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Aliases for PLEKHA2 Gene

Aliases for PLEKHA2 Gene

  • Pleckstrin Homology Domain Containing, Family A (Phosphoinositide Binding Specific) Member 2 2 3
  • TAPP2 3 4 6
  • Pleckstrin Homology Domain-Containing, Family A (Phosphoinositide Binding Specific) Member 2 2 3
  • PH Domain-Containing Family A Member 2 3 4
  • Tandem PH Domain Containing Protein-2 2 3
  • Tandem PH Domain-Containing Protein 2 3 4
  • TAPP-2 3 4
  • Pleckstrin Homology Domain-Containing Family A Member 2 3

External Ids for PLEKHA2 Gene

Summaries for PLEKHA2 Gene

GeneCards Summary for PLEKHA2 Gene

PLEKHA2 (Pleckstrin Homology Domain Containing, Family A (Phosphoinositide Binding Specific) Member 2) is a Protein Coding gene. Among its related pathways are Class I PI3K signaling events and B Cell Receptor Signaling Pathway (WikiPathways). GO annotations related to this gene include PDZ domain binding and fibronectin binding. An important paralog of this gene is PLEKHA1.

UniProtKB/Swiss-Prot for PLEKHA2 Gene

  • Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHA2 Gene

Genomics for PLEKHA2 Gene

Genomic Location for PLEKHA2 Gene

Start:
38,901,235 bp from pter
End:
38,973,912 bp from pter
Size:
72,678 bases
Orientation:
Plus strand

Genomic View for PLEKHA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLEKHA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHA2 Gene

Regulatory Elements for PLEKHA2 Gene

Proteins for PLEKHA2 Gene

  • Protein details for PLEKHA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB19-PKHA2_HUMAN
    Recommended name:
    Pleckstrin homology domain-containing family A member 2
    Protein Accession:
    Q9HB19
    Secondary Accessions:

    Protein attributes for PLEKHA2 Gene

    Size:
    425 amino acids
    Molecular mass:
    47255 Da
    Quaternary structure:
    • Binds MPDZ and PTPN13.
    SequenceCaution:
    • Sequence=AAG15201.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PLEKHA2 Gene

Proteomics data for PLEKHA2 Gene at MOPED

Post-translational modifications for PLEKHA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLEKHA2 Gene

No data available for DME Specific Peptides for PLEKHA2 Gene

Domains for PLEKHA2 Gene

Gene Families for PLEKHA2 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for PLEKHA2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

PKHA2_HUMAN
Domain:
  • Contains 2 PH domains.:
    • Q9HB19
genes like me logo Genes that share domains with PLEKHA2: view

Function for PLEKHA2 Gene

Molecular function for PLEKHA2 Gene

UniProtKB/Swiss-Prot Function: Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity).

Gene Ontology (GO) - Molecular Function for PLEKHA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IMP 19786618
GO:0005515 protein binding IPI 19786618
GO:0005545 1-phosphatidylinositol binding --
GO:0008289 lipid binding IEA --
GO:0030165 PDZ domain binding --
genes like me logo Genes that share ontologies with PLEKHA2: view
genes like me logo Genes that share phenotypes with PLEKHA2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PLEKHA2 Gene

Localization for PLEKHA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLEKHA2 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLEKHA2 Gene COMPARTMENTS Subcellular localization image for PLEKHA2 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PLEKHA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 19786618
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IDA 19786618
GO:0043234 protein complex IDA 19786618
genes like me logo Genes that share ontologies with PLEKHA2: view

Pathways for PLEKHA2 Gene

genes like me logo Genes that share pathways with PLEKHA2: view

Pathways by source for PLEKHA2 Gene

Interacting Proteins for PLEKHA2 Gene

Gene Ontology (GO) - Biological Process for PLEKHA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001954 positive regulation of cell-matrix adhesion IMP 19786618
genes like me logo Genes that share ontologies with PLEKHA2: view

Transcripts for PLEKHA2 Gene

Unigene Clusters for PLEKHA2 Gene

Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHA2 Gene

No ASD Table

Relevant External Links for PLEKHA2 Gene

GeneLoc Exon Structure for
PLEKHA2
ECgene alternative splicing isoforms for
PLEKHA2

Expression for PLEKHA2 Gene

mRNA expression in normal human tissues for PLEKHA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PLEKHA2 Gene

SOURCE GeneReport for Unigene cluster for PLEKHA2 Gene Hs.369123

mRNA Expression by UniProt/SwissProt for PLEKHA2 Gene

Q9HB19-PKHA2_HUMAN
Tissue specificity: Highly expressed in heart, kidney, spleen and peripheral blood leukocytes. Detected at lower levels in brain, skeletal muscle, colon, thymus, liver, small intestine, placenta and lung
genes like me logo Genes that share expressions with PLEKHA2: view

Orthologs for PLEKHA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLEKHA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLEKHA2 36
  • 99.47 (n)
  • 99.73 (a)
PLEKHA2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLEKHA2 36
  • 89.49 (n)
  • 92.24 (a)
PLEKHA2 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLEKHA2 36
  • 90.04 (n)
  • 90.82 (a)
PLEKHA2 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plekha2 36
  • 86.12 (n)
  • 88.71 (a)
Plekha2 16
Plekha2 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLEKHA2 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLEKHA2 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plekha2 36
  • 84.94 (n)
  • 87.06 (a)
chicken
(Gallus gallus)
Aves PLEKHA2 36
  • 72.65 (n)
  • 76.66 (a)
TAPP2 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLEKHA2 37
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plekha2 36
  • 63.25 (n)
  • 63.75 (a)
zebrafish
(Danio rerio)
Actinopterygii PLEKHA2 37
  • 51 (a)
OneToOne
si:ch211-204d2.4 36
  • 57.84 (n)
  • 56.88 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
OneToMany
Species with no ortholog for PLEKHA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLEKHA2 Gene

ENSEMBL:
Gene Tree for PLEKHA2 (if available)
TreeFam:
Gene Tree for PLEKHA2 (if available)

Paralogs for PLEKHA2 Gene

Paralogs for PLEKHA2 Gene

Selected SIMAP similar genes for PLEKHA2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PLEKHA2: view

Variants for PLEKHA2 Gene

Sequence variations from dbSNP and Humsavar for PLEKHA2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2010445 -- 38,902,614(-) AGATA(G/T)ATTAA intron-variant
rs2056170 -- 38,906,198(+) GGCTG(C/T)GTGCC intron-variant
rs4076625 -- 38,936,939(-) GGGGA(C/T)GTGCA intron-variant
rs4257977 -- 38,905,729(+) GCCCA(G/T)GCTGG intron-variant
rs4301415 -- 38,966,733(+) GTGCT(C/G)CGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLEKHA2 Gene

Variant ID Type Subtype PubMed ID
nsv465637 CNV Loss 19166990
nsv522550 CNV Loss 19592680
nsv516960 CNV Loss 19592680

Relevant External Links for PLEKHA2 Gene

HapMap Linkage Disequilibrium report
PLEKHA2

Disorders for PLEKHA2 Gene

Relevant External Links for PLEKHA2

Genetic Association Database (GAD)
PLEKHA2
Human Genome Epidemiology (HuGE) Navigator
PLEKHA2
genes like me logo Genes that share disorders with PLEKHA2: view

No data available for UniProtKB/Swiss-Prot for PLEKHA2 Gene

Publications for PLEKHA2 Gene

  1. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. (PMID: 11001876) Dowler S.J. … Alessi D.R. (Biochem. J. 2000) 2 3 4
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  5. The tandem PH domain-containing protein 2 (TAPP2) regulates chemokine-induced cytoskeletal reorganization and malignant B cell migration. (PMID: 23460911) Li H. … Marshall A.J. (PLoS ONE 2013) 3

Products for PLEKHA2 Gene

Sources for PLEKHA2 Gene

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