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Aliases for PLEKHA7 Gene

Aliases for PLEKHA7 Gene

  • Pleckstrin Homology Domain Containing, Family A Member 7 2 3
  • PH Domain-Containing Family A Member 7 4

External Ids for PLEKHA7 Gene

Previous GeneCards Identifiers for PLEKHA7 Gene

  • GC11M016765
  • GC11M016809
  • GC11M016493

Summaries for PLEKHA7 Gene

GeneCards Summary for PLEKHA7 Gene

PLEKHA7 (Pleckstrin Homology Domain Containing, Family A Member 7) is a Protein Coding gene. Diseases associated with PLEKHA7 include primary angle-closure glaucoma. Among its related pathways are Stabilization and expansion of the E-cadherin adherens junction. GO annotations related to this gene include phospholipid binding and delta-catenin binding. An important paralog of this gene is PLEKHA5.

UniProtKB/Swiss-Prot for PLEKHA7 Gene

  • Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHA7 Gene

Genomics for PLEKHA7 Gene

Regulatory Elements for PLEKHA7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PLEKHA7 Gene

Start:
16,777,297 bp from pter
End:
17,014,443 bp from pter
Size:
237,147 bases
Orientation:
Minus strand

Genomic View for PLEKHA7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLEKHA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHA7 Gene

Proteins for PLEKHA7 Gene

  • Protein details for PLEKHA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IQ23-PKHA7_HUMAN
    Recommended name:
    Pleckstrin homology domain-containing family A member 7
    Protein Accession:
    Q6IQ23
    Secondary Accessions:
    • B4DK33
    • B4DWC3
    • Q86VZ7

    Protein attributes for PLEKHA7 Gene

    Size:
    1121 amino acids
    Molecular mass:
    127135 Da
    Quaternary structure:
    • Interacts with KIAA1543/Nezha and CTNND1.
    SequenceCaution:
    • Sequence=AAH33239.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG62985.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PLEKHA7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLEKHA7 Gene

Proteomics data for PLEKHA7 Gene at MOPED

Post-translational modifications for PLEKHA7 Gene

  • Ubiquitination at Lys669, Lys745, and Lys751
  • Modification sites at PhosphoSitePlus

Other Protein References for PLEKHA7 Gene

No data available for DME Specific Peptides for PLEKHA7 Gene

Domains for PLEKHA7 Gene

Gene Families for PLEKHA7 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for PLEKHA7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PLEKHA7 Gene

Graphical View of Domain Structure for InterPro Entry

Q6IQ23

UniProtKB/Swiss-Prot:

PKHA7_HUMAN :
  • Q6IQ23
Domain:
  • Contains 1 PH domain.
  • Contains 2 WW domains.
genes like me logo Genes that share domains with PLEKHA7: view

Function for PLEKHA7 Gene

Molecular function for PLEKHA7 Gene

UniProtKB/Swiss-Prot Function: Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site.

Gene Ontology (GO) - Molecular Function for PLEKHA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0070097 delta-catenin binding IDA 19041755
genes like me logo Genes that share ontologies with PLEKHA7: view

Phenotypes for PLEKHA7 Gene

genes like me logo Genes that share phenotypes with PLEKHA7: view

Animal Model Products

CRISPR Products

miRNA for PLEKHA7 Gene

miRTarBase miRNAs that target PLEKHA7

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PLEKHA7 Gene

Localization for PLEKHA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLEKHA7 Gene

Cell junction, adherens junction. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to zonula adherens, recruited via its interaction with CTNND1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLEKHA7 Gene COMPARTMENTS Subcellular localization image for PLEKHA7 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for PLEKHA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 19041755
GO:0005915 zonula adherens IDA 19041755
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with PLEKHA7: view

Pathways for PLEKHA7 Gene

genes like me logo Genes that share pathways with PLEKHA7: view

Pathways by source for PLEKHA7 Gene

Gene Ontology (GO) - Biological Process for PLEKHA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045218 zonula adherens maintenance IMP 19041755
GO:0090136 epithelial cell-cell adhesion IMP 19041755
genes like me logo Genes that share ontologies with PLEKHA7: view

Transcripts for PLEKHA7 Gene

Unigene Clusters for PLEKHA7 Gene

Pleckstrin homology domain containing, family A member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLEKHA7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHA7 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^
SP1: - - - - -
SP2: -
SP3:
SP4:
SP5:
SP6: - - -
SP7: - -
SP8: - - - - - - - - - - - - - - - - - - - - - - - -
SP9:

ExUns: 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28a · 28b
SP1: - -
SP2: - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8: - - - - - -
SP9:

Relevant External Links for PLEKHA7 Gene

GeneLoc Exon Structure for
PLEKHA7
ECgene alternative splicing isoforms for
PLEKHA7

Expression for PLEKHA7 Gene

mRNA expression in normal human tissues for PLEKHA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLEKHA7 Gene

This gene is overexpressed in Esophagus - Mucosa (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PLEKHA7 Gene

SOURCE GeneReport for Unigene cluster for PLEKHA7 Gene Hs.12332

genes like me logo Genes that share expressions with PLEKHA7: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PLEKHA7 Gene

Orthologs for PLEKHA7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PLEKHA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLEKHA7 35
  • 99.49 (n)
  • 99.71 (a)
PLEKHA7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLEKHA7 35
  • 90.51 (n)
  • 92.98 (a)
PLEKHA7 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLEKHA7 35
  • 90.73 (n)
  • 93.86 (a)
PLEKHA7 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plekha7 35
  • 85.72 (n)
  • 89.2 (a)
Plekha7 16
Plekha7 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLEKHA7 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLEKHA7 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLEKHA7 35
  • 69 (n)
  • 72.72 (a)
PLEKHA7 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLEKHA7 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plekha7 35
  • 65.06 (n)
  • 61.06 (a)
zebrafish
(Danio rerio)
Actinopterygii plekha7a 36
  • 50 (a)
OneToMany
plekha7b 35
  • 64.99 (n)
  • 63.77 (a)
plekha7b 36
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG34383 36
  • 8 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BOI2 38
Species with no ortholog for PLEKHA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLEKHA7 Gene

ENSEMBL:
Gene Tree for PLEKHA7 (if available)
TreeFam:
Gene Tree for PLEKHA7 (if available)

Paralogs for PLEKHA7 Gene

Paralogs for PLEKHA7 Gene

Selected SIMAP similar genes for PLEKHA7 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with PLEKHA7: view

Variants for PLEKHA7 Gene

Sequence variations from dbSNP and Humsavar for PLEKHA7 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs832 -- 16,974,723(+) CTCTT(A/C)TTATC intron-variant
rs1555 -- 16,897,947(-) GATAT(C/G)TGAAT intron-variant
rs2668 -- 16,974,919(+) ACAGA(G/T)AATCC intron-variant
rs2669 -- 16,974,813(+) CTTAG(C/G)ACAAT intron-variant
rs2670 -- 16,974,830(+) TGTAG(C/T)TTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLEKHA7 Gene

Variant ID Type Subtype PubMed ID
nsv832077 CNV Loss 17160897
esv2744146 CNV Deletion 23290073
esv2744147 CNV Deletion 23290073
esv2744148 CNV Deletion 23290073
esv2744149 CNV Deletion 23290073
esv2744150 CNV Deletion 23290073
esv1010246 CNV Deletion 20482838
nsv825770 CNV Gain 20364138
nsv7688 CNV Loss 18451855
essv3438 CNV CNV 17122850
nsv7689 CNV Loss 18451855
esv2653384 CNV Deletion 19546169
esv2185277 CNV Deletion 18987734
esv3619 CNV Deletion 18987735
esv2744151 CNV Deletion 23290073
esv2667499 CNV Deletion 23128226
esv1324947 CNV Deletion 17803354
esv5847 CNV Loss 19470904
esv2744152 CNV Deletion 23290073
esv2744154 CNV Deletion 23290073
nsv825771 CNV Gain 20364138
nsv467711 CNV Gain 19166990

Relevant External Links for PLEKHA7 Gene

HapMap Linkage Disequilibrium report
PLEKHA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHA7 Gene

Disorders for PLEKHA7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PLEKHA7 Gene including...

Search for PLEKHA7 Gene in MalaCards »

(1) University of Copenhagen DISEASES for PLEKHA7 Gene

Relevant External Links for PLEKHA7

Genetic Association Database (GAD)
PLEKHA7
Human Genome Epidemiology (HuGE) Navigator
PLEKHA7
genes like me logo Genes that share disorders with PLEKHA7: view

No data available for UniProtKB/Swiss-Prot for PLEKHA7 Gene

Publications for PLEKHA7 Gene

  1. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. (PMID: 19041755) Meng W. … Takeichi M. (Cell 2008) 3 4
  2. Genome-wide association study of blood pressure and hypertension. (PMID: 19430479) Levy D. … van Duijn C.M. (Nat. Genet. 2009) 3 48
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population. (PMID: 20414254) Hong K.W. … Oh B. (J. Hum. Genet. 2010) 3 48
  5. Blood pressure and hypertension are associated with 7 loci in the Japanese population. (PMID: 20479155) Takeuchi F. … Kato N. (Circulation 2010) 3 48

Products for PLEKHA7 Gene

Sources for PLEKHA7 Gene

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