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Aliases for PLEKHA5 Gene

Aliases for PLEKHA5 Gene

  • Pleckstrin Homology Domain Containing, Family A Member 5 2 3
  • PEPP2 3 4 6
  • PH Domain-Containing Family A Member 5 3 4
  • KIAA1686 4 6
  • PEPP-2 3 4
  • Pleckstrin Homology Domain-Containing Family A Member 5 3
  • Phosphoinositol 3-Phosphate-Binding Protein-2 3
  • Phosphoinositol 3-Phosphate-Binding Protein 2 4

External Ids for PLEKHA5 Gene

Previous GeneCards Identifiers for PLEKHA5 Gene

  • GC12P019174
  • GC12P019282
  • GC12P019052

Summaries for PLEKHA5 Gene

GeneCards Summary for PLEKHA5 Gene

PLEKHA5 (Pleckstrin Homology Domain Containing, Family A Member 5) is a Protein Coding gene. GO annotations related to this gene include 1-phosphatidylinositol binding. An important paralog of this gene is PLEKHA7.

Gene Wiki entry for PLEKHA5 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHA5 Gene

Genomics for PLEKHA5 Gene

Regulatory Elements for PLEKHA5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PLEKHA5 Gene

Start:
19,129,692 bp from pter
End:
19,376,400 bp from pter
Size:
246,709 bases
Orientation:
Plus strand

Genomic View for PLEKHA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLEKHA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHA5 Gene

Proteins for PLEKHA5 Gene

  • Protein details for PLEKHA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAU0-PKHA5_HUMAN
    Recommended name:
    Pleckstrin homology domain-containing family A member 5
    Protein Accession:
    Q9HAU0
    Secondary Accessions:
    • A0JP03
    • B4DGS1
    • E9PHQ3
    • F5H0I0
    • Q6NSF8
    • Q86ST7
    • Q8N3K6
    • Q96DY9
    • Q9BVR4
    • Q9C0H7
    • Q9H924
    • Q9NVK8

    Protein attributes for PLEKHA5 Gene

    Size:
    1116 amino acids
    Molecular mass:
    127464 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH70174.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91742.1; Type=Frameshift; Positions=759; Evidence={ECO:0000305}; Sequence=BAB14419.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB21777.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLEKHA5 Gene

    Alternative splice isoforms for PLEKHA5 Gene

neXtProt entry for PLEKHA5 Gene

Proteomics data for PLEKHA5 Gene at MOPED

Post-translational modifications for PLEKHA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLEKHA5 Gene

Domains for PLEKHA5 Gene

Gene Families for PLEKHA5 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for PLEKHA5 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9HAU0

UniProtKB/Swiss-Prot:

PKHA5_HUMAN :
  • Q9HAU0
Domain:
  • Specifically interacts with PI3P, PI4P, PI5P, and PI(3,5)P2.
  • Contains 1 PH domain.
  • Contains 2 WW domains.
genes like me logo Genes that share domains with PLEKHA5: view

Function for PLEKHA5 Gene

Gene Ontology (GO) - Molecular Function for PLEKHA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16713569
GO:0005545 1-phosphatidylinositol binding NAS 11001876
GO:0010314 phosphatidylinositol-5-phosphate binding IEA --
GO:0032266 phosphatidylinositol-3-phosphate binding IEA --
GO:0070273 phosphatidylinositol-4-phosphate binding IEA --
genes like me logo Genes that share ontologies with PLEKHA5: view

Phenotypes for PLEKHA5 Gene

MGI mutant phenotypes for PLEKHA5:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with PLEKHA5: view

Animal Model Products

CRISPR Products

miRNA for PLEKHA5 Gene

miRTarBase miRNAs that target PLEKHA5

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLEKHA5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PLEKHA5 Gene

Localization for PLEKHA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLEKHA5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLEKHA5 Gene COMPARTMENTS Subcellular localization image for PLEKHA5 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PLEKHA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PLEKHA5: view

Pathways for PLEKHA5 Gene

SuperPathways for PLEKHA5 Gene

No Data Available

Interacting Proteins for PLEKHA5 Gene

Gene Ontology (GO) - Biological Process for PLEKHA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0061458 reproductive system development IEA --
genes like me logo Genes that share ontologies with PLEKHA5: view

No data available for Pathways by source for PLEKHA5 Gene

Transcripts for PLEKHA5 Gene

Unigene Clusters for PLEKHA5 Gene

Pleckstrin homology domain containing, family A member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLEKHA5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHA5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: -
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -

ExUns: 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b · 29c ^ 30a · 30b ^ 31a · 31b ^ 32a · 32b · 32c
SP1: -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for PLEKHA5 Gene

GeneLoc Exon Structure for
PLEKHA5
ECgene alternative splicing isoforms for
PLEKHA5

Expression for PLEKHA5 Gene

mRNA expression in normal human tissues for PLEKHA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PLEKHA5 Gene

SOURCE GeneReport for Unigene cluster for PLEKHA5 Gene Hs.188614

mRNA Expression by UniProt/SwissProt for PLEKHA5 Gene

Q9HAU0-PKHA5_HUMAN
Tissue specificity: Highly expressed in heart and kidney.
genes like me logo Genes that share expressions with PLEKHA5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PLEKHA5 Gene

Orthologs for PLEKHA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLEKHA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLEKHA5 35
  • 99.57 (n)
  • 99.35 (a)
cow
(Bos Taurus)
Mammalia PLEKHA5 35
  • 90.02 (n)
  • 92.25 (a)
PLEKHA5 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLEKHA5 35
  • 93.42 (n)
  • 94.07 (a)
PLEKHA5 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plekha5 35
  • 85.65 (n)
  • 87.52 (a)
Plekha5 16
Plekha5 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLEKHA5 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLEKHA5 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plekha5 35
  • 85.49 (n)
  • 87.55 (a)
chicken
(Gallus gallus)
Aves PLEKHA5 35
  • 77.81 (n)
  • 78.46 (a)
PLEKHA5 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLEKHA5 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11613 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7383 35
zebrafish
(Danio rerio)
Actinopterygii plekha5 35
  • 61.67 (n)
  • 61.31 (a)
plekha5 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG34383 36
  • 9 (a)
OneToMany
Species with no ortholog for PLEKHA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLEKHA5 Gene

ENSEMBL:
Gene Tree for PLEKHA5 (if available)
TreeFam:
Gene Tree for PLEKHA5 (if available)

Paralogs for PLEKHA5 Gene

Paralogs for PLEKHA5 Gene

Selected SIMAP similar genes for PLEKHA5 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PLEKHA5: view

Variants for PLEKHA5 Gene

Sequence variations from dbSNP and Humsavar for PLEKHA5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs8601 -- 19,376,134(-) TAAGC(A/G)GTAAC utr-variant-3-prime
rs704158 -- 19,296,869(+) TGGAA(A/C/G/T)GTGTT intron-variant
rs704159 -- 19,297,616(+) AGAGC(A/G)AGGCT intron-variant
rs704160 -- 19,299,368(+) CCATA(A/T)CACCT intron-variant
rs704161 -- 19,306,657(+) TGACT(A/G)ATCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLEKHA5 Gene

Variant ID Type Subtype PubMed ID
esv2422206 CNV Duplication 17116639
esv2422261 CNV Duplication 17116639
nsv428274 CNV Loss 18775914
esv2422498 CNV Duplication 17116639
nsv470273 CNV Gain 18288195
nsv516362 CNV Gain+Loss 19592680
nsv898851 CNV Loss 21882294
esv33101 CNV Gain 17666407
esv1008021 CNV Insertion 20482838
esv1027404 CNV Insertion 17803354
esv2745617 CNV Deletion 23290073
nsv469131 CNV Gain 19166990
esv2663408 CNV Deletion 23128226
dgv1386n71 CNV Gain 21882294
dgv188n27 CNV Gain 19166990
nsv898854 CNV Gain 21882294
nsv832346 CNV Loss 17160897

Relevant External Links for PLEKHA5 Gene

HapMap Linkage Disequilibrium report
PLEKHA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHA5 Gene

Disorders for PLEKHA5 Gene

Relevant External Links for PLEKHA5

Genetic Association Database (GAD)
PLEKHA5
genes like me logo Genes that share disorders with PLEKHA5: view

No data available for UniProtKB/Swiss-Prot for PLEKHA5 Gene

Publications for PLEKHA5 Gene

  1. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. (PMID: 11001876) Dowler S.J. … Alessi D.R. (Biochem. J. 2000) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for PLEKHA5 Gene

  • antibodies-online peptides for PLEKHA5
  • antibodies-online antibodies for PLEKHA5
  • antibodies-online kits for PLEKHA5

Sources for PLEKHA5 Gene

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