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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLEKHB1 Gene

protein-coding   GIFtS: 52
GCID: GC11P073357

Pleckstrin Homology Domain Containing, Family B (Evectins)...

(Previous names: PH domain containing, retinal 1)
(Previous symbol: PHRET1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pleckstrin Homology Domain Containing, Family B (Evectins) Member 11 2     PH Domain-Containing Protein In Retina 12 3
PHRET11 2 3     evectin-12
KPL12 3 5     PH Domain Containing Protein In Retina 12
PHR12 3 5     Pleckstrin Homology Domain-Containing Family B Member 12
PH Domain Containing, Retinal 11 2     EVT13
Pleckstrin Homology Domain Retinal Protein 12 3     Evectin-13
PH Domain-Containing Family B Member 12 3     

External Ids:    HGNC: 190791   Entrez Gene: 584732   Ensembl: ENSG000000213007   OMIM: 6076515   UniProtKB: Q9UF113   

Export aliases for PLEKHB1 gene to outside databases

Previous GC identifers: GC11P074896 GC11P073579 GC11P073083 GC11P073022 GC11P069652


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PLEKHB1 Gene: 
PLEKHB1 (pleckstrin homology domain containing, family B (evectins) member 1) is a protein-coding gene. Diseases associated with PLEKHB1 include retinitis, and neuronitis. GO annotations related to this gene include protein homodimerization activity and signal transducer activity. An important paralog of this gene is PLEKHB2.

UniProtKB/Swiss-Prot: PKHB1_HUMAN, Q9UF11
Function: Required for proper localization of retinogeniculate projections but not for eye-specific segregation
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLEKHB1 gene promoter:
         Bach1   Pax-5   GCNF   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PLEKHB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PLEKHB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLEKHB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5-q14.1   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.5-q14.1

PLEKHB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLEKHB1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P073357:  view genomic region     (about GC identifiers)

Start:
73,357,223 bp from pter      End:
73,373,864 bp from pter
Size:
16,642 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PKHB1_HUMAN, Q9UF11 (See protein sequence)
Recommended Name: Pleckstrin homology domain-containing family B member 1  
Size: 243 amino acids; 27186 Da
Subunit: Homodimer. Interacts (via PH domain) with MYO1C. Interacts (via PH domain) with MYO7A (By similarity).
Binds transducins
Subcellular location: Membrane. Cytoplasm (By similarity). Note=Localizes to the apical juxta-nuclear Golgi region
of the cytoplasm (By similarity). Membrane-associated. Highly expressed in the outer segments of photoreceptor
cells, both in rods and cones
Secondary accessions: A8K0Q5 B2RBP1 B7Z716 Q9UBF5 Q9UI37 Q9UI44
Alternative splicing: 4 isoforms:  Q9UF11-1   Q9UF11-2   Q9UF11-3   Q9UF11-4   

Explore the universe of human proteins at neXtProt for PLEKHB1: NX_Q9UF11

Explore proteomics data for PLEKHB1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UF11

  • PLEKHB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLEKHB1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001123505.1  NP_001123506.1  NP_001123507.1  NP_001123508.1  NP_067023.1  

    ENSEMBL proteins: 
     ENSP00000346127   ENSP00000381505   ENSP00000440122   ENSP00000227214   ENSP00000381507  
     ENSP00000441224   ENSP00000443899   ENSP00000445990   ENSP00000439714   ENSP00000438809  
     ENSP00000445807   ENSP00000444453   ENSP00000442136   ENSP00000442616   ENSP00000440102  
     ENSP00000441558  

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    Cloud-Clone Corp. Proteins for PLEKHB1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0016021integral to membrane IDA10585447

    PLEKHB1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    2 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UF11

    ProtoNet protein and cluster: Q9UF11

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: PKHB1_HUMAN, Q9UF11
    Similarity: Contains 1 PH domain


    PLEKHB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PKHB1_HUMAN, Q9UF11
    Function: Required for proper localization of retinogeniculate projections but not for eye-specific segregation
    (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS10585447
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
    GO:0008022protein C-terminus binding IEA--
    GO:0042803protein homodimerization activity IEA--
         
    PLEKHB1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PLEKHB1:
     Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Plekhb1):
     normal 

    PLEKHB1 for phenotypes           About GeneDecksing

    Animal Models:
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHB1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLEKHB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/16 Interacting proteins for PLEKHB1 (Q9UF113 ENSP000003461274) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713, ENSP000002636404I2D: score=4 STRING: ENSP00000263640
    GNGT1P632113, ENSP000002485724I2D: score=1 STRING: ENSP00000248572
    MYO7AQ134023, ENSP000003863314I2D: score=1 STRING: ENSP00000386331
    TGFBR1P368973, ENSP000003641334I2D: score=4 STRING: ENSP00000364133
    SMAD1Q157973, ENSP000003057694I2D: score=4 STRING: ENSP00000305769
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007602phototransduction NAS10585447
    GO:0045595regulation of cell differentiation IEA--

    PLEKHB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PLEKHB1 (PKHB1)

    Search CenterWatch for drugs/clinical trials and news about PLEKHB1 / PKHB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLEKHB1 gene (5 alternative transcripts): 
    NM_001130033.1  NM_001130034.1  NM_001130035.1  NM_001130036.1  NM_021200.2  

    Unigene Cluster for PLEKHB1:

    Pleckstrin homology domain containing, family B (evectins) member 1
    Hs.445489  [show with all ESTs]
    Unigene Representative Sequence: U89715
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000354190(uc001oua.3) ENST00000398492(uc001oub.3) ENST00000536527
    ENST00000227214(uc010rrh.1 uc001oud.3 uc009ytq.3) ENST00000398494(uc001ouc.3)
    ENST00000543085 ENST00000544532 ENST00000545798 ENST00000539157 ENST00000546251
    ENST00000535582 ENST00000538227 ENST00000541760 ENST00000543524 ENST00000541597
    ENST00000535129 ENST00000542389 ENST00000540431
    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate PLEKHB1:
    hsa-miR-141 hsa-miR-200a hsa-miR-664*
    SwitchGear 3'UTR luciferase reporter plasmidPLEKHB1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB209716.1 AF081583.1 AF093249.1 AF100612.1 AF101054.1 AK289620.1 AK289909.1 AK290109.1 
    AK296033.1 AK301299.1 AK311158.1 AK314748.1 BC008075.2 U89715.1 

    24/30 DOTS entries (see all 30):

    DT.75103321  DT.100826945  DT.97862096  DT.100826942  DT.75103322  DT.100826946  DT.95118213  DT.120678826 
    DT.120678790  DT.100826943  DT.120678788  DT.120678842  DT.40210732  DT.100826939  DT.100826940  DT.100826941 
    DT.120678795  DT.120678815  DT.120678820  DT.120678831  DT.120678839  DT.120678843  DT.205387  DT.218973 

    24/439 AceView cDNA sequences (see all 439):

    BM128497 AI459793 BM694152 BE348520 BU179812 T34932 BM694258 BE277415 
    AI306509 AA339033 BP361768 AI457677 AI081726 AA317646 AA339520 BM694257 
    BQ682578 BU838218 H85357 CD251485 Z40616 T33755 AI286075 BU728009 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHB1 (see all 15)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ·
    SP1:        -     -     -     -     -     -                 -                       -                       -           -                 -                     
    SP2:                                -     -                 -                       -                       -           -                 -                     
    SP3:        -     -     -     -     -     -                 -                       -                       -           -     -           -                     
    SP4:                                -     -                 -                       -                       -           -     -           -                     
    SP5:                                      -                 -                       -                       -           -     -           -                     

    ExUns: 13d · 13e · 13f · 13g · 13h · 13i
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for PLEKHB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLEKHB1 expression in normal human tissues (normalized intensities)      PLEKHB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAACAATTG
    PLEKHB1 Expression
    About this image


    PLEKHB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Thalamus
             Globus Pallidus   
     
     Bone (Muscoskeletal System)    fully expand to see all 12 entries
             Endochondral Facial Bones
             skeleton/pectoral girdle and thoracic body wall/scapula   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 6 entries
             Meckel's Cartilage
             sensory organ/nose/nasal septum   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             skeleton/cranium/chondrocranium   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             Human Retinal Pigment Epithelial Cells (HRPEpiC)   

    See PLEKHB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLEKHB1

    SOURCE GeneReport for Unigene cluster: Hs.445489

    UniProtKB/Swiss-Prot: PKHB1_HUMAN, Q9UF11
    Tissue specificity: Highly expressed in retina and brain. Levels are very low or not detectable in all other
    tissues tested

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PLEKHB1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plekhb11 , 5 pleckstrin homology domain containing, family B (evectins) more1, 5 87.65(n)1
    93.83(a)1
      7 (54.36 cM)5
    272761  NM_013746.31  NP_038774.11 
     1006428925 
    chicken
    (Gallus gallus)
    Aves PLEKHB11 pleckstrin homology domain containing, family B (evectins) more 71.78(n)
    64.55(a)
      419064  NM_001012546.1  NP_001012564.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLEKHB16
    Uncharacterized protein
    67(a)
    1 ↔ 1
    AAWZ02039054(7888-8025)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.147212 Transcribed sequence with weak similarity to protein more 76.28(n)    CF150842.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5666591 uncharacterized LOC566659 52.97(n)
    47.03(a)
      566659  XM_003199372.1  XP_003199420.1 


    ENSEMBL Gene Tree for PLEKHB1 (if available)
    TreeFam Gene Tree for PLEKHB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLEKHB1 gene
    PLEKHB22  
    1 SIMAP similar gene for PLEKHB1 using alignment to 13 protein entries:     PKHB1_HUMAN (see all proteins):
    PLEKHB2

    PLEKHB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/434 SNPs in PLEKHB1 are shown (see all 434)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1920246621,2
    --73219485(+) GAGGCA/GGAGGT 2 -- us2k10--------
    rs1839532081,2
    --73219519(+) CTGCAC/TTCCAG 2 -- us2k10--------
    rs1861311791,2
    --73219550(+) CCATCA/TAAAAA 2 -- us2k10--------
    rs1116953681,2
    C,F--73219649(+) CCGGGC/TGCAGT 2 -- us2k13Minor allele frequency- T:0.07CSA NA EA 242
    rs1122954651,2
    F--73219662(+) CTCACG/ACCTGT 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1128101441,2
    C,F--73219674(+) ATCCCG/ACTCTC 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1484478571,2
    --73219694(+) AGAGGA/CGGGAG 2 -- us2k10--------
    rs1424716101,2
    --73219742(+) AATATA/GGCGAG 2 -- us2k10--------
    rs1406210341,2
    C--73219769(+) AAAGG-/AAAAAA 2 -- us2k10--------
    rs24626191,2
    C,F--73219914(+) atctcC/Tgcctc 2 -- us2k14Minor allele frequency- T:0.29NA CSA 7

    HapMap Linkage Disequilibrium report for PLEKHB1 (73357223 - 73373864 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PLEKHB1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv528592CNV Loss19592680
    nsv525173CNV Loss19592680
    nsv521125CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607651    OMIM disorders: --

    2 diseases for PLEKHB1:    About MalaCards
    retinitis    neuronitis


    PLEKHB1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PLEKHB1
    Human Genome Epidemiology (HuGE) Navigator: PLEKHB1 (4 documents)

    Export disorders for PLEKHB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLEKHB1 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with PLEKHB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PHR1 encodes an abundant, pleckstrin homology domain-containing integral membrane protein in the photoreceptor outer segments. (PubMed id 10585447)1, 2, 3, 9 Xu S.... Valle D. (1999)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. KPL1, which encodes a novel PH domain-containing protein, is induced during ciliated cell differentiation of rat tracheal epithelial cells. (PubMed id 10923244)1, 2 Andrews K.L.... Ostrowski L.E. (2000)
    6. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (2013)
    7. PHR1 is a vesicle-bound protein abundantly expressed in mature olfactory neurons. (PubMed id 20301200)1 Tan B....Valle D. (2010)
    8. Genome-wide copy number variation analysis in attenti on-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree. (PubMed id 20308990)1 Lesch K.P....Ullmann R. (2010)
    9. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    10. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58473 HGNC: 19079 AceView: PLEKHB1 Ensembl:ENSG00000021300 euGenes: HUgn58473
    ECgene: PLEKHB1 H-InvDB: PLEKHB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLEKHB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLEKHB1 gene:
    Search GeneIP for patents involving PLEKHB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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