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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLEKHA2 Gene

protein-coding   GIFtS: 50
GCID: GC08P038776

Pleckstrin Homology Domain Containing, Family A (Phosphoinositide...

(Previous names: pleckstrin homology domain-containing, family A (phosphoinositide...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pleckstrin Homology Domain Containing, Family A (Phosphoinositide
Binding Specific) Member 21 2
     Tandem PH Domain-Containing Protein 22 3
TAPP22 3 5     TAPP-22 3
Pleckstrin Homology Domain-Containing, Family A (Phosphoinositide Binding
Specific) Member 21 2
     PH Domain-Containing Family A Member 22 3
Tandem PH Domain Containing Protein-21 2     Pleckstrin Homology Domain-Containing Family A Member 22

External Ids:    HGNC: 143361   Entrez Gene: 593392   Ensembl: ENSG000001694997   OMIM: 6077735   UniProtKB: Q9HB193   

Export aliases for PLEKHA2 gene to outside databases

Previous GC identifers: GC08U990120 GC08M038973 GC08P038499 GC08P038877 GC08P037294


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PLEKHA2 Gene: 
PLEKHA2 (pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2) is a protein-coding gene. Diseases associated with PLEKHA2 include t-cell leukemia, and leukemia, and among its related super-pathways are CD28 Signaling in T-Helper Cell and IL-2 Pathway. GO annotations related to this gene include PDZ domain binding and fibronectin binding. An important paralog of this gene is PLEKHA1.

UniProtKB/Swiss-Prot: PKHA2_HUMAN, Q9HB19
Function: Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other
phosphoinositides. May recruit other proteins to the plasma membrane (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLEKHA2 gene promoter:
         Nkx3-1 v4   Pax-6   Nkx3-1 v1   NF-E2 p45   RORalpha2   Nkx3-1 v2   Nkx6-1   IRF-7A   Nkx3-1 v3   NF-E2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PLEKHA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLEKHA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.22   Ensembl cytogenetic band:  8p11.22   HGNC cytogenetic band: 8p11.21

PLEKHA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLEKHA2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P038776:  view genomic region     (about GC identifiers)

Start:
38,758,753 bp from pter      End:
38,831,431 bp from pter
Size:
72,679 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PKHA2_HUMAN, Q9HB19 (See protein sequence)
Recommended Name: Pleckstrin homology domain-containing family A member 2  
Size: 425 amino acids; 47255 Da
Subunit: Binds MPDZ and PTPN13 (By similarity)
Subcellular location: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity).
Nucleus (By similarity). Note=Locates to the plasma membrane after treatments that stimulate the production of
PtdIns3,4P2 (By similarity)
Sequence caution: Sequence=AAG15201.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for PLEKHA2: NX_Q9HB19

Explore proteomics data for PLEKHA2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HB19

  • PLEKHA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLEKHA2 Protein Expression
    REFSEQ proteins: NP_067636.1  
    ENSEMBL proteins: 
     ENSP00000430938   ENSP00000429956   ENSP00000393860  

    Human Recombinant Protein Products for PLEKHA2: 
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    Novus Biologicals PLEKHA2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PLEKHA2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA19786618
    GO:0005886plasma membrane IEA--
    GO:0016020membrane IDA19786618
    GO:0043234protein complex IDA19786618

    PLEKHA2 for ontologies           About GeneDecksing



    PLEKHA2 Antibody Products: 
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    Assay Products for PLEKHA2: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    2 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9HB19

    ProtoNet protein and cluster: Q9HB19

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: PKHA2_HUMAN, Q9HB19
    Similarity: Contains 2 PH domains


    PLEKHA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PKHA2_HUMAN, Q9HB19
    Function: Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other
    phosphoinositides. May recruit other proteins to the plasma membrane (By similarity)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IMP19786618
    GO:0005515protein binding IPI19786618
    GO:0005543phospholipid binding ----
    GO:00055451-phosphatidylinositol binding IEA--
    GO:0030165PDZ domain binding IEA--
         
    PLEKHA2 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Plekha2):
     cardiovascular system  homeostasis/metabolism  muscle  normal 

    PLEKHA2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PLEKHA2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PLEKHA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLEKHA2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLEKHA2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLEKHA2
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate PLEKHA2 (see all 39):
    hsa-miR-4307 hsa-miR-4328 hsa-miR-513a-5p hsa-miR-16-1* hsa-miR-570 hsa-miR-9 hsa-miR-296-5p hsa-miR-556-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PLEKHA2
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHA2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PLEKHA2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1ICos-ICosL Pathway in T-Helper Cell
    ICos-ICosL Pathway in T-Helper Cell0.66
    2ErbB4 Pathway
    PI3K Signaling in B-Lymphocyte0.35
    3B Cell Receptor Signaling Pathway
    B Cell Receptor Signaling Pathway
    4Class I PI3K signaling events
    Class I PI3K signaling events

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLEKHA2
        ICos-ICosL Pathway in T-Helper Cell
    PI3K Signaling in B-Lymphocyte

    2 BioSystems Pathways for PLEKHA2
        B Cell Receptor Signaling Pathway
    Class I PI3K signaling events


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLEKHA2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/8 Interacting proteins for PLEKHA2 (Q9HB192, 3 ENSP000003938604) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN13Q129232, 3, ENSP000003947944MINT-65967 MINT-65961 I2D: score=1 STRING: ENSP00000394794
    MPDZO759702, 3, ENSP000003704104MINT-65963 I2D: score=2 STRING: ENSP00000370410
    PLEKHA1Q9HB213, ENSP000003579864I2D: score=1 STRING: ENSP00000357986
    AXIN2Q9Y2T13I2D: score=1 
    CSNK1A1P487293I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001954positive regulation of cell-matrix adhesion IMP19786618

    PLEKHA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PLEKHA2 (PKHA2)

    Search CenterWatch for drugs/clinical trials and news about PLEKHA2 / PKHA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLEKHA2 gene: 
    NM_021623.1  

    Unigene Cluster for PLEKHA2:

    Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
    Hs.369123  [show with all ESTs]
    Unigene Representative Sequence: NM_021623
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521746 ENST00000518571 ENST00000388745 ENST00000519640 ENST00000521784
    ENST00000518070 ENST00000521382 ENST00000518939 ENST00000521123 ENST00000420274(uc003xmi.4 uc011lce.2)

    miRNA
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    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate PLEKHA2 (see all 39):
    hsa-miR-4307 hsa-miR-4328 hsa-miR-513a-5p hsa-miR-16-1* hsa-miR-570 hsa-miR-9 hsa-miR-296-5p hsa-miR-556-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLEKHA2
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLEKHA2
    Sirion Biotech Customized lentivirus for stable overexpression of PLEKHA2 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLEKHA2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLEKHA2

    Additional mRNA sequence: 

    AF286164.1 AK057205.1 AK098787.1 AK291842.1 AK296068.1 AK309020.1 

    10 DOTS entries:

    DT.91648608  DT.208149  DT.116708  DT.100676000  DT.99942610  DT.97807384  DT.100821347  DT.91648661 
    DT.95151080  DT.95374354 

    24/224 AceView cDNA sequences (see all 224):

    BX107876 BM683747 AI185428 CA394111 BM909358 BE463447 AI923309 AW263694 
    AA700416 AW272449 BX090739 CR605978 BM770599 CA424097 BE327868 BU618507 
    AA368980 BM683671 BQ935467 AA482333 BQ775392 AI335824 AI701661 BQ898790 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLEKHA2 expression in normal human tissues (normalized intensities)      PLEKHA2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAATACTG
    PLEKHA2 Expression
    About this image


    PLEKHA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Small Pre B-Cells Hematopoietic Bone Marrow
             neutrophils   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Endothelium (Cardiovascular System)
             Peripheral blood-derived endothelial progenitor cells
     
     Lymph (Hematopoietic System)
             lymph node   
     
     Cartilage (Muscoskeletal System)
             Meckel's Cartilage

    See PLEKHA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLEKHA2

    SOURCE GeneReport for Unigene cluster: Hs.369123

    UniProtKB/Swiss-Prot: PKHA2_HUMAN, Q9HB19
    Tissue specificity: Highly expressed in heart, kidney, spleen and peripheral blood leukocytes. Detected at lower
    levels in brain, skeletal muscle, colon, thymus, liver, small intestine, placenta and lung

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLEKHA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PLEKHA2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plekha21 , 5 pleckstrin homology domain-containing, family A (phosphoinositide more1, 5 86.12(n)1
    88.71(a)1
      8 (13.70 cM)5
    834361  NM_031257.31  NP_112547.11 
     250391445 
    chicken
    (Gallus gallus)
    Aves PLEKHA21 pleckstrin homology domain containing, family A (phosphoinositide more 72.65(n)
    76.66(a)
      395435  NM_204698.1  NP_990029.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLEKHA26
    --
    --
    75(a)
    38(a)
    1 ↔ 1
    possible ortholog
    GL344023.1(16794-44469)
    AAWZ02038017(1780-5447)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-204d2.41 si:ch211-204d2.4 57.92(n)
    57.4(a)
      100003662  NM_001128363.1  NP_001121835.1 


    ENSEMBL Gene Tree for PLEKHA2 (if available)
    TreeFam Gene Tree for PLEKHA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLEKHA2 gene
    PLEKHA12  
    1 SIMAP similar gene for PLEKHA2 using alignment to 4 protein entries:     PKHA2_HUMAN (see all proteins):
    PLEKHA1

    PLEKHA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1419 SNPs in PLEKHA2 are shown (see all 1419)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1396042521,2
    C--38756761(+) CCCCAC/TGGGGA 1 -- us2k10--------
    rs1450927271,2
    --38756944(+) TAGCAC/TCTACT 1 -- us2k10--------
    rs1826331011,2
    --38756973(+) TCAACA/GCTTCA 1 -- us2k10--------
    rs1880017221,2
    --38757038(+) TGCCCA/GGGGGT 1 -- us2k10--------
    rs756433391,2
    F--38757081(+) ATCCAG/AGTTCC 1 -- us2k11Minor allele frequency- A:0.01EA 120
    rs1910834671,2
    --38757163(+) ATGAAC/TGGGGA 1 -- us2k10--------
    rs1508796351,2
    --38757175(+) AAAAAA/TGACAT 1 -- us2k10--------
    rs1484005131,2
    C--38757204(+) GGAAA-/TGTGTG
    TGTGTGTG
    TGTGT
    1 -- us2k10--------
    rs1997972291,2
    C--38757204(+) GGAAA-/TGTGTGTGTG
    TGTGTGTGTGTG
    TGTGT
    1 -- us2k10--------
    rs1457535811,2
    --38757231(+) TGTGT-/GTGTGTGTG
    TGTGTGTGTGTG
    TTTTG
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PLEKHA2 (38758753 - 38831431 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PLEKHA2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv516960CNV Loss19592680
    nsv522550CNV Loss19592680
    nsv465637CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607773    OMIM disorders: --

    2 diseases for PLEKHA2:    About MalaCards
    t-cell leukemia    leukemia


    PLEKHA2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PLEKHA2
    Human Genome Epidemiology (HuGE) Navigator: PLEKHA2 (1 document)

    Export disorders for PLEKHA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLEKHA2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with PLEKHA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. (PubMed id 11001876)1, 2, 3 Dowler S.J.... Alessi D.R. (2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (2006)
    4. The tandem PH domain-containing protein 2 (TAPP2) regu lates chemokine-induced cytoskeletal reorganization and malignant B cell migrati on. (PubMed id 23460911)1 Li H....Marshall A.J. (2013)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. TAPP2 links phosphoinositide 3-kinase signaling to B- cell adhesion through interaction with the cytoskeletal protein utrophin: expre ssion of a novel cell adhesion-promoting complex in B-cell leukemia. (PubMed id 19786618)1 Costantini J.L....Marshall A.J. (2009)
    8. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 59339 HGNC: 14336 AceView: PLEKHA2 Ensembl:ENSG00000169499 euGenes: HUgn59339
    ECgene: PLEKHA2 H-InvDB: PLEKHA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLEKHA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLEKHA2 gene:
    Search GeneIP for patents involving PLEKHA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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