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GIFtS

PLEKHA2 Gene

protein-coding   GIFtS: 50
GCID: GC08P038776

pleckstrin homology domain containing, family A (phosphoinositide...

(Previous names: pleckstrin homology domain-containing, family A (phosphoinositide...)
 Explore 2 diseases affiliated with
PLEKHA2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PLEKHA2    

Aliases
for PLEKHA2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Pleckstrin Homology Domain Containing, Family A (Phosphoinositide Binding
Specific) Member 21 2
     TAPP-22 3
TAPP21 2 3 5     PH Domain-Containing Family A Member 22 3
Pleckstrin Homology Domain-Containing, Family A (Phosphoinositide Binding
Specific) Member 21 2
     Pleckstrin Homology Domain-Containing Family A Member 22
Tandem PH Domain-Containing Protein 22 3     Tandem PH Domain Containing Protein-22

External Ids:    HGNC: 143361   Entrez Gene: 593392   Ensembl: ENSG000001694997   OMIM: 6077735   UniProtKB: Q9HB193   

Export aliases for PLEKHA2 gene to outside databases

Previous GC identifers: GC08U990120 GC08M038973 GC08P038499 GC08P038877 GC08P037294


Summaries
for PLEKHA2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: PKHA2_HUMAN, Q9HB19
Function: Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides.
May recruit other proteins to the plasma membrane (By similarity)




Genomic Views
for PLEKHA2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLEKHA2 gene promoter:
         Nkx3-1 v4   Pax-6   Nkx3-1 v1   NF-E2 p45   RORalpha2   Nkx3-1 v2   Nkx6-1   IRF-7A   Nkx3-1 v3   NF-E2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PLEKHA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLEKHA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.22   Ensembl cytogenetic band:  8p11.22   HGNC cytogenetic band: 8p11.21

PLEKHA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLEKHA2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P038776:  view genomic region     (about GC identifiers)

Start:
 38,758,753 bp from pter      End:
 38,831,431 bp from pter
Size:
 72,679 bases      Orientation:
 plus strand

Proteins
for PLEKHA2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PKHA2_HUMAN, Q9HB19 (See protein sequence)
Recommended Name: Pleckstrin homology domain-containing family A member 2  
Size: 425 amino acids; 47255 Da
Subunit: Binds MPDZ and PTPN13 (By similarity)
Subcellular location: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Nucleus
(By similarity). Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2 (By
similarity)
Sequence caution: Sequence=AAG15201.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for PLEKHA2: NX_Q9HB19

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HB19

    • PLEKHA2 Protein expression data from MOPED and PaxDb:    About this image 
    PLEKHA2 Protein Expression
    REFSEQ proteins: NP_067636.1  
    ENSEMBL proteins: 
     ENSP00000430938   ENSP00000429956   ENSP00000393860   ENSP00000444386  

    Human Recombinant Protein Products for PLEKHA2: 
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    OriGene Purified Protein: PLEKHA2
    OriGene Protein Over-expression Lysate: PLEKHA2
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    Novus Biologicals PLEKHA2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PLEKHA2

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA19786618
    GO:0005886plasma membrane IEA--
    GO:0016020membrane IDA19786618
    GO:0043234protein complex IDA19786618

    PLEKHA2 for ontologies           About GeneDecksing



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    Assay Products for PLEKHA2: 
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    Uscn ELISAs and CLIAs for PLEKHA2

    Protein Domains /
    Families
    for PLEKHA2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PLEKHA2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9HB19

    ProtoNet protein and cluster: Q9HB19

    1 Blocks protein family: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: PKHA2_HUMAN, Q9HB19
    Similarity: Contains 2 PH domains


    Function
    for PLEKHA2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PKHA2_HUMAN, Q9HB19
    Function: Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides.
    May recruit other proteins to the plasma membrane (By similarity)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IMP19786618
    GO:0005515protein binding IPI19786618
    GO:0005543phospholipid binding ----
    GO:00055451-phosphatidylinositol binding IEA--
    GO:0030165PDZ domain binding IEA--
         
    PLEKHA2 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Plekha2):
     cardiovascular system  homeostasis/metabolism  muscle  normal 

    PLEKHA2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PLEKHA2 

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLEKHA2
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate PLEKHA2 (see all 39):
    hsa-miR-4307 hsa-miR-4328 hsa-miR-513a-5p hsa-miR-16-1* hsa-miR-570 hsa-miR-9 hsa-miR-296-5p hsa-miR-556-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLEKHA2 (see all 4)
    OriGene shRNA RFP: PLEKHA2
    OriGene siRNA: PLEKHA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLEKHA2
    Sirion Biotech Custom design and validation of potent shRNA sequences against PLEKHA2 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PLEKHA2
    Sirion Biotech Customized adenovirus for overexpression of PLEKHA2 
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHA2


    Pathways & Interactions
    for PLEKHA2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1ICos-ICosL Pathway in T-Helper Cell
    		ICos-ICosL Pathway in T-Helper Cell1.00
    2B Cell Receptor Signaling Pathway
    		B Cell Receptor Signaling Pathway1.00
    3Class I PI3K signaling events
    		Class I PI3K signaling events1.00
    4B cell receptor signaling pathway
    		PI3K Signaling in B-Lymphocyte0.35

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLEKHA2
        ICos-ICosL Pathway in T-Helper Cell
    PI3K Signaling in B-Lymphocyte

    2 BioSystems Pathways for PLEKHA2 
        B Cell Receptor Signaling Pathway
    Class I PI3K signaling events


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLEKHA2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/8 Interacting proteins for PLEKHA2 (Q9HB192, 3 ENSP000003938604) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN13Q129232, 3, ENSP000003947944MINT-65967 MINT-65961 I2D: score=1 STRING: ENSP00000394794
    MPDZO759702, 3, ENSP000003704104MINT-65963 I2D: score=2 STRING: ENSP00000370410
    PLEKHA1Q9HB213, ENSP000003579864I2D: score=1 STRING: ENSP00000357986
    AXIN2Q9Y2T13I2D: score=1 
    CSNK1A1P487293I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001954positive regulation of cell-matrix adhesion IMP19786618

    PLEKHA2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PLEKHA2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PLEKHA2
    Search CenterWatch for drugs/clinical trials and news about PLEKHA2 / PKHA2 

    Transcripts
    for PLEKHA2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PLEKHA2 gene: 
    NM_021623.1  

    Unigene Cluster for PLEKHA2:

    Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
    Hs.369123  [show with all ESTs]
    Unigene Representative Sequence: NM_021623
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521746 ENST00000518571 ENST00000388745 ENST00000519640 ENST00000521784
    ENST00000518070 ENST00000521382 ENST00000518939 ENST00000521123 ENST00000420274(uc003xmi.4 uc011lce.2)
    ENST00000535929

    miRNA
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    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate PLEKHA2 (see all 39):
    hsa-miR-4307 hsa-miR-4328 hsa-miR-513a-5p hsa-miR-16-1* hsa-miR-570 hsa-miR-9 hsa-miR-296-5p hsa-miR-556-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLEKHA2 (see all 4)
    OriGene shRNA RFP: PLEKHA2
    OriGene siRNA: PLEKHA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLEKHA2
    Sirion Biotech Custom design and validation of potent shRNA sequences against PLEKHA2 
    Clone
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    GenScript: all cDNA clones in your preferred vector: PLEKHA2 (NM_021623)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLEKHA2
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    Additional cDNA sequence: 

    AF286164.1 AK057205.1 AK098787.1 AK291842.1 AK296068.1 AK309020.1 

    10 DOTS entries:

    DT.91648608  DT.208149  DT.116708  DT.100676000  DT.99942610  DT.97807384  DT.100821347  DT.91648661 
    DT.95151080  DT.95374354 

    24/224 AceView cDNA sequences (see all 224):

    BM683671 BM770599 AI335824 BU618507 AA469115 BQ935467 AA721234 BE327868 
    AA368980 AA700416 CA424097 BE463447 AW272449 AW575742 AI701661 AA482333 
    BM909358 BQ775392 BQ898790 BX090739 BX107876 AW263694 AI185428 AI474921 

    GeneLoc Exon Structure


    Expression
    for PLEKHA2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLEKHA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAAATACTG
    PLEKHA2 Expression
    About this image

    PLEKHA2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainMedulla OblongataBrain
    CartilageMeckel's CartilageCartilage
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PLEKHA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLEKHA2

    SOURCE GeneReport for Unigene cluster: Hs.369123

    UniProtKB/Swiss-Prot: PKHA2_HUMAN, Q9HB19
    Tissue specificity: Highly expressed in heart, kidney, spleen and peripheral blood leukocytes. Detected at lower levels
    in brain, skeletal muscle, colon, thymus, liver, small intestine, placenta and lung

        SABiosciences Custom PCR Arrays for PLEKHA2
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHA2

    Orthologs
    for PLEKHA2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PLEKHA2 gene from 3/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PLEKHA21 pleckstrin homology domain containing, family A (phosphoinositide more 72.65(n)
    76.66(a)    		   395435  NM_204698.1  NP_990029.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PLEKHA26
    		 --
    		 78(a)
    		 1 ↔ 1
    		 GL344023.1(16817-43335)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-204d2.41 si:ch211-204d2.4 57.92(n)
    57.4(a)    		   100003662  NM_001128363.1  NP_001121835.1 


    ENSEMBL Gene Tree for PLEKHA2 (if available)
    TreeFam Gene Tree for PLEKHA2 (if available) 

    Paralogs
    for PLEKHA2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLEKHA2 gene
    PLEKHA12  
    2 SIMAP similar genes for PLEKHA2 using alignment to 5 protein entries:     PKHA2_HUMAN (see all proteins):
    PLEKHA1    GAB2

    PLEKHA2 for paralogs           About GeneDecksing



    Genomic Variants
    for PLEKHA2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1192 NCBI SNPs in PLEKHA2 are shown (see all 1192)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1396042521,2
    		--38756761(+) CCCCAC/TGGGGA 1 -- us2k10--------
    rs1450927271,2
    		--38756944(+) TAGCAC/TCTACT 1 -- us2k10--------
    rs1826331011,2
    		--38756973(+) TCAACA/GCTTCA 1 -- us2k10--------
    rs1880017221,2
    		--38757038(+) TGCCCA/GGGGGT 1 -- us2k10--------
    rs756433391,2
    		--38757081(+) ATCCAG/AGTTCC 1 -- us2k11Minor allele frequency- A:0.01EA 120
    rs1910834671,2
    		--38757163(+) ATGAAC/TGGGGA 1 -- us2k10--------
    rs1508796351,2
    		--38757175(+) AAAAAA/TGACAT 1 -- us2k10--------
    rs1484005131,2
    		C--38757204(+) GGAAA-/TGTGTG
    TGTGTGTG    TGTGT     		1 -- us2k10--------
    rs1457535811,2
    		--38757231(+) TGTGT-/GTGTGTGTG
    TGTGTGTGTGTG    TTTTG     		1 -- us2k10--------
    rs100814321,2
    		C,F,A--38757464(+) GCCCCT/CCTCCC 1 -- us2k1 tfbs3 trp37Minor allele frequency- C:0.41NA WA EA 366

    HapMap Linkage Disequilibrium report for PLEKHA2 (38758753 - 38831431 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PLEKHA2
         2 CNVs: 52518 52517

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    Disorders / Diseases
    for PLEKHA2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PLEKHA2 for disorders           About GeneDecksing

    OMIM gene information: 607773    OMIM disorders: --

    2 diseases for PLEKHA2:    About MalaCards
    t-cell leukemia    leukemia

    Human Genome Epidemiology (HuGE) Navigator: PLEKHA2 (1 document)

    Export disorders for PLEKHA2 gene to outside databases

    Publications
    for PLEKHA2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLEKHA2 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with PLEKHA2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. (PubMed id 11001876)1, 2, 3 Dowler S.J.... Alessi D.R. (2000)
    2. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (2006)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. TAPP2 links phosphoinositide 3-kinase signaling to B- cell adhesion through interaction with the cytoskeletal protein utrophin: expre ssion of a novel cell adhesion-promoting complex in B-cell leukemia. (PubMed id 19786618)1 Costantini J.L....Marshall A.J. (2009)
    7. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    External Searches for PLEKHA2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing PLEKHA2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 59339 HGNC: 14336 AceView: PLEKHA2 Ensembl:ENSG00000169499 euGenes: HUgn59339
    ECgene: PLEKHA2 H-InvDB: PLEKHA2

    Other Databases showing PLEKHA2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PLEKHA2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLEKHA2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PLEKHA2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PLEKHA2 gene:
    Search GeneIP for patents involving PLEKHA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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