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Aliases for PLEKHA2 Gene

Aliases for PLEKHA2 Gene

  • Pleckstrin Homology Domain Containing A2 2 3 5
  • Pleckstrin Homology Domain-Containing, Family A (Phosphoinositide Binding Specific) Member 2 2 3
  • Pleckstrin Homology Domain Containing, Family A (Phosphoinositide Binding Specific) Member 2 2 3
  • PH Domain-Containing Family A Member 2 3 4
  • Tandem PH Domain Containing Protein-2 2 3
  • Tandem PH Domain-Containing Protein 2 3 4
  • TAPP-2 3 4
  • TAPP2 3 4

External Ids for PLEKHA2 Gene

Previous GeneCards Identifiers for PLEKHA2 Gene

  • GC08U990120
  • GC08M038973
  • GC08P038499
  • GC08P038776
  • GC08P037294

Summaries for PLEKHA2 Gene

GeneCards Summary for PLEKHA2 Gene

PLEKHA2 (Pleckstrin Homology Domain Containing A2) is a Protein Coding gene. Among its related pathways are Class I PI3K signaling events and IL-2 Pathway. GO annotations related to this gene include lipid binding and fibronectin binding. An important paralog of this gene is PLEKHA1.

UniProtKB/Swiss-Prot for PLEKHA2 Gene

  • Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHA2 Gene

Genomics for PLEKHA2 Gene

Regulatory Elements for PLEKHA2 Gene

Enhancers for PLEKHA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLEKHA2 on UCSC Golden Path with GeneCards custom track

Promoters for PLEKHA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLEKHA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLEKHA2 Gene

38,901,235 bp from pter
38,973,912 bp from pter
72,678 bases
Plus strand

Genomic View for PLEKHA2 Gene

Genes around PLEKHA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLEKHA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLEKHA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHA2 Gene

Proteins for PLEKHA2 Gene

  • Protein details for PLEKHA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pleckstrin homology domain-containing family A member 2
    Protein Accession:

    Protein attributes for PLEKHA2 Gene

    425 amino acids
    Molecular mass:
    47255 Da
    Quaternary structure:
    • Binds MPDZ and PTPN13.
    • Sequence=AAG15201.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PLEKHA2 Gene

Proteomics data for PLEKHA2 Gene at MOPED

Post-translational modifications for PLEKHA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLEKHA2 Gene

No data available for DME Specific Peptides for PLEKHA2 Gene

Domains & Families for PLEKHA2 Gene

Gene Families for PLEKHA2 Gene

Protein Domains for PLEKHA2 Gene


Suggested Antigen Peptide Sequences for PLEKHA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 PH domains.
  • Contains 2 PH domains.
genes like me logo Genes that share domains with PLEKHA2: view

Function for PLEKHA2 Gene

Molecular function for PLEKHA2 Gene

UniProtKB/Swiss-Prot Function:
Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity).

Gene Ontology (GO) - Molecular Function for PLEKHA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IMP 19786618
GO:0005545 1-phosphatidylinositol binding IEA --
GO:0030165 PDZ domain binding IEA,IBA --
GO:0035091 phosphatidylinositol binding IBA --
genes like me logo Genes that share ontologies with PLEKHA2: view
genes like me logo Genes that share phenotypes with PLEKHA2: view

Animal Model Products

CRISPR Products

miRNA for PLEKHA2 Gene

miRTarBase miRNAs that target PLEKHA2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLEKHA2 Gene

Localization for PLEKHA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLEKHA2 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for PLEKHA2 Gene COMPARTMENTS Subcellular localization image for PLEKHA2 gene
Compartment Confidence
nucleus 4
plasma membrane 4
cytosol 3

Gene Ontology (GO) - Cellular Components for PLEKHA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with PLEKHA2: view

Pathways & Interactions for PLEKHA2 Gene

genes like me logo Genes that share pathways with PLEKHA2: view

Pathways by source for PLEKHA2 Gene

Interacting Proteins for PLEKHA2 Gene

Gene Ontology (GO) - Biological Process for PLEKHA2 Gene


No data available for SIGNOR curated interactions for PLEKHA2 Gene

Drugs & Compounds for PLEKHA2 Gene

No Compound Related Data Available

Transcripts for PLEKHA2 Gene

Unigene Clusters for PLEKHA2 Gene

Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHA2 Gene

No ASD Table

Relevant External Links for PLEKHA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLEKHA2 Gene

mRNA expression in normal human tissues for PLEKHA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLEKHA2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.2), Monocytes (10.2), Vitreous humor (9.1), and Lymph node (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLEKHA2 Gene

SOURCE GeneReport for Unigene cluster for PLEKHA2 Gene Hs.369123

mRNA Expression by UniProt/SwissProt for PLEKHA2 Gene

Tissue specificity: Highly expressed in heart, kidney, spleen and peripheral blood leukocytes. Detected at lower levels in brain, skeletal muscle, colon, thymus, liver, small intestine, placenta and lung.
genes like me logo Genes that share expression patterns with PLEKHA2: view

Protein tissue co-expression partners for PLEKHA2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for PLEKHA2 Gene

Orthologs for PLEKHA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLEKHA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PLEKHA2 35
  • 89.49 (n)
  • 92.24 (a)
  • 92 (a)
(Canis familiaris)
Mammalia PLEKHA2 35
  • 90.04 (n)
  • 90.82 (a)
  • 91 (a)
(Mus musculus)
Mammalia Plekha2 35
  • 86.12 (n)
  • 88.71 (a)
Plekha2 16
Plekha2 36
  • 89 (a)
(Pan troglodytes)
Mammalia PLEKHA2 35
  • 99.47 (n)
  • 99.73 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Plekha2 35
  • 84.94 (n)
  • 87.06 (a)
(Monodelphis domestica)
Mammalia PLEKHA2 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia PLEKHA2 36
  • 72 (a)
(Gallus gallus)
Aves PLEKHA2 35
  • 72.65 (n)
  • 76.66 (a)
TAPP2 36
  • 74 (a)
(Anolis carolinensis)
Reptilia PLEKHA2 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia plekha2 35
  • 63.25 (n)
  • 63.75 (a)
(Danio rerio)
Actinopterygii si:ch211-204d2.4 35
  • 57.84 (n)
  • 56.88 (a)
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
Species with no ortholog for PLEKHA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLEKHA2 Gene

Gene Tree for PLEKHA2 (if available)
Gene Tree for PLEKHA2 (if available)

Paralogs for PLEKHA2 Gene

Paralogs for PLEKHA2 Gene

(1) SIMAP similar genes for PLEKHA2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PLEKHA2: view

Variants for PLEKHA2 Gene

Sequence variations from dbSNP and Humsavar for PLEKHA2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs59439576 - 38,952,236(+) TTACA(A/T)CCCCA intron-variant, reference, missense
rs2056170 -- 38,906,198(+) GGCTG(C/T)GTGCC intron-variant
rs7835508 -- 38,925,109(+) CACGA(C/T)GTAAT intron-variant
rs7836041 -- 38,910,266(+) ATACA(G/T)TTTTT intron-variant
rs7840719 -- 38,908,882(+) gctca(C/T)gcctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLEKHA2 Gene

Variant ID Type Subtype PubMed ID
nsv465637 CNV Loss 19166990
nsv522550 CNV Loss 19592680
nsv516960 CNV Loss 19592680

Variation tolerance for PLEKHA2 Gene

Gene Damage Index Score: 2.22; 39.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PLEKHA2 Gene

Disorders for PLEKHA2 Gene

Relevant External Links for PLEKHA2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PLEKHA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLEKHA2 Gene

Publications for PLEKHA2 Gene

  1. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. (PMID: 11001876) Dowler S.J. … Alessi D.R. (Biochem. J. 2000) 2 3 4 67
  2. The tandem PH domain-containing protein 2 (TAPP2) regulates chemokine-induced cytoskeletal reorganization and malignant B cell migration. (PMID: 23460911) Li H. … Marshall A.J. (PLoS ONE 2013) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemia. (PMID: 19786618) Costantini J.L. … Marshall A.J. (Blood 2009) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for PLEKHA2 Gene

Sources for PLEKHA2 Gene