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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLEKHA7 Gene

protein-coding   GIFtS: 53
GCID: GC11M016809

Pleckstrin Homology Domain Containing, Family A Member 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pleckstrin Homology Domain Containing, Family A Member 71 2
PH Domain-Containing Family A Member 72 3
Pleckstrin Homology Domain Containing, Family A Member 22
Pleckstrin Homology Domain-Containing Family A Member 72

External Ids:    HGNC: 270491   Entrez Gene: 1441002   Ensembl: ENSG000001666897   OMIM: 6126865   UniProtKB: Q6IQ233   

Export aliases for PLEKHA7 gene to outside databases

Previous GC identifers: GC11M016765 GC11M016493


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PLEKHA7 Gene: 
PLEKHA7 (pleckstrin homology domain containing, family A member 7) is a protein-coding gene. Diseases associated with PLEKHA7 include primary angle-closure glaucoma, and essential hypertension. GO annotations related to this gene include phospholipid binding and delta-catenin binding. An important paralog of this gene is PLEKHA6.

UniProtKB/Swiss-Prot: PKHA7_HUMAN, Q6IQ23
Function: Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha,
which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to
the junctional site




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLEKHA7 gene promoter:
         p53   Pax-5   HNF-3beta   Max   JunD   FOXC1   FOXJ2 (long isoform)   FOXJ2   TGIF   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLEKHA7 promoter sequence
   Search SABiosciences Chromatin IP Primers for PLEKHA7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLEKHA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15

PLEKHA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLEKHA7 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M016809:  view genomic region     (about GC identifiers)

Start:
16,799,842 bp from pter      End:
17,035,990 bp from pter
Size:
236,149 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PKHA7_HUMAN, Q6IQ23 (See protein sequence)
Recommended Name: Pleckstrin homology domain-containing family A member 7  
Size: 1121 amino acids; 127135 Da
Subunit: Interacts with KIAA1543/Nezha and CTNND1
Subcellular location: Cell junction, adherens junction. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing
center, centrosome. Note=Localizes to zonula adherens, recruited via its interaction with CTNND1
Sequence caution: Sequence=AAH33239.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAG62985.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DK33 B4DWC3 Q86VZ7
Alternative splicing: 3 isoforms:  Q6IQ23-1   Q6IQ23-2   Q6IQ23-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PLEKHA7: NX_Q6IQ23

Explore proteomics data for PLEKHA7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6IQ23

  • PLEKHA7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLEKHA7 Protein Expression
    REFSEQ proteins: NP_778228.3  
    ENSEMBL proteins: 
     ENSP00000435389   ENSP00000347883   ENSP00000433467   ENSP00000434812   ENSP00000431455  
     ENSP00000435806   ENSP00000416895  

    Human Recombinant Protein Products for PLEKHA7: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PLEKHA7 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA19041755
    GO:0005915zonula adherens IDA19041755
    GO:0030054cell junction IDA--

    PLEKHA7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    3 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry Q6IQ23

    ProtoNet protein and cluster: Q6IQ23

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: PKHA7_HUMAN, Q6IQ23
    Similarity: Contains 1 PH domain
    Similarity: Contains 2 WW domains


    PLEKHA7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PKHA7_HUMAN, Q6IQ23
    Function: Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha,
    which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to
    the junctional site

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
    GO:0070097delta-catenin binding IDA19041755
         
    PLEKHA7 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PLEKHA7:
     Decreased TP53 protein express  Decreased viability of wild-ty  Increased G1 DNA content 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidPLEKHA7 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PLEKHA7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Stabilization and expansion of the E-cadherin adherens junction
    Stabilization and expansion of the E-cadherin adherens junction


    1 BioSystems Pathway for PLEKHA7
        Stabilization and expansion of the E-cadherin adherens junction


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLEKHA7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for PLEKHA7 (Q6IQ233 ENSP000003478834) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP20Q9Y2K63, ENSP000003138114I2D: score=2 STRING: ENSP00000313811
    CTNND1O607163, ENSP000003820044I2D: score=1 STRING: ENSP00000382004
    CAMSAP3Q9P1Y53, ENSP000004167974I2D: score=1 STRING: ENSP00000416797
    CDH1P128303, ENSP000002617694I2D: score=1 STRING: ENSP00000261769
    KIFC3Q9BVG83, ENSP000003689764I2D: score=1 STRING: ENSP00000368976
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045218zonula adherens maintenance IMP19041755
    GO:0090136epithelial cell-cell adhesion IMP19041755

    PLEKHA7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PLEKHA7 (PKHA7)

    Search CenterWatch for drugs/clinical trials and news about PLEKHA7 / PKHA7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLEKHA7 gene: 
    NM_175058.4  

    Unigene Cluster for PLEKHA7:

    Pleckstrin homology domain containing, family A member 7
    Hs.12332  [show with all ESTs]
    Unigene Representative Sequence: BC071599
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531066(uc010rcu.1) ENST00000529049 ENST00000533901 ENST00000355661(uc001mmn.3 uc001mmo.3)
    ENST00000531776 ENST00000332954(uc001mmm.3) ENST00000530489(uc010rcv.2)
    ENST00000525781 ENST00000532079 ENST00000533251 ENST00000525177 ENST00000525581
    ENST00000525049 ENST00000531079 ENST00000528376 ENST00000528637 ENST00000529213
    ENST00000448080
    miRNA
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    Additional mRNA sequence: 

    AK296371.1 AK301465.1 BC033239.1 BC041452.1 BC071599.1 BX648885.1 

    14 DOTS entries:

    DT.311630  DT.101980999  DT.100017453  DT.100740218  DT.120738397  DT.120738420  DT.311629  DT.91658869 
    DT.102836815  DT.120738382  DT.120738477  DT.91747444  DT.95151547  DT.120738418 

    24/71 AceView cDNA sequences (see all 71):

    AA384807 AI261298 BX648885 AL044181 AW135567 AI473098 BG386570 AW474245 
    CD723930 AA613010 AI262082 BC041452 NM_175058 F13486 BC071599 AI613497 
    BC033239 AW614571 BQ881231 BX400016 CD644364 AI697364 BM471409 BX283325 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHA7 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^
    SP1:                          -     -     -                 -                                                                 -                                 
    SP2:                                                                                                                          -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28a · 28b
    SP1:              -     -                                 
    SP2:              -     -                                 
    SP3:                                                      
    SP4:                    -                                 
    SP5:                                                      


    ECgene alternative splicing isoforms for PLEKHA7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLEKHA7 expression in normal human tissues (normalized intensities)      PLEKHA7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCTTAATA
    PLEKHA7 Expression
    About this image


    PLEKHA7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Colon (Gastrointestinal Tract)
             colonic mucosa   
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Epithelium (Respiratory System)
             bronchial epithelial cells   
     
     Placenta (Extraembryonic Tissues)

    See PLEKHA7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLEKHA7

    SOURCE GeneReport for Unigene cluster: Hs.12332
        SABiosciences Custom PCR Arrays for PLEKHA7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHA7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PLEKHA7 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plekha71 , 5 pleckstrin homology domain containing, family A member more1, 5 85.72(n)1
    89.2(a)1
      7 (61.42 cM)5
    2337651  NM_172743.21  NP_766331.11 
     1161234935 
    chicken
    (Gallus gallus)
    Aves PLEKHA71 pleckstrin homology domain containing, family A member more 68.99(n)
    72.45(a)
      423069  XM_421001.2  XP_421001.2 
    lizard
    (Anolis carolinensis)
    Reptilia PLEKHA76
    pleckstrin homology domain containing, family A me...
    63(a)
    1 ↔ 1
    1(66327388-66525731)
    zebrafish
    (Danio rerio)
    Actinopterygii plekha7b1 pleckstrin homology domain containing, family A member more 65.48(n)
    64.77(a)
      100005106  XM_001344205.3  XP_001344241.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG343836
    --
    6(a)
    1 → many
    3R(9540931-9590389)


    ENSEMBL Gene Tree for PLEKHA7 (if available)
    TreeFam Gene Tree for PLEKHA7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLEKHA7 gene
    PLEKHA62  PLEKHA42  PLEKHA52  
    3 SIMAP similar genes for PLEKHA7 using alignment to 7 protein entries:     PKHA7_HUMAN (see all proteins):
    PLEKHA4    PLEKHA5    WWC2

    PLEKHA7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4851 SNPs in PLEKHA7 are shown (see all 4851)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs79409711,2
    A,H--16808758(+) GAGAAC/TAGAGC 1 -- int14Minor allele frequency- T:0.00NS EA 418
    rs1453037501,2
    --16808895(+) TCCCTC/TCAGAA 1 -- int10--------
    rs1926282701,2
    C--16808898(+) CTCCAA/GAACCC 1 -- int10--------
    rs1144572161,2
    C,F--16808922(+) ATATTC/TGCACA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs3734094571,2
    C--16808954(+) TCTCA-/AATATGAC 1 -- cds10--------
    rs2011394061,2
    C--16808957(+) TCAATA/GACTCC 1 -- int10--------
    rs1379488201,2
    --16809005(+) TATTGC/TTGGAA 1 -- int10--------
    rs815691,2
    C,F,O,A,H--16809023(-) CTTCAA/GTTGCC 1 -- int118Minor allele frequency- N:0.00EA NA WA CSA 773
    rs1416987161,2
    --16809065(+) CACAAA/GGAAAA 1 -- int10--------
    rs79512211,2
    A,H--16809073(+) AAACAC/TTCATT 1 -- int14Minor allele frequency- T:0.00NS EA 418

    HapMap Linkage Disequilibrium report for PLEKHA7 (16799842 - 17035990 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/22 variations for PLEKHA7 (see all 22):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2744148CNV Deletion23290073
    esv2667499CNV Deletion23128226
    esv2744151CNV Deletion23290073
    esv2744152CNV Deletion23290073
    esv2653384CNV Deletion19546169
    esv2744149CNV Deletion23290073
    esv2744154CNV Deletion23290073
    esv2185277CNV Deletion18987734
    esv1010246CNV Deletion20482838
    esv2744147CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612686    OMIM disorders: --

    5 diseases for PLEKHA7:    About MalaCards
    primary angle-closure glaucoma    essential hypertension    glaucoma    hypertension
    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for PLEKHA7:
    Primary angle-closure glaucoma

    PLEKHA7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PLEKHA7
    Human Genome Epidemiology (HuGE) Navigator: PLEKHA7 (6 documents)

    Export disorders for PLEKHA7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLEKHA7 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with PLEKHA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1, 4 Wain L.V....van Duijn C.M. (2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Blood pressure and hypertension are associated with 7 loci in the Japanese population. (PubMed id 20479155)1, 4 Takeuchi F....Kato N. (2010)
    4. Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population. (PubMed id 20414254)1, 4 Hong K.W....Oh B. (2010)
    5. Genome-wide association study of blood pressure and hypertension. (PubMed id 19430479)1, 4 Levy D....van Duijn C.M. (2009)
    6. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. (PubMed id 19041755)1, 2 Meng W....Takeichi M. (2008)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    8. Genotype-phenotype analysis of SNPs associated with pr imary angle closure glaucoma (rs1015213, rs3753841 and rs11024102) and ocular bi ometry in the EPIC-Norfolk Eye Study. (PubMed id 23505305)1 Day A.C....Foster P.J. (2013)
    9. 14-3-3 proteins sequester a pool of soluble TRIM32 ubi quitin ligase to repress autoubiquitylation and cytoplasmic body formation. (PubMed id 23444366)1 Ichimura T....Hachiya N. (2013)
    10. Genetic up-regulation and overexpression of PLEKHA7 di fferentiates invasive lobular carcinomas from invasive ductal carcinomas. (PubMed id 22542108)1 Castellana B....Lerma E. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 144100 HGNC: 27049 AceView: PLEKHA7 Ensembl:ENSG00000166689 euGenes: HUgn144100
    ECgene: PLEKHA7 H-InvDB: PLEKHA7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLEKHA7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLEKHA7 gene:
    Search GeneIP for patents involving PLEKHA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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