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PLEKHA5 Gene

protein-coding   GIFtS: 51
GCID: GC12P019282

Pleckstrin Homology Domain Containing, Family A Member 5

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pleckstrin Homology Domain Containing, Family A Member 51 2     KIAA16863 5
PEPP22 3 5     Phosphoinositol 3-Phosphate-Binding Protein-22
PEPP-22 3     Pleckstrin Homology Domain-Containing Family A Member 52
PH Domain-Containing Family A Member 52 3     Phosphoinositol 3-Phosphate-Binding Protein 23

External Ids:    HGNC: 300361   Entrez Gene: 544772   Ensembl: ENSG000000521267   OMIM: 6077705   UniProtKB: Q9HAU03   

Export aliases for PLEKHA5 gene to outside databases

Previous GC identifers: GC12P019174 GC12P019052


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PLEKHA5 Gene:
PLEKHA5 (pleckstrin homology domain containing, family A member 5) is a protein-coding gene. GO annotations related to this gene include 1-phosphatidylinositol binding. An important paralog of this gene is PLEKHA6.

Gene Wiki entry for PLEKHA5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLEKHA5 gene promoter:
         GR   Pax-6   GR-beta   Lmo2   Tal-1beta   NF-kappaB   E47   GR-alpha   NF-kappaB1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLEKHA5 promoter sequence
   Search Chromatin IP Primers for PLEKHA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLEKHA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12

PLEKHA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLEKHA5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P019282:  view genomic region     (about GC identifiers)

Start:
19,282,626 bp from pter      End:
19,529,334 bp from pter
Size:
246,709 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PKHA5_HUMAN, Q9HAU0 (See protein sequence)
Recommended Name: Pleckstrin homology domain-containing family A member 5  
Size: 1116 amino acids; 127464 Da
Sequence caution: Sequence=AAH70174.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAA91742.1; Type=Frameshift; Positions=759; Sequence=BAB14419.1; Type=Erroneous
initiation; Sequence=BAB21777.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for PLEKHA5:
2DKP (3D)    
Secondary accessions: A0JP03 B4DGS1 E9PHQ3 F5H0I0 Q6NSF8 Q86ST7 Q8N3K6 Q96DY9 Q9BVR4 Q9C0H7
Q9H924 Q9NVK8
Alternative splicing: 8 isoforms:  Q9HAU0-1   Q9HAU0-2   Q9HAU0-3   Q9HAU0-4   Q9HAU0-5   Q9HAU0-6   Q9HAU0-7   Q9HAU0-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PLEKHA5: NX_Q9HAU0

Explore proteomics data for PLEKHA5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PLEKHA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001137293.2  NP_001177789.2  NP_001243399.1  NP_001243716.1  NP_061885.2  

    ENSEMBL proteins: 
     ENSP00000439396   ENSP00000404296   ENSP00000299275   ENSP00000439673   ENSP00000446308  
     ENSP00000440371   ENSP00000441777   ENSP00000443553   ENSP00000325155   ENSP00000347560  
     ENSP00000352104   ENSP00000311239   ENSP00000400411   ENSP00000439837   ENSP00000440611  

    PLEKHA5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PLEKHA5

     
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    antibodies-online peptides for PLEKHA5

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    antibodies-online antibodies for PLEKHA5 (8 products) 

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    antibodies-online kits for PLEKHA5 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    3 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry Q9HAU0

    ProtoNet protein and cluster: Q9HAU0

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: PKHA5_HUMAN, Q9HAU0
    Domain: Specifically interacts with PI3P, PI4P, PI5P, and PI(3,5)P2
    Similarity: Contains 1 PH domain
    Similarity: Contains 2 WW domains


    Find genes that share domains with PLEKHA5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16713569
    GO:00055451-phosphatidylinositol binding NAS11001876
         
    Find genes that share ontologies with PLEKHA5           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Plekha5):
     no phenotypic analysis 

    Find genes that share phenotypes with PLEKHA5           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PLEKHA5

    miRNA
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    miRTarBase miRNAs that target PLEKHA5:
    hsa-mir-155-5p (MIRT020804), hsa-mir-25-3p (MIRT050272)

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    Selected qRT-PCR Assays for microRNAs that regulate PLEKHA5 (see all 20):
    hsa-miR-320a hsa-miR-137 hsa-miR-376b hsa-miR-15a hsa-miR-421 hsa-miR-424 hsa-miR-3658 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidPLEKHA5 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PKHA5_HUMAN, Q9HAU0: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with PLEKHA5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLEKHA5
    Interactions:

        Search GeneGlobe Interaction Network for PLEKHA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLEKHA5 (Q9HAU01, 3 ENSP000002992754) via UniProtKB, MINT, STRING, and/or I2D (see all 110)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATN1P542591, 3, ENSP000003490764EBI-945934,EBI-945980 I2D: score=1 STRING: ENSP00000349076
    ATXN1P542531, 3, ENSP000002447694EBI-945934,EBI-930964 I2D: score=1 STRING: ENSP00000244769
    RBFOX1Q9NWB11, 3, ENSP000003091174EBI-945934,EBI-945906 I2D: score=1 STRING: ENSP00000309117
    ARHGEF9O433073, ENSP000002534014I2D: score=3 STRING: ENSP00000253401
    C10orf118Q7Z3E23, ENSP000003582934I2D: score=3 STRING: ENSP00000358293
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with PLEKHA5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PLEKHA5 (PKHA5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLEKHA5 gene (5 alternative transcripts): 
    NM_001143821.2  NM_001190860.2  NM_001256470.1  NM_001256787.1  NM_019012.5  

    Unigene Cluster for PLEKHA5:

    Pleckstrin homology domain containing, family A member 5
    Hs.188614  [show with all ESTs]
    Unigene Representative Sequence: NM_001143821
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000540972(uc001rdz.4) ENST00000429027(uc010sie.2 uc001rec.1)
    ENST00000299275(uc009zio.3) ENST00000538714(uc001rea.3) ENST00000535357
    ENST00000538034 ENST00000538305 ENST00000536974(uc010sih.1) ENST00000534979
    ENST00000510738 ENST00000538677 ENST00000538068 ENST00000537027 ENST00000538972
    ENST00000317589 ENST00000355397(uc001reb.3 uc009zin.3) ENST00000359180
    ENST00000309364
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PLEKHA5 (see all 20):
    hsa-miR-320a hsa-miR-137 hsa-miR-376b hsa-miR-15a hsa-miR-421 hsa-miR-424 hsa-miR-3658 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidPLEKHA5 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PLEKHA5
      QuantiFast Probe-based Assays in human, mouse, rat PLEKHA5

    Additional mRNA sequence: 

    AB051473.2 AB642244.1 AF302150.1 AJ270694.1 AK001529.1 AK023127.1 AK026344.1 AK056054.1 
    AK294739.1 AK295151.1 AK296277.1 AK297391.1 AL834259.1 BC000969.2 BC004164.2 BC013133.2 
    BC044245.1 BC070174.1 BC127092.1 

    20 DOTS entries:

    DT.313097  DT.97819412  DT.100823412  DT.95231459  DT.92458664  DT.91975606  DT.95271462  DT.75170814 
    DT.75103237  DT.100823414  DT.70104086  DT.92458658  DT.121210968  DT.441953  DT.99958994  DT.100665858 
    DT.100671797  DT.456210  DT.95271464  DT.99967003 

    Selected AceView cDNA sequences (see all 226):

    AI023279 AI990628 AA386119 BM693672 AI637851 AA232541 AA232094 BF431537 
    NM_019012 CB153372 BE207328 AI611031 AI499219 AL600061 AL834259 AI810566 
    T59650 AI636889 BC070174 AA410224 AF302150 AA232093 AW439876 BP335984 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHA5 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                                                                                                  -     -           -     -                                 
    SP2:                                                                                      -     -     -     -           -     -                                 
    SP3:                                                                                      -     -     -     -           -     -                                 
    SP4:                                                                                                                                                        -   
    SP5:                                                                                                        -           -     -                                 

    ExUns: 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b · 29c ^ 30a · 30b ^ 31a · 31b ^ 32a · 32b · 32c
    SP1:        -                                                                                             
    SP2:  -     -                                   -                                                         
    SP3:  -     -                                   -                                                         
    SP4:  -     -     -                             -                                                         
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for PLEKHA5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLEKHA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAATAAAT
    PLEKHA5 Expression
    About this image


    PLEKHA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Natural Killer Cells Peripheral Blood
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Adrenal Gland (Endocrine System)
    PLEKHA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLEKHA5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.188614

    UniProtKB/Swiss-Prot: PKHA5_HUMAN, Q9HAU0
    Tissue specificity: Highly expressed in heart and kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PLEKHA5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plekha51 , 5 pleckstrin homology domain containing, family A member more1, 5 85.65(n)1
    87.52(a)1
      6 (70.34 cM)5
    1091351  NM_144920.31  NP_659169.31 
     1404240995 
    chicken
    (Gallus gallus)
    Aves PLEKHA51 pleckstrin homology domain containing, family A member more 77.81(n)
    78.46(a)
      418183  XM_004937972.1  XP_004938029.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLEKHA56
    pleckstrin homology domain containing, family A me...
    76(a)
    1 ↔ 1
    5(9017528-9221493)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.116132 Xenopus laevis transcribed sequence with weak similarity more 74.27(n)    BJ067775.1 
    zebrafish
    (Danio rerio)
    Actinopterygii plekha51 pleckstrin homology domain containing, family A member more 61.67(n)
    61.31(a)
      567300  XM_005164475.1  XP_005164532.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG343836
    --
    9(a)
    1 → many
    3R(9540931-9590389)


    ENSEMBL Gene Tree for PLEKHA5 (if available)
    TreeFam Gene Tree for PLEKHA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLEKHA5 gene
    PLEKHA62  PLEKHA42  PLEKHA72  
    3 SIMAP similar genes for PLEKHA5 using alignment to 8 protein entries:     PKHA5_HUMAN (see all proteins):
    KIAA0053    PLEKHA7    FAM109A

    Find genes that share paralogs with PLEKHA5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLEKHA5 (see all 5371)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2017471161,2
    Cuntested119436352(+) CCTTCC/G/TACTCA 8 S syn11EU 1323
    rs609752661,2
    C--19161693(+) TGGCA-/GTA   
      GAACTT
    CACTG
    4 -- int10--------
    rs39836101,2
    C--19172923(+) TTTTT-/GT/TG 
            
    TTGTT
    4 -- int11CSA 2
    rs562349411,2
    C--19181959(+) TTTTT-/T/TT  
            
    GGTTT
    4 -- int11NA 2
    rs1174197801,2
    C,F--19280774(+) TTCTAC/TATCAT 4 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1826525571,2
    --19281090(+) CTTGTC/GTAATT 4 -- us2k10--------
    rs1495490951,2
    --19281123(+) TGGCCG/TCTCTT 4 -- us2k10--------
    rs1870073531,2
    C--19281219(+) AAAGGA/GCATTG 4 -- us2k10--------
    rs1441323961,2
    --19281328(+) AGAGAC/TAGAGG 4 -- us2k10--------
    rs1917890021,2
    C--19281358(+) AGTCAC/GAACAC 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for PLEKHA5 (19282626 - 19529334 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PLEKHA5 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663408CNV Deletion23128226
    esv2745617CNV Deletion23290073
    esv2422206CNV Duplication17116639
    esv2422261CNV Duplication17116639
    esv2422498CNV Duplication17116639
    esv1008021CNV Insertion20482838
    esv1027404CNV Insertion17803354
    nsv832346CNV Loss17160897
    nsv428274CNV Loss18775914
    nsv898851CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLEKHA5
    DNA2.0 Custom Variant and Variant Library Synthesis for PLEKHA5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607770    OMIM disorders: --


    Find genes that share disorders with PLEKHA5           About GenesLikeMe

    Genetic Association Database (GAD): PLEKHA5

    Export disorders for PLEKHA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLEKHA5 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with PLEKHA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. (PubMed id 11001876)1, 2, 3 Dowler S.J.... Alessi D.R. (Biochem. J. 2000)
    2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    3. Identification and characterization of splicing variants of PLEKHA5 (Plekha5) during brain development. (PubMed id 22037487)1, 2 Yamada K.... Wakamatsu N. (Gene 2012)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    9. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54477 HGNC: 30036 AceView: PLEKHA5 Ensembl:ENSG00000052126 euGenes: HUgn54477
    ECgene: PLEKHA5 H-InvDB: PLEKHA5

    (According to HUGE)
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    HUGE: KIAA1686

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PLEKHA5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLEKHA5 gene:
    Search GeneIP for patents involving PLEKHA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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