
  • 80.77 (n)
(Monodelphis domestica)
Mammalia PLEKHG1 35
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia PLEKHG1 35
  • 70 (a)
(Gallus gallus)
Aves PLEKHG1 34 35
  • 68.39 (n)
(Anolis carolinensis)
Reptilia PLEKHG1 35
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia plekhg1 34
  • 60.93 (n)
Str.4007 34
(Danio rerio)
Actinopterygii LOC101886810 34
  • 70.65 (n)
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta GEFmeso 35
  • 17 (a)
(Caenorhabditis elegans)
Secernentea uig-1 35
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
Species where no ortholog for PLEKHG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLEKHG1 Gene

Gene Tree for PLEKHG1 (if available)
Gene Tree for PLEKHG1 (if available)

Paralogs for PLEKHG1 Gene

(2) SIMAP similar genes for PLEKHG1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PLEKHG1: view

Variants for PLEKHG1 Gene

Sequence variations from dbSNP and Humsavar for PLEKHG1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs193920959 Uncertain significance 150,831,404(+) CAAAG(C/T)GGAGC intron-variant, reference, missense
rs10046223 -- 150,614,201(+) CTGTA(A/G)AGCTA intron-variant
rs10046301 -- 150,804,007(+) ACATG(C/T)ATGTT intron-variant
rs10046455 -- 150,804,064(+) CCTAT(C/T)CTTGT intron-variant
rs10046456 -- 150,804,115(+) CTCTG(G/T)CCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLEKHG1 Gene

Variant ID Type Subtype PubMed ID
dgv10964n54 CNV gain 21841781
esv1000462 CNV deletion 20482838
esv2086893 CNV deletion 18987734
esv2292678 CNV deletion 18987734
esv2664886 CNV deletion 23128226
esv2732887 CNV deletion 23290073
esv2732888 CNV deletion 23290073
esv3436812 CNV duplication 20981092
esv3540635 CNV deletion 23714750
esv3571466 CNV loss 25503493
esv3611236 CNV loss 21293372
esv3611237 CNV loss 21293372
nsv1021285 CNV gain 25217958
nsv1077479 CNV duplication 25765185
nsv1109825 CNV deletion 24896259
nsv1115727 CNV duplication 24896259
nsv437526 CNV loss 16327808
nsv464080 CNV loss 19166990
nsv522403 CNV loss 19592680
nsv5539 CNV insertion 18451855
nsv604851 CNV loss 21841781
nsv969457 CNV duplication 23825009

Variation tolerance for PLEKHG1 Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.33; 70.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLEKHG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHG1 Gene

Disorders for PLEKHG1 Gene

Relevant External Links for PLEKHG1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PLEKHG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLEKHG1 Gene

Publications for PLEKHG1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. (PMID: 22488850) Zuo L. … Luo X. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2012) 3 46 64
  3. Polymorphisms in predicted miRNA binding sites and osteoporosis. (PMID: 20641033) Lei S.F. … Deng H.W. (J. Bone Miner. Res. 2011) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Genome-wide association study of panic disorder in the Japanese population. (PMID: 19165232) Otowa T. … Okazaki Y. (J. Hum. Genet. 2009) 3 46 64

Products for PLEKHG1 Gene

Sources for PLEKHG1 Gene

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