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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLEKHG1 Gene

protein-coding   GIFtS: 48
GCID: GC06P150920

pleckstrin homology domain containing, family G (with RhoGef...

 Explore 1 disease affiliated with
PLEKHG1 via our new
 Human Malady Compendium 
Biological research products
for PLEKHG1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member
11 2
ARHGEF411 2
KIAA12091 3
Pleckstrin Homology Domain-Containing Family G Member 12

External Ids:    HGNC: 208841   Entrez Gene: 574802   Ensembl: ENSG000001202787   UniProtKB: Q9ULL13   

Export aliases for PLEKHG1 gene to outside databases

Previous GC identifers: GC06P150997 GC06P151073 GC06P151013 GC06P148515


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLEKHG1 gene promoter:
         MEF-2A   AML1a   p53   MEF-2   aMEF-2   E47   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PLEKHG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PLEKHG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLEKHG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.1   Ensembl cytogenetic band:  6q25.1   HGNC cytogenetic band: 6q25.1

PLEKHG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLEKHG1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P150920:  view genomic region     (about GC identifiers)

Start:
150,920,999 bp from pter      End:
151,164,799 bp from pter
Size:
243,801 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PKHG1_HUMAN, Q9ULL1 (See protein sequence)
Recommended Name: Pleckstrin homology domain-containing family G member 1  
Size: 1385 amino acids; 155439 Da
Secondary accessions: Q5T1F2

Explore the universe of human proteins at neXtProt for PLEKHG1: NX_Q9ULL1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9ULL1

  • PLEKHG1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001025055.1  
    ENSEMBL proteins: 
     ENSP00000356295   ENSP00000351318   ENSP00000433107   ENSP00000356297  

    Human Recombinant Protein Products: 
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    Uscn Proteins for PLEKHG1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--


    PLEKHG1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PLEKHG1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PLEKHG1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9ULL1

    ProtoNet protein and cluster: Q9ULL1

    2 Blocks protein families:
    IPB000219 DH domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: PKHG1_HUMAN, Q9ULL1
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
    Products:
        
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLEKHG1
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    hsa-miR-676 hsa-miR-4307 hsa-miR-520d-5p hsa-miR-1224-3p hsa-miR-106a hsa-miR-16-1* hsa-miR-218 hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidPLEKHG1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLEKHG1 (see all 4)
    OriGene shRNA RFP: PLEKHG1
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHG1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005543phospholipid binding IEA--


    PLEKHG1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PLEKHG1:
     Decreased viability with pacli  Increased gamma-H2AX phosphory 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Plekhg1):
     hematopoietic system  immune system 

    PLEKHG1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLEKHG1

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035023regulation of Rho protein signal transduction IEA--


    PLEKHG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PLEKHG1
    Search CenterWatch for drugs/clinical trials and news about PLEKHG1 / PKHG1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLEKHG1 gene: 
    NM_001029884.1  

    Unigene Cluster for PLEKHG1:

    Pleckstrin homology domain containing, family G (with RhoGef domain) member 1
    Hs.189781  [show with all ESTs]
    Unigene Representative Sequence: NM_001029884
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367326 ENST00000358517(uc011eem.1 uc003qnz.2) ENST00000475490
    ENST00000367328(uc011eel.1 uc003qny.1)

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLEKHG1
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate PLEKHG1 (see all 27):
    hsa-miR-676 hsa-miR-4307 hsa-miR-520d-5p hsa-miR-1224-3p hsa-miR-106a hsa-miR-16-1* hsa-miR-218 hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidPLEKHG1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLEKHG1 (see all 4)
    OriGene shRNA RFP: PLEKHG1
    OriGene siRNA: PLEKHG1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLEKHG1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLEKHG1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLEKHG1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PLEKHG1 (NM_001029884)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLEKHG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLEKHG1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLEKHG1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLEKHG1

    Additional cDNA sequence: 

    AB033035.1 AJ420468.1 AK056300.1 AK293288.1 AK294798.1 AK307631.1 BC089428.1 BC140864.1 
    BC151134.1 

    3 DOTS entries:

    DT.208151  DT.75163224  DT.97762352 

    24/88 AceView cDNA sequences (see all 88):

    BQ004504 AA719089 AA719072 AA404653 AI148832 BU607617 AW628704 AA737629 
    CR606130 AI003646 BM747026 R02147 AB033035 AL545703 AA361039 N70181 
    AA829505 CA438343 AK056300 AI207794 AI564265 AL600191 AI138891 CB990736 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLEKHG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTGTATTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    PLEKHG1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PLEKHG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLEKHG1

    SOURCE GeneReport for Unigene cluster: Hs.189781
        SABiosciences Custom PCR Arrays for PLEKHG1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PLEKHG1 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PLEKHG11 pleckstrin homology domain containing, family G (with more 68.27(n)
    68.15(a)
      421632  XM_419671.3  XP_419671.3 
    lizard
    (Anolis carolinensis)
    Reptilia PLEKHG16
    --
    64(a)
    1 ↔ 1
    GL343259.1(726240-780461)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.40072 Transcribed sequence with weak similarity to protein more 77.67(n)    137718971 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5567271 pleckstrin homology domain-containing family G member more 47.43(n)
    38.9(a)
      556727  XM_679600.5  XP_684692.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta GEFmeso6
    Guanine nucleotide exchange factor in mesoderm
    12(a)
    possible ortholog
    2R(14441624-14499260)
    worm
    (Caenorhabditis elegans)
    Secernentea uig-16
    UNC-112-Interacting Guanine nucleotide exchange fa...
    18(a)
    possible ortholog
    V(13273553-13295900)


    ENSEMBL Gene Tree for PLEKHG1 (if available)
    TreeFam Gene Tree for PLEKHG1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLEKHG1 gene
    ARHGEF62  VAV12  PLEKHG22  PLEKHG32  PREX22  ARHGEF72  TIAM12  SPATA132  
    TIAM22  ARHGEF92  VAV32  VAV22  ARHGEF42  PREX12  
    2 SIMAP similar genes for PLEKHG1 using alignment to 5 protein entries:     PKHG1_HUMAN (see all proteins):
    PLEKHG3    PLEKHG2

    PLEKHG1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4777 NCBI SNPs in PLEKHG1 are shown (see all 4777    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470829881,2
    --150919177(+) AAGTTC/TGAGGC 1 -- us2k10--------
    rs1837793381,2
    --150919205(+) CGTGAA/CCCCGG 1 -- us2k10--------
    rs1434496041,2
    --150919216(+) TCTAC-/AAAAAA 1 -- us2k10--------
    rs94787631,2
    --150919326(+) ctacaA/Gtgagc 1 -- us2k10--------
    rs1419823501,2
    --150919348(+) CCACCA/GCACTC 1 -- us2k10--------
    rs750269711,2
    F,--150919380(+) ATCCCG/ATCTCA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs799592611,2
    F,--150919454(+) TTCCAA/GGTTGT 1 -- us2k11Minor allele frequency- G:0.08WA 118
    rs10137071,2
    C--150919612(+) CACTTC/TTAACA 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1506985831,2
    --150919719(+) AAAGGC/TGACTA 1 -- us2k10--------
    rs1389898311,2
    --150919739(+) CTGTCA/GACCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PLEKHG1 (150920999 - 151164799 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for PLEKHG1
         1 CNV: 44233
         2 Indels: 10783 47020

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PLEKHG1 for disorders           About GeneDecksing

    1 disease for PLEKHG1:    About MalaCards
    panic disorder

    1 disease from the University of Copenhagen DISEASES database for PLEKHG1:
    Panic disorder
    Human Genome Epidemiology (HuGE) Navigator: PLEKHG1 (4 documents)

    Export disorders for PLEKHG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLEKHG1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with PLEKHG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    3. Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. (PubMed id 22488850)1 Zuo L....Luo X. (2012)
    4. Polymorphisms in predicted miRNA binding sites and os teoporosis. (PubMed id 20641033)1 Lei S.F....Deng H.W. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. Genome-wide association study of panic disorder in the Japanese population. (PubMed id 19165232)1 Otowa T....Okazaki Y. (2009)
    7. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57480 HGNC: 20884 AceView: PLEKHG1 Ensembl:ENSG00000120278 euGenes: HUgn57480
    ECgene: PLEKHG1 H-InvDB: PLEKHG1

    (According to HUGE)
    About This Section
    HUGE: KIAA1209

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLEKHG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLEKHG1 gene:
    Search GeneIP for patents involving PLEKHG1

    GeneCards and IP:
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    In Situ Hybridization Assays from
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     PLEKHG1 Proteins, Antibodies, CLIAs, and ELISAs
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     SwitchGear 3'UTR luciferase reporter plasmids for PLEKHG1
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     ThermoFisher Antibodies for PLEKHG1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLEKHG1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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